Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 213 (07 Apr 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Huntingtin

Gene

HTT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in microtubule-mediated transport or vesicle function.
Promotes the formation of autophagic vesicles.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P42858

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9022692, Regulation of MECP2 expression and activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P42858

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P42858

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P42858, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Huntingtin
Alternative name(s):
Huntington disease protein
Short name:
HD protein
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTT
Synonyms:HD, IT15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4851, HTT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613004, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P42858

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000197386.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Huntington disease (HD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder characterized by involuntary movements (chorea), general motor impairment, psychiatric disorders and dementia. Onset of the disease occurs usually in the third or fourth decade of life. Onset and clinical course depend on the degree of poly-Gln repeat expansion, longer expansions resulting in earlier onset and more severe clinical manifestations. Neuropathology of Huntington disease displays a distinctive pattern with loss of neurons, especially in the caudate and putamen.
Related information in OMIM
Lopes-Maciel-Rodan syndrome (LOMARS)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by developmental regression in infancy, delayed psychomotor development, severe intellectual disability, and cerebral and cerebellar atrophy. Additional features include swallowing problems, dystonia, bradykinesia, and continuous manual stereotypies without chorea. Some patients manifest seizures.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079026703P → L in LOMARS. 1 PublicationCorresponds to variant dbSNP:rs768047421Ensembl.1
Natural variantiVAR_0790272717F → L in LOMARS. 1 PublicationCorresponds to variant dbSNP:rs1085307052Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi495I → A: Inhibits interaction with ZDHHC13 and ZDHHC17. 1 Publication1
Mutagenesisi498 – 499QP → AA: Abolishes interaction with ZDHHC17. 1 Publication2
Mutagenesisi498Q → A: Inhibits interaction with ZDHHC13 and ZDHHC17. 1 Publication1
Mutagenesisi499P → A: Inhibits interaction with ZDHHC13 and ZDHHC17. 1 Publication1
Mutagenesisi511D → A: Loss of proteolytic cleavage. 1 Publication1
Mutagenesisi528D → A: No effect on proteolytic cleavage. 1 Publication1
Mutagenesisi550D → E: Loss of proteolytic cleavage. Loss of myristoylation. 1 Publication1
Mutagenesisi551G → A: Loss of myristoylation. 2 Publications1
Mutagenesisi551G → S: Loss of myristoylation. 1 Publication1
Mutagenesisi584D → A: Loss of proteolytic cleavage. 1 Publication1

Keywords - Diseasei

Disease variant, Mental retardation, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
3064

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
HTT

MalaCards human disease database

More...
MalaCardsi
HTT
MIMi143100, phenotype
617435, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000197386

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
399, Huntington disease
248111, Juvenile Huntington disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164741646

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P42858, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5514

Drug and drug target database

More...
DrugBanki
DB09130, Copper

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HTT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434520

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000839421 – 3142HuntingtinAdd BLAST3142
ChainiPRO_0000447477551 – 584Huntingtin, myristoylated N-terminal fragmentAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9N6-acetyllysine1 Publication1
Modified residuei176N6-acetyllysine1 Publication1
Modified residuei234N6-acetyllysine1 Publication1
Modified residuei343N6-acetyllysine1 Publication1
Modified residuei411PhosphoserineCombined sources1
Modified residuei417PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei432PhosphoserineCombined sources1
Modified residuei442N6-acetyllysine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi551N-myristoyl glycine2 Publications1
Modified residuei640PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Modified residuei1179Phosphoserine; by CDK51 Publication1
Modified residuei1199Phosphoserine; by CDK5Combined sources1 Publication1
Modified residuei1870PhosphoserineCombined sources1
Modified residuei1874PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by caspases downstream of the polyglutamine stretch (PubMed:8696339, PubMed:9535906, PubMed:10770929, PubMed:29802276). The resulting N-terminal fragments are cytotoxic and provokes apoptosis (PubMed:10770929).4 Publications
Forms with expanded polyglutamine expansion are specifically ubiquitinated by SYVN1, which promotes their proteasomal degradation.1 Publication
Phosphorylation at Ser-1179 and Ser-1199 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.1 Publication
Myristoylated at Gly-551, following proteolytic cleavage at Asp-550.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei511 – 512Cleavage; by caspase-31 Publication2
Sitei528 – 529Cleavage; by caspase-3Sequence analysis2
Sitei550 – 551Cleavage; by caspase-31 Publication2
Sitei584 – 585Cleavage; by caspase-61 Publication2
Sitei587 – 588Cleavage; by caspase-3Sequence analysis2

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P42858

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P42858

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P42858

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P42858

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P42858

PeptideAtlas

More...
PeptideAtlasi
P42858

PRoteomics IDEntifications database

More...
PRIDEi
P42858

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55561

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P42858

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P42858

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P42858

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P42858

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197386, Expressed in sural nerve and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P42858, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P42858, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197386, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PFN1 (PubMed:18573880).

Interacts through its N-terminus with PRPF40A (PubMed:9700202).

Interacts with PQBP1 (PubMed:10332029).

Interacts with SETD2 (PubMed:9700202, PubMed:10958656, PubMed:11461154).

Interacts with SH3GLB1 (By similarity).

Interacts with SYVN (PubMed:17141218).

Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch (PubMed:15654337).

Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635).

Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635, PubMed:28882895, PubMed:28757145).

Interacts with F8A1/F8A2/F8A3 (PubMed:29466333, PubMed:16476778).

Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A (PubMed:16476778).

