UniProtKB - P42831 (CCL2_PIG)
Protein
C-C motif chemokine 2
Gene
CCL2
Organism
Sus scrofa (Pig)
Status
Functioni
Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).By similarity
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: GO_Central
GO - Biological processi
- astrocyte cell migration Source: Ensembl
- cellular response to fibroblast growth factor stimulus Source: Ensembl
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to organic cyclic compound Source: Ensembl
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- cytoskeleton organization Source: Ensembl
- eosinophil chemotaxis Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- lymphocyte chemotaxis Source: GO_Central
- macrophage chemotaxis Source: Ensembl
- MAPK cascade Source: Ensembl
- monocyte chemotaxis Source: GO_Central
- negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- negative regulation of glial cell apoptotic process Source: Ensembl
- negative regulation of natural killer cell chemotaxis Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of vascular endothelial cell proliferation Source: Ensembl
- neutrophil chemotaxis Source: GO_Central
- positive regulation of calcium ion import Source: Ensembl
- positive regulation of endothelial cell apoptotic process Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of synaptic transmission, glutamatergic Source: UniProtKB
- protein kinase B signaling Source: Ensembl
- regulation of cell shape Source: Ensembl
- sensory perception of pain Source: UniProtKB
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-SSC-380108, Chemokine receptors bind chemokines |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 2Alternative name(s): Monocyte chemoattractant protein 1 Monocyte chemotactic protein 1 Short name: MCP-1 Small-inducible cytokine A2 |
Gene namesi | Name:CCL2 Synonyms:SCYA2 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | By similarityAdd BLAST | 23 | |
ChainiPRO_0000005153 | 24 – 99 | C-C motif chemokine 2Add BLAST | 76 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | Pyrrolidone carboxylic acidBy similarity | 1 | |
Disulfide bondi | 34 ↔ 59 | By similarity | ||
Disulfide bondi | 35 ↔ 75 | By similarity |
Post-translational modificationi
Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).By similarity
N-Glycosylated.By similarity
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acidProteomic databases
PaxDbi | P42831 |
Expressioni
Gene expression databases
Bgeei | ENSSSCG00000017723, Expressed in ileum and 38 other tissues |
ExpressionAtlasi | P42831, baseline |
Genevisiblei | P42831, SS |
Interactioni
Subunit structurei
Monomer or homodimer; in equilibrium (By similarity). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (By similarity).
By similarityGO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000018779 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine beta (chemokine CC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S6ZP, Eukaryota |
GeneTreei | ENSGT01020000230553 |
HOGENOMi | CLU_141716_1_0_1 |
InParanoidi | P42831 |
OMAi | CYTFTSK |
OrthoDBi | 1575018at2759 |
TreeFami | TF334888 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P42831-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVSAALLCL LLTAATFCTQ VLAQPDAINS PVTCCYTLTS KKISMQRLMS
60 70 80 90
YRRVTSSKCP KEAVIFKTIA GKEICAEPKQ KWVQDSISHL DKKNQTPKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48479 mRNA Translation: CAA88370.1 X79416 mRNA Translation: CAA55945.1 |
PIRi | JC2136 |
RefSeqi | NP_999379.1, NM_214214.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48479 mRNA Translation: CAA88370.1 X79416 mRNA Translation: CAA55945.1 |
PIRi | JC2136 |
RefSeqi | NP_999379.1, NM_214214.1 |
3D structure databases
SMRi | P42831 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000018779 |
Proteomic databases
PaxDbi | P42831 |
Genome annotation databases
Organism-specific databases
CTDi | 6347 |
Phylogenomic databases
eggNOGi | ENOG502S6ZP, Eukaryota |
GeneTreei | ENSGT01020000230553 |
HOGENOMi | CLU_141716_1_0_1 |
InParanoidi | P42831 |
OMAi | CYTFTSK |
OrthoDBi | 1575018at2759 |
TreeFami | TF334888 |
Enzyme and pathway databases
Reactomei | R-SSC-380108, Chemokine receptors bind chemokines |
Gene expression databases
Bgeei | ENSSSCG00000017723, Expressed in ileum and 38 other tissues |
ExpressionAtlasi | P42831, baseline |
Genevisiblei | P42831, SS |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL2_PIG | |
Accessioni | P42831Primary (citable) accession number: P42831 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families