CXCL5

Functionⁱ

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.1 Publication

GO - Molecular functionⁱ

chemokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24695525

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral immune response mediated by antimicrobial peptide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 7929219
cellular response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemotaxis
Source: ProtInc
Traceable author statementⁱ
- 10820279
G protein-coupled receptor signaling pathway Source: Reactome
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
leukocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10463948
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10820279

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C motif chemokine 5 Alternative name(s): ENA-78(1-78) Epithelial-derived neutrophil-activating protein 78 Neutrophil-activating peptide ENA-78 Small-inducible cytokine B5 Cleaved into the following 2 chains: ENA-78(8-78) ENA-78(9-78)
Gene namesⁱ	Name:CXCL5 Synonyms:ENA78, SCYB5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163735.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10642 CXCL5
MIMⁱ	600324 gene
neXtProtⁱ	NX_P42830

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6374
Open Targets More...OpenTargetsⁱ	ENSG00000163735
PharmGKBⁱ	PA35573

Polymorphism and mutation databases

DMDMⁱ	1169525

DMDMⁱ

1169525

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 36	2 PublicationsAdd BLAST	36
ChainⁱPRO_0000005075	37 – 114	C-X-C motif chemokine 5Add BLAST	78
ChainⁱPRO_0000005076	44 – 114	ENA-78(8-78)Add BLAST	71
ChainⁱPRO_0000005077	45 – 114	ENA-78(9-78)Add BLAST	70

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	49 ↔ 75	Combined sources1 Publication
Disulfide bondⁱ	51 ↔ 91	Combined sources1 Publication

Post-translational modificationⁱ

N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	44 – 45	Cleavage; by cathepsin G		2

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	P42830
PaxDbⁱ	P42830
PeptideAtlas More...PeptideAtlasⁱ	P42830
PRIDEⁱ	P42830
ProteomicsDBⁱ	55559

PTM databases

iPTMnetⁱ	P42830
PhosphoSitePlusⁱ	P42830

Miscellaneous databases

PMAP-CutDBⁱ	P42830

PMAP-CutDBⁱ

P42830

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163735 Expressed in 123 organ(s), highest expression level in smooth muscle tissue
CleanExⁱ	HS_CXCL5
ExpressionAtlasⁱ	P42830 baseline and differential
Genevisibleⁱ	P42830 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065474

HPAⁱ

HPA065474

Interactionⁱ

Subunit structureⁱ

Monomer (PubMed:24695525). Homodimer (PubMed:24695525).1 Publication

GO - Molecular functionⁱ

chemokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24695525

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112276, 2 interactors
Database of interacting proteins More...DIPⁱ	DIP-5911N
IntActⁱ	P42830, 14 interactors
STRINGⁱ	9606.ENSP00000296027

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	60 – 62	Combined sources	3
Beta strandⁱ	63 – 69	Combined sources	7
Beta strandⁱ	79 – 87	Combined sources	9
Beta strandⁱ	89 – 92	Combined sources	4
Helixⁱ	97 – 108	Combined sources	12
Turnⁱ	109 – 112	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P42830
SMRⁱ	P42830
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J4TR Eukaryota ENOG41117DC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062901
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG107789
InParanoidⁱ	P42830
KEGG Orthology (KO) More...KOⁱ	K05506
OMAⁱ	LRCVCLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G132U
PhylomeDBⁱ	P42830
TreeFamⁱ	TF333433

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P42830-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV 
        60         70         80         90        100
CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK 
       110 
KVIQKILDGG NKEN

Length:114

Mass (Da):11,972

Last modified:November 1, 1995 - v1

Checksum:ⁱ56B21EE86AE952D3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X78686 mRNA Translation: CAA55355.1 U12709 Genomic DNA Translation: AAA62475.1 L37036 Genomic DNA Translation: AAA86426.1 AF349466 Genomic DNA Translation: AAK29641.1 BC008376 mRNA Translation: AAH08376.1 AJ315732 Genomic DNA Translation: CAC42884.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34006.1
PIRⁱ	JC2433 A55010
NCBI Reference Sequences More...RefSeqⁱ	NP_002985.1, NM_002994.4
UniGeneⁱ	Hs.89714