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P42858
With#Exp.IntAct
AAMDC [Q9H7C9]3EBI-466029,EBI-10308705
ABHD17C [Q6PCB6]21EBI-466029,EBI-22011868
ABT1 [Q9ULW3]9EBI-466029,EBI-2602396
ACTB [P60709]3EBI-466029,EBI-353944
ACTG1 [P63261]16EBI-466029,EBI-351292
ACTR1B [P42025]3EBI-466029,EBI-367493
ADIPOQ [Q15848]9EBI-466029,EBI-10827839
AFG3L2 [Q9Y4W6]3EBI-466029,EBI-358755
AGK [Q53H12]3EBI-466029,EBI-2269837
AGK - isoform 2 [Q53H12-2]12EBI-466029,EBI-25944242
AHDC1 [Q5TGY3]12EBI-466029,EBI-948813
AK3 [Q9UIJ7]9EBI-466029,EBI-3916527
AKR1A1 [P14550]6EBI-466029,EBI-372388
AKT1 [P31749]3EBI-466029,EBI-296087
ALDH1L2 [Q3SY69]3EBI-466029,EBI-6916128
ALDOA - isoform 2 [P04075-2]6EBI-466029,EBI-10194102
ALG2 [Q9H553]3EBI-466029,EBI-25806804
ANKHD1 - isoform 3 [Q8IWZ3-3]3EBI-466029,EBI-25833200
ANKRD13D - isoform 2 [Q6ZTN6-2]9EBI-466029,EBI-25840993
ANKRD45 - isoform 2 [Q5TZF3-1]3EBI-466029,EBI-22011535
AOC3 [Q16853]3EBI-466029,EBI-3921628
AP2B1 - isoform 2 [P63010-2]18EBI-466029,EBI-11529439
AP3B1 [O00203]6EBI-466029,EBI-1044383
AP3M1 [Q9Y2T2]3EBI-466029,EBI-2371151
APP [P05067]6EBI-466029,EBI-77613
ARCN1 [P48444]3EBI-466029,EBI-1044491
ARFGAP3 [Q9NP61]22EBI-466029,EBI-2875816
ARFIP2 [P53365]3EBI-466029,EBI-638194
ARHGAP24 [Q8N264]3EBI-466029,EBI-988764
ARHGAP29 - isoform 2 [Q52LW3-2]3EBI-466029,EBI-22012297
ARL16 [Q0P5N6]18EBI-466029,EBI-10186132
ARMCX5 [Q6P1M9]6EBI-466029,EBI-10252512
ARNT2 [Q86TN1]9EBI-466029,EBI-25844820
ASB3 - isoform 3 [Q9Y575-3]6EBI-466029,EBI-14199987
ASCL4 [Q6XD76]6EBI-466029,EBI-10254793
ASIC4 - isoform 3 [Q96FT7-4]3EBI-466029,EBI-9089489
ASPH - isoform 6 [Q12797-6]6EBI-466029,EBI-12092171
ASPH - isoform 7 [Q12797-7]3EBI-466029,EBI-25953099
ATG4C [Q96DT6]15EBI-466029,EBI-3225845
ATL1 [Q8WXF7]18EBI-466029,EBI-2410266
ATP5F1A [P25705]3EBI-466029,EBI-351437
ATP5PB [P24539]3EBI-466029,EBI-1044810
ATP5PO [P48047]6EBI-466029,EBI-355815
ATP6AP1 [Q15904]3EBI-466029,EBI-714667
ATP6V0D1 [P61421]6EBI-466029,EBI-954063
ATP6V1B2 [P21281]3EBI-466029,EBI-4290814
ATP6V1H [Q9UI12]3EBI-466029,EBI-724719
BAIAP2 - isoform 3 [Q9UQB8-3]18EBI-466029,EBI-9091996
BAIAP2 - isoform 6 [Q9UQB8-6]18EBI-466029,EBI-9092016
BATF [Q16520]12EBI-466029,EBI-749503
BAZ1A [Q9NRL2]4EBI-466029,EBI-927511
BBX - isoform 3 [Q8WY36-3]6EBI-466029,EBI-22013474
BCAP31 [P51572]4EBI-466029,EBI-77683
BECN1 [Q14457]14EBI-466029,EBI-949378
BEX3 [Q00994]6EBI-466029,EBI-741753
BIRC5 [O15392]15EBI-466029,EBI-518823
BPESC1 [Q9GZL8]15EBI-466029,EBI-25861458
BRCA1 - isoform 6 [P38398-6]3EBI-466029,EBI-25833510
BRK1 [Q8WUW1]6EBI-466029,EBI-2837444
C11orf49 - isoform 2 [Q9H6J7-2]6EBI-466029,EBI-13328871
C12orf74 [Q32Q52]12EBI-466029,EBI-12891828
C1D [Q13901]6EBI-466029,EBI-3844053
C1orf94 [Q6P1W5]3EBI-466029,EBI-946029
C1QTNF3 [Q9BXJ4]3EBI-466029,EBI-10697546
C20orf141 [Q9NUB4]6EBI-466029,EBI-9088162
C22orf39 - isoform 2 [Q6P5X5-2]3EBI-466029,EBI-10692329
C7orf31 [Q8N865]3EBI-466029,EBI-10174456
C7orf50 [Q9BRJ6]6EBI-466029,EBI-751612
C9orf16 [Q9BUW7]6EBI-466029,EBI-752084
CABCOCO1 [Q8IVU9]3EBI-466029,EBI-21771960
CALM3 [P0DP25]10EBI-466029,EBI-397435
CAMK1 [Q14012]3EBI-466029,EBI-6380130
CAMKK1 - isoform 2 [Q8N5S9-2]9EBI-466029,EBI-25850646
CAPN10 [Q9HC96]12EBI-466029,EBI-3915761
CASP1 - isoform Gamma [P29466-3]3EBI-466029,EBI-12248206
CASP3 [P42574]9EBI-466029,EBI-524064
CASP6 [P55212]15EBI-466029,EBI-718729
CASP7 [P55210]12EBI-466029,EBI-523958
CBL [P22681]18EBI-466029,EBI-518228
CBSL [P0DN79]12EBI-466029,EBI-14245939
CBWD3 [Q5JTY5]6EBI-466029,EBI-723434
CBX1 [P83916]15EBI-466029,EBI-78129
CCDC120 [Q96HB5]3EBI-466029,EBI-744556
CCDC7 - isoform 3 [Q96M83-3]18EBI-466029,EBI-18211613
CCDC9 [Q9Y3X0]3EBI-466029,EBI-2557532
CCIN [Q13939]3EBI-466029,EBI-25879469
CCNB1IP1 [Q9NPC3]6EBI-466029,EBI-745269
CCNC [P24863]9EBI-466029,EBI-395261
CCNE2 [O96020]6EBI-466029,EBI-375033
CCNG1 [P51959]3EBI-466029,EBI-3905829
CCT2 [P78371]6EBI-466029,EBI-357407
CCT5 [P48643]3EBI-466029,EBI-355710
CCT6A [P40227]10EBI-466029,EBI-356687
CCT8 [P50990]4EBI-466029,EBI-356507
CD59 [P13987]10EBI-466029,EBI-297972
CDC42EP4 [Q9H3Q1]3EBI-466029,EBI-744665
CDC5L [Q99459]3EBI-466029,EBI-374880
CDC7 [O00311]3EBI-466029,EBI-374980
CDCA7 [Q9BWT1]3EBI-466029,EBI-7054803
CDH13 [P55290]6EBI-466029,EBI-7205595
CDS2 [O95674]9EBI-466029,EBI-3913685
CENPS [Q8N2Z9]3EBI-466029,EBI-5529649
CENPV [Q7Z7K6]15EBI-466029,EBI-1210604
CEP126 [Q9P2H0]2EBI-466029,EBI-473176
CEP55 [Q53EZ4]9EBI-466029,EBI-747776
CEP63 - isoform 3 [Q96MT8-3]12EBI-466029,EBI-11522539
CEP70 - isoform 3 [Q8NHQ1-3]6EBI-466029,EBI-11526150
CETN2 [P41208]13EBI-466029,EBI-1789926
CHCHD2 [Q9Y6H1]10EBI-466029,EBI-2321769
CHCHD3 [Q9NX63]6EBI-466029,EBI-743375
CHD3 [Q12873]3EBI-466029,EBI-523590
CHMP1A [Q9HD42]12EBI-466029,EBI-1057156
CHMP2A [O43633]3EBI-466029,EBI-2692789
CHMP4B [Q9H444]7EBI-466029,EBI-749627
CIDEB [Q9UHD4]3EBI-466029,EBI-7062247
CKM [P06732]3EBI-466029,EBI-4287089
CLEC11A [Q9Y240]12EBI-466029,EBI-3957044
CLEC2B [Q92478]9EBI-466029,EBI-13350535
CLPP [Q16740]6EBI-466029,EBI-1056029
CLRN3 [Q8NCR9]9EBI-466029,EBI-9091272
CNOT10 [Q9H9A5]4EBI-466029,EBI-1054261
CNOT10 - isoform 3 [Q9H9A5-3]3EBI-466029,EBI-25957177
CNOT7 [Q9UIV1]13EBI-466029,EBI-2105113
CNP [P09543]10EBI-466029,EBI-1059219
COG8 [Q96MW5]12EBI-466029,EBI-720875
COPB1 [P53618]6EBI-466029,EBI-359063
COPS3 [Q9UNS2]22EBI-466029,EBI-350590
COX4I1 [Q86WV2]3EBI-466029,EBI-10260134
COX5B [P10606]7EBI-466029,EBI-1053725
COX6A1 [P12074]4EBI-466029,EBI-2115950
COX6C [P09669]4EBI-466029,EBI-715040
CPSF3 [Q9UKF6]3EBI-466029,EBI-1044699
CPT1B [A2RRE8]6EBI-466029,EBI-25865477
CRACR2A [Q9BSW2]9EBI-466029,EBI-739773
CREB1 [P16220]3EBI-466029,EBI-711855
CREBBP [Q92793]2EBI-466029,EBI-81215
CRELD2 - isoform 2 [Q6UXH1-2]6EBI-466029,EBI-21670927
CRK [P46108]3EBI-466029,EBI-886
CRMP1 [Q14194]14EBI-466029,EBI-473101
CRYAA2 [A0A140G945]3EBI-466029,EBI-25838900
CRYBA2 [P53672]3EBI-466029,EBI-750444
CSF2 [P04141]15EBI-466029,EBI-1809826
CSNK1D - isoform 2 [P48730-2]15EBI-466029,EBI-9087876
CSRP3 [P50461]3EBI-466029,EBI-5658719
CTBP2 - isoform 3 [P56545-3]3EBI-466029,EBI-10171902
CTNNB1 [P35222]14EBI-466029,EBI-491549
CUL3 [Q13618]3EBI-466029,EBI-456129
CUL5 [Q93034]10EBI-466029,EBI-1057139
CXorf38 [Q8TB03]15EBI-466029,EBI-12024320
CYC1 [P08574]7EBI-466029,EBI-1224514
CYP3A5 [P20815]3EBI-466029,EBI-3908011
DALRD3 - isoform 2 [Q5D0E6-2]9EBI-466029,EBI-9090939
DAPP1 [Q9UN19]9EBI-466029,EBI-3918199
DAXX [Q9UER7]15EBI-466029,EBI-77321
DAZAP2 [Q15038]3EBI-466029,EBI-724310
DBNL [Q9UJU6]3EBI-466029,EBI-751783
DCAF7 [P61962]10EBI-466029,EBI-359808
DCLRE1B [Q9H816]9EBI-466029,EBI-3508943
DCTN2 [Q13561]12EBI-466029,EBI-715074
DCTN4 [Q9UJW0]3EBI-466029,EBI-2134033
DDX20 [Q9UHI6]6EBI-466029,EBI-347658
DDX21 [Q9NR30]3EBI-466029,EBI-357942
DDX39A [O00148]3EBI-466029,EBI-348253
DDX41 [Q9UJV9]6EBI-466029,EBI-1046350
DELE1 [Q14154]18EBI-466029,EBI-2805660
DENND2B [P78524]3EBI-466029,EBI-962633
DES [P17661]9EBI-466029,EBI-1055572
DEUP1 [Q05D60]15EBI-466029,EBI-748597
DIPK1A - isoform 2 [Q5T7M9-2]3EBI-466029,EBI-25960650
DLD [P09622]3EBI-466029,EBI-353366
DLST [P36957]3EBI-466029,EBI-351007
