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UniProtKB - P42787 (CBPD_DROME)

Entry version 186 (16 Oct 2019)
Sequence version 2 (21 Feb 2001)
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Protein

Carboxypeptidase D

Gene

svr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the proper melanization and sclerotization of the cuticle.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Releases C-terminal Arg and Lys from polypeptides. EC:3.4.17.22

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.0 for carboxypeptidase domain 1, and 5.0-6.0 for domain 2.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi101Zinc 1; catalyticBy similarity1
Metal bindingi104Zinc 1; catalyticBy similarity1
Metal bindingi217Zinc 1; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei305Proton donor/acceptor 1By similarity1
Metal bindingi517Zinc 2; catalyticBy similarity1
Metal bindingi520Zinc 2; catalyticBy similarity1
Metal bindingi626Zinc 2; catalyticBy similarity1
Active sitei730Proton donor/acceptor 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.17.22 1994

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-432722 Golgi Associated Vesicle Biogenesis

Protein family/group databases

MEROPS protease database

More...MEROPSi		M14.037

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carboxypeptidase D (EC:3.4.17.22)
Alternative name(s):
Metallocarboxypeptidase D
Protein silver
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:svr
Synonyms:CPD, CpepE
ORF Names:CG4122
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0004648 svr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 1312ExtracellularSequence analysisAdd BLAST1287
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1313 – 1333HelicalSequence analysisAdd BLAST21
Topological domaini1334 – 1406CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cuticle, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000440526 – 1406Carboxypeptidase DAdd BLAST1381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi612N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi652N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi808N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi981N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1251N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1380Phosphoserine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P42787

PRoteomics IDEntifications database

More...PRIDEi		P42787

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P42787

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Embryonic and adult stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0004648 Expressed in 24 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P42787 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P42787 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		57568, 3 interactors

Protein interaction database and analysis system

More...IntActi		P42787, 2 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0089126

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P42787

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 446Domain 1Add BLAST421
Regioni447 – 865Domain 2Add BLAST419
Regioni866 – 1313Domain 3Add BLAST448

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1343 – 1345Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2649 Eukaryota
ENOG410XX0H LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156919

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P42787

KEGG Orthology (KO)

More...KOi		K07752

Identification of Orthologs from Complete Genome Data

More...OMAi		GNHERIA

Database for complete collections of gene phylogenies

More...PhylomeDBi		P42787

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR015567 Pept_M14B_carboxypept_D2
IPR000834 Peptidase_M14

