UniProtKB - P42737 (BCA2_ARATH)
Protein
Beta carbonic anhydrase 2, chloroplastic
Gene
BCA2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Reversible hydration of carbon dioxide. This isoform ensures the supply of bicarbonate for pep carboxylase.
Catalytic activityi
- EC:4.2.1.1
: C4 acid pathway Pathwayi
This protein is involved in the pathway C4 acid pathway, which is part of Photosynthesis.View all proteins of this organism that are known to be involved in the pathway C4 acid pathway and in Photosynthesis.
GO - Molecular functioni
- carbonate dehydratase activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- carbon utilization Source: InterPro
- cyanate catabolic process Source: GO_Central
- defense response to bacterium Source: TAIR
Keywordsi
Molecular function | Lyase |
Ligand | Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00322 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta carbonic anhydrase 2, chloroplastic (EC:4.2.1.1)Short name: AtbCA2 Short name: AtbetaCA2 Alternative name(s): Beta carbonate dehydratase 2 |
Gene namesi | Name:BCA2 Synonyms:CA18, CA2 Ordered Locus Names:At5g14740 ORF Names:T9L3.40 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G14740 |
TAIRi | locus:2185460 AT5G14740 |
Subcellular locationi
Isoform 1 :
Chloroplast
- chloroplast 1 Publication
Chloroplast
- chloroplast Source: TAIR
- chloroplast envelope Source: TAIR
- chloroplast stroma Source: TAIR
- chloroplast thylakoid membrane Source: TAIR
Cytosol
- cytosol Source: TAIR
Extracellular region or secreted
- apoplast Source: TAIR
Other locations
Keywords - Cellular componenti
Chloroplast, Cytoplasm, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Transit peptidei | 1 – 71 | ChloroplastSequence analysisAdd BLAST | 71 | ||
ChainiPRO_0000077458 | 72 – 331 | Beta carbonic anhydrase 2, chloroplasticAdd BLAST | 260 | ||
Isoform 2 (identifier: P42737-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 107 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 170 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 198 | PhosphotyrosineCombined sources | 1 | ||
Modified residuei | 275 | S-nitrosocysteineBy similarity | 1 | ||
Isoform 2 (identifier: P42737-2) | |||||
Modified residuei | 2 | N-acetylglycineCombined sources | 1 |
Keywords - PTMi
Acetylation, Phosphoprotein, S-nitrosylationProteomic databases
PaxDbi | P42737 |
PRIDEi | P42737 |
2D gel databases
SWISS-2DPAGEi | P42737 |
PTM databases
iPTMneti | P42737 |
Expressioni
Tissue specificityi
Strongly expressed in aerial tissues including leaves, stems, flowers and siliques. Accumulates in mesophyll cells.2 Publications
Inductioni
Expression reduced by 20% under dark conditions.
Gene expression databases
ExpressionAtlasi | P42737 baseline and differential |
Genevisiblei | P42737 AT |
Interactioni
Protein-protein interaction databases
BioGridi | 16603, 2 interactors |
IntActi | P42737, 50 interactors |
STRINGi | 3702.AT5G14740.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the beta-class carbonic anhydrase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1578 Eukaryota COG0288 LUCA |
HOGENOMi | HOG000125183 |
InParanoidi | P42737 |
KOi | K01673 |
OMAi | ETAIGPR |
OrthoDBi | 1136193at2759 |
Family and domain databases
Gene3Di | 3.40.1050.10, 1 hit |
InterProi | View protein in InterPro IPR001765 Carbonic_anhydrase IPR015892 Carbonic_anhydrase_CS IPR036874 Carbonic_anhydrase_sf |
Pfami | View protein in Pfam PF00484 Pro_CA, 1 hit |
SMARTi | View protein in SMART SM00947 Pro_CA, 1 hit |
SUPFAMi | SSF53056 SSF53056, 1 hit |
PROSITEi | View protein in PROSITE PS00704 PROK_CO2_ANHYDRASE_1, 1 hit PS00705 PROK_CO2_ANHYDRASE_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist. According to EST sequences.