DLX3 [O60479]3EBI-466029,EBI-3908248
DNAJA1 [P31689]17EBI-466029,EBI-347834
DNAJA3 [Q96EY1]5EBI-466029,EBI-356767
DNAJB4 [Q9UDY4]3EBI-466029,EBI-356960
DNAJB6 - isoform B [O75190-2]3EBI-466029,EBI-12593112
DNAJC11 [Q9NVH1]3EBI-466029,EBI-1055336
DNAJC21 [Q5F1R6]6EBI-466029,EBI-2654581
DNAJC4 [Q9NNZ3]12EBI-466029,EBI-4397791
DNALI1 [O14645]15EBI-466029,EBI-395638
DNM1 [Q05193]3EBI-466029,EBI-713135
DNM2 - isoform 2 [P50570-2]6EBI-466029,EBI-10968534
DNTTIP1 [Q9H147]15EBI-466029,EBI-2795449
DPAGT1 [Q9H3H5]3EBI-466029,EBI-3922860
DPYSL2 [Q16555]3EBI-466029,EBI-1104711
DPYSL5 [Q9BPU6]9EBI-466029,EBI-724653
DYNC1H1 [Q14204]8EBI-466029,EBI-356015
DYNLL1 [P63167]10EBI-466029,EBI-349105
E2F8 [A0AVK6]12EBI-466029,EBI-7779316
ECH1 [Q13011]2EBI-466029,EBI-711968
EDF1 [O60869]6EBI-466029,EBI-781301
EDRF1 [Q3B7T1]18EBI-466029,EBI-2870947
EEF1A2 [Q05639]3EBI-466029,EBI-354943
EEF1B2 [P24534]7EBI-466029,EBI-354334
EEF1D [P29692]6EBI-466029,EBI-358607
EEF2 [P13639]3EBI-466029,EBI-352560
EFEMP1 [Q12805]3EBI-466029,EBI-536772
EIF1AY [O14602]6EBI-466029,EBI-286439
EIF2S2 [P20042]12EBI-466029,EBI-711977
EIF2S3 [P41091]3EBI-466029,EBI-1054228
EIF3G [O75821]4EBI-466029,EBI-366632
EIF3I [Q13347]13EBI-466029,EBI-354047
EIF4A2 - isoform 2 [Q14240-2]3EBI-466029,EBI-10232522
EIF4E2 [O60573]4EBI-466029,EBI-398610
EIF5 [P55010]3EBI-466029,EBI-286450
ELP1 [O95163]4EBI-466029,EBI-347559
EMILIN1 - isoform 2 [Q9Y6C2-2]3EBI-466029,EBI-11748557
ENKUR [Q8TC29]6EBI-466029,EBI-9246952
ENO1 [P06733]13EBI-466029,EBI-353877
ENTPD2 [Q9Y5L3]3EBI-466029,EBI-3913907
ENTPD5 [O75356]3EBI-466029,EBI-7416931
EPB41L1 [A0A0C4DH22]6EBI-466029,EBI-25865535
EPS8L1 - isoform 3 [Q8TE68-3]3EBI-466029,EBI-21574901
ERCC6L [Q2NKX8]20EBI-466029,EBI-1042535
ERICH2 [A1L162]3EBI-466029,EBI-2682520
ERP27 [Q96DN0]3EBI-466029,EBI-953772
ESRP1 - isoform 3 [Q6NXG1-3]6EBI-466029,EBI-21567429
EVL - isoform 1 [Q9UI08-2]20EBI-466029,EBI-6448852
EWSR1 - isoform 4 [Q01844-4]3EBI-466029,EBI-25896785
EXOC5 [O00471]3EBI-466029,EBI-949824
EYA3 [Q99504]6EBI-466029,EBI-9089567
EZR [P15311]4EBI-466029,EBI-1056902
F8A3 [P23610]3EBI-466029,EBI-5663973
FAM111B [Q6SJ93]12EBI-466029,EBI-6309082
FAM163A [Q96GL9]12EBI-466029,EBI-11793142
FAM167A [Q96KS9]6EBI-466029,EBI-10290462
FAM76B - isoform 3 [Q5HYJ3-3]6EBI-466029,EBI-11956087
FAM78A [Q5JUQ0]3EBI-466029,EBI-21900888
FAM9A [Q8IZU1]18EBI-466029,EBI-8468186
FANCF [Q9NPI8]3EBI-466029,EBI-81589
FANK1 [Q8TC84]3EBI-466029,EBI-21975404
FARSB [Q9NSD9]3EBI-466029,EBI-353803
FASN [P49327]13EBI-466029,EBI-356658
FASTKD1 [Q53R41]9EBI-466029,EBI-3957005
FBH1 [Q8NFZ0]6EBI-466029,EBI-724767
FBP1 [P09467]3EBI-466029,EBI-712740
FEZ1 [Q99689]6EBI-466029,EBI-396435
FEZ2 [Q9UHY8]18EBI-466029,EBI-396453
FHL3 [Q13643]9EBI-466029,EBI-741101
FICD [Q9BVA6]3EBI-466029,EBI-3907198
FKBP2 [P26885]6EBI-466029,EBI-719873
FLOT1 [O75955]4EBI-466029,EBI-603643
FNBP4 [Q8N3X1]6EBI-466029,EBI-310600
FOXD4L6 [Q3SYB3]6EBI-466029,EBI-6425864
FOXR1 [Q6PIV2]12EBI-466029,EBI-10253815
FSBP - isoform 2 [O95073-2]3EBI-466029,EBI-10696047
FTL [P02792]20EBI-466029,EBI-713279
FYN - isoform 3 [P06241-3]12EBI-466029,EBI-10691738
FZD4 [Q9ULV1]9EBI-466029,EBI-2466380
G2E3 [Q7L622]6EBI-466029,EBI-751757
G3BP1 [Q13283]16EBI-466029,EBI-1047359
GAB2 [Q9UQC2]3EBI-466029,EBI-975200
GALNT4 [Q8N4A0]12EBI-466029,EBI-21555925
GAPDH [P04406]7EBI-466029,EBI-354056
GCA [P28676]3EBI-466029,EBI-947242
GFAP [P14136]10EBI-466029,EBI-744302
GFOD1 [Q9NXC2]9EBI-466029,EBI-8799578
GIMAP2 [Q9UG22]6EBI-466029,EBI-15891037
GIT1 [Q9Y2X7]10EBI-466029,EBI-466061
GLIPR1 [P48060]3EBI-466029,EBI-2833130
GNAO1 [P09471]7EBI-466029,EBI-715087
GNB1 [P62873]10EBI-466029,EBI-357130
GNB2 [P62879]10EBI-466029,EBI-356942
GOLGA2 [Q08379]3EBI-466029,EBI-618309
GOLPH3L [Q9H4A5]20EBI-466029,EBI-4403434
GPC3 [Q8IYG2]3EBI-466029,EBI-25896879
GPM6A [P51674]4EBI-466029,EBI-7187133
GPM6A [Q86YB0]3EBI-466029,EBI-25966592
GPR141 [Q7Z602]3EBI-466029,EBI-21649723
GPRASP2 [Q96D09]5EBI-466029,EBI-473189
GPX7 [Q96SL4]3EBI-466029,EBI-749411
GRAP [Q13588]12EBI-466029,EBI-2847510
GRIK2 [Q8IY40]9EBI-466029,EBI-25832107
GSK3A [P49840]6EBI-466029,EBI-1044067
GTF3C3 [Q9Y5Q9]12EBI-466029,EBI-1054873
GTPBP4 [Q9BZE4]3EBI-466029,EBI-1056249
H2AP [O75409]16EBI-466029,EBI-6447217
H2BC9 [Q93079]18EBI-466029,EBI-352469
H3-5 [Q6NXT2]15EBI-466029,EBI-2868501
H3C12 [P68431]20EBI-466029,EBI-79722
H3C15 [Q71DI3]18EBI-466029,EBI-750650
H4C9 [P62805]3EBI-466029,EBI-302023
HADHA [P40939]3EBI-466029,EBI-356720
HAP1 - isoform 2 [P54257-2]8EBI-466029,EBI-9392340
HAUS7 [Q99871]18EBI-466029,EBI-395719
HAX1 [O00165]14EBI-466029,EBI-357001
hCG_1998195 [Q8N779]15EBI-466029,EBI-10267476
HDAC10 [Q969S8]21EBI-466029,EBI-301762
HDAC6 [Q9UBN7]9EBI-466029,EBI-301697
HES4 [Q9HCC6]12EBI-466029,EBI-2680288
HEY2 [Q9UBP5]2EBI-466029,EBI-750630
HIP1 [O00291]7EBI-466029,EBI-473886
HIRIP3 [Q9BW71]6EBI-466029,EBI-723624
HK3 [P52790]3EBI-466029,EBI-2965780
HMBS [P08397]3EBI-466029,EBI-9090148
HMG20A [Q9NP66]2EBI-466029,EBI-740641
HMG20B [Q9P0W2]3EBI-466029,EBI-713401
HMGB1 [P09429]13EBI-466029,EBI-389432
HNRNPC [P07910]7EBI-466029,EBI-357966
HNRNPC - isoform C1 [P07910-2]9EBI-466029,EBI-5280084
HNRNPK [P61978]12EBI-466029,EBI-304185
HOXA5 [P20719]9EBI-466029,EBI-8470697
HOXC11 [O43248]7EBI-466029,EBI-2652631
HOXC4 [P09017]16EBI-466029,EBI-3923226
HPRT1 [P00492]15EBI-466029,EBI-748210
HSPA1A [P0DMV8]10EBI-466029,EBI-11820565
HSPA2 [P54652]3EBI-466029,EBI-356991
HSPA8 [P11142]14EBI-466029,EBI-351896
itself11EBI-466029,EBI-466029
HYAL2 [Q12891]9EBI-466029,EBI-2806068
HYPK [Q9NX55]4EBI-466029,EBI-1048743
ID2 [Q02363]6EBI-466029,EBI-713450
IFT20 - isoform 2 [Q8IY31-2]6EBI-466029,EBI-11742277
IFT20 - isoform 3 [Q8IY31-3]18EBI-466029,EBI-9091197
IFT57 [Q9NWB7]3EBI-466029,EBI-725672
IGFBP4 [P22692]6EBI-466029,EBI-2831948
IL16 - isoform 2 [Q14005-2]15EBI-466029,EBI-17178971
IMMT [Q16891]7EBI-466029,EBI-473801
IMPA1 - isoform 3 [P29218-3]6EBI-466029,EBI-12330251
ING4 [Q9UNL4]3EBI-466029,EBI-2866661
ING5 - isoform 2 [Q8WYH8-2]18EBI-466029,EBI-21602071
INO80E [Q8NBZ0]3EBI-466029,EBI-769401
IPO4 [Q8TEX9]7EBI-466029,EBI-395967
IPO5 - isoform 3 [O00410-3]3EBI-466029,EBI-9641587
IQSEC1 - isoform 2 [Q6DN90-2]18EBI-466029,EBI-21911304
JAKMIP1 [Q96N16]10EBI-466029,EBI-2680803
KAT5 [Q92993]15EBI-466029,EBI-399080
KCNAB2 [Q13303]3EBI-466029,EBI-948729
KCNMB2 [Q9Y691]3EBI-466029,EBI-7932244
KCTD15 - isoform 2 [Q96SI1-2]6EBI-466029,EBI-12382297
KCTD17 [Q8N5Z5]3EBI-466029,EBI-743960
KIAA0040 [A0A384DVV8]3EBI-466029,EBI-20764875
KIAA0408 [Q6ZU52]6EBI-466029,EBI-739493
KIAA1217 - isoform 6 [Q5T5P2-6]3EBI-466029,EBI-10188326
KLF11 [O14901]7EBI-466029,EBI-948266
KLF12 [Q9Y4X4]3EBI-466029,EBI-750750
KLF3 [P57682]6EBI-466029,EBI-8472267
KLHL12 [Q53G59]3EBI-466029,EBI-740929
KLHL20 [Q9Y2M5]9EBI-466029,EBI-714379
KLK8 [O60259]3EBI-466029,EBI-3915857
KMO - isoform 2 [O15229-2]3EBI-466029,EBI-21870540
KNSTRN [Q9Y448]3EBI-466029,EBI-373334
KPNA3 [O00505]11EBI-466029,EBI-358297
KRT18 [P05783]6EBI-466029,EBI-297888
KRT19 [P08727]6EBI-466029,EBI-742756
KRT20 [P35900]9EBI-466029,EBI-742094
KRT33B [Q14525]12EBI-466029,EBI-1049638
KRTAP10-7 [P60409]9EBI-466029,EBI-10172290