The PANTHER Classification System

More...PANTHERi		PTHR11532:SF73 PTHR11532:SF73, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00246 Peptidase_M14, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00765 CRBOXYPTASEA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00631 Zn_pept, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49464 SSF49464, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 2 hits
PS00133 CARBOXYPEPT_ZN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P42787-1) [UniParc]FASTAAdd to basket
Also known as: B, 1B long tail-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTLGLLFAS IGIAVLAMGV PHCRGYTIKE DESFLQQPHY ASQEQLEDLF 
        60         70         80         90        100
AGLEKAYPNQ AKVHFLGRSL EGRNLLALQI SRNTRSRNLL TPPVKYIANM 
       110        120        130        140        150
HGDETVGRQL LVYMAQYLLG NHERISDLGQ LVNSTDIYLV PTMNPDGYAL 
       160        170        180        190        200
SQEGNCESLP NYVGRGNAAN IDLNRDFPDR LEQSHVHQLR AQSRQPETAA 
       210        220        230        240        250
LVNWIVSKPF VLSANFHGGA VVASYPYDNS LAHNECCEES LTPDDRVFKQ 
       260        270        280        290        300
LAHTYSDNHP IMRKGNNCND SFSGGITNGA HWYELSGGMQ DFNYAFSNCF 
       310        320        330        340        350
ELTIELSCCK YPAASTLPQE WQRNKASLLQ LLRQAHIGIK GLVTDASGFP 
       360        370        380        390        400
IADANVYVAG LEEKPMRTSK RGEYWRLLTP GLYSVHASAF GYQTSAPQQV 
       410        420        430        440        450
RVTNDNQEAL RLDFKLAPVE TNFDGNFRKV KVERSEPPQK LKKQFNGFLT 
       460        470        480        490        500
PTKYEHHNFT AMESYLRAIS SSYPSLTRLY SIGKSVQGRD LWVLEIFATP 
       510        520        530        540        550
GSHVPGVPEF KYVANMHGNE VVGKELLLIL TKYMLERYGN DDRITKLVNG 
       560        570        580        590        600
TRMHFLYSMN PDGYEISIEG DRTGGVGRAN AHGIDLNRNF PDQYGTDRFN 
       610        620        630        640        650
KVTEPEVAAV MNWTLSLPFV LSANLHGGSL VANYPFDDNE NDFNDPFMRL 
       660        670        680        690        700
RNSSINGRKP NPTEDNALFK HLAGIYSNAH PTMYLGQPCE LFQNEFFPDG 
       710        720        730        740        750
ITNGAQWYSV TGGMQDWNYV RAGCLELTIE MGCDKFPKAA ELSRYWEDHR 
       760        770        780        790        800
EPLLQFIEQV HCGIHGFVHS TIGTPIAGAV VRLDGANHST YSQVFGDYWK 
       810        820        830        840        850
LALPGRHNLT VLGDNYAPLR MEVEVPDVHP FEMRMDITLM PDDPQHWASA 
       860        870        880        890        900
NDFRIIENVV NTRYHTNPQV RARLAELENQ NGQIASFGYA DSEFGTIFNY 
       910        920        930        940        950
LKMTSDIGEP EEHKYKLLVV SSLYDTTAPL GREILLNLIR HLVEGFKLQD 
       960        970        980        990       1000
TSVVELLKRS VIYFLPQTSK FQNVFDMYNS NTSICDPVLG DELAERILGP 
      1010       1020       1030       1040       1050
ETDQAKDVFL QFLRSERFDL MLTFGAGNSD LNYPKGDSVL VKFAHRMQRT 
      1060       1070       1080       1090       1100
EFNYSPLQCP PSATRQLHRE TTERLTNMMY RIYNLPVYTL GISCCRMPHQ 
      1110       1120       1130       1140       1150
KKIASVWRKN IDKIKNFLAL VKTGVSGLVQ NDKGQPLREA YVRLLEHDRI 
      1160       1170       1180       1190       1200
INVTKNVARF QLMLPHGLYG LEVTAPNYES QMIKVDVEDG RVTELGIIRM 
      1210       1220       1230       1240       1250
HPFTLIRGVV LELPNNDNRA TTSIAGVVLD ESNHPVRNAK VSVVGQTQLR 
      1260       1270       1280       1290       1300
NFTGSMGQYR ISAVPLGTIT LKVEAPRHLE ATRQMHLIQG GLATENVVFH 
      1310       1320       1330       1340       1350
LKVNEHVFGL PRFLFILCAS VLIIVGVIVC VLCAQFWFYR RHRGDKPYYN 
      1360       1370       1380       1390       1400
FSLLPQRGKE QFGLEDDDGG DDGETELFRS PIKRELSQRA HLVNNQTNYS 

FIIQAA
Length:1,406
Mass (Da):158,789
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7CF31AEC21363BD
GO
Isoform 2 (identifier: P42787-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     2-152: PTLGLLFASI...MNPDGYALSQ → NTCL

Show »
Length:1,259
Mass (Da):142,410
Checksum:iAD4C718C35869632
GO
Isoform 3 (identifier: P42787-3) [UniParc]FASTAAdd to basket
Also known as: 1A long tail-1, D

