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UniProtKB - P42703 (LIFR_MOUSE)

Entry version 179 (10 Feb 2021)
Sequence version 1 (01 Nov 1995)
Previous versions | rss
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Protein

Leukemia inhibitory factor receptor

Gene

Lifr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-6788467, IL-6-type cytokine receptor ligand interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukemia inhibitory factor receptor
Short name:
LIF receptor
Short name:
LIF-R
Alternative name(s):
D-factor/LIF receptor
CD_antigen: CD118
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lifr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:96788, Lifr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini44 – 828ExtracellularSequence analysisAdd BLAST785
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei829 – 853HelicalSequence analysisAdd BLAST25
Topological domaini854 – 1092CytoplasmicSequence analysisAdd BLAST239

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 43Sequence analysisAdd BLAST43
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001090344 – 1092Leukemia inhibitory factor receptorAdd BLAST1049

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 631 Publication
Disulfide bondi80 ↔ 881 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi164N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi199N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi208 ↔ 2651 Publication
Glycosylationi238N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi261N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi336 ↔ 3461 Publication
Glycosylationi385N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi402N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi421N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi440N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi453N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi461 ↔ 5061 Publication
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi647N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi675N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei922PhosphoserineBy similarity1
Modified residuei1039PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-3515

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P42703

MaxQB - The MaxQuant DataBase

More...MaxQBi		P42703

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P42703

PeptideAtlas

More...PeptideAtlasi		P42703

PRoteomics IDEntifications database

More...PRIDEi		P42703

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2478, 4 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P42703, 16 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P42703

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P42703

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta, liver, kidney, heart, lung, brain, and embryos. The liver may be the primary site of synthesis of the secreted form.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000054263, Expressed in cochlea and 311 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P42703, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P42703, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201163, 7 interactors

Database of interacting proteins

More...DIPi		DIP-5772N

Protein interaction database and analysis system

More...IntActi		P42703, 4 interactors

Molecular INTeraction database

More...MINTi		P42703

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000126137

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P42703, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P42703

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P42703

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 126Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST82
Domaini330 – 429Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini430 – 529Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini533 – 624Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST92
Domaini622 – 714Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93
Domaini719 – 828Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi514 – 518WSXWS motif5
Motifi864 – 872Box 1 motif9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 2 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQF6, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155776

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_283805_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P42703

Identification of Orthologs from Complete Genome Data

More...OMAi		GYKPQMR

Database of Orthologous Groups

More...OrthoDBi		331447at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P42703

TreeFam database of animal gene trees

More...TreeFami		TF338122

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR003529, Hematopoietin_rcpt_Gp130_CS
IPR013783, Ig-like_fold
IPR040817, LIFR_D2
IPR040901, LIFR_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 1 hit
PF17971, LIFR_D2, 1 hit
PF18207, LIFR_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 4 hits
PS01353, HEMATOPO_REC_L_F2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P42703-1) [UniParc]FASTAAdd to basket
Also known as: Membrane