KRTAP11-1 [Q8IUC1]3EBI-466029,EBI-1052037
KRTAP8-1 [Q8IUC2]6EBI-466029,EBI-10261141
KRTAP9-2 [Q9BYQ4]9EBI-466029,EBI-1044640
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-466029,EBI-11985629
LANCL1 [O43813]10EBI-466029,EBI-3046631
LARP4B [Q92615]3EBI-466029,EBI-1052558
LCA5L [O95447]18EBI-466029,EBI-8473670
LCE1B [Q5T7P3]15EBI-466029,EBI-10245913
LDB1 - isoform 3 [Q86U70-2]3EBI-466029,EBI-11979761
LDHAL6B [Q9BYZ2]18EBI-466029,EBI-1108377
LDHB [P07195]9EBI-466029,EBI-358748
LDOC1 [O95751]5EBI-466029,EBI-740738
LGALS14 [Q8TCE9]3EBI-466029,EBI-10274069
LHX5 [Q9H2C1]15EBI-466029,EBI-25835523
LHX6 [Q9UPM6]12EBI-466029,EBI-10258746
LHX8 [Q68G74]12EBI-466029,EBI-8474075
LIN28A [Q9H9Z2]18EBI-466029,EBI-2462365
LINC00518 [Q8N0U6]6EBI-466029,EBI-10264791
LMAN2L [Q9H0V9]3EBI-466029,EBI-9091707
LNX1 [Q8TBB1]6EBI-466029,EBI-739832
LNX2 [Q8N448]3EBI-466029,EBI-2340947
LOC401296 [A2RU56]9EBI-466029,EBI-9088215
LONRF2 [Q1L5Z9]3EBI-466029,EBI-2510853
LPIN1 [Q14693]12EBI-466029,EBI-5278370
LRRC45 [Q96CN5]3EBI-466029,EBI-2805176
LRRFIP1 [Q32MZ4]3EBI-466029,EBI-1369100
LSM8 [O95777]15EBI-466029,EBI-347779
LUC7L2 [Q9Y383]9EBI-466029,EBI-352851
LYG1 [Q8N1E2]3EBI-466029,EBI-13309213
MAF1 [Q9H063]3EBI-466029,EBI-720354
MAGEA3 [P43357]6EBI-466029,EBI-5651459
MAGEB18 [Q96M61]16EBI-466029,EBI-741835
MAGEB6 [Q8N7X4]2EBI-466029,EBI-6447163
MALSU1 [Q96EH3]6EBI-466029,EBI-2339737
MAP3K5 [Q99683]6EBI-466029,EBI-476263
MAT1A [Q00266]3EBI-466029,EBI-967087
MATR3 [P43243]4EBI-466029,EBI-352602
MAZ - isoform 2 [P56270-2]3EBI-466029,EBI-12068586
MBD1 [Q9UIS9]2EBI-466029,EBI-867196
MBD4 - isoform 2 [O95243-2]19EBI-466029,EBI-6448717
MCRS1 [Q96EZ8]3EBI-466029,EBI-348259
MEAF6 [Q9HAF1]6EBI-466029,EBI-399266
MECP2 [P51608]18EBI-466029,EBI-1189067
MED15 [Q96RN5]3EBI-466029,EBI-394506
MED15 - isoform 2 [Q96RN5-2]6EBI-466029,EBI-11030807
MED22 - isoform Surf5A [Q15528-2]12EBI-466029,EBI-12954271
MED28 [Q9H204]9EBI-466029,EBI-514199
MED30 [Q96HR3]3EBI-466029,EBI-394659
MED31 [Q9Y3C7]9EBI-466029,EBI-394707
MEOX1 [P50221]19EBI-466029,EBI-2864512
METTL27 [Q8N6F8]9EBI-466029,EBI-8487781
MGARP [Q8TDB4]21EBI-466029,EBI-4397720
MICAL2 [O94851]3EBI-466029,EBI-2804835
MKL1 [A4FUJ8]15EBI-466029,EBI-21250407
MKNK1 [Q9BUB5]18EBI-466029,EBI-73837
MKRN2 [Q9H000]12EBI-466029,EBI-2341005
MMUT [P22033]12EBI-466029,EBI-2690467
MNAT1 [P51948]9EBI-466029,EBI-716139
MNDA [P41218]18EBI-466029,EBI-2829677
MOG - isoform 13 [Q16653-13]12EBI-466029,EBI-24226707
MORF4L2 [Q15014]12EBI-466029,EBI-399257
MPND [Q8N594]3EBI-466029,EBI-2512452
MPP5 [Q8N3R9]3EBI-466029,EBI-2513978
MRE11 [P49959]5EBI-466029,EBI-396513
MRFAP1 [Q9Y605]19EBI-466029,EBI-995714
MRFAP1L1 [Q96HT8]21EBI-466029,EBI-748896
MRPL13 [Q9BYD1]3EBI-466029,EBI-1054936
MSH5 - isoform 4 [O43196-4]3EBI-466029,EBI-25860238
MSRB2 [Q9Y3D2]12EBI-466029,EBI-9092052
MSX2 [P35548]12EBI-466029,EBI-6447480
MT2A [P02795]6EBI-466029,EBI-996616
MTSS1 [O43312]3EBI-466029,EBI-473954
MTUS1 - isoform 3 [Q9ULD2-3]3EBI-466029,EBI-18051665
MTUS1 - isoform 4 [Q9ULD2-4]9EBI-466029,EBI-25866497
NACAD [O15069]15EBI-466029,EBI-7108375
NAP1L2 [Q9ULW6]3EBI-466029,EBI-3911716
NAPA [P54920]3EBI-466029,EBI-749652
NBR1 [Q14596]3EBI-466029,EBI-742698
NCF1 [P14598]6EBI-466029,EBI-395044
NCLN [Q969V3]9EBI-466029,EBI-1056979
NCOR1 [O75376]3EBI-466029,EBI-347233
NDN [Q99608]6EBI-466029,EBI-718177
NDUFA13 [Q9P0J0]4EBI-466029,EBI-372742
NDUFA9 [Q16795]7EBI-466029,EBI-1045087
NDUFB10 [O96000]13EBI-466029,EBI-1246371
NDUFB10 - isoform 2 [O96000-2]3EBI-466029,EBI-25930682
NDUFB9 [Q9Y6M9]10EBI-466029,EBI-713654
NDUFS1 - isoform 5 [P28331-5]6EBI-466029,EBI-25876328
NDUFS5 [O43920]7EBI-466029,EBI-1246091
NEBL [O76041]18EBI-466029,EBI-2880203
NEFL [I6L9F6]9EBI-466029,EBI-10178578
NEK8 [Q86SG6]3EBI-466029,EBI-1752987
NEUROD1 [Q13562]6EBI-466029,EBI-3908303
NFKB1 - isoform 2 [P19838-2]3EBI-466029,EBI-1452242
NGEF [Q8N5V2]3EBI-466029,EBI-718372
NHP2 [Q9NX24]3EBI-466029,EBI-1050064
NLK [Q9UBE8]3EBI-466029,EBI-366978
NLRP1 [Q96AM0]3EBI-466029,EBI-25860999
NME4 [O00746]20EBI-466029,EBI-744871
NME5 [P56597]6EBI-466029,EBI-740667
NMES1 [Q9C002]3EBI-466029,EBI-3905285
NOD1 [Q9Y239]9EBI-466029,EBI-1051262
NPFF - isoform 2 [O15130-2]18EBI-466029,EBI-25840002
NPTN - isoform 1 [Q9Y639-1]6EBI-466029,EBI-12839590
NR1H3 - isoform 2 [Q13133-2]3EBI-466029,EBI-12699353
NR2C2AP [Q86WQ0]3EBI-466029,EBI-10260040
NSMF - isoform 6 [Q6X4W1-6]6EBI-466029,EBI-25842707
NUDT1 - isoform p18 [P36639-4]6EBI-466029,EBI-25834643
NUDT4 [Q9NZJ9]6EBI-466029,EBI-4280066
NUFIP2 [Q7Z417]6EBI-466029,EBI-1210753
NUP58 [Q9BVL2]7EBI-466029,EBI-2811583
NXT2 - isoform 3 [Q9NPJ8-3]15EBI-466029,EBI-10698339
ODF2L [Q96GC1]3EBI-466029,EBI-12176953
OGDH [Q02218]3EBI-466029,EBI-747213
OOSP2 [Q86WS3]9EBI-466029,EBI-25888682
OPCML [Q6B0I4]3EBI-466029,EBI-25954356
OPTN [Q96CV9]13EBI-466029,EBI-748974
OPTN - isoform 2 [Q96CV9-2]18EBI-466029,EBI-9091423
OSTF1 [Q92882]5EBI-466029,EBI-1051152
OTOGL [Q3ZCN5]3EBI-466029,EBI-25954043
P3H3 - isoform 2 [Q8IVL6-2]6EBI-466029,EBI-12149899
P4HA1 [P13674]5EBI-466029,EBI-1237386
PACS1 [Q6VY07]18EBI-466029,EBI-2555014
PACSIN1 [Q9BY11]3EBI-466029,EBI-721769
PAK2 [Q13177]2EBI-466029,EBI-1045887
PAK5 [Q9P286]3EBI-466029,EBI-741896
PALMD [Q9NP74]6EBI-466029,EBI-2811699
PAQR7 [Q86WK9]3EBI-466029,EBI-10694587
PARK7 [Q99497]6EBI-466029,EBI-1164361
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-466029,EBI-11022007
PBX4 [Q9BYU1]3EBI-466029,EBI-10302990
PCDHGB1 - isoform 2 [Q9Y5G3-2]3EBI-466029,EBI-21584477
PCSK4 - isoform 2 [Q6UW60-2]3EBI-466029,EBI-25960845
PDE1A - isoform 4 [P54750-4]3EBI-466029,EBI-25952361
PDK2 [Q15119]10EBI-466029,EBI-726271
PDLIM5 [Q96HC4]9EBI-466029,EBI-751267
PDPK1 - isoform 4 [O15530-4]6EBI-466029,EBI-9087775
PDZK1IP1 [Q13113]21EBI-466029,EBI-716063
PELI1 [Q96FA3]3EBI-466029,EBI-448369
PELO [Q9BRX2]12EBI-466029,EBI-1043580
PES1 [O00541]3EBI-466029,EBI-1053271
PFDN5 [Q99471]3EBI-466029,EBI-357275
PFN2 [P35080]7EBI-466029,EBI-473138
PIAS1 [O75925]19EBI-466029,EBI-629434
PIAS4 [Q8N2W9]6EBI-466029,EBI-473160
PIBF1 [Q8WXW3]3EBI-466029,EBI-2558770
PICK1 [Q9NRD5]3EBI-466029,EBI-79165
PIH1D2 [Q8WWB5]3EBI-466029,EBI-10232538
PIK3CA [P42336]3EBI-466029,EBI-2116585
PIK3R1 [P27986]7EBI-466029,EBI-79464
PIK3R1 - isoform 2 [P27986-2]18EBI-466029,EBI-9090282
PIK3R2 [O00459]6EBI-466029,EBI-346930
PIK3R3 [Q92569]18EBI-466029,EBI-79893
PINK1 [Q9BXM7]9EBI-466029,EBI-2846068
PIWIL1 [Q96J94]3EBI-466029,EBI-527417
PKM [P14618]9EBI-466029,EBI-353408
PLA2G1B [Q9BS22]3EBI-466029,EBI-25961917
PLA2G4C [Q9UP65]12EBI-466029,EBI-25848809
PLEC [Q15149]4EBI-466029,EBI-297903
PLXNA4 - isoform 3 [Q9HCM2-3]3EBI-466029,EBI-25962330
PMF1 - isoform 3 [Q6P1K2-3]3EBI-466029,EBI-12906008
POC1A [Q8NBT0]15EBI-466029,EBI-2557132
PPA2 - isoform 3 [Q9H2U2-3]3EBI-466029,EBI-25972548
PPA2 - isoform 5 [Q9H2U2-6]3EBI-466029,EBI-25972564
PPARA [Q07869]3EBI-466029,EBI-78615
PPARD - isoform 2 [Q03181-2]3EBI-466029,EBI-10223258
PPARG [P37231]16EBI-466029,EBI-781384
PPGB [Q59EV6]10EBI-466029,EBI-14210385
PPIH [O43447]10EBI-466029,EBI-1055615
PPL [O60437]8EBI-466029,EBI-368321
PPP1CA [P62136]10EBI-466029,EBI-357253