This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P42737-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVPFWTTVSR NGSSDSETTL QSASKATKQY KYPSLRPSHR LSLLFLFPFH
60 70 80 90 100
LSANGACFRC TCFSHFKLEL RRMGNESYED AIEALKKLLI EKDDLKDVAA
110 120 130 140 150
AKVKKITAEL QAASSSDSKS FDPVERIKEG FVTFKKEKYE TNPALYGELA
160 170 180 190 200
KGQSPKYMVF ACSDSRVCPS HVLDFHPGDA FVVRNIANMV PPFDKVKYAG
210 220 230 240 250
VGAAIEYAVL HLKVENIVVI GHSACGGIKG LMSFPLDGNN STDFIEDWVK
260 270 280 290 300
ICLPAKSKVL AESESSAFED QCGRCEREAV NVSLANLLTY PFVREGVVKG
310 320 330
TLALKGGYYD FVNGSFELWE LQFGISPVHS I
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MQY4 | A8MQY4_ARATH | Carbonic anhydrase | CA2 BETA CA2, BETA CARBONIC ANHYDRASE 2, CA18, CARBONIC ANHYDRASE 18, CARBONIC ANHYDRASE 2 | 310 | Annotation score: | ||
F4K873 | F4K873_ARATH | Carbonic anhydrase | CA2 BETA CA2, BETA CARBONIC ANHYDRASE 2, CA18, CARBONIC ANHYDRASE 18, CARBONIC ANHYDRASE 2 | 330 | Annotation score: | ||
F4K875 | F4K875_ARATH | Carbonic anhydrase | CA2 BETA CA2, BETA CARBONIC ANHYDRASE 2, CA18, CARBONIC ANHYDRASE 18, CARBONIC ANHYDRASE 2 | 330 | Annotation score: |
Sequence cautioni
The sequence AAA50156 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAG40063 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAG41445 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAN31799 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAN31810 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAC01873 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 – 110 | EL → DV in AAA50156 (PubMed:7520589).Curated | 2 | |
Sequence conflicti | 287 – 288 | LL → RC in AAA50156 (PubMed:7520589).Curated | 2 | |
Sequence conflicti | 310 | D → A in AAA50156 (PubMed:7520589).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055068 | 1 – 73 | MVPFW…ELRRM → M in isoform 2. 3 PublicationsAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL391149 Genomic DNA Translation: CAC01873.1 Sequence problems. CP002688 Genomic DNA Translation: AED92068.1 CP002688 Genomic DNA Translation: AED92069.1 CP002688 Genomic DNA Translation: ANM68481.1 CP002688 Genomic DNA Translation: ANM68482.1 CP002688 Genomic DNA Translation: ANM68483.1 CP002688 Genomic DNA Translation: ANM68484.1 AF324712 mRNA Translation: AAG40063.1 Different initiation. AF326863 mRNA Translation: AAG41445.1 Different initiation. AF339686 mRNA Translation: AAK00368.1 AF428428 mRNA Translation: AAL16197.1 BT000652 mRNA Translation: AAN31799.1 Different initiation. BT000663 mRNA Translation: AAN31810.1 Different initiation. AK317585 mRNA Translation: BAH20249.1 L18901 mRNA Translation: AAA50156.1 Different initiation. Z26538 mRNA Translation: CAA81309.1 |
RefSeqi | NP_001330235.1, NM_001343359.1 [P42737-2] NP_001330236.1, NM_001343360.1 [P42737-2] NP_001330237.1, NM_001343361.1 [P42737-2] NP_001330238.1, NM_001343362.1 [P42737-2] NP_568303.2, NM_121478.4 [P42737-1] NP_974782.1, NM_203053.2 [P42737-2] |
Genome annotation databases
EnsemblPlantsi | AT5G14740.1; AT5G14740.1; AT5G14740 [P42737-1] AT5G14740.2; AT5G14740.2; AT5G14740 [P42737-2] AT5G14740.6; AT5G14740.6; AT5G14740 [P42737-2] AT5G14740.7; AT5G14740.7; AT5G14740 [P42737-2] AT5G14740.8; AT5G14740.8; AT5G14740 [P42737-2] AT5G14740.9; AT5G14740.9; AT5G14740 [P42737-2] |
GeneIDi | 831326 |
Gramenei | AT5G14740.1; AT5G14740.1; AT5G14740 [P42737-1] AT5G14740.2; AT5G14740.2; AT5G14740 [P42737-2] AT5G14740.6; AT5G14740.6; AT5G14740 [P42737-2] AT5G14740.7; AT5G14740.7; AT5G14740 [P42737-2] AT5G14740.8; AT5G14740.8; AT5G14740 [P42737-2] AT5G14740.9; AT5G14740.9; AT5G14740 [P42737-2] |