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAYSWWRQP SWMVDNKRSR MTPNLPWLLS ALTLLHLTMH ANGLKRGVQD 
        60         70         80         90        100
LKCTTNNMRV WDCTWPAPLG VSPGTVKDIC IKDRFHSCHP LETTNVKIPA 
       110        120        130        140        150
LSPGDHEVTI NYLNGFQSKF TLNEKDVSLI PETPEILDLS ADFFTSSLLL 
       160        170        180        190        200
KWNDRGSALP HPSNATWEIK VLQNPRTEPV ALVLLNTMLS GKDTVQHWNW 
       210        220        230        240        250
TSDLPLQCAT HSVSIRWHID SPHFSGYKEW SDWSPLKNIS WIRNTETNVF 
       260        270        280        290        300
PQDKVVLAGS NMTICCMSPT KVLSGQIGNT LRPLIHLYGQ TVAIHILNIP 
       310        320        330        340        350
VSENSGTNII FITDDDVYGT VVFAGYPPDV PQKLSCETHD LKEIICSWNP 
       360        370        380        390        400
GRITGLVGPR NTEYTLFESI SGKSAVFHRI EGLTNETYRL GVQMHPGQEI 
       410        420        430        440        450
HNFTLTGRNP LGQAQSAVVI NVTERVAPHD PTSLKVKDIN STVVTFSWYL 
       460        470        480        490        500
PGNFTKINLL CQIEICKANS KKEVRNATIR GAEDSTYHVA VDKLNPYTAY 
       510        520        530        540        550
TFRVRCSSKT FWKWSRWSDE KRHLTTEATP SKGPDTWREW SSDGKNLIVY 
       560        570        580        590        600
WKPLPINEAN GKILSYNVSC SLNEETQSVL EIFDPQHRAE IQLSKNDYII 
       610        620        630        640        650
SVVARNSAGS SPPSKIASME IPNDDITVEQ AVGLGNRIFL TWRHDPNMTC 
       660        670        680        690        700
DYVIKWCNSS RSEPCLLDWR KVPSNSTETV IESDQFQPGV RYNFYLYGCT 
       710        720        730        740        750
NQGYQLLRSI IGYVEELAPI VAPNFTVEDT SADSILVKWD DIPVEELRGF 
       760        770        780        790        800
LRGYLFYFQK GERDTPKTRS LEPHHSDIKL KNITDISQKT LRIADLQGKT 
       810        820        830        840        850
SYHLVLRAYT HGGLGPEKSM FVVTKENSVG LIIAILIPVA VAVIVGVVTS 
       860        870        880        890        900
ILCYRKREWI KETFYPDIPN PENCKALQFQ KSVCEGSNAL KTLEMNPCTP 
       910        920        930        940        950
NNVEVLESRS IVPKIEDTEI ISPVAERPGE RSEVDPENHV VVSYCPPIIE 
       960        970        980        990       1000
EEITNPAADE VGGASQVVYI DVQSMYQPQA KAEEEQDVDP VVVAGYKPQM 
      1010       1020       1030       1040       1050
RLPISPAVED TAAEDEEGKT AGYRPQANVN TWNLVSPDSP RSTDSNNEVV 
      1060       1070       1080       1090 
SFGSPCSINS RQFLIPPKDE DSPKSNGGGW SFTNFFQNKP ND
Length:1,092
Mass (Da):122,574
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F02BBC8E154DE70
GO
Isoform 2 (identifier: P42703-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     718-719: AP → EA
     720-1092: Missing.

Show »
Length:719
Mass (Da):81,287
Checksum:i4DF1779816B06D2B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRT7A0A2I3BRT7_MOUSE
Leukemia inhibitory factor receptor
Lifr
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001686718 – 719AP → EA in isoform 2. 4 Publications2
Alternative sequenceiVSP_001687720 – 1092Missing in isoform 2. 4 PublicationsAdd BLAST373

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S73496 mRNA Translation: AAC60698.1
S73495 mRNA Translation: AAC60697.1
D26177 mRNA Translation: BAA05165.1
D17444 mRNA Translation: BAA04258.1
BC031929 mRNA Translation: AAH31929.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27369.1 [P42703-1]
CCDS49577.1 [P42703-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JX0312

NCBI Reference Sequences

More...RefSeqi		NP_001106857.1, NM_001113386.1 [P42703-2]
NP_038612.1, NM_013584.2 [P42703-1]
XP_006520030.1, XM_006519967.3
XP_006520032.1, XM_006519969.3 [P42703-1]
XP_006520033.1, XM_006519970.3 [P42703-2]
XP_006520034.1, XM_006519971.2 [P42703-2]
XP_011243628.1, XM_011245326.2 [P42703-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000067190; ENSMUSP00000064551; ENSMUSG00000054263 [P42703-1]
ENSMUST00000164529; ENSMUSP00000131434; ENSMUSG00000054263 [P42703-2]
ENSMUST00000171588; ENSMUSP00000126137; ENSMUSG00000054263 [P42703-1]
ENSMUST00000226471; ENSMUSP00000154750; ENSMUSG00000054263 [P42703-1]
ENSMUST00000226934; ENSMUSP00000153968; ENSMUSG00000054263 [P42703-2]
ENSMUST00000227727; ENSMUSP00000154181; ENSMUSG00000054263 [P42703-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		16880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:16880

