The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P42830 (CXCL5_HUMAN)
Protein
C-X-C motif chemokine 5
Gene
CXCL5
Organism
Homo sapiens (Human)
Status
Functioni
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
1 PublicationGO - Molecular functioni
- chemokine activity Source: GO_Central
- CXCR chemokine receptor binding Source: GO_Central
- identical protein binding Source: UniProtKB
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
- cell-cell signaling Source: ProtInc
- cellular response to lipopolysaccharide Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: ProtInc
- inflammatory response Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- positive regulation of cell population proliferation Source: ProtInc
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
PathwayCommonsi | P42830 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P42830 |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 5Alternative name(s): ENA-78(1-78) Epithelial-derived neutrophil-activating protein 78 Neutrophil-activating peptide ENA-78 Small-inducible cytokine B5 Cleaved into the following 2 chains: |
Gene namesi | Name:CXCL5 Synonyms:ENA78, SCYB5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10642, CXCL5 |
MIMi | 600324, gene |
neXtProti | NX_P42830 |
VEuPathDBi | HostDB:ENSG00000163735 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6374 |
OpenTargetsi | ENSG00000163735 |
PharmGKBi | PA35573 |
Miscellaneous databases
Pharosi | P42830, Tbio |
Genetic variation databases
BioMutai | CXCL5 |
DMDMi | 1169525 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 36 | 2 PublicationsAdd BLAST | 36 | |
ChainiPRO_0000005075 | 37 – 114 | C-X-C motif chemokine 5Add BLAST | 78 | |
ChainiPRO_0000005076 | 44 – 114 | ENA-78(8-78)Add BLAST | 71 | |
ChainiPRO_0000005077 | 45 – 114 | ENA-78(9-78)Add BLAST | 70 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 75 | Combined sources1 Publication | ||
Disulfide bondi | 51 ↔ 91 | Combined sources1 Publication |
Post-translational modificationi
N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 44 – 45 | Cleavage; by cathepsin G | 2 |
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | P42830 |
MassIVEi | P42830 |
PaxDbi | P42830 |
PeptideAtlasi | P42830 |
PRIDEi | P42830 |
ProteomicsDBi | 55559 |
PTM databases
iPTMneti | P42830 |
PhosphoSitePlusi | P42830 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163735, Expressed in smooth muscle tissue and 139 other tissues |
ExpressionAtlasi | P42830, baseline and differential |
Genevisiblei | P42830, HS |
Organism-specific databases
HPAi | ENSG00000163735, Group enriched (lymphoid tissue, salivary gland) |
Interactioni
Subunit structurei
Binary interactionsi
P42830
GO - Molecular functioni
- chemokine activity Source: GO_Central
- CXCR chemokine receptor binding Source: GO_Central
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112276, 50 interactors |
DIPi | DIP-5911N |
IntActi | P42830, 16 interactors |
STRINGi | 9606.ENSP00000296027 |
Miscellaneous databases
RNActi | P42830, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P42830 |
BMRBi | P42830 |
SMRi | P42830 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000163567 |
HOGENOMi | CLU_143902_1_0_1 |
InParanoidi | P42830 |
OMAi | CVCLQTT |
OrthoDBi | 1556509at2759 |
PhylomeDBi | P42830 |
TreeFami | TF333433 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P42830-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV
60 70 80 90 100
CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK
110
KVIQKILDGG NKEN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78686 mRNA Translation: CAA55355.1 U12709 Genomic DNA Translation: AAA62475.1 L37036 Genomic DNA Translation: AAA86426.1 AF349466 Genomic DNA Translation: AAK29641.1 BC008376 mRNA Translation: AAH08376.1 AJ315732 Genomic DNA Translation: CAC42884.1 |
CCDSi | CCDS34006.1 |
PIRi | JC2433, A55010 |
RefSeqi | NP_002985.1, NM_002994.4 |
Genome annotation databases
Ensembli | ENST00000296027.5; ENSP00000296027.4; ENSG00000163735.7 |
GeneIDi | 6374 |
KEGGi | hsa:6374 |
MANE-Selecti | ENST00000296027.5; ENSP00000296027.4; NM_002994.5; NP_002985.1 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CXCL5 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78686 mRNA Translation: CAA55355.1 U12709 Genomic DNA Translation: AAA62475.1 L37036 Genomic DNA Translation: AAA86426.1 AF349466 Genomic DNA Translation: AAK29641.1 BC008376 mRNA Translation: AAH08376.1 AJ315732 Genomic DNA Translation: CAC42884.1 |
CCDSi | CCDS34006.1 |
PIRi | JC2433, A55010 |
RefSeqi | NP_002985.1, NM_002994.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MGS | NMR | - | A/B | 37-114 | [»] | |
AlphaFoldDBi | P42830 | |||||
BMRBi | P42830 | |||||
SMRi | P42830 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112276, 50 interactors |
DIPi | DIP-5911N |
IntActi | P42830, 16 interactors |
STRINGi | 9606.ENSP00000296027 |
PTM databases
iPTMneti | P42830 |
PhosphoSitePlusi | P42830 |
Genetic variation databases
BioMutai | CXCL5 |
DMDMi | 1169525 |
Proteomic databases
EPDi | P42830 |
MassIVEi | P42830 |
PaxDbi | P42830 |
PeptideAtlasi | P42830 |
PRIDEi | P42830 |
ProteomicsDBi | 55559 |
Protocols and materials databases
ABCDi | P42830, 2 sequenced antibodies |
Antibodypediai | 13336, 548 antibodies from 35 providers |
DNASUi | 6374 |
Genome annotation databases
Ensembli | ENST00000296027.5; ENSP00000296027.4; ENSG00000163735.7 |
GeneIDi | 6374 |
KEGGi | hsa:6374 |
MANE-Selecti | ENST00000296027.5; ENSP00000296027.4; NM_002994.5; NP_002985.1 |
Organism-specific databases
CTDi | 6374 |
DisGeNETi | 6374 |
GeneCardsi | CXCL5 |
HGNCi | HGNC:10642, CXCL5 |
HPAi | ENSG00000163735, Group enriched (lymphoid tissue, salivary gland) |
MIMi | 600324, gene |
neXtProti | NX_P42830 |
OpenTargetsi | ENSG00000163735 |
PharmGKBi | PA35573 |
VEuPathDBi | HostDB:ENSG00000163735 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000163567 |
HOGENOMi | CLU_143902_1_0_1 |
InParanoidi | P42830 |
OMAi | CVCLQTT |
OrthoDBi | 1556509at2759 |
PhylomeDBi | P42830 |
TreeFami | TF333433 |
Enzyme and pathway databases
PathwayCommonsi | P42830 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P42830 |
Miscellaneous databases
BioGRID-ORCSi | 6374, 15 hits in 1039 CRISPR screens |
GeneWikii | CXCL5 |
GenomeRNAii | 6374 |
Pharosi | P42830, Tbio |
PROi | PR:P42830 |
RNActi | P42830, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163735, Expressed in smooth muscle tissue and 139 other tissues |
ExpressionAtlasi | P42830, baseline and differential |
Genevisiblei | P42830, HS |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCL5_HUMAN | |
Accessioni | P42830Primary (citable) accession number: P42830 Secondary accession number(s): Q96QE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families