KEGGi | ath:AT5G14740 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL391149 Genomic DNA Translation: CAC01873.1 Sequence problems. CP002688 Genomic DNA Translation: AED92068.1 CP002688 Genomic DNA Translation: AED92069.1 CP002688 Genomic DNA Translation: ANM68481.1 CP002688 Genomic DNA Translation: ANM68482.1 CP002688 Genomic DNA Translation: ANM68483.1 CP002688 Genomic DNA Translation: ANM68484.1 AF324712 mRNA Translation: AAG40063.1 Different initiation. AF326863 mRNA Translation: AAG41445.1 Different initiation. AF339686 mRNA Translation: AAK00368.1 AF428428 mRNA Translation: AAL16197.1 BT000652 mRNA Translation: AAN31799.1 Different initiation. BT000663 mRNA Translation: AAN31810.1 Different initiation. AK317585 mRNA Translation: BAH20249.1 L18901 mRNA Translation: AAA50156.1 Different initiation. Z26538 mRNA Translation: CAA81309.1 |
RefSeqi | NP_001330235.1, NM_001343359.1 [P42737-2] NP_001330236.1, NM_001343360.1 [P42737-2] NP_001330237.1, NM_001343361.1 [P42737-2] NP_001330238.1, NM_001343362.1 [P42737-2] NP_568303.2, NM_121478.4 [P42737-1] NP_974782.1, NM_203053.2 [P42737-2] |
3D structure databases
SMRi | P42737 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 16603, 2 interactors |
IntActi | P42737, 50 interactors |
STRINGi | 3702.AT5G14740.1 |
PTM databases
iPTMneti | P42737 |
2D gel databases
SWISS-2DPAGEi | P42737 |
Proteomic databases
PaxDbi | P42737 |
PRIDEi | P42737 |
Genome annotation databases
EnsemblPlantsi | AT5G14740.1; AT5G14740.1; AT5G14740 [P42737-1] AT5G14740.2; AT5G14740.2; AT5G14740 [P42737-2] AT5G14740.6; AT5G14740.6; AT5G14740 [P42737-2] AT5G14740.7; AT5G14740.7; AT5G14740 [P42737-2] AT5G14740.8; AT5G14740.8; AT5G14740 [P42737-2] AT5G14740.9; AT5G14740.9; AT5G14740 [P42737-2] |
GeneIDi | 831326 |
Gramenei | AT5G14740.1; AT5G14740.1; AT5G14740 [P42737-1] AT5G14740.2; AT5G14740.2; AT5G14740 [P42737-2] AT5G14740.6; AT5G14740.6; AT5G14740 [P42737-2] AT5G14740.7; AT5G14740.7; AT5G14740 [P42737-2] AT5G14740.8; AT5G14740.8; AT5G14740 [P42737-2] AT5G14740.9; AT5G14740.9; AT5G14740 [P42737-2] |
KEGGi | ath:AT5G14740 |
Organism-specific databases
Araporti | AT5G14740 |
TAIRi | locus:2185460 AT5G14740 |
Phylogenomic databases
eggNOGi | KOG1578 Eukaryota COG0288 LUCA |
HOGENOMi | HOG000125183 |
InParanoidi | P42737 |
KOi | K01673 |
OMAi | ETAIGPR |
OrthoDBi | 1136193at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00322 |
Miscellaneous databases
PROi | PR:P42737 |
Gene expression databases
ExpressionAtlasi | P42737 baseline and differential |
Genevisiblei | P42737 AT |
Family and domain databases
Gene3Di | 3.40.1050.10, 1 hit |
InterProi | View protein in InterPro IPR001765 Carbonic_anhydrase IPR015892 Carbonic_anhydrase_CS IPR036874 Carbonic_anhydrase_sf |
Pfami | View protein in Pfam PF00484 Pro_CA, 1 hit |
SMARTi | View protein in SMART SM00947 Pro_CA, 1 hit |
SUPFAMi | SSF53056 SSF53056, 1 hit |
PROSITEi | View protein in PROSITE PS00704 PROK_CO2_ANHYDRASE_1, 1 hit PS00705 PROK_CO2_ANHYDRASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCA2_ARATH | |
Accessioni | P42737Primary (citable) accession number: P42737 Secondary accession number(s): B9DHN2 Q9LER2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | July 9, 2014 | |
Last modified: | October 16, 2019 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways