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Protein

Ubiquitin-conjugating enzyme E2 2

Gene

UBC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • DNA repair Source: GO_Central
  • histone H2B ubiquitination Source: TAIR
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  • protein polyubiquitination Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: TAIR
  • vegetative to reproductive phase transition of meristem Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.3.2.B5 399
ReactomeiR-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 2
Ubiquitin carrier protein 2
Ubiquitin-conjugating enzyme E2-17 kDa 2
Ubiquitin-protein ligase 2
Gene namesi
Name:UBC2
Ordered Locus Names:At2g02760
ORF Names:T20F6.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G02760
TAIRilocus:2058806 AT2G02760

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825711 – 152Ubiquitin-conjugating enzyme E2 2Add BLAST152

Proteomic databases

PaxDbiP42745
PRIDEiP42745

Expressioni

Tissue specificityi

Expressed in all tissues examined. Lower levels found in leaves.1 Publication

Inductioni

Not induced by heat shock.1 Publication

Gene expression databases

ExpressionAtlasiP42745 baseline and differential
GenevisibleiP42745 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207, 2 interactors
IntActiP42745, 2 interactors
STRINGi3702.AT2G02760.1

Structurei

3D structure databases

ProteinModelPortaliP42745
SMRiP42745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0419 Eukaryota
COG5078 LUCA
HOGENOMiHOG000233454
InParanoidiP42745
KOiK10573
OMAiCHAIING
OrthoDBiEOG09360PJJ
PhylomeDBiP42745

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPARKRLM RDFKRLQQDP PAGISGAPQD NNIMLWNAVI FGPDDTPWDG
60 70 80 90 100
GTFKLSLQFS EDYPNKPPTV RFVSRMFHPN IYADGSICLD ILQNQWSPIY
110 120 130 140 150
DVAAILTSIQ SLLCDPNPNS PANSEAARMF SESKREYNRR VREVVEQSWT

AD
Length:152
Mass (Da):17,279
Last modified:November 1, 1995 - v1
Checksum:i266CD41930C38629
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19353 Genomic DNA Translation: AAA32899.1
Y13031 mRNA Translation: CAA73476.1
DQ027017 mRNA Translation: AAY44843.1
AC002521 Genomic DNA Translation: AAC05346.1
CP002685 Genomic DNA Translation: AEC05621.1
CP002685 Genomic DNA Translation: ANM63049.1
CP002685 Genomic DNA Translation: ANM63050.1
CP002685 Genomic DNA Translation: ANM63051.1
AF370558 mRNA Translation: AAK48985.1
AY072479 mRNA Translation: AAL66894.1
PIRiS43783
RefSeqiNP_001325162.1, NM_001335136.1
NP_001325163.1, NM_001335134.1
NP_001325164.1, NM_001335135.1
NP_565289.1, NM_126331.4
UniGeneiAt.203

Genome annotation databases

EnsemblPlantsiAT2G02760.1; AT2G02760.1; AT2G02760
AT2G02760.2; AT2G02760.2; AT2G02760
AT2G02760.3; AT2G02760.3; AT2G02760
AT2G02760.4; AT2G02760.4; AT2G02760
GeneIDi814805
GrameneiAT2G02760.1; AT2G02760.1; AT2G02760
AT2G02760.2; AT2G02760.2; AT2G02760
AT2G02760.3; AT2G02760.3; AT2G02760
AT2G02760.4; AT2G02760.4; AT2G02760
KEGGiath:AT2G02760

Similar proteinsi

Entry informationi

Entry nameiUBC2_ARATH
AccessioniPrimary (citable) accession number: P42745
Secondary accession number(s): Q4TZ07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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