PPP1R16B [Q96T49]3EBI-466029,EBI-10293968
PPP1R21 - isoform 5 [Q6ZMI0-5]9EBI-466029,EBI-25835994
PPP2R5E [Q16537]15EBI-466029,EBI-968374
PPP6R2 - isoform 4 [O75170-4]3EBI-466029,EBI-11079164
PQBP1 [O60828]3EBI-466029,EBI-713867
PRIM1 [P49642]3EBI-466029,EBI-726050
PRKACA [P17612]3EBI-466029,EBI-476586
PRMT2 [P55345]3EBI-466029,EBI-78458
PRNP [P04156]13EBI-466029,EBI-977302
PRO0132 [Q53TL4]3EBI-466029,EBI-25960611
PRPF31 [Q8WWY3]3EBI-466029,EBI-1567797
PRPF40A [O75400]15EBI-466029,EBI-473291
PRPF40A - isoform 2 [O75400-2]9EBI-466029,EBI-5280197
PRRC1 [Q96M27]7EBI-466029,EBI-2560879
PRUNE2 [A0A0C4DFM3]3EBI-466029,EBI-25830870
PSMA1 [P25786]3EBI-466029,EBI-359352
PSMA4 [P25789]4EBI-466029,EBI-359310
PSMA6 [P60900]4EBI-466029,EBI-357793
PSMA7 [O14818]13EBI-466029,EBI-603272
PSMB1 [P20618]7EBI-466029,EBI-372273
PSMB2 [P49721]7EBI-466029,EBI-359335
PSMB3 [P49720]3EBI-466029,EBI-603340
PSMB6 [P28072]3EBI-466029,EBI-359288
PSMB8 - isoform 2 [P28062-2]3EBI-466029,EBI-372312
PSMC3 [P17980]6EBI-466029,EBI-359720
PSMD14 [O00487]7EBI-466029,EBI-722193
PSMD3 [O43242]3EBI-466029,EBI-357622
PSMD4 [P55036]5EBI-466029,EBI-359318
PSMD7 [P51665]10EBI-466029,EBI-357659
PTCH1 - isoform M [Q13635-3]3EBI-466029,EBI-14199621
PTGDS [P41222]3EBI-466029,EBI-948821
PTK6 [Q13882]4EBI-466029,EBI-1383632
PUF60 - isoform 2 [Q9UHX1-2]6EBI-466029,EBI-11529177
PUF60 - isoform 6 [Q9UHX1-6]9EBI-466029,EBI-11085298
QARS1 [P47897]6EBI-466029,EBI-347462
RAB35 [Q15286]3EBI-466029,EBI-722275
RAB5B [P61020]3EBI-466029,EBI-399401
RAD23A [P54725]3EBI-466029,EBI-746453
RAE1 [P78406]4EBI-466029,EBI-724495
RAN [P62826]6EBI-466029,EBI-286642
RANGAP1 [P46060]10EBI-466029,EBI-396091
RAPGEF4 [Q8WZA2]3EBI-466029,EBI-948476
RAPSN - isoform 2 [Q13702-2]18EBI-466029,EBI-22012855
RASA1 [P20936]3EBI-466029,EBI-1026476
RASL11A [Q6T310]3EBI-466029,EBI-4401868
RASSF1 - isoform C [Q9NS23-4]3EBI-466029,EBI-438710
RASSF2 [P50749]3EBI-466029,EBI-960081
RASSF5 - isoform 2 [Q8WWW0-2]3EBI-466029,EBI-960502
RBFOX2 - isoform 3 [O43251-3]3EBI-466029,EBI-11531589
RBM11 [P57052]9EBI-466029,EBI-741332
RBM5 [P52756]6EBI-466029,EBI-714003
RBPMS - isoform C [Q93062-3]3EBI-466029,EBI-740343
RCAN3 [Q9UKA8]18EBI-466029,EBI-9091952
RCN1 [Q15293]3EBI-466029,EBI-948278
REXO4 [Q9GZR2]3EBI-466029,EBI-2856313
RIMKLA [Q8IXN7]3EBI-466029,EBI-21890191
RINT1 [Q6NUQ1]3EBI-466029,EBI-726876
RIPPLY2 [Q5TAB7]6EBI-466029,EBI-10246897
RNF111 - isoform 2 [Q6ZNA4-2]18EBI-466029,EBI-21535400
RNF112 [Q9ULX5]21EBI-466029,EBI-25829984
RNF183 [Q96D59]3EBI-466029,EBI-743938
RNF20 [Q5VTR2]24EBI-466029,EBI-2372238
RNF38 - isoform 2 [Q9H0F5-2]21EBI-466029,EBI-25866807
RNF40 [O75150]12EBI-466029,EBI-744408
RPL13 [P26373]10EBI-466029,EBI-356849
RPL13 [Q6NZ55]3EBI-466029,EBI-10252046
RPL15 [P61313]3EBI-466029,EBI-443462
RPL18 [Q07020]12EBI-466029,EBI-352694
RPL19 [P84098]6EBI-466029,EBI-916524
RPL22 [P35268]3EBI-466029,EBI-354533
RPL26L1 [Q9UNX3]3EBI-466029,EBI-2949703
RPL27 [P61353]6EBI-466029,EBI-352760
RPL31 [P62899]3EBI-466029,EBI-1053664
RPL4 [P36578]14EBI-466029,EBI-348313
RPS12 [P25398]3EBI-466029,EBI-354542
RPS15A [P62244]3EBI-466029,EBI-347895
RPS19 [P39019]3EBI-466029,EBI-354451
RPS27A [P62979]6EBI-466029,EBI-357375
RPS3 [P23396]3EBI-466029,EBI-351193
RPS5 [P46782]3EBI-466029,EBI-350569
RTN1 - isoform RTN1-C [Q16799-3]9EBI-466029,EBI-10180131
RUFY4 [Q6ZNE9]3EBI-466029,EBI-10181525
RUSC1-AS1 [Q66K80]6EBI-466029,EBI-10248967
RUSF1 [Q96GQ5]3EBI-466029,EBI-8636004
RXRG [P48443]18EBI-466029,EBI-712405
RYBP [Q8N488]9EBI-466029,EBI-752324
S100P [P25815]9EBI-466029,EBI-743700
SAMD3 - isoform 2 [Q8N6K7-2]3EBI-466029,EBI-11528848
SAMD4A [G3V2R1]3EBI-466029,EBI-21264240
SAP30 [O75446]3EBI-466029,EBI-632609
SASS6 [Q6UVJ0]15EBI-466029,EBI-1570153
SCAPER - isoform 3 [Q9BY12-3]6EBI-466029,EBI-25837959
SCFD1 [Q8WVM8]3EBI-466029,EBI-722569
SCLT1 - isoform 3 [Q96NL6-3]3EBI-466029,EBI-25961722
SCRN1 - isoform 2 [Q12765-2]3EBI-466029,EBI-12027936
SDCBP [O00560]12EBI-466029,EBI-727004
SEC13 - isoform 3 [P55735-3]15EBI-466029,EBI-12235008
SEC23B [Q15437]3EBI-466029,EBI-742673
SECISBP2 [Q96T21]3EBI-466029,EBI-954116
SEPTIN4 [O43236]3EBI-466029,EBI-1047513
SEPTIN6 [Q14141]18EBI-466029,EBI-745901
SEPTIN7 - isoform 2 [Q16181-2]9EBI-466029,EBI-10176094
SERTAD1 [Q9UHV2]3EBI-466029,EBI-748601
SETD2 [Q9BYW2]4EBI-466029,EBI-945869
SETDB1 - isoform 2 [Q15047-2]15EBI-466029,EBI-9090795
SF3A3 [Q12874]3EBI-466029,EBI-1051880
SF3B3 [Q15393]3EBI-466029,EBI-346977
SFXN3 [A0A1P0AYU5]9EBI-466029,EBI-14193895
SGSM1 - isoform 3 [Q2NKQ1-4]12EBI-466029,EBI-10182463
SH3GL1 [Q99961]3EBI-466029,EBI-697911
SH3GL3 [Q99963]9EBI-466029,EBI-473910
SH3GLB2 [Q9NR46]3EBI-466029,EBI-749607
SHLD1 [Q8IYI0]3EBI-466029,EBI-2560428
SIK3 - isoform 3 [Q9Y2K2-7]3EBI-466029,EBI-17172855
SIN3A [Q96ST3]4EBI-466029,EBI-347218
SLC1A2 [P43004]12EBI-466029,EBI-3440986
SLC25A11 [Q02978]6EBI-466029,EBI-359174
SLC25A3 - isoform B [Q00325-2]3EBI-466029,EBI-5456178
SLC44A5 [Q8NCS7]3EBI-466029,EBI-21504521
SMARCB1 [Q12824]9EBI-466029,EBI-358419
SMARCC2 - isoform 2 [Q8TAQ2-2]3EBI-466029,EBI-11990400
SMARCD1 [Q96GM5]12EBI-466029,EBI-358489
SMN2 - isoform SMN-delta7 [Q16637-3]9EBI-466029,EBI-395447
SMURF1 - isoform Short [Q9HCE7-2]6EBI-466029,EBI-9845742
SNAP25 - isoform 2 [P60880-2]9EBI-466029,EBI-12177361
SNAP29 [O95721]3EBI-466029,EBI-490676
SNCA [P37840]4EBI-466029,EBI-985879
SNRPD2 [P62316]3EBI-466029,EBI-297993
SNRPF [P62306]3EBI-466029,EBI-356900
SNW1 [Q13573]12EBI-466029,EBI-632715
SNX12 [Q9UMY4]3EBI-466029,EBI-1752602
SNX2 [O60749]6EBI-466029,EBI-1046690
SNX33 [Q8WV41]6EBI-466029,EBI-2481535
SOCS4 [Q8WXH5]3EBI-466029,EBI-3942425
SORBS1 [Q9BX66]4EBI-466029,EBI-433642
SOX14 [O95416]12EBI-466029,EBI-9087806
SOX7 [Q9BT81]15EBI-466029,EBI-7239117
SP3 [Q02447]4EBI-466029,EBI-348158
SP6 [Q3SY56]3EBI-466029,EBI-11175533
SPAG8 - isoform 2 [Q99932-2]18EBI-466029,EBI-11959123
SPANXC [Q9NY87]3EBI-466029,EBI-10316585
SPATA12 [Q7Z6I5]3EBI-466029,EBI-10696971
SPATA22 [Q8NHS9]9EBI-466029,EBI-7067260
SPATA2L [Q8IUW3]6EBI-466029,EBI-2510414
SPCS3 [P61009]6EBI-466029,EBI-6166040
SPIB [Q01892]18EBI-466029,EBI-2800992
SPINK13 [Q1W4C9]3EBI-466029,EBI-25953827
SPRED2 [Q7Z698]6EBI-466029,EBI-7082156
SQSTM1 [Q13501]8EBI-466029,EBI-307104
SREBF1 [P36956]3EBI-466029,EBI-948313
SRGAP1 [Q7Z6B7]4EBI-466029,EBI-2481729
SRGAP2 [O75044]3EBI-466029,EBI-1051034
SRGAP3 [O43295]4EBI-466029,EBI-368166
SRGAP3 [Q8IXS7]3EBI-466029,EBI-18616594
SRRT [Q9BXP5]3EBI-466029,EBI-712721
SRRT - isoform 3 [Q9BXP5-3]6EBI-466029,EBI-25866384
SRRT - isoform 4 [Q9BXP5-4]3EBI-466029,EBI-16701991
SSB [P05455]3EBI-466029,EBI-358037
SSU72 [Q9NP77]3EBI-466029,EBI-2515416
ST13 [P50502]13EBI-466029,EBI-357285
STAM2 [O75886]6EBI-466029,EBI-373258
STAR [P49675]3EBI-466029,EBI-722932
STN1 [Q9H668]3EBI-466029,EBI-746930
STRAP [Q9Y3F4]4EBI-466029,EBI-727414
STRC [A1L378]6EBI-466029,EBI-22013242
STUB1 [Q9UNE7]12EBI-466029,EBI-357085
STX16 - isoform E [O14662-5]15EBI-466029,EBI-9089968
STXBP1 [P61764]7EBI-466029,EBI-960169
SULT4A1 - isoform 2 [Q9BR01-2]15EBI-466029,EBI-25831443
SUMF2 [Q8NBJ7]6EBI-466029,EBI-723091
SUMO1 [P63165]3EBI-466029,EBI-80140