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MPTLGLLFAS...MNPDGYALSQ → MLFFCLALII...CNPDGFAKAK

Show »
Length:1,404
Mass (Da):158,519
Checksum:i8A22898B7FBCDCB4
GO
Isoform 4 (identifier: P42787-4) [UniParc]FASTAAdd to basket
Also known as: H

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MPTLGLLFAS...MNPDGYALSQ → MLFFCLALII...CNPDGFAKAK
     1385-1406: ELSQRAHLVNNQTNYSFIIQAA → GMTIQPYFDE...LHNNGNKRRH

Note: No experimental confirmation available.
Show »
Length:1,437
Mass (Da):162,436
Checksum:i0F38E501B4E326D4
GO
Isoform 5 (identifier: P42787-5) [UniParc]FASTAAdd to basket
Also known as: 1B long tail-2, G

The sequence of this isoform differs from the canonical sequence as follows:
     1385-1406: ELSQRAHLVNNQTNYSFIIQAA → GMTIQPYFDE...LHNNGNKRRH

Show »
Length:1,439
Mass (Da):162,706
Checksum:iEB058FE1253F2DF7
GO
Isoform 6 (identifier: P42787-6) [UniParc]FASTAAdd to basket
Also known as: 1A short, E

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MPTLGLLFAS...MNPDGYALSQ → MLFFCLALII...CNPDGFAKAK
     426-435: NFRKVKVERS → ISSFYSPYYF
     436-1406: Missing.

Show »
Length:433
Mass (Da):48,291
Checksum:iF4E23AA4E1FFE4FA
GO
Isoform 7 (identifier: P42787-7) [UniParc]FASTAAdd to basket
Also known as: 1B short, F

The sequence of this isoform differs from the canonical sequence as follows:
     426-435: NFRKVKVERS → ISSFYSPYYF
     436-1406: Missing.

Show »
Length:435
Mass (Da):48,562
Checksum:iBA5776BCECFD85C2
GO
Isoform 8 (identifier: P42787-8) [UniParc]FASTAAdd to basket
Also known as: G, I

The sequence of this isoform differs from the canonical sequence as follows:
     2-152: PTLGLLFASI...MNPDGYALSQ → NTCL
     1385-1406: ELSQRAHLVNNQTNYSFIIQAA → GMTIQPYFDE...LHNNGNKRRH

Note: No experimental confirmation available.
Show »
Length:1,292
Mass (Da):146,328
Checksum:iFAC618E7B2A5CCD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3DME3D3DME3_DROME
LP15968p
svr cc, CG18503, CG32818, CP, CPD
435Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2J9Z1X2J9Z1_DROME
Silver, isoform N
svr cc, CG18503, CG32818, CP, CPD
1,439Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6AWJ5Q6AWJ5_DROME
LP12324p
svr cc, CG18503, CG32818, CP, CPD
433Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA91650 differs from that shown. Reason: Frameshift.Curated
The sequence AAC46486 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti733C → Y in AAA91650 (PubMed:7568156).Curated1
Sequence conflicti1041V → E in ABM92809 (Ref. 5) Curated1
Sequence conflicti1041V → E in AAA91650 (PubMed:7568156).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0007731 – 152MPTLG…YALSQ → MLFFCLALIIGCAVGEYSEV RVIQEEDNFLESPHYLKNEE IGDLFSQLAKDYPDLAQTYT IGKSLEDRPIYALALSAPTG ESKNGDLLRPMVKLVANIQG DEAVGRQMVLYMAEYLATHY DGDPKVQALLNLTEIHFLPT CNPDGFAKAK in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_0374952 – 152PTLGL…YALSQ → NTCL in isoform 2 and isoform 8. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_000775426 – 435NFRKVKVERS → ISSFYSPYYF in isoform 6 and isoform 7. 1 Publication10
Alternative sequenceiVSP_000776436 – 1406Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST971
Alternative sequenceiVSP_0007791385 – 1406ELSQR…IIQAA → GMTIQPYFDEEQLERILHTD DDDDDGPHMEPELDVADDSE DDIVMLHNNGNKRRH in isoform 4, isoform 5 and isoform 8. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF545816 mRNA Translation: AAN73045.1
AF545817 mRNA Translation: AAN73046.1
AF545818 mRNA Translation: AAN73047.1
AF545819 mRNA Translation: AAN73048.1
AF545820 mRNA Translation: AAN73049.1
AE014298 Genomic DNA Translation: AAF45514.2
AE014298 Genomic DNA Translation: AAF45515.4
AE014298 Genomic DNA Translation: AAO41630.2
AE014298 Genomic DNA Translation: AAS65237.1
AE014298 Genomic DNA Translation: AAS65238.1
AE014298 Genomic DNA Translation: AAS65239.1
AE014298 Genomic DNA Translation: AAS65240.1
AE014298 Genomic DNA Translation: ACL82874.1
AL009147 Genomic DNA Translation: CAA15634.1
AL009147 Genomic DNA Translation: CAA15635.1
BT029935 mRNA Translation: ABM92809.1
BT099720 mRNA Translation: ACV53084.1
BT100310 mRNA Translation: ACZ52622.1
U29591 mRNA Translation: AAA91650.1 Frameshift.
U29592 mRNA Translation: AAA91651.1
U03883 Genomic DNA Translation: AAC46486.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...PIRi		T13284
T13420
T13421

