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Entry version 157 (17 Jun 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Low affinity vacuolar monovalent cation/H(+) antiporter

Gene

VNX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in promoting intracellular monovalent cation sequestration via the exchange of monovalent cations and especially Na+ for hydrogen ions across the vacuolar membrane.1 Publication

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=22.4 mM for Na+ transport1 Publication
  2. KM=82.2 mM for K+ transport1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processIon transport, Sodium transport, Transport
    LigandSodium

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    YEAST:G3O-33306-MONOMER

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P42839

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.19.7.1 the ca(2+):cation antiporter (caca) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Low affinity vacuolar monovalent cation/H(+) antiporter
    Alternative name(s):
    Vacuolar Na(+)/H(+) exchanger
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:VNX1
    Ordered Locus Names:YNL321W
    ORF Names:N0339
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    FungiDB:YNL321W

    Saccharomyces Genome Database

    More...
    SGDi
    S000005265 VNX1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 244CytoplasmicSequence analysisAdd BLAST244
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
    Topological domaini266 – 408VacuolarSequence analysisAdd BLAST143
    Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
    Topological domaini430 – 494CytoplasmicSequence analysisAdd BLAST65
    Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
    Topological domaini516 – 530VacuolarSequence analysisAdd BLAST15
    Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
    Topological domaini552 – 560CytoplasmicSequence analysis9
    Transmembranei561 – 581HelicalSequence analysisAdd BLAST21
    Topological domaini582 – 587VacuolarSequence analysis6
    Transmembranei588 – 608HelicalSequence analysisAdd BLAST21
    Topological domaini609 – 626CytoplasmicSequence analysisAdd BLAST18
    Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
    Topological domaini648 – 686VacuolarSequence analysisAdd BLAST39
    Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
    Topological domaini708 – 746CytoplasmicSequence analysisAdd BLAST39
    Transmembranei747 – 767HelicalSequence analysisAdd BLAST21
    Topological domaini768 – 783VacuolarSequence analysisAdd BLAST16
    Transmembranei784 – 804HelicalSequence analysisAdd BLAST21
    Topological domaini805 – 816CytoplasmicSequence analysisAdd BLAST12
    Transmembranei817 – 837HelicalSequence analysisAdd BLAST21
    Topological domaini838 – 851VacuolarSequence analysisAdd BLAST14
    Transmembranei852 – 872HelicalSequence analysisAdd BLAST21
    Topological domaini873 – 885CytoplasmicSequence analysisAdd BLAST13
    Transmembranei886 – 906HelicalSequence analysisAdd BLAST21
    Topological domaini907 – 908VacuolarSequence analysis2

    Keywords - Cellular componenti

    Membrane, Vacuole

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002095051 – 908Low affinity vacuolar monovalent cation/H(+) antiporterAdd BLAST908

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphothreonineCombined sources1
    Modified residuei32PhosphoserineCombined sources1
    Modified residuei33PhosphothreonineCombined sources1
    Modified residuei110PhosphoserineCombined sources1
    Modified residuei118PhosphothreonineCombined sources1
    Modified residuei121PhosphoserineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P42839

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P42839

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P42839

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P42839

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    35519, 57 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-4268N

    STRING: functional protein association networks

    More...
    STRINGi
    4932.YNL321W

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P42839 protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000016897

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_001583_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P42839

    KEGG Orthology (KO)

    More...
    KOi
    K07300

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WKYTIDG

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR004837 NaCa_Exmemb
    IPR005185 YccF