SUMO3 [P55854]9EBI-466029,EBI-474067
SYCE3 [A1L190]15EBI-466029,EBI-10283466
SYMPK [Q92797]3EBI-466029,EBI-1051992
SYMPK - isoform 2 [Q92797-2]9EBI-466029,EBI-21560407
SYP [P08247]13EBI-466029,EBI-9071725
SYT15 - isoform 2 [Q9BQS2-2]3EBI-466029,EBI-13373352
SYT2 [Q8N9I0]10EBI-466029,EBI-8032987
SYT3 [Q9BQG1]12EBI-466029,EBI-17284568
SYT6 - isoform 2 [Q5T7P8-2]3EBI-466029,EBI-10246152
TACC1 [O75410]4EBI-466029,EBI-624237
TACC1 - isoform 7 [O75410-7]12EBI-466029,EBI-12007872
TADA2B - isoform 3 [Q86TJ2-3]3EBI-466029,EBI-18173581
TAGLN2 [P37802]3EBI-466029,EBI-1056740
TALDO1 [P37837]3EBI-466029,EBI-1056712
TANK [Q6NW12]9EBI-466029,EBI-25948253
TANK [Q92844]3EBI-466029,EBI-356349
TANK - isoform 3 [Q92844-3]3EBI-466029,EBI-25967460
TAOK3 [Q9H2K8]3EBI-466029,EBI-1384100
TASOR2 [Q5VWN6]12EBI-466029,EBI-745958
TBC1D5 [Q92609]3EBI-466029,EBI-742381
TBP [Q32MN6]9EBI-466029,EBI-10239991
TBR1 [Q16650]12EBI-466029,EBI-1047158
TBX22 [Q9Y458]12EBI-466029,EBI-6427217
TCERG1 [O14776]9EBI-466029,EBI-473271
TCP1 [P17987]3EBI-466029,EBI-356553
TCP10L [Q8TDR4]3EBI-466029,EBI-3923210
TEAD1 - isoform 2 [P28347-2]18EBI-466029,EBI-12151837
TEN1 [Q86WV5]9EBI-466029,EBI-2562799
TENT5B [Q96A09]6EBI-466029,EBI-752030
TERF2 - isoform 2 [Q15554-4]15EBI-466029,EBI-25840535
TEX55 [Q96M34]3EBI-466029,EBI-25961624
TFF2 [Q03403]18EBI-466029,EBI-4314702
TFG [Q92734]3EBI-466029,EBI-357061
TGDS [O95455]3EBI-466029,EBI-1761487
TGFBR2 [P37173]3EBI-466029,EBI-296151
TGM2 - isoform 2 [P21980-2]6EBI-466029,EBI-25842075
TIGD1 [Q96MW7]9EBI-466029,EBI-9091586
TIMM8A [O60220]15EBI-466029,EBI-1049822
TLE5 [Q08117]3EBI-466029,EBI-717810
TM6SF1 - isoform 2 [Q9BZW5-2]3EBI-466029,EBI-25852210
TMA16 [Q96EY4]3EBI-466029,EBI-1045338
TMEM106B [Q9NUM4]3EBI-466029,EBI-10490807
TMEM115 [Q12893]3EBI-466029,EBI-8633987
TMEM205 [Q6UW68]3EBI-466029,EBI-6269551
TMEM239 - isoform 2 [Q8WW34-2]3EBI-466029,EBI-11528917
TMEM30A - isoform 2 [Q9NV96-2]3EBI-466029,EBI-12921610
TMEM43 [Q9BTV4]3EBI-466029,EBI-721293
TMEM47 [Q9BQJ4]3EBI-466029,EBI-13370320
TMTC1 - isoform 4 [Q8IUR5-4]6EBI-466029,EBI-9089156
TMUB2 - isoform 4 [Q71RG4-4]6EBI-466029,EBI-25831574
TNFAIP1 [Q13829]3EBI-466029,EBI-2505861
TNFRSF11B [O00300]3EBI-466029,EBI-15481185
TNFSF15 [O95150]3EBI-466029,EBI-16355546
TNIP3 [Q96KP6]9EBI-466029,EBI-2509913
TNXB - isoform 3 [P22105-1]3EBI-466029,EBI-20753895
TOMM22 [Q9NS69]6EBI-466029,EBI-1047508
TP53 [P04637]19EBI-466029,EBI-366083
TPI1 [P60174]6EBI-466029,EBI-717475
TRAF2 [Q12933]3EBI-466029,EBI-355744
TRAFD1 [O14545]5EBI-466029,EBI-1396921
TRIM21 [P19474]21EBI-466029,EBI-81290
TRIM35 - isoform 2 [Q9UPQ4-2]9EBI-466029,EBI-17716262
TRIM49 [P0CI25]9EBI-466029,EBI-6427421
TRIP10 - isoform 2 [Q15642-2]18EBI-466029,EBI-6550597
TRIP6 [Q15654]3EBI-466029,EBI-742327
TTC1 [Q99614]9EBI-466029,EBI-742074
TTC19 [Q6DKK2]3EBI-466029,EBI-948354
TTC23 - isoform 3 [Q5W5X9-3]18EBI-466029,EBI-9090990
TUBA1A [Q71U36]3EBI-466029,EBI-302552
TUBB [P07437]9EBI-466029,EBI-350864
TUBB6 [Q9BUF5]3EBI-466029,EBI-356735
TUBGCP4 - isoform 2 [Q9UGJ1-2]6EBI-466029,EBI-10964469
TWIST1 [Q15672]3EBI-466029,EBI-1797287
TWIST2 [Q8WVJ9]15EBI-466029,EBI-1797313
TXN2 [Q99757]3EBI-466029,EBI-2932492
TXNDC11 [Q6PKC3]7EBI-466029,EBI-749812
U2AF1 [Q01081]3EBI-466029,EBI-632461
UBA1 [P22314]3EBI-466029,EBI-709688
UBAC1 [Q9BSL1]26EBI-466029,EBI-749370
UBC [P0CG48]3EBI-466029,EBI-3390054
UBE2D4 [Q9Y2X8]3EBI-466029,EBI-745527
UBE2H [P62256]3EBI-466029,EBI-2129909
UBE2I [P63279]3EBI-466029,EBI-80168
UBE2K [P61086]24EBI-466029,EBI-473850
UBQLN2 [Q9UHD9]12EBI-466029,EBI-947187
UFD1 [Q92890]7EBI-466029,EBI-1994090
ULK1 [O75385]8EBI-466029,EBI-908831
USH1G [Q495M9]3EBI-466029,EBI-8601749
USP18 [Q9UMW8]3EBI-466029,EBI-356206
USP2 - isoform 3 [O75604-3]6EBI-466029,EBI-10696113
USP24 [Q9UPU5]21EBI-466029,EBI-1642365
USP32 - isoform 2 [Q8NFA0-2]18EBI-466029,EBI-12220239
USP9X [Q93008]8EBI-466029,EBI-302524
UTP14A [Q9BVJ6]4EBI-466029,EBI-473284
UTP6 [Q9NYH9]3EBI-466029,EBI-749211
VAC14 [Q08AM6]3EBI-466029,EBI-2107455
VAT1L [Q9HCJ6]3EBI-466029,EBI-10234766
VCP [P55072]10EBI-466029,EBI-355164
VDAC2 [P45880]22EBI-466029,EBI-354022
VHL - isoform 2 [P40337-2]12EBI-466029,EBI-12157263
VIL1 - isoform 2 [P09327-2]3EBI-466029,EBI-25958818
VIM [P08670]4EBI-466029,EBI-353844
VPS28 [Q9UK41]16EBI-466029,EBI-727424
VPS37A [Q8NEZ2]6EBI-466029,EBI-2850578
VPS4B [O75351]3EBI-466029,EBI-2514459
WAC [Q9BTA9]5EBI-466029,EBI-749118
WAC - isoform 4 [Q9BTA9-5]3EBI-466029,EBI-25956668
WBP4 [O75554]3EBI-466029,EBI-7251981
WDFY3 [Q8IZQ1]10EBI-466029,EBI-1569256
WDR61 [Q9GZS3]22EBI-466029,EBI-358545
WDR91 [A4D1P6]16EBI-466029,EBI-718046
WTAP - isoform 2 [Q15007-2]3EBI-466029,EBI-25840023
WWP2 [O00308]9EBI-466029,EBI-743923
XAB2 [Q9HCS7]3EBI-466029,EBI-295232
XAGE3 [Q8WTP9]3EBI-466029,EBI-6448284
XRCC6 [P12956]21EBI-466029,EBI-353208
YIF1A [O95070]12EBI-466029,EBI-2799703
YWHAB [P31946]11EBI-466029,EBI-359815
YY1AP1 - isoform 2 [Q9H869-2]3EBI-466029,EBI-12150045
ZBP1 [Q9H171]6EBI-466029,EBI-6264672
ZBTB16 [Q05516]4EBI-466029,EBI-711925
ZBTB24 - isoform 2 [O43167-2]9EBI-466029,EBI-25842419
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-466029,EBI-14104088
ZCCHC12 [Q6PEW1]3EBI-466029,EBI-748373
ZDHHC17 [Q8IUH5]30EBI-466029,EBI-524753
ZDHHC19 - isoform 3 [Q8WVZ1-3]3EBI-466029,EBI-25961277
ZFC3H1 [G3V1X1]5EBI-466029,EBI-6448783
ZFP2 [Q6ZN57]12EBI-466029,EBI-7236323
ZFYVE19 [Q96K21]21EBI-466029,EBI-6448240
ZHX1 [Q9UKY1]6EBI-466029,EBI-347767
ZHX1-C8orf76 [Q96EF9]18EBI-466029,EBI-25830993
ZKSCAN3 [Q9BRR0]3EBI-466029,EBI-1965777
ZKSCAN8 [Q15776]9EBI-466029,EBI-2602314
ZMAT2 [Q96NC0]20EBI-466029,EBI-2682299
ZMYM6 - isoform 4 [O95789-4]3EBI-466029,EBI-12949277
ZNF138 [P52744]9EBI-466029,EBI-10746567
ZNF180 - isoform 4 [Q9UJW8-4]9EBI-466029,EBI-12055755
ZNF19 [P17023]3EBI-466029,EBI-12884200
ZNF2 [Q9BSG1]3EBI-466029,EBI-8489229
ZNF281 [Q9Y2X9]3EBI-466029,EBI-396200
ZNF286A [Q9HBT8]9EBI-466029,EBI-10754950
ZNF302 - isoform 2 [Q9NR11-2]3EBI-466029,EBI-12988373
ZNF366 [Q8N895]15EBI-466029,EBI-2813661
ZNF436 [Q9C0F3]15EBI-466029,EBI-8489702
ZNF444 - isoform 2 [Q8N0Y2-2]9EBI-466029,EBI-12010736
ZNF497 [Q6ZNH5]9EBI-466029,EBI-10486136
ZNF500 [O60304]6EBI-466029,EBI-18234077
ZNF557 - isoform 2 [Q8N988-2]12EBI-466029,EBI-10699005
ZNF57 [Q68EA5]15EBI-466029,EBI-8490788
ZNF572 [Q7Z3I7]9EBI-466029,EBI-10172590
ZNF641 - isoform 2 [Q96N77-2]18EBI-466029,EBI-12939666
ZNF655 [Q8N720]14EBI-466029,EBI-625509
ZNF697 [Q5TEC3]3EBI-466029,EBI-25845217
ZNF829 - isoform 3 [Q3KNS6-3]6EBI-466029,EBI-18036029
ZSCAN9 [O15535]9EBI-466029,EBI-751531
ZXDC [Q2QGD7]3EBI-466029,EBI-1538838
A8K3Q93EBI-466029,EBI-10174314
A8K87821EBI-466029,EBI-25831303
B7Z3E86EBI-466029,EBI-25831617
Q0VG736EBI-466029,EBI-25953074
Q7L8T76EBI-466029,EBI-25831943
Q86V286EBI-466029,EBI-10259496
Q96IQ66EBI-466029,EBI-10295632
Dync1i1 [O88485] from Mus musculus.2EBI-466029,EBI-492834
Hap1 [P54256] from Rattus norvegicus.3EBI-466029,EBI-994539
Hsd17b4 [P51660] from Mus musculus.15EBI-466029,EBI-8328056
Itpr1 [P29994] from Rattus norvegicus.2EBI-466029,EBI-8614640
Ppif [Q99KR7] from Mus musculus.3EBI-466029,EBI-6455001

