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Entry version 143 (11 Dec 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Ribonuclease 1

Gene

RNS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May remobilize phosphate, particularly when cells senesce or when phosphate becomes limiting.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • RNA + H(2)O = an (RNA fragment)-3'-nucleoside-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA fragment).PROSITE-ProRule annotation EC:4.6.1.19

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei65By similarity1
Active sitei119By similarity1
Active sitei123By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Lyase, Nuclease
Biological processStress response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease 1 (EC:4.6.1.19)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNS1
Ordered Locus Names:At2g02990
ORF Names:T17M13.16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G02990

The Arabidopsis Information Resource

More...
TAIRi
locus:2056755 AT2G02990

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003096623 – 230Ribonuclease 1Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi80 ↔ 126By similarity
Disulfide bondi186 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P42813

PRoteomics IDEntifications database

More...
PRIDEi
P42813

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By phosphate starvation.

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P42813 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P42813 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P42813, 6 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G02990.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P42813

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNase T2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1642 Eukaryota
ENOG4111M7G LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000238569

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P42813

KEGG Orthology (KO)

More...
KOi
K01166

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFWTHEW

Database of Orthologous Groups

More...
OrthoDBi
994722at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P42813

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01061 RNase_T2_euk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033697 Ribonuclease_T2_eukaryotic
IPR001568 RNase_T2-like
IPR036430 RNase_T2-like_sf
IPR018188 RNase_T2_His_AS_1
IPR033130 RNase_T2_His_AS_2

The PANTHER Classification System

More...
PANTHERi
PTHR11240 PTHR11240, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00445 Ribonuclease_T2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55895 SSF55895, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00530 RNASE_T2_1, 1 hit
PS00531 RNASE_T2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P42813-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILLASLCL ISLLVILPSV FSASSSSEDF DFFYFVQQWP GSYCDTQKKC
60 70 80 90 100
CYPNSGKPAA DFGIHGLWPN YKDGTYPSNC DASKPFDSST ISDLLTSMKK
110 120 130 140 150
SWPTLACPSG SGEAFWEHEW EKHGTCSESV IDQHEYFQTA LNLKQKTNLL
160 170 180 190 200
GALTKAGINP DGKSYSLESI RDSIKESIGF TPWVECNRDG SGNSQLYQVY
210 220 230
LCVDRSGSGL IECPVFPHGK CGAEIEFPSF
Length:230
Mass (Da):25,397
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFD132D39F02505A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABK28493 differs from that shown. Reason: Erroneous termination. Extended C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39 – 41WPG → GXP AA sequence (PubMed:9188482).Curated3
Sequence conflicti82A → D in AAM63798 (Ref. 6) Curated1
Sequence conflicti130 – 131VI → GY in CAA81782 (Ref. 7) Curated2
Sequence conflicti203V → A in CAA81782 (Ref. 7) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U05206 mRNA Translation: AAC48925.1
AC004138 Genomic DNA Translation: AAC32917.1
CP002685 Genomic DNA Translation: AEC05652.1
AY072413 mRNA Translation: AAL62405.1
AY114710 mRNA Translation: AAM48029.1
DQ446504 mRNA Translation: ABE65814.1
DQ652992 mRNA Translation: ABK28493.1 Sequence problems.
AY086747 mRNA Translation: AAM63798.1
Z27289 mRNA Translation: CAA81782.1
Z27290 mRNA Translation: CAA81783.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A84443

NCBI Reference Sequences

More...
RefSeqi
NP_178399.1, NM_126351.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G02990.1; AT2G02990.1; AT2G02990

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
814828

Gramene; a comparative resource for plants

More...
Gramenei
AT2G02990.1; AT2G02990.1; AT2G02990

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G02990

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05206 mRNA Translation: AAC48925.1
AC004138 Genomic DNA Translation: AAC32917.1
CP002685 Genomic DNA Translation: AEC05652.1
AY072413 mRNA Translation: AAL62405.1
AY114710 mRNA Translation: AAM48029.1
DQ446504 mRNA Translation: ABE65814.1
DQ652992 mRNA Translation: ABK28493.1 Sequence problems.
AY086747 mRNA Translation: AAM63798.1
Z27289 mRNA Translation: CAA81782.1
Z27290 mRNA Translation: CAA81783.1
PIRiA84443
RefSeqiNP_178399.1, NM_126351.3

3D structure databases

SMRiP42813
ModBaseiSearch...

Protein-protein interaction databases

BioGridi230, 6 interactors
IntActiP42813, 6 interactors
STRINGi3702.AT2G02990.1

Proteomic databases

PaxDbiP42813
PRIDEiP42813

Genome annotation databases

EnsemblPlantsiAT2G02990.1; AT2G02990.1; AT2G02990
GeneIDi814828
GrameneiAT2G02990.1; AT2G02990.1; AT2G02990
KEGGiath:AT2G02990

Organism-specific databases

AraportiAT2G02990
TAIRilocus:2056755 AT2G02990

Phylogenomic databases

eggNOGiKOG1642 Eukaryota
ENOG4111M7G LUCA
HOGENOMiHOG000238569
InParanoidiP42813
KOiK01166
OMAiQFWTHEW
OrthoDBi994722at2759
PhylomeDBiP42813

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P42813

Gene expression databases

ExpressionAtlasiP42813 baseline and differential
GenevisibleiP42813 AT

Family and domain databases

CDDicd01061 RNase_T2_euk, 1 hit
Gene3Di3.90.730.10, 1 hit
InterProiView protein in InterPro
IPR033697 Ribonuclease_T2_eukaryotic
IPR001568 RNase_T2-like
IPR036430 RNase_T2-like_sf
IPR018188 RNase_T2_His_AS_1
IPR033130 RNase_T2_His_AS_2
PANTHERiPTHR11240 PTHR11240, 1 hit
PfamiView protein in Pfam
PF00445 Ribonuclease_T2, 1 hit
SUPFAMiSSF55895 SSF55895, 1 hit
PROSITEiView protein in PROSITE
PS00530 RNASE_T2_1, 1 hit
PS00531 RNASE_T2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNS1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42813
Secondary accession number(s): A0MEM0
, Q1PF62, Q42188, Q6LAC8, Q8LC78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 11, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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