Genome annotation databases

Ensemblⁱ	ENST00000296027; ENSP00000296027; ENSG00000163735
GeneIDⁱ	6374
KEGGⁱ	hsa:6374

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P42830	C-X-C motif chemokine		HUMAN		114	UniRef100_P42830
UPI0000144FC9		HUMAN		78

Protein	Similar proteins		Species	Score	Length	Source
P42830	C-X-C motif chemokine		HUMAN		114	UniRef90_P42830
C-X-C motif chemokine		PANTR		114
C-X-C motif chemokine		PANPA		114
C-X-C motif chemokine		NOMLE		114
C-X-C motif chemokine		GORGO		114
+1

Protein	Similar proteins		Species	Score	Length	Source
P42830	C-X-C motif chemokine 6		HUMAN		114	UniRef50_P42830
C-X-C motif chemokine		NOMLE		114
C-X-C motif chemokine		GORGO		114
C-X-C motif chemokine		PANPA		114
C-X-C motif chemokine		PANTR		114
+49

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CXCL5 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X78686 mRNA Translation: CAA55355.1 U12709 Genomic DNA Translation: AAA62475.1 L37036 Genomic DNA Translation: AAA86426.1 AF349466 Genomic DNA Translation: AAK29641.1 BC008376 mRNA Translation: AAH08376.1 AJ315732 Genomic DNA Translation: CAC42884.1
CCDSⁱ	CCDS34006.1
PIRⁱ	JC2433 A55010
RefSeqⁱ	NP_002985.1, NM_002994.4
UniGeneⁱ	Hs.89714

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MGS	NMR	-	A/B	37-114	[»]
ProteinModelPortalⁱ	P42830
SMRⁱ	P42830
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112276, 2 interactors
DIPⁱ	DIP-5911N
IntActⁱ	P42830, 14 interactors
STRINGⁱ	9606.ENSP00000296027

PTM databases

iPTMnetⁱ	P42830
PhosphoSitePlusⁱ	P42830

Polymorphism and mutation databases

DMDMⁱ	1169525

DMDMⁱ

1169525

Proteomic databases

EPDⁱ	P42830
PaxDbⁱ	P42830
PeptideAtlasⁱ	P42830
PRIDEⁱ	P42830
ProteomicsDBⁱ	55559

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6374
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000296027; ENSP00000296027; ENSG00000163735
GeneIDⁱ	6374
KEGGⁱ	hsa:6374

Organism-specific databases

CTDⁱ	6374
DisGeNETⁱ	6374
EuPathDBⁱ	HostDB:ENSG00000163735.6
GeneCardsⁱ	CXCL5
HGNCⁱ	HGNC:10642 CXCL5
HPAⁱ	HPA065474
MIMⁱ	600324 gene
neXtProtⁱ	NX_P42830
OpenTargetsⁱ	ENSG00000163735
PharmGKBⁱ	PA35573
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4TR Eukaryota ENOG41117DC LUCA
GeneTreeⁱ	ENSGT00530000062901
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG107789
InParanoidⁱ	P42830
KOⁱ	K05506
OMAⁱ	LRCVCLQ
OrthoDBⁱ	EOG091G132U
PhylomeDBⁱ	P42830
TreeFamⁱ	TF333433

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiⁱ	CXCL5
GenomeRNAiⁱ	6374
PMAP-CutDBⁱ	P42830
Protein Ontology More...PROⁱ	PR:P42830
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163735 Expressed in 123 organ(s), highest expression level in smooth muscle tissue
CleanExⁱ	HS_CXCL5
ExpressionAtlasⁱ	P42830 baseline and differential
Genevisibleⁱ	P42830 HS

Family and domain databases

CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXCL5_HUMAN
Accessionⁱ	P42830Primary (citable) accession number: P42830 Secondary accession number(s): Q96QE1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P42830 (CXCL5_HUMAN)

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C-X-C motif chemokine 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