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Protein

Cyclin-D3-1

Gene

CYCD3-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the control of the cell cycle at the G1/S (start) transition. Activates the G1/S phase transition in response to cytokinin hormone signal, but declines in response to sucrose starvation leading to G1 arrest. Involved in the induction of mitotic cell division. Plays an important role in the switch from cell proliferation to the final stages of differentiation during plant development. May not be involved in the activation of cell cycle in the root apical meristem (RAM) in the early phase of seed germination. Promotes divisions in the guard cells (GCs) after the guard mother cells (GMC) symmetric division (PubMed:24687979).6 Publications

Miscellaneous

Plants overexpressing CYCD3-1 show extensive leaf curling, disorganized meristems, increased leaf number, late flowering and delayed senescence. CYCD3-1 is a highly unstable protein whose proteolysis is mediated by a proteasome-dependent pathway, and whose levels are highly dependent on the rate of protein synthesis.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G1/S transition of mitotic cell cycle Source: TAIR
  • guard mother cell differentiation Source: UniProtKB
  • response to cytokinin Source: TAIR
  • response to sucrose Source: TAIR
  • seed development Source: TAIR

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-D3-1
Alternative name(s):
Cyclin-delta-3
Short name:
Cyclin-d3
G1/S-specific cyclin-D3-1
Short name:
CycD3;1
Gene namesi
Name:CYCD3-1
Synonyms:CYCD3
Ordered Locus Names:At4g34160
ORF Names:F28A23.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G34160
TAIRilocus:2124331 AT4G34160

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi343S → A: Alteration of the cell cycle regulatory activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804471 – 376Cyclin-D3-1Add BLAST376

Post-translational modificationi

Phosphorylated.2 Publications

Proteomic databases

PaxDbiP42753

Expressioni

Tissue specificityi

Highly expressed in roots and at lower levels in leaves and flowers. Expressed in vegetative shoot meristem and inflorescence.3 Publications

Developmental stagei

Expressed 2 hours before the S phase and remains constant therafter.2 Publications

Inductioni

By cytokinin. Induction by cytokinin is blocked by auxin, but not by cycloheximide. Induced by sucrose and glucose. Induced by 24-epi-brassinolide. Down-regulated by sucrose starvation.5 Publications

Gene expression databases

ExpressionAtlasiP42753 baseline and differential
GenevisibleiP42753 AT

Interactioni

Subunit structurei

Interacts with the C-terminal domain of CDKA-1. Interacts with KRP1/ICK1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKA-1P241005EBI-1253610,EBI-371713

Protein-protein interaction databases

BioGridi14846, 14 interactors
ELMiP42753
IntActiP42753, 9 interactors
STRINGi3702.AT4G34160.1

Structurei

3D structure databases

ProteinModelPortaliP42753
SMRiP42753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGiKOG0656 Eukaryota
ENOG410XRKC LUCA
HOGENOMiHOG000242458
InParanoidiP42753
KOiK14505
OMAiHFQRDKP
OrthoDBiEOG09360IA7
PhylomeDBiP42753

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P42753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRKEEESR EEQSNSFLLD ALYCEEEKWD DEGEEVEENS SLSSSSSPFV
60 70 80 90 100
VLQQDLFWED EDLVTLFSKE EEQGLSCLDD VYLSTDRKEA VGWILRVNAH
110 120 130 140 150
YGFSTLAAVL AITYLDKFIC SYSLQRDKPW MLQLVSVACL SLAAKVEETQ
160 170 180 190 200
VPLLLDFQVE ETKYVFEAKT IQRMELLILS TLEWKMHLIT PISFVDHIIR
210 220 230 240 250
RLGLKNNAHW DFLNKCHRLL LSVISDSRFV GYLPSVVAAA TMMRIIEQVD
260 270 280 290 300
PFDPLSYQTN LLGVLNLTKE KVKTCYDLIL QLPVDRIGLQ IQIQSSKKRK
310 320 330 340 350
SHDSSSSLNS PSCVIDANPF NSDESSNDSW SASSCNPPTS SSSPQQQPPL
360 370
KKMRGAEENE KKKPILHLPW AIVATP
Length:376
Mass (Da):42,702
Last modified:February 15, 2005 - v3
Checksum:iFFC95F2B8031BEC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288G → C in CAA58287 (PubMed:7696881).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83371 mRNA Translation: CAA58287.1
AL021961 Genomic DNA Translation: CAA17556.1
AL161584 Genomic DNA Translation: CAB80133.1
CP002687 Genomic DNA Translation: AEE86335.1
AK221712 mRNA Translation: BAD95437.1
PIRiT05420
RefSeqiNP_195142.1, NM_119579.3
UniGeneiAt.22721

Genome annotation databases

EnsemblPlantsiAT4G34160.1; AT4G34160.1; AT4G34160
GeneIDi829564
GrameneiAT4G34160.1; AT4G34160.1; AT4G34160
KEGGiath:AT4G34160

Similar proteinsi

Entry informationi

Entry nameiCCD31_ARATH
AccessioniPrimary (citable) accession number: P42753
Secondary accession number(s): O49489, Q56XG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 15, 2005
Last modified: April 25, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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