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UniProtKB - P42703 (LIFR_MOUSE)

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Protein

Leukemia inhibitory factor receptor

Gene

Lifr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Leukemia inhibitory factor receptor
Short name:
LIF receptor
Short name:
LIF-R
Alternative name(s):
D-factor/LIF receptor
CD_antigen: CD118
Gene namesi
Name:Lifr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96788 Lifr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 828ExtracellularSequence analysisAdd BLAST785
Transmembranei829 – 853HelicalSequence analysisAdd BLAST25
Topological domaini854 – 1092CytoplasmicSequence analysisAdd BLAST239

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000001090344 – 1092Leukemia inhibitory factor receptorAdd BLAST1049

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 631 Publication
Disulfide bondi80 ↔ 881 Publication
Glycosylationi164N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi199N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi208 ↔ 2651 Publication
Glycosylationi238N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi261N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi336 ↔ 3461 Publication
Glycosylationi385N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi402N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi421N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi440N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi453N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi461 ↔ 5061 Publication
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi647N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi675N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei922PhosphoserineBy similarity1
Modified residuei1039PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP42703
PaxDbiP42703
PeptideAtlasiP42703
PRIDEiP42703

PTM databases

iPTMnetiP42703
PhosphoSitePlusiP42703

Expressioni

Tissue specificityi

Placenta, liver, kidney, heart, lung, brain, and embryos. The liver may be the primary site of synthesis of the secreted form.

Gene expression databases

BgeeiENSMUSG00000054263
CleanExiMM_LIFR
GenevisibleiP42703 MM

Interactioni

Subunit structurei

Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi201163, 3 interactors
DIPiDIP-5772N
IntActiP42703, 4 interactors
MINTiP42703
STRINGi10090.ENSMUSP00000064551

Structurei

3D structure databases

ProteinModelPortaliP42703
SMRiP42703
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42703

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 126Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST82
Domaini330 – 429Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini430 – 529Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini533 – 624Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST92
Domaini622 – 714Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93
Domaini719 – 828Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi514 – 518WSXWS motif5
Motifi864 – 872Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 2 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF1V Eukaryota
ENOG410ZMDF LUCA
GeneTreeiENSGT00550000074436
HOGENOMiHOG000113324
HOVERGENiHBG006266
InParanoidiP42703
KOiK05058
OMAiFYPDIPN
OrthoDBiEOG091G00RF
PhylomeDBiP42703
TreeFamiTF338122

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P42703-1) [UniParc]FASTAAdd to basket
Also known as: Membrane

