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Protein

Mitochondrial DnaJ homolog 2

Gene

MDJ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial biogenesis and protein folding. Participates in the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner, probably by stimulating activity of mtHSP70 (SSC1).2 Publications

Miscellaneous

Present with 573 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ATPase activator activity Source: SGD

GO - Biological processi

  • protein import into mitochondrial matrix Source: SGD

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Stress response, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33312-MONOMER

Protein family/group databases

MoonDBiP42834 Predicted
TCDBi3.A.8.1.1 the mitochondrial protein translocase (mpt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial DnaJ homolog 2
Gene namesi
Name:MDJ2
Ordered Locus Names:YNL328C
ORF Names:N0315
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL328C
SGDiS000005272 MDJ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710941 – 146Mitochondrial DnaJ homolog 2Add BLAST146

Proteomic databases

MaxQBiP42834
PaxDbiP42834
PRIDEiP42834

Interactioni

Subunit structurei

Interacts with PAM16/TIM16 and is recruited by the PAM complex.1 Publication

Protein-protein interaction databases

BioGridi35513, 24 interactors
DIPiDIP-4690N
IntActiP42834, 8 interactors
STRINGi4932.YNL328C

Structurei

3D structure databases

ProteinModelPortaliP42834
SMRiP42834
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 146JPROSITE-ProRule annotationAdd BLAST62

Phylogenomic databases

GeneTreeiENSGT00390000017303
HOGENOMiHOG000115841
InParanoidiP42834
OMAiMVRDRYR
OrthoDBiEOG092C5SDV

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLPIIIGLG VTMVALSVKS GLNAWTVYKT LSPLTIAKLN NIRIENPTAG
60 70 80 90 100
YRDALKFKSS LIDEELKNRL NQYQGGFAPR MTEPEALLIL DISAREINHL
110 120 130 140
DEKLLKKKHR KAMVRNHPDR GGSPYMAAKI NEAKEVLERS VLLRKR
Length:146
Mass (Da):16,474
Last modified:November 1, 1995 - v1
Checksum:i36AC6362E15CEE71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46259 Genomic DNA Translation: CAA86370.1
Z71604 Genomic DNA Translation: CAA96260.1
AY692768 Genomic DNA Translation: AAT92787.1
BK006947 Genomic DNA Translation: DAA10235.1
PIRiS55861
RefSeqiNP_014071.1, NM_001183166.1

Genome annotation databases

EnsemblFungiiYNL328C; YNL328C; YNL328C
GeneIDi855388
KEGGisce:YNL328C

Similar proteinsi

Entry informationi

Entry nameiMDJ2_YEAST
AccessioniPrimary (citable) accession number: P42834
Secondary accession number(s): D6W0L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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