NCBI Reference Sequences

More...RefSeqi		NP_001138141.1, NM_001144669.2 [P42787-8]
NP_001284742.1, NM_001297813.1 [P42787-6]
NP_001284743.1, NM_001297814.1 [P42787-7]
NP_001284744.1, NM_001297815.1 [P42787-5]
NP_525032.2, NM_080293.4 [P42787-1]
NP_726675.3, NM_166846.5 [P42787-4]
NP_788852.2, NM_176679.3 [P42787-1]
NP_996319.1, NM_206596.2 [P42787-5]
NP_996320.1, NM_206597.2 [P42787-7]
NP_996321.1, NM_206598.3 [P42787-6]
NP_996322.1, NM_206599.2 [P42787-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0070081; FBpp0070080; FBgn0004648 [P42787-1]
FBtr0070084; FBpp0089123; FBgn0004648 [P42787-3]
FBtr0070085; FBpp0089124; FBgn0004648 [P42787-6]
FBtr0070086; FBpp0089125; FBgn0004648 [P42787-7]
FBtr0070087; FBpp0089126; FBgn0004648 [P42787-5]
FBtr0290016; FBpp0288455; FBgn0004648 [P42787-4]
FBtr0290017; FBpp0288456; FBgn0004648 [P42787-8]
FBtr0340146; FBpp0309132; FBgn0004648 [P42787-6]
FBtr0344737; FBpp0311069; FBgn0004648 [P42787-7]
FBtr0344738; FBpp0311070; FBgn0004648 [P42787-1]
FBtr0344739; FBpp0311071; FBgn0004648 [P42787-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		30998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG4122

