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Protein

C-X-C motif chemokine 5

Gene

CXCL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.1 Publication

GO - Molecular functioni

  • chemokine activity Source: GO_Central
  • identical protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 5
Alternative name(s):
ENA-78(1-78)
Epithelial-derived neutrophil-activating protein 78
Neutrophil-activating peptide ENA-78
Small-inducible cytokine B5
Cleaved into the following 2 chains:
Gene namesi
Name:CXCL5
Synonyms:ENA78, SCYB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163735.6
HGNCiHGNC:10642 CXCL5
MIMi600324 gene
neXtProtiNX_P42830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6374
OpenTargetsiENSG00000163735
PharmGKBiPA35573

Polymorphism and mutation databases

DMDMi1169525

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 362 PublicationsAdd BLAST36
ChainiPRO_000000507537 – 114C-X-C motif chemokine 5Add BLAST78
ChainiPRO_000000507644 – 114ENA-78(8-78)Add BLAST71
ChainiPRO_000000507745 – 114ENA-78(9-78)Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 75Combined sources1 Publication
Disulfide bondi51 ↔ 91Combined sources1 Publication

Post-translational modificationi

N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei44 – 45Cleavage; by cathepsin G2

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP42830
PaxDbiP42830
PeptideAtlasiP42830
PRIDEiP42830
ProteomicsDBi55559

PTM databases

iPTMnetiP42830
PhosphoSitePlusiP42830

Miscellaneous databases

PMAP-CutDBiP42830

Expressioni

Gene expression databases

BgeeiENSG00000163735 Expressed in 123 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CXCL5
ExpressionAtlasiP42830 baseline and differential
GenevisibleiP42830 HS

Organism-specific databases

HPAiHPA065474

Interactioni

Subunit structurei

Monomer (PubMed:24695525). Homodimer (PubMed:24695525).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112276, 2 interactors
DIPiDIP-5911N
IntActiP42830, 14 interactors
STRINGi9606.ENSP00000296027

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP42830
SMRiP42830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4TR Eukaryota
ENOG41117DC LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP42830
KOiK05506
OMAiLRCVCLQ
OrthoDBiEOG091G132U
PhylomeDBiP42830
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42830-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV
60 70 80 90 100
CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK
110
KVIQKILDGG NKEN
Length:114
Mass (Da):11,972
Last modified:November 1, 1995 - v1
Checksum:i56B21EE86AE952D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78686 mRNA Translation: CAA55355.1
U12709 Genomic DNA Translation: AAA62475.1
L37036 Genomic DNA Translation: AAA86426.1
AF349466 Genomic DNA Translation: AAK29641.1
BC008376 mRNA Translation: AAH08376.1
AJ315732 Genomic DNA Translation: CAC42884.1
CCDSiCCDS34006.1
PIRiJC2433 A55010
RefSeqiNP_002985.1, NM_002994.4
UniGeneiHs.89714

Genome annotation databases

EnsembliENST00000296027; ENSP00000296027; ENSG00000163735
GeneIDi6374
KEGGihsa:6374

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXCL5 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78686 mRNA Translation: CAA55355.1
U12709 Genomic DNA Translation: AAA62475.1
L37036 Genomic DNA Translation: AAA86426.1
AF349466 Genomic DNA Translation: AAK29641.1
BC008376 mRNA Translation: AAH08376.1
AJ315732 Genomic DNA Translation: CAC42884.1
CCDSiCCDS34006.1
PIRiJC2433 A55010
RefSeqiNP_002985.1, NM_002994.4
UniGeneiHs.89714

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MGSNMR-A/B37-114[»]
ProteinModelPortaliP42830
SMRiP42830
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112276, 2 interactors
DIPiDIP-5911N
IntActiP42830, 14 interactors
STRINGi9606.ENSP00000296027

PTM databases

iPTMnetiP42830
PhosphoSitePlusiP42830

Polymorphism and mutation databases

DMDMi1169525

Proteomic databases

EPDiP42830
PaxDbiP42830
PeptideAtlasiP42830
PRIDEiP42830
ProteomicsDBi55559

Protocols and materials databases

DNASUi6374
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296027; ENSP00000296027; ENSG00000163735
GeneIDi6374
KEGGihsa:6374

Organism-specific databases

CTDi6374
DisGeNETi6374
EuPathDBiHostDB:ENSG00000163735.6
GeneCardsiCXCL5
HGNCiHGNC:10642 CXCL5
HPAiHPA065474
MIMi600324 gene
neXtProtiNX_P42830
OpenTargetsiENSG00000163735
PharmGKBiPA35573
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4TR Eukaryota
ENOG41117DC LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP42830
KOiK05506
OMAiLRCVCLQ
OrthoDBiEOG091G132U
PhylomeDBiP42830
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiCXCL5
GenomeRNAii6374
PMAP-CutDBiP42830
PROiPR:P42830
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163735 Expressed in 123 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CXCL5
ExpressionAtlasiP42830 baseline and differential
GenevisibleiP42830 HS

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL5_HUMAN
AccessioniPrimary (citable) accession number: P42830
Secondary accession number(s): Q96QE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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