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01699 Na_Ca_ex, 2 hits
    PF03733 YccF, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P42839-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAKNNHISAS GNSTSGDHRL KEEVLTPTTS ASTPHRIFSV DDDPKEIQND
    60 70 80 90 100
    IRYLEGLHEG LKFALHANKS KRSVSSQSPI VHSSNNTLHH HEHQQHLPPT
    110 120 130 140 150
    LESLSSKSHS VPDLNTATPS SPKRMHSSIR ELPHDDNDDE DANDDSRFII
    160 170 180 190 200
    HDSHGHDLLI DEINCQSPSH LENNDQASNA SSTESFTLRE RQDAINETHP
    210 220 230 240 250
    FGIRIWKPAL YKKHRSVQRT AAQDIHETQL KTITWEVTCS NVLWFILFGF
    260 270 280 290 300
    PIAILFYSAA IVVFLLGGGG LVTNSAKEYS KCLYKLANYF LWPFGKMVYL
    310 320 330 340 350
    LQDEQYLQED KDEGISMQQF YNWVTSYSNR LVFHQSQAKF QQREDHPAPA
    360 370 380 390 400
    TESSSLMPPA NTTATPLNSN HPSYNSIRHE IPHAAAQRRY FGRGKWSWGR
    410 420 430 440 450
    VLFYTIFHLV LQPILAVLSL CLWLLVFTIP MSNVLWQIMY HCRRHPLALG
    460 470 480 490 500
    FKYVENSSQS HENEITQQQL NKNILLCTFR AAGWHYYKYT VDGTNVIVVN
    510 520 530 540 550
    LISIVFFTIF DFYVLKNFLH WKTWFTYESS IFILCLTSTI PLAFYIGQAV
    560 570 580 590 600
    ASISAQTSMG VGAVINAFFS TIVEIFLYCV ALQQKKGLLV EGSMIGSILG
    610 620 630 640 650
    AVLLLPGLSM CGGALNRKTQ RYNPASAGVS SALLIFSMIV MFVPTVLYEI
    660 670 680 690 700
    YGGYSVNCAD GANDRDCTFS HPPLKFNRLF THVIQPMSIS CAIVLFCAYI
    710 720 730 740 750
    IGLWFTLRTH AKMIWQLPIA DPTSTAPEQQ EQNSHDAPNW SRSKSTCILL
    760 770 780 790 800
    MSTLLYAIIA EILVSCVDAV LEDIPSLNPK FLGLTIFALI PNTTEFLNAI
    810 820 830 840 850
    SFAIHGNVAL SMEIGSAYAL QVCLLQIPSL VIYSIFYTWN VKKSMINIRT
    860 870 880 890 900
    QMFPLVFPRW DIFGAMTSVF MFTYLYAEGK SNYFKGSMLI LLYIIIVVGF

    YFQGALSE
    Length:908
    Mass (Da):102,499
    Last modified:November 1, 1995 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i180E0EEC77DC111E
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    Z46259 Genomic DNA Translation: CAA86376.1
    Z71597 Genomic DNA Translation: CAA96252.1
    BK006947 Genomic DNA Translation: DAA10241.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S51293

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_014078.1, NM_001183159.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    YNL321W_mRNA; YNL321W; YNL321W

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    855395

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    sce:YNL321W

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z46259 Genomic DNA Translation: CAA86376.1
    Z71597 Genomic DNA Translation: CAA96252.1
    BK006947 Genomic DNA Translation: DAA10241.1
    PIRiS51293
    RefSeqiNP_014078.1, NM_001183159.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi35519, 57 interactors
    DIPiDIP-4268N
    STRINGi4932.YNL321W

    Protein family/group databases

    TCDBi2.A.19.7.1 the ca(2+):cation antiporter (caca) family

    PTM databases

    iPTMnetiP42839

    Proteomic databases

    MaxQBiP42839
    PaxDbiP42839
    PRIDEiP42839

    Genome annotation databases

    EnsemblFungiiYNL321W_mRNA; YNL321W; YNL321W
    GeneIDi855395
    KEGGisce:YNL321W

    Organism-specific databases

    EuPathDBiFungiDB:YNL321W
    SGDiS000005265 VNX1

    Phylogenomic databases

    GeneTreeiENSGT00390000016897
    HOGENOMiCLU_001583_0_0_1
    InParanoidiP42839
    KOiK07300
    OMAiWKYTIDG

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33306-MONOMER
    SABIO-RKiP42839

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P42839
    RNActiP42839 protein

    Family and domain databases

    InterProiView protein in InterPro
    IPR004837 NaCa_Exmemb
    IPR005185 YccF
    PfamiView protein in Pfam
    PF01699 Na_Ca_ex, 2 hits
    PF03733 YccF, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVNX1_YEAST
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42839
    Secondary accession number(s): D6W0M5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: June 17, 2020
    This is version 157 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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