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109314, 363 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P42858

Database of interacting proteins

More...
DIPi
DIP-32492N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P42858

Protein interaction database and analysis system

More...
IntActi
P42858, 1109 interactors

Molecular INTeraction database

More...
MINTi
P42858

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347184

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P42858

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P42858, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P42858

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P42858

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P42858

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati204 – 241HEAT 1Add BLAST38
Repeati246 – 283HEAT 2Add BLAST38
Repeati316 – 360HEAT 3Add BLAST45
Repeati802 – 839HEAT 4Add BLAST38
Repeati902 – 940HEAT 5Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3 – 13Sufficient for interaction with TPR1 PublicationAdd BLAST11
Regioni491 – 502Interaction with ZDHHC171 PublicationAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2395 – 2404Nuclear export signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 38Poly-GlnAdd BLAST21
Compositional biasi39 – 49Poly-ProAdd BLAST11
Compositional biasi63 – 78Poly-ProAdd BLAST16
Compositional biasi1437 – 1440Poly-Thr4
Compositional biasi2341 – 2345Poly-Glu5
Compositional biasi2638 – 2643Poly-Glu6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the huntingtin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR1D, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015863

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000428_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P42858

Identification of Orthologs from Complete Genome Data

More...
OMAi
LHPEAFF

Database of Orthologous Groups

More...
OrthoDBi
33894at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P42858

TreeFam database of animal gene trees

More...
TreeFami
TF323608

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000091, Huntingtin
IPR028426, Huntingtin_fam
IPR024613, Huntingtin_middle-repeat

The PANTHER Classification System

More...
PANTHERi
PTHR10170, PTHR10170, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12372, DUF3652, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00375, HUNTINGTIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P42858-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLEKLMKA FESLKSFQQQ QQQQQQQQQQ QQQQQQQQPP PPPPPPPPPQ
60 70 80 90 100
LPQPPPQAQP LLPQPQPPPP PPPPPPGPAV AEEPLHRPKK ELSATKKDRV
110 120 130 140 150
NHCLTICENI VAQSVRNSPE FQKLLGIAME LFLLCSDDAE SDVRMVADEC
160 170 180 190 200
LNKVIKALMD SNLPRLQLEL YKEIKKNGAP RSLRAALWRF AELAHLVRPQ
210 220 230 240 250
KCRPYLVNLL PCLTRTSKRP EESVQETLAA AVPKIMASFG NFANDNEIKV
260 270 280 290 300
LLKAFIANLK SSSPTIRRTA AGSAVSICQH SRRTQYFYSW LLNVLLGLLV
310 320 330 340 350
PVEDEHSTLL ILGVLLTLRY LVPLLQQQVK DTSLKGSFGV TRKEMEVSPS
360 370 380 390 400
AEQLVQVYEL TLHHTQHQDH NVVTGALELL QQLFRTPPPE LLQTLTAVGG
410 420 430 440 450
IGQLTAAKEE SGGRSRSGSI VELIAGGGSS CSPVLSRKQK GKVLLGEEEA
460 470 480 490 500
LEDDSESRSD VSSSALTASV KDEISGELAA SSGVSTPGSA GHDIITEQPR
510 520 530 540 550
SQHTLQADSV DLASCDLTSS ATDGDEEDIL SHSSSQVSAV PSDPAMDLND
560 570 580 590 600
GTQASSPISD SSQTTTEGPD SAVTPSDSSE IVLDGTDNQY LGLQIGQPQD
610 620 630 640 650
EDEEATGILP DEASEAFRNS SMALQQAHLL KNMSHCRQPS DSSVDKFVLR
660 670 680 690 700
DEATEPGDQE NKPCRIKGDI GQSTDDDSAP LVHCVRLLSA SFLLTGGKNV
710 720 730 740 750
LVPDRDVRVS VKALALSCVG AAVALHPESF FSKLYKVPLD TTEYPEEQYV
760 770 780 790 800
SDILNYIDHG DPQVRGATAI LCGTLICSIL SRSRFHVGDW MGTIRTLTGN
810 820 830 840 850
TFSLADCIPL LRKTLKDESS VTCKLACTAV RNCVMSLCSS SYSELGLQLI
860 870 880 890 900
IDVLTLRNSS YWLVRTELLE TLAEIDFRLV SFLEAKAENL HRGAHHYTGL
910 920 930 940 950
LKLQERVLNN VVIHLLGDED PRVRHVAAAS LIRLVPKLFY KCDQGQADPV
960 970 980 990 1000
VAVARDQSSV YLKLLMHETQ PPSHFSVSTI TRIYRGYNLL PSITDVTMEN
1010 1020 1030 1040 1050
NLSRVIAAVS HELITSTTRA LTFGCCEALC LLSTAFPVCI WSLGWHCGVP
1060 1070 1080 1090 1100
PLSASDESRK SCTVGMATMI LTLLSSAWFP LDLSAHQDAL ILAGNLLAAS
1110 1120 1130 1140 1150
APKSLRSSWA SEEEANPAAT KQEEVWPALG DRALVPMVEQ LFSHLLKVIN
1160 1170 1180 1190 1200
ICAHVLDDVA PGPAIKAALP SLTNPPSLSP IRRKGKEKEP GEQASVPLSP
1210 1220 1230 1240 1250
KKGSEASAAS RQSDTSGPVT TSKSSSLGSF YHLPSYLKLH DVLKATHANY
1260 1270 1280 1290 1300
KVTLDLQNST EKFGGFLRSA LDVLSQILEL ATLQDIGKCV EEILGYLKSC
1310 1320 1330 1340 1350
FSREPMMATV CVQQLLKTLF GTNLASQFDG LSSNPSKSQG RAQRLGSSSV
1360 1370 1380 1390 1400
RPGLYHYCFM APYTHFTQAL ADASLRNMVQ AEQENDTSGW FDVLQKVSTQ
1410 1420 1430 1440 1450
LKTNLTSVTK NRADKNAIHN HIRLFEPLVI KALKQYTTTT CVQLQKQVLD
1460 1470 1480 1490 1500
LLAQLVQLRV NYCLLDSDQV FIGFVLKQFE YIEVGQFRES EAIIPNIFFF
1510 1520 1530 1540 1550
LVLLSYERYH SKQIIGIPKI IQLCDGIMAS GRKAVTHAIP ALQPIVHDLF
1560 1570 1580 1590 1600
VLRGTNKADA GKELETQKEV VVSMLLRLIQ YHQVLEMFIL VLQQCHKENE
1610 1620 1630 1640 1650
DKWKRLSRQI ADIILPMLAK QQMHIDSHEA LGVLNTLFEI LAPSSLRPVD
1660 1670 1680 1690 1700
MLLRSMFVTP NTMASVSTVQ LWISGILAIL RVLISQSTED IVLSRIQELS
1710 1720 1730 1740 1750
FSPYLISCTV INRLRDGDST STLEEHSEGK QIKNLPEETF SRFLLQLVGI
1760 1770 1780 1790 1800
LLEDIVTKQL KVEMSEQQHT FYCQELGTLL MCLIHIFKSG MFRRITAAAT
1810 1820 1830 1840 1850
RLFRSDGCGG SFYTLDSLNL RARSMITTHP ALVLLWCQIL LLVNHTDYRW
1860 1870 1880 1890 1900
WAEVQQTPKR HSLSSTKLLS PQMSGEEEDS DLAAKLGMCN REIVRRGALI
1910 1920 1930 1940 1950
LFCDYVCQNL HDSEHLTWLI VNHIQDLISL SHEPPVQDFI SAVHRNSAAS
1960 1970 1980 1990 2000
GLFIQAIQSR CENLSTPTML KKTLQCLEGI HLSQSGAVLT LYVDRLLCTP
2010 2020 2030 2040 2050
FRVLARMVDI LACRRVEMLL AANLQSSMAQ LPMEELNRIQ EYLQSSGLAQ
2060 2070 2080 2090 2100
RHQRLYSLLD RFRLSTMQDS LSPSPPVSSH PLDGDGHVSL ETVSPDKDWY
2110 2120 2130 2140 2150
VHLVKSQCWT RSDSALLEGA ELVNRIPAED MNAFMMNSEF NLSLLAPCLS
2160 2170 2180 2190 2200
LGMSEISGGQ KSALFEAARE VTLARVSGTV QQLPAVHHVF QPELPAEPAA
2210 2220 2230 2240 2250
YWSKLNDLFG DAALYQSLPT LARALAQYLV VVSKLPSHLH LPPEKEKDIV
2260 2270 2280 2290 2300
KFVVATLEAL SWHLIHEQIP LSLDLQAGLD CCCLALQLPG LWSVVSSTEF
2310 2320 2330 2340 2350
VTHACSLIYC VHFILEAVAV QPGEQLLSPE RRTNTPKAIS EEEEEVDPNT
2360 2370 2380 2390 2400
QNPKYITAAC EMVAEMVESL QSVLALGHKR NSGVPAFLTP LLRNIIISLA
2410 2420 2430 2440 2450
RLPLVNSYTR VPPLVWKLGW SPKPGGDFGT AFPEIPVEFL QEKEVFKEFI
2460 2470 2480 2490 2500
YRINTLGWTS RTQFEETWAT LLGVLVTQPL VMEQEESPPE EDTERTQINV
2510 2520 2530 2540 2550
LAVQAITSLV LSAMTVPVAG NPAVSCLEQQ PRNKPLKALD TRFGRKLSII
2560 2570 2580 2590 2600
RGIVEQEIQA MVSKRENIAT HHLYQAWDPV PSLSPATTGA LISHEKLLLQ
2610 2620 2630 2640 2650
INPERELGSM SYKLGQVSIH SVWLGNSITP LREEEWDEEE EEEADAPAPS
2660 2670 2680 2690 2700
SPPTSPVNSR KHRAGVDIHS CSQFLLELYS RWILPSSSAR RTPAILISEV
2710 2720 2730 2740 2750
VRSLLVVSDL FTERNQFELM YVTLTELRRV HPSEDEILAQ YLVPATCKAA
2760 2770 2780 2790 2800
AVLGMDKAVA EPVSRLLEST LRSSHLPSRV GALHGVLYVL ECDLLDDTAK
2810 2820 2830 2840 2850
QLIPVISDYL LSNLKGIAHC VNIHSQQHVL VMCATAFYLI ENYPLDVGPE
2860 2870 2880 2890 2900
FSASIIQMCG VMLSGSEEST PSIIYHCALR GLERLLLSEQ LSRLDAESLV
2910 2920 2930 2940 2950
KLSVDRVNVH SPHRAMAALG LMLTCMYTGK EKVSPGRTSD PNPAAPDSES
2960 2970 2980 2990 3000
VIVAMERVSV LFDRIRKGFP CEARVVARIL PQFLDDFFPP QDIMNKVIGE
3010 3020 3030 3040 3050
FLSNQQPYPQ FMATVVYKVF QTLHSTGQSS MVRDWVMLSL SNFTQRAPVA
3060 3070 3080 3090 3100
MATWSLSCFF VSASTSPWVA AILPHVISRM GKLEQVDVNL FCLVATDFYR
3110 3120 3130 3140
HQIEEELDRR AFQSVLEVVA APGSPYHRLL TCLRNVHKVT TC
Length:3,142
Mass (Da):347,603
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA267509E84D52F0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA07H0YA07_HUMAN
Huntingtin
HTT
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISR3A0A3B3ISR3_HUMAN
Huntingtin
HTT
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU25A0A3B3IU25_HUMAN
Huntingtin
HTT
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITM9A0A3B3ITM9_HUMAN
Huntingtin
HTT
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU44A0A3B3IU44_HUMAN
Huntingtin
HTT
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti823C → S in BAA36753 (PubMed:11013077).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-Gln region of HTT is highly polymorphic (10 to 35 repeats) in the normal population and is expanded to about 36-120 repeats in Huntington disease patients. The repeat length usually increases in successive generations, but contracts also on occasion. The adjacent poly-Pro region is also polymorphic and varies between 7-12 residues. Polyglutamine expansion leads to elevated susceptibility to apopain cleavage and likely result in accelerated neuronal apoptosis (PubMed:8696339).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00526818Q → QQQ. 1
Natural variantiVAR_081737551G → E Inhibits proteolytic cleavage at D-550; abolishes post-translational myristoylation; results in increased cleavage at D-511. 1 PublicationCorresponds to variant dbSNP:rs118005095Ensembl.1
Natural variantiVAR_079026703P → L in LOMARS. 1 PublicationCorresponds to variant dbSNP:rs768047421Ensembl.1
Natural variantiVAR_060170893G → R. Corresponds to variant dbSNP:rs363075Ensembl.1
Natural variantiVAR_0601711064V → I. Corresponds to variant dbSNP:rs35892913Ensembl.1
Natural variantiVAR_0601721091I → M. Corresponds to variant dbSNP:rs1143646Ensembl.1
Natural variantiVAR_0601731173T → A. Corresponds to variant dbSNP:rs3025843Ensembl.1
Natural variantiVAR_0601741260T → M Found in a patient with Rett syndrome-like phenotype; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs34315806Ensembl.1
Natural variantiVAR_0540171382E → A. Corresponds to variant dbSNP:rs3025837Ensembl.1
Natural variantiVAR_0601751385N → H. Corresponds to variant dbSNP:rs3025837Ensembl.1
Natural variantiVAR_0601761720T → N. Corresponds to variant dbSNP:rs363125Ensembl.1
Natural variantiVAR_0601772113D → Y. Corresponds to variant dbSNP:rs1143648Ensembl.1
Natural variantiVAR_0601782309Y → H. Corresponds to variant dbSNP:rs362331Ensembl.1
Natural variantiVAR_0790272717F → L in LOMARS. 1 PublicationCorresponds to variant dbSNP:rs1085307052Ensembl.1
Natural variantiVAR_0601792786V → I1 PublicationCorresponds to variant dbSNP:rs362272Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L12392 mRNA Translation: AAB38240.1
AB016794 mRNA Translation: BAA36753.1
Z49154 Genomic DNA Translation: CAA89024.1
Z49155 Genomic DNA Translation: CAA89025.1
Z49208 Genomic DNA No translation available.
Z49769 Genomic DNA Translation: CAA89839.1
Z68756 Genomic DNA No translation available.
Z69649 Genomic DNA No translation available.
L27350 Genomic DNA No translation available.
L27351 Genomic DNA No translation available.
L27352 Genomic DNA No translation available.
L27353 Genomic DNA No translation available.
L27354 Genomic DNA No translation available.
L34020 Genomic DNA No translation available.
L20431 mRNA Translation: AAA52702.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A46068

