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Protein

Neuronal vesicle trafficking-associated protein 1

Gene

NSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).By similarity2 Publications

GO - Molecular functioni

  • clathrin light chain binding Source: GO_Central
  • signaling receptor binding Source: Ensembl

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal vesicle trafficking-associated protein 1Curated
Alternative name(s):
Neuron-enriched endosomal protein of 21 kDa1 Publication
Neuron-specific protein family member 1Imported
Gene namesi
Name:NSG1Imported
Synonyms:D4S2341 Publication, NEEP211 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168824.14
HGNCiHGNC:18790 NSG1
MIMi607645 gene
neXtProtiNX_P42857

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 82CytoplasmicBy similarityAdd BLAST82
Transmembranei83 – 103Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini104 – 185LumenalBy similarityAdd BLAST82

Keywords - Cellular componenti

Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27065
OpenTargetsiENSG00000168824

Polymorphism and mutation databases

BioMutaiNSG1
DMDMi1168680

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643631 – 185Neuronal vesicle trafficking-associated protein 1Add BLAST185

Proteomic databases

EPDiP42857
PaxDbiP42857
PeptideAtlasiP42857
PRIDEiP42857
ProteomicsDBi55560

PTM databases

iPTMnetiP42857
PhosphoSitePlusiP42857

Expressioni

Inductioni

Up-regulated by TP53 after DNA damage (PubMed:20599942). Up-regulated by genotoxic stress (PubMed:20878061).2 Publications

Gene expression databases

BgeeiENSG00000168824 Expressed in 208 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasiP42857 baseline and differential
GenevisibleiP42857 HS

Organism-specific databases

HPAiHPA035775

Interactioni

Subunit structurei

Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12 (By similarity). Interacts with APP; could regulate APP processing (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117976, 4 interactors
IntActiP42857, 33 interactors
STRINGi9606.ENSP00000381049

Structurei

3D structure databases

ProteinModelPortaliP42857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 164Required for GRIP1 interactionBy similarityAdd BLAST36

Sequence similaritiesi

Belongs to the NSG family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IM0N Eukaryota
ENOG410YBAS LUCA
GeneTreeiENSGT00390000000483
HOGENOMiHOG000030909
HOVERGENiHBG012403
InParanoidiP42857
OMAiVYQYEQP
OrthoDBiEOG091G0LR0
PhylomeDBiP42857

Family and domain databases

InterProiView protein in InterPro
IPR009431 NSG
PANTHERiPTHR28546 PTHR28546, 1 hit
PfamiView protein in Pfam
PF06387 Calcyon, 1 hit
PIRSFiPIRSF002383 Calcyon, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P42857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKLGNNFAE KGTKQPLLED GFDTIPLMTP LDVNQLQFPP PDKVVVKTKT
60 70 80 90 100
EYEPDRKKGK ARPPQIAEFT VSITEGVTER FKVSVLVLFA LAFLTCVVFL
110 120 130 140 150
VVYKVYKYDR ACPDGFVLKN TQCIPEGLES YYAEQDSSAR EKFYTVINHY
160 170 180
NLAKQSITRS VSPWMSVLSE EKLSEQETEA AEKSA
Length:185
Mass (Da):20,913
Last modified:November 1, 1995 - v1
Checksum:i4B7086C18BC11605
GO
Isoform 2 (identifier: P42857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-81: Missing.

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):16,467
Checksum:iA6081780937EB3B6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YYJ2A0A0A6YYJ2_HUMAN
Neuron-specific protein family memb...
NSG1
146Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05433343 – 81Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98529 Genomic DNA Translation: AAA60152.1
M98528 Genomic DNA Translation: AAA60355.1
AK301911 mRNA Translation: BAG63337.1
AC105415 Genomic DNA No translation available.
AC110814 Genomic DNA No translation available.
BC001745 mRNA Translation: AAH01745.1
BC034227 mRNA Translation: AAH34227.1
CCDSiCCDS3376.1 [P42857-1]
RefSeqiNP_001035190.1, NM_001040101.1 [P42857-1]
NP_001274692.1, NM_001287763.1 [P42857-1]
NP_055207.1, NM_014392.4 [P42857-1]
XP_016863511.1, XM_017008022.1
UniGeneiHs.518595