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAYSWWRQP SWMVDNKRSR MTPNLPWLLS ALTLLHLTMH ANGLKRGVQD 
        60         70         80         90        100
LKCTTNNMRV WDCTWPAPLG VSPGTVKDIC IKDRFHSCHP LETTNVKIPA 
       110        120        130        140        150
LSPGDHEVTI NYLNGFQSKF TLNEKDVSLI PETPEILDLS ADFFTSSLLL 
       160        170        180        190        200
KWNDRGSALP HPSNATWEIK VLQNPRTEPV ALVLLNTMLS GKDTVQHWNW 
       210        220        230        240        250
TSDLPLQCAT HSVSIRWHID SPHFSGYKEW SDWSPLKNIS WIRNTETNVF 
       260        270        280        290        300
PQDKVVLAGS NMTICCMSPT KVLSGQIGNT LRPLIHLYGQ TVAIHILNIP 
       310        320        330        340        350
VSENSGTNII FITDDDVYGT VVFAGYPPDV PQKLSCETHD LKEIICSWNP 
       360        370        380        390        400
GRITGLVGPR NTEYTLFESI SGKSAVFHRI EGLTNETYRL GVQMHPGQEI 
       410        420        430        440        450
HNFTLTGRNP LGQAQSAVVI NVTERVAPHD PTSLKVKDIN STVVTFSWYL 
       460        470        480        490        500
PGNFTKINLL CQIEICKANS KKEVRNATIR GAEDSTYHVA VDKLNPYTAY 
       510        520        530        540        550
TFRVRCSSKT FWKWSRWSDE KRHLTTEATP SKGPDTWREW SSDGKNLIVY 
       560        570        580        590        600
WKPLPINEAN GKILSYNVSC SLNEETQSVL EIFDPQHRAE IQLSKNDYII 
       610        620        630        640        650
SVVARNSAGS SPPSKIASME IPNDDITVEQ AVGLGNRIFL TWRHDPNMTC 
       660        670        680        690        700
DYVIKWCNSS RSEPCLLDWR KVPSNSTETV IESDQFQPGV RYNFYLYGCT 
       710        720        730        740        750
NQGYQLLRSI IGYVEELAPI VAPNFTVEDT SADSILVKWD DIPVEELRGF 
       760        770        780        790        800
LRGYLFYFQK GERDTPKTRS LEPHHSDIKL KNITDISQKT LRIADLQGKT 
       810        820        830        840        850
SYHLVLRAYT HGGLGPEKSM FVVTKENSVG LIIAILIPVA VAVIVGVVTS 
       860        870        880        890        900
ILCYRKREWI KETFYPDIPN PENCKALQFQ KSVCEGSNAL KTLEMNPCTP 
       910        920        930        940        950
NNVEVLESRS IVPKIEDTEI ISPVAERPGE RSEVDPENHV VVSYCPPIIE 
       960        970        980        990       1000
EEITNPAADE VGGASQVVYI DVQSMYQPQA KAEEEQDVDP VVVAGYKPQM 
      1010       1020       1030       1040       1050
RLPISPAVED TAAEDEEGKT AGYRPQANVN TWNLVSPDSP RSTDSNNEVV 
      1060       1070       1080       1090 
SFGSPCSINS RQFLIPPKDE DSPKSNGGGW SFTNFFQNKP ND
Length:1,092
Mass (Da):122,574
Last modified:November 1, 1995 - v1
Checksum:i6F02BBC8E154DE70
GO
Isoform 2 (identifier: P42703-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     718-719: AP → EA
     720-1092: Missing.

Show »
Length:719
Mass (Da):81,287
Checksum:i4DF1779816B06D2B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001686718 – 719AP → EA in isoform 2. 4 Publications2
Alternative sequenceiVSP_001687720 – 1092Missing in isoform 2. 4 PublicationsAdd BLAST373

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73496 mRNA Translation: AAC60698.1
S73495 mRNA Translation: AAC60697.1
D26177 mRNA Translation: BAA05165.1
D17444 mRNA Translation: BAA04258.1
BC031929 mRNA Translation: AAH31929.1
CCDSiCCDS27369.1 [P42703-1]
CCDS49577.1 [P42703-2]
PIRiJX0312
RefSeqiNP_001106857.1, NM_001113386.1 [P42703-2]
NP_038612.1, NM_013584.2 [P42703-1]
XP_006520030.1, XM_006519967.3
XP_006520032.1, XM_006519969.3 [P42703-1]
XP_006520033.1, XM_006519970.3 [P42703-2]
XP_006520034.1, XM_006519971.2 [P42703-2]
XP_011243628.1, XM_011245326.2 [P42703-1]
UniGeneiMm.149720

Genome annotation databases

EnsembliENSMUST00000067190; ENSMUSP00000064551; ENSMUSG00000054263 [P42703-1]
ENSMUST00000164529; ENSMUSP00000131434; ENSMUSG00000054263 [P42703-2]
ENSMUST00000171588; ENSMUSP00000126137; ENSMUSG00000054263 [P42703-1]
ENSMUST00000226471; ENSMUSP00000154750; ENSMUSG00000054263 [P42703-1]
ENSMUST00000226934; ENSMUSP00000153968; ENSMUSG00000054263 [P42703-2]
ENSMUST00000227727; ENSMUSP00000154181; ENSMUSG00000054263 [P42703-2]
GeneIDi16880
KEGGimmu:16880
UCSCiuc007vdw.2 mouse [P42703-2]
uc007vdx.2 mouse [P42703-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLIFR_MOUSE
AccessioniPrimary (citable) accession number: P42703
Secondary accession number(s): Q5I0Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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