UCSC genome browser

More...UCSCi		uc007vdw.2, mouse [P42703-2]
uc007vdx.2, mouse [P42703-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73496 mRNA Translation: AAC60698.1
S73495 mRNA Translation: AAC60697.1
D26177 mRNA Translation: BAA05165.1
D17444 mRNA Translation: BAA04258.1
BC031929 mRNA Translation: AAH31929.1
CCDSiCCDS27369.1 [P42703-1]
CCDS49577.1 [P42703-2]
PIRiJX0312
RefSeqiNP_001106857.1, NM_001113386.1 [P42703-2]
NP_038612.1, NM_013584.2 [P42703-1]
XP_006520030.1, XM_006519967.3
XP_006520032.1, XM_006519969.3 [P42703-1]
XP_006520033.1, XM_006519970.3 [P42703-2]
XP_006520034.1, XM_006519971.2 [P42703-2]
XP_011243628.1, XM_011245326.2 [P42703-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q7NX-ray4.00A/C50-529[»]
SMRiP42703
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi201163, 7 interactors
DIPiDIP-5772N
IntActiP42703, 4 interactors
MINTiP42703
STRINGi10090.ENSMUSP00000126137

PTM databases

GlyConnecti2478, 4 N-Linked glycans (3 sites)
GlyGeniP42703, 16 sites
iPTMnetiP42703
PhosphoSitePlusiP42703

Proteomic databases

CPTACinon-CPTAC-3515
jPOSTiP42703
MaxQBiP42703
PaxDbiP42703
PeptideAtlasiP42703
PRIDEiP42703

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4137, 447 antibodies

Genome annotation databases

EnsembliENSMUST00000067190; ENSMUSP00000064551; ENSMUSG00000054263 [P42703-1]
ENSMUST00000164529; ENSMUSP00000131434; ENSMUSG00000054263 [P42703-2]
ENSMUST00000171588; ENSMUSP00000126137; ENSMUSG00000054263 [P42703-1]
ENSMUST00000226471; ENSMUSP00000154750; ENSMUSG00000054263 [P42703-1]
ENSMUST00000226934; ENSMUSP00000153968; ENSMUSG00000054263 [P42703-2]
ENSMUST00000227727; ENSMUSP00000154181; ENSMUSG00000054263 [P42703-2]
GeneIDi16880
KEGGimmu:16880
UCSCiuc007vdw.2, mouse [P42703-2]
uc007vdx.2, mouse [P42703-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3977
MGIiMGI:96788, Lifr

Phylogenomic databases

eggNOGiENOG502QQF6, Eukaryota
GeneTreeiENSGT00940000155776
HOGENOMiCLU_283805_0_0_1
InParanoidiP42703
OMAiGYKPQMR
OrthoDBi331447at2759
PhylomeDBiP42703
TreeFamiTF338122

Enzyme and pathway databases

ReactomeiR-MMU-6788467, IL-6-type cytokine receptor ligand interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		16880, 2 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Lifr, mouse
EvolutionaryTraceiP42703

Protein Ontology

More...PROi		PR:P42703
RNActiP42703, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000054263, Expressed in cochlea and 311 other tissues
ExpressionAtlasiP42703, baseline and differential
GenevisibleiP42703, MM

Family and domain databases

CDDicd00063, FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR003529, Hematopoietin_rcpt_Gp130_CS
IPR013783, Ig-like_fold
IPR040817, LIFR_D2
IPR040901, LIFR_N
PfamiView protein in Pfam
PF00041, fn3, 1 hit
PF17971, LIFR_D2, 1 hit
PF18207, LIFR_N, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 5 hits
SUPFAMiSSF49265, SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 4 hits
PS01353, HEMATOPO_REC_L_F2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIFR_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42703
Secondary accession number(s): Q5I0Y2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 10, 2021
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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