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Protein

60S ribosomal protein L35

Gene

RPL35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication

GO - Molecular functioni

  • mRNA binding Source: ProtInc
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L35
Alternative name(s):
Large ribosomal subunit protein uL291 Publication
Gene namesi
Name:RPL35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136942.14
HGNCiHGNC:10344 RPL35
neXtProtiNX_P42766

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi11224
MalaCardsiRPL35
OpenTargetsiENSG00000136942
PharmGKBiPA34727

Polymorphism and mutation databases

BioMutaiRPL35

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001305332 – 12360S ribosomal protein L35Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19N6-acetyllysineCombined sources1
Cross-linki25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei29PhosphoserineCombined sources1
Modified residuei43N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP42766
MaxQBiP42766
PaxDbiP42766
PeptideAtlasiP42766
PRIDEiP42766
ProteomicsDBi55549
TopDownProteomicsiP42766

2D gel databases

SWISS-2DPAGEiP42766

PTM databases

CarbonylDBiP42766
iPTMnetiP42766
PhosphoSitePlusiP42766
SwissPalmiP42766

Expressioni

Gene expression databases

BgeeiENSG00000136942
CleanExiHS_RPL35
ExpressionAtlasiP42766 baseline and differential
GenevisibleiP42766 HS

Organism-specific databases

HPAiHPA006047

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication

Protein-protein interaction databases

BioGridi116392, 130 interactors
CORUMiP42766
IntActiP42766, 30 interactors
MINTiP42766
STRINGi9606.ENSP00000259469

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lh1-123[»]
4V6Xelectron microscopy5.00Ch1-123[»]
5AJ0electron microscopy3.50Ah1-123[»]
5LKSelectron microscopy3.60Lh1-123[»]
5T2Celectron microscopy3.60b1-123[»]
6EK0electron microscopy2.90Lh1-123[»]
ProteinModelPortaliP42766
SMRiP42766
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3436 Eukaryota
COG0255 LUCA
GeneTreeiENSGT00390000016384
HOVERGENiHBG000862
InParanoidiP42766
KOiK02918
OMAiTVINAKQ
OrthoDBiEOG091G1422
PhylomeDBiP42766
TreeFamiTF314951

Family and domain databases

HAMAPiMF_00374 Ribosomal_L29, 1 hit
InterProiView protein in InterPro
IPR001854 Ribosomal_L29/L35
IPR036049 Ribosomal_L29/L35_sf
IPR018254 Ribosomal_L29_CS
PfamiView protein in Pfam
PF00831 Ribosomal_L29, 1 hit
SUPFAMiSSF46561 SSF46561, 1 hit
TIGRFAMsiTIGR00012 L29, 1 hit
PROSITEiView protein in PROSITE
PS00579 RIBOSOMAL_L29, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIKARDLR GKKKEELLKQ LDDLKVELSQ LRVAKVTGGA ASKLSKIRVV
60 70 80 90 100
RKSIARVLTV INQTQKENLR KFYKGKKYKP LDLRPKKTRA MRRRLNKHEE
110 120
NLKTKKQQRK ERLYPLRKYA VKA
Length:123
Mass (Da):14,551
Last modified:January 23, 2007 - v2
Checksum:i92B7694A97AC725D
GO

Sequence cautioni

The sequence CAI39638 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122K → R in AAH10919 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12465 mRNA Translation: AAA51648.1
CR456877 mRNA Translation: CAG33158.1
AK291072 mRNA Translation: BAF83761.1
AL354928 Genomic DNA Translation: CAI39638.1 Sequence problems.
AL354928 Genomic DNA Translation: CAI39639.1
BC000348 mRNA Translation: AAH00348.1
BC010919 mRNA Translation: AAH10919.1
BC071915 mRNA Translation: AAH71915.1
BC094828 mRNA Translation: AAH94828.1
AB046409 Genomic DNA Translation: BAB21255.1
CCDSiCCDS6858.1
PIRiG01477
RefSeqiNP_009140.1, NM_007209.3
UniGeneiHs.182825

Genome annotation databases

EnsembliENST00000348462; ENSP00000259469; ENSG00000136942
GeneIDi11224
KEGGihsa:11224
UCSCiuc004boy.2 human

Similar proteinsi

Entry informationi

Entry nameiRL35_HUMAN
AccessioniPrimary (citable) accession number: P42766
Secondary accession number(s): A8K4V7
, Q4VBY5, Q5JTN5, Q6IBC7, Q96QJ7, Q9BYF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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