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF545816 mRNA Translation: AAN73045.1
AF545817 mRNA Translation: AAN73046.1
AF545818 mRNA Translation: AAN73047.1
AF545819 mRNA Translation: AAN73048.1
AF545820 mRNA Translation: AAN73049.1
AE014298 Genomic DNA Translation: AAF45514.2
AE014298 Genomic DNA Translation: AAF45515.4
AE014298 Genomic DNA Translation: AAO41630.2
AE014298 Genomic DNA Translation: AAS65237.1
AE014298 Genomic DNA Translation: AAS65238.1
AE014298 Genomic DNA Translation: AAS65239.1
AE014298 Genomic DNA Translation: AAS65240.1
AE014298 Genomic DNA Translation: ACL82874.1
AL009147 Genomic DNA Translation: CAA15634.1
AL009147 Genomic DNA Translation: CAA15635.1
BT029935 mRNA Translation: ABM92809.1
BT099720 mRNA Translation: ACV53084.1
BT100310 mRNA Translation: ACZ52622.1
U29591 mRNA Translation: AAA91650.1 Frameshift.
U29592 mRNA Translation: AAA91651.1
U03883 Genomic DNA Translation: AAC46486.1 Sequence problems.
PIRiT13284
T13420
T13421
RefSeqiNP_001138141.1, NM_001144669.2 [P42787-8]
NP_001284742.1, NM_001297813.1 [P42787-6]
NP_001284743.1, NM_001297814.1 [P42787-7]
NP_001284744.1, NM_001297815.1 [P42787-5]
NP_525032.2, NM_080293.4 [P42787-1]
NP_726675.3, NM_166846.5 [P42787-4]
NP_788852.2, NM_176679.3 [P42787-1]
NP_996319.1, NM_206596.2 [P42787-5]
NP_996320.1, NM_206597.2 [P42787-7]
NP_996321.1, NM_206598.3 [P42787-6]
NP_996322.1, NM_206599.2 [P42787-3]

3D structure databases

SMRiP42787
ModBaseiSearch...

Protein-protein interaction databases

BioGridi57568, 3 interactors
IntActiP42787, 2 interactors
STRINGi7227.FBpp0089126

Protein family/group databases

MEROPSiM14.037

PTM databases

iPTMnetiP42787

Proteomic databases

PaxDbiP42787
PRIDEiP42787

Genome annotation databases

EnsemblMetazoaiFBtr0070081; FBpp0070080; FBgn0004648 [P42787-1]
FBtr0070084; FBpp0089123; FBgn0004648 [P42787-3]
FBtr0070085; FBpp0089124; FBgn0004648 [P42787-6]
FBtr0070086; FBpp0089125; FBgn0004648 [P42787-7]
FBtr0070087; FBpp0089126; FBgn0004648 [P42787-5]
FBtr0290016; FBpp0288455; FBgn0004648 [P42787-4]
FBtr0290017; FBpp0288456; FBgn0004648 [P42787-8]
FBtr0340146; FBpp0309132; FBgn0004648 [P42787-6]
FBtr0344737; FBpp0311069; FBgn0004648 [P42787-7]
FBtr0344738; FBpp0311070; FBgn0004648 [P42787-1]
FBtr0344739; FBpp0311071; FBgn0004648 [P42787-5]
GeneIDi30998
KEGGidme:Dmel_CG4122

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		30998
FlyBaseiFBgn0004648 svr

Phylogenomic databases

eggNOGiKOG2649 Eukaryota
ENOG410XX0H LUCA
GeneTreeiENSGT00940000156919
InParanoidiP42787
KOiK07752
OMAiGNHERIA
PhylomeDBiP42787

Enzyme and pathway databases

BRENDAi3.4.17.22 1994
ReactomeiR-DME-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		svr fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		30998

Protein Ontology

More...PROi		PR:P42787

Gene expression databases

BgeeiFBgn0004648 Expressed in 24 organ(s), highest expression level in head
ExpressionAtlasiP42787 differential
GenevisibleiP42787 DM

Family and domain databases

InterProiView protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR015567 Pept_M14B_carboxypept_D2
IPR000834 Peptidase_M14
PANTHERiPTHR11532:SF73 PTHR11532:SF73, 3 hits
PfamiView protein in Pfam
PF00246 Peptidase_M14, 2 hits
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00631 Zn_pept, 2 hits
SUPFAMiSSF49464 SSF49464, 4 hits
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 2 hits
PS00133 CARBOXYPEPT_ZN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPD_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42787
Secondary accession number(s): A2RVE4
, B7Z112, C7LAH0, D0Z763, O46058, Q24094, Q24095, Q9W5F3, Q9W5F4, Q9W5F5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 21, 2001
Last modified: October 16, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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