Genome annotation databases

EnsembliENST00000397958; ENSP00000381049; ENSG00000168824 [P42857-1]
ENST00000421177; ENSP00000388823; ENSG00000168824 [P42857-1]
ENST00000433139; ENSP00000408833; ENSG00000168824 [P42857-1]
ENST00000504171; ENSP00000425803; ENSG00000168824 [P42857-2]
ENST00000505246; ENSP00000421841; ENSG00000168824 [P42857-1]
ENST00000506380; ENSP00000425423; ENSG00000168824 [P42857-1]
ENST00000513555; ENSP00000426358; ENSG00000168824 [P42857-1]
ENST00000513829; ENSP00000425345; ENSG00000168824 [P42857-1]
ENST00000621129; ENSP00000480081; ENSG00000168824 [P42857-1]
GeneIDi27065
KEGGihsa:27065
UCSCiuc003ghz.4 human [P42857-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98529 Genomic DNA Translation: AAA60152.1
M98528 Genomic DNA Translation: AAA60355.1
AK301911 mRNA Translation: BAG63337.1
AC105415 Genomic DNA No translation available.
AC110814 Genomic DNA No translation available.
BC001745 mRNA Translation: AAH01745.1
BC034227 mRNA Translation: AAH34227.1
CCDSiCCDS3376.1 [P42857-1]
RefSeqiNP_001035190.1, NM_001040101.1 [P42857-1]
NP_001274692.1, NM_001287763.1 [P42857-1]
NP_055207.1, NM_014392.4 [P42857-1]
XP_016863511.1, XM_017008022.1
UniGeneiHs.518595

3D structure databases

ProteinModelPortaliP42857
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117976, 4 interactors
IntActiP42857, 33 interactors
STRINGi9606.ENSP00000381049

PTM databases

iPTMnetiP42857
PhosphoSitePlusiP42857

Polymorphism and mutation databases

BioMutaiNSG1
DMDMi1168680

Proteomic databases

EPDiP42857
PaxDbiP42857
PeptideAtlasiP42857
PRIDEiP42857
ProteomicsDBi55560

Protocols and materials databases

DNASUi27065
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397958; ENSP00000381049; ENSG00000168824 [P42857-1]
ENST00000421177; ENSP00000388823; ENSG00000168824 [P42857-1]
ENST00000433139; ENSP00000408833; ENSG00000168824 [P42857-1]
ENST00000504171; ENSP00000425803; ENSG00000168824 [P42857-2]
ENST00000505246; ENSP00000421841; ENSG00000168824 [P42857-1]
ENST00000506380; ENSP00000425423; ENSG00000168824 [P42857-1]
ENST00000513555; ENSP00000426358; ENSG00000168824 [P42857-1]
ENST00000513829; ENSP00000425345; ENSG00000168824 [P42857-1]
ENST00000621129; ENSP00000480081; ENSG00000168824 [P42857-1]
GeneIDi27065
KEGGihsa:27065
UCSCiuc003ghz.4 human [P42857-1]

Organism-specific databases

CTDi27065
DisGeNETi27065
EuPathDBiHostDB:ENSG00000168824.14
GeneCardsiNSG1
HGNCiHGNC:18790 NSG1
HPAiHPA035775
MIMi607645 gene
neXtProtiNX_P42857
OpenTargetsiENSG00000168824
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IM0N Eukaryota
ENOG410YBAS LUCA
GeneTreeiENSGT00390000000483
HOGENOMiHOG000030909
HOVERGENiHBG012403
InParanoidiP42857
OMAiVYQYEQP
OrthoDBiEOG091G0LR0
PhylomeDBiP42857

Miscellaneous databases

ChiTaRSiNSG1 human
GenomeRNAii27065
PROiPR:P42857
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168824 Expressed in 208 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasiP42857 baseline and differential
GenevisibleiP42857 HS

Family and domain databases

InterProiView protein in InterPro
IPR009431 NSG
PANTHERiPTHR28546 PTHR28546, 1 hit
PfamiView protein in Pfam
PF06387 Calcyon, 1 hit
PIRSFiPIRSF002383 Calcyon, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNSG1_HUMAN
AccessioniPrimary (citable) accession number: P42857
Secondary accession number(s): B4DXC5, Q49AQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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