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Entry version 150 (16 Oct 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Essential for maintenance of the cell wall protein 1

Gene

EMW1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the maintenance of the cell wall integrity.1 Publication

Miscellaneous

Present with 8070 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • fungal-type cell wall organization Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33300-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Essential for maintenance of the cell wall protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EMW1
Ordered Locus Names:YNL313C
ORF Names:N0364
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YNL313C

Saccharomyces Genome Database

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SGDi
S000005257 EMW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002033651 – 904Essential for maintenance of the cell wall protein 1Add BLAST904

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P42842

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P42842

PRoteomics IDEntifications database

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PRIDEi
P42842

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P42842

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Target of SBF and MBF transcription factor complexes that activate gene expression during the G1/S transition of the cell cycle.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
35526, 44 interactors

Database of interacting proteins

More...
DIPi
DIP-6783N

Protein interaction database and analysis system

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IntActi
P42842, 20 interactors

Molecular INTeraction database

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MINTi
P42842

STRING: functional protein association networks

More...
STRINGi
4932.YNL313C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P42842

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati510 – 544TPR 1Add BLAST35
Repeati563 – 596TPR 2Add BLAST34
Repeati603 – 636TPR 3Add BLAST34
Repeati637 – 670TPR 4Add BLAST34
Repeati671 – 704TPR 5Add BLAST34
Repeati706 – 739TPR 6Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi149 – 158Poly-Leu10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC27 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P42842

Identification of Orthologs from Complete Genome Data

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OMAi
IWENYML

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P42842-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METLLHAKLL LSAEVESLKS GSFDQTYVKK AEHIISGESY QLVQQFVDKF
60 70 80 90 100
KGKISISGEI STSSVIAALN DFLNVEVFKM GQENEMLFLA IALLQTFIQN
110 120 130 140 150
NYTGPAARLK AISGLFGKTG IEIGAVNTAL SRSLAIMGQP AYEFMDDPLY
160 170 180 190 200
LVLSLLLLER ITGQKSLFDV TPDQEIPLPI ISAESTPGLL AVAYWWWARA
210 220 230 240 250
LLTQLSLIPE PSGFQASVAS AIYQSADLAY AITKELPESI HEDFKRELCA
260 270 280 290 300
MYYLENVKCS LAINTEHLCL PSLTRAKKIT NFEFVMTGAR ATRTKYQQKA
310 320 330 340 350
HAGLIILAKS FTFQNFALRT TSATPETFAL ESDLLLEKPH FESIADEPLD
360 370 380 390 400
EQIYSKRQKV DLNEGYEEDK LLPLALRQEN IPKLLLDLNP NDQPTLSDYD
410 420 430 440 450
NIQLLLRLYT IKNTTPAKDP LVEEELTALL SRILYQNGDK NWSIFARSLW
460 470 480 490 500
ERSIIETTKA KTIERGLLQM QSLVEELDLK IKSKLVPSSS EINVASRLSY
510 520 530 540 550
IHQLPFIPRW QLDATLAEKY MSLGILKSAV EIYERLGMAC ETALCYAAVG
560 570 580 590 600
DEKKAEEILL QRINENDSDA RAYSILGDIK QDPSLWEKSW EIGKYVNAKN
610 620 630 640 650
SLAKYYFNPP PKSGAQPNYS ATLKHLNDSL RQYPLSFETW YFYGCVGLQC
660 670 680 690 700
GKMQIAAEAF TRCVSLDPYH ALSWSNLSAA YTKMDKLKEA YSCLKRAISC
710 720 730 740 750
DAQKNWKIWE NYMLVAVKLN EWEDVLTACK QLVSIRRDKS GEGSIDLPII
760 770 780 790 800
EKLVELLVTS EYPEEPQQLS YFQKSCTEFI CNTLPQVITT SARCWRLVAR
810 820 830 840 850
VELWRKRPWA ALECHEKAYR AISHNPDLEV EEKVWNDTVD ACEDLVAAYE
860 870 880 890 900
SLGEMEGKYG PGSLVCKDWK YKCRSTIKAL MSKGKGRWDD SPGWDRLVEA

RSQI
Length:904
Mass (Da):102,336
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7170398FA95A0BD8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z46259 Genomic DNA Translation: CAA86383.1
Z71588 Genomic DNA Translation: CAA96242.1
Z71589 Genomic DNA Translation: CAA96243.1
BK006947 Genomic DNA Translation: DAA10248.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51299

NCBI Reference Sequences

More...
RefSeqi
NP_014086.1, NM_001183151.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL313C_mRNA; YNL313C; YNL313C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855403

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL313C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46259 Genomic DNA Translation: CAA86383.1
Z71588 Genomic DNA Translation: CAA96242.1
Z71589 Genomic DNA Translation: CAA96243.1
BK006947 Genomic DNA Translation: DAA10248.1
PIRiS51299
RefSeqiNP_014086.1, NM_001183151.1

3D structure databases

SMRiP42842
ModBaseiSearch...

Protein-protein interaction databases

BioGridi35526, 44 interactors
DIPiDIP-6783N
IntActiP42842, 20 interactors
MINTiP42842
STRINGi4932.YNL313C

PTM databases

iPTMnetiP42842

Proteomic databases

MaxQBiP42842
PaxDbiP42842
PRIDEiP42842

Genome annotation databases

EnsemblFungiiYNL313C_mRNA; YNL313C; YNL313C
GeneIDi855403
KEGGisce:YNL313C

Organism-specific databases

EuPathDBiFungiDB:YNL313C
SGDiS000005257 EMW1

Phylogenomic databases

InParanoidiP42842
OMAiIWENYML

Enzyme and pathway databases

BioCyciYEAST:G3O-33300-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P42842

Family and domain databases

InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMW1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42842
Secondary accession number(s): D6W0N2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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