NCBI Reference Sequences

More...
RefSeqi
NP_002102.4, NM_002111.8

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355072; ENSP00000347184; ENSG00000197386

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3064

UCSC genome browser

More...
UCSCi
uc062uto.1, human

Keywords - Coding sequence diversityi

Triplet repeat expansion

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Huntingtin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12392 mRNA Translation: AAB38240.1
AB016794 mRNA Translation: BAA36753.1
Z49154 Genomic DNA Translation: CAA89024.1
Z49155 Genomic DNA Translation: CAA89025.1
Z49208 Genomic DNA No translation available.
Z49769 Genomic DNA Translation: CAA89839.1
Z68756 Genomic DNA No translation available.
Z69649 Genomic DNA No translation available.
L27350 Genomic DNA No translation available.
L27351 Genomic DNA No translation available.
L27352 Genomic DNA No translation available.
L27353 Genomic DNA No translation available.
L27354 Genomic DNA No translation available.
L34020 Genomic DNA No translation available.
L20431 mRNA Translation: AAA52702.1
PIRiA46068
RefSeqiNP_002102.4, NM_002111.8

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D3Xmodel-A199-325[»]
2LD0NMR-A1-17[»]
2LD2NMR-A1-17[»]
3IO4X-ray3.63A/B/C1-64[»]
3IO6X-ray3.70A/B/C1-64[»]
3IORX-ray3.60A/B/C1-64[»]
3IOTX-ray3.50A/B/C1-64[»]
3IOUX-ray3.70A/B/C1-64[»]
3IOVX-ray3.70A/B/C1-64[»]
3IOWX-ray3.50A/B/C1-64[»]
3LRHX-ray2.60B/D/F/H/J/L/N/P5-18[»]
4FE8X-ray3.00A/B/C1-64[»]
4FEBX-ray2.80A/B/C1-64[»]
4FECX-ray3.00A/B/C1-64[»]
4FEDX-ray2.81A/B/C1-64[»]
4RAVX-ray2.50E/F1-17[»]
6EZ8electron microscopy4.00A1-3142[»]
6N8CNMR-A/B/C/D2-24[»]
6RMHelectron microscopy9.60A1-3142[»]
6X9Oelectron microscopy2.60A1-3142[»]
6YEJelectron microscopy18.20A18-3142[»]
BMRBiP42858
SMRiP42858
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109314, 363 interactors
CORUMiP42858
DIPiDIP-32492N
ELMiP42858
IntActiP42858, 1109 interactors
MINTiP42858
STRINGi9606.ENSP00000347184

Chemistry databases

BindingDBiP42858
ChEMBLiCHEMBL5514
DrugBankiDB09130, Copper

Protein family/group databases

MoonDBiP42858, Predicted

PTM databases

iPTMnetiP42858
MetOSiteiP42858
PhosphoSitePlusiP42858
SwissPalmiP42858

Genetic variation databases

BioMutaiHTT
DMDMi296434520

Proteomic databases

EPDiP42858
jPOSTiP42858
MassIVEiP42858
MaxQBiP42858
PaxDbiP42858
PeptideAtlasiP42858
PRIDEiP42858
ProteomicsDBi55561

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P42858, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3449, 794 antibodies

Genome annotation databases

EnsembliENST00000355072; ENSP00000347184; ENSG00000197386
GeneIDi3064
KEGGihsa:3064
UCSCiuc062uto.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3064
DisGeNETi3064

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HTT
GeneReviewsiHTT
HGNCiHGNC:4851, HTT
HPAiENSG00000197386, Low tissue specificity
MalaCardsiHTT
MIMi143100, phenotype
613004, gene
617435, phenotype
neXtProtiNX_P42858
OpenTargetsiENSG00000197386
Orphaneti399, Huntington disease
248111, Juvenile Huntington disease
PharmGKBiPA164741646
VEuPathDBiHostDB:ENSG00000197386.10

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QR1D, Eukaryota
GeneTreeiENSGT00390000015863
HOGENOMiCLU_000428_0_0_1
InParanoidiP42858
OMAiLHPEAFF
OrthoDBi33894at2759
PhylomeDBiP42858
TreeFamiTF323608

Enzyme and pathway databases

PathwayCommonsiP42858
ReactomeiR-HSA-9022692, Regulation of MECP2 expression and activity
SignaLinkiP42858
SIGNORiP42858

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3064, 27 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HTT, human
EvolutionaryTraceiP42858

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Huntingtin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3064
PharosiP42858, Tchem

Protein Ontology

More...
PROi
PR:P42858
RNActiP42858, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197386, Expressed in sural nerve and 179 other tissues
ExpressionAtlasiP42858, baseline and differential
GenevisibleiP42858, HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000091, Huntingtin
IPR028426, Huntingtin_fam
IPR024613, Huntingtin_middle-repeat
PANTHERiPTHR10170, PTHR10170, 1 hit
PfamiView protein in Pfam
PF12372, DUF3652, 1 hit
PRINTSiPR00375, HUNTINGTIN
SUPFAMiSSF48371, SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42858
Secondary accession number(s): Q9UQB7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again