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Protein

Cyclin-dependent kinase 4 inhibitor C

Gene

CDKN2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-69231 Cyclin D associated events in G1
SIGNORiP42773

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor C
Alternative name(s):
Cyclin-dependent kinase 6 inhibitor
p18-INK4c
p18-INK6
Gene namesi
Name:CDKN2C
Synonyms:CDKN6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000123080.10
HGNCiHGNC:1789 CDKN2C
MIMi603369 gene
neXtProtiNX_P42773

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1031
MalaCardsiCDKN2C
OpenTargetsiENSG00000123080
Orphaneti652 Multiple endocrine neoplasia type 1
PharmGKBiPA26322

Polymorphism and mutation databases

BioMutaiCDKN2C
DMDMi1168870

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441861 – 168Cyclin-dependent kinase 4 inhibitor CAdd BLAST168

Proteomic databases

EPDiP42773
PaxDbiP42773
PeptideAtlasiP42773
PRIDEiP42773
ProteomicsDBi55557

PTM databases

iPTMnetiP42773
PhosphoSitePlusiP42773

Expressioni

Tissue specificityi

Highest levels found in skeletal muscle. Also found in pancreas and heart.

Gene expression databases

BgeeiENSG00000123080 Expressed in 225 organ(s), highest expression level in adipose tissue
CleanExiHS_CDKN2C
ExpressionAtlasiP42773 baseline and differential
GenevisibleiP42773 HS

Organism-specific databases

HPAiCAB005303
CAB018398
HPA019057
HPA019764

Interactioni

Subunit structurei

Heterodimer of p18 with CDK6.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107465, 52 interactors
IntActiP42773, 42 interactors
MINTiP42773
STRINGi9606.ENSP00000262662

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP42773
SMRiP42773
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42773

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 33ANK 1Add BLAST30
Repeati37 – 65ANK 2Add BLAST29
Repeati69 – 98ANK 3Add BLAST30
Repeati102 – 132ANK 4Add BLAST31

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiP42773
KOiK06622
OMAiKHTASKV
OrthoDBiEOG091G0PMC
PhylomeDBiP42773
TreeFamiTF333311

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

P42773-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN
160
EVVSLMQANG AGGATNLQ
Length:168
Mass (Da):18,127
Last modified:November 1, 1995 - v1
Checksum:i5D66AFA715186E9A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00149072A → P in breast cancer; loss of CDK6 interaction. 2 Publications1
Natural variantiVAR_038604126T → M1 PublicationCorresponds to variant dbSNP:rs17851380Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17074 mRNA Translation: AAC50074.1
AF041248 mRNA Translation: AAC39782.1
AF041250, AF041249 Genomic DNA Translation: AAC39783.1
AY094608 Genomic DNA Translation: AAM11873.1
BC000598 mRNA Translation: AAH00598.1
BC005041 mRNA Translation: AAH05041.1
BC016173 mRNA Translation: AAH16173.1
CCDSiCCDS555.1
PIRiA55479
RefSeqiNP_001253.1, NM_001262.2
NP_523240.1, NM_078626.2
UniGeneiHs.525324

Genome annotation databases

EnsembliENST00000262662; ENSP00000262662; ENSG00000123080
ENST00000371761; ENSP00000360826; ENSG00000123080
ENST00000396148; ENSP00000379452; ENSG00000123080
GeneIDi1031
KEGGihsa:1031

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17074 mRNA Translation: AAC50074.1
AF041248 mRNA Translation: AAC39782.1
AF041250, AF041249 Genomic DNA Translation: AAC39783.1
AY094608 Genomic DNA Translation: AAM11873.1
BC000598 mRNA Translation: AAH00598.1
BC005041 mRNA Translation: AAH05041.1
BC016173 mRNA Translation: AAH16173.1
CCDSiCCDS555.1
PIRiA55479
RefSeqiNP_001253.1, NM_001262.2
NP_523240.1, NM_078626.2
UniGeneiHs.525324

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BU9NMR-A1-168[»]
1G3NX-ray2.90B/F1-168[»]
1IHBX-ray1.95A/B1-162[»]
1MX2X-ray2.25A/B1-168[»]
1MX4X-ray2.00A/B1-168[»]
1MX6X-ray2.00A/B1-168[»]
ProteinModelPortaliP42773
SMRiP42773
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107465, 52 interactors
IntActiP42773, 42 interactors
MINTiP42773
STRINGi9606.ENSP00000262662

PTM databases

iPTMnetiP42773
PhosphoSitePlusiP42773

Polymorphism and mutation databases

BioMutaiCDKN2C
DMDMi1168870

Proteomic databases

EPDiP42773
PaxDbiP42773
PeptideAtlasiP42773
PRIDEiP42773
ProteomicsDBi55557

Protocols and materials databases

DNASUi1031
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262662; ENSP00000262662; ENSG00000123080
ENST00000371761; ENSP00000360826; ENSG00000123080
ENST00000396148; ENSP00000379452; ENSG00000123080
GeneIDi1031
KEGGihsa:1031

Organism-specific databases

CTDi1031
DisGeNETi1031
EuPathDBiHostDB:ENSG00000123080.10
GeneCardsiCDKN2C
HGNCiHGNC:1789 CDKN2C
HPAiCAB005303
CAB018398
HPA019057
HPA019764
MalaCardsiCDKN2C
MIMi603369 gene
neXtProtiNX_P42773
OpenTargetsiENSG00000123080
Orphaneti652 Multiple endocrine neoplasia type 1
PharmGKBiPA26322
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiP42773
KOiK06622
OMAiKHTASKV
OrthoDBiEOG091G0PMC
PhylomeDBiP42773
TreeFamiTF333311

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-69231 Cyclin D associated events in G1
SIGNORiP42773

Miscellaneous databases

EvolutionaryTraceiP42773
GeneWikiiCDKN2C
GenomeRNAii1031
PROiPR:P42773
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123080 Expressed in 225 organ(s), highest expression level in adipose tissue
CleanExiHS_CDKN2C
ExpressionAtlasiP42773 baseline and differential
GenevisibleiP42773 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2C_HUMAN
AccessioniPrimary (citable) accession number: P42773
Secondary accession number(s): Q8TB83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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