UniProtKB - P42703 (LIFR_MOUSE)
Protein
Leukemia inhibitory factor receptor
Gene
Lifr
Organism
Mus musculus (Mouse)
Status
Functioni
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
GO - Molecular functioni
- ciliary neurotrophic factor receptor binding Source: MGI
- cytokine binding Source: MGI
- cytokine receptor activity Source: GO_Central
- growth factor binding Source: MGI
- leukemia inhibitory factor receptor activity Source: MGI
- oncostatin-M receptor activity Source: Ensembl
GO - Biological processi
- animal organ regeneration Source: MGI
- ciliary neurotrophic factor-mediated signaling pathway Source: MGI
- cytokine-mediated signaling pathway Source: MGI
- leukemia inhibitory factor signaling pathway Source: MGI
- negative regulation of muscle cell apoptotic process Source: MGI
- neuron projection morphogenesis Source: MGI
- oncostatin-M-mediated signaling pathway Source: MGI
- positive regulation of cell population proliferation Source: MGI
- response to cytokine Source: MGI
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-MMU-6788467, IL-6-type cytokine receptor ligand interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Leukemia inhibitory factor receptorShort name: LIF receptor Short name: LIF-R Alternative name(s): D-factor/LIF receptor CD_antigen: CD118 |
Gene namesi | Name:Lifr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96788, Lifr |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 44 – 828 | ExtracellularSequence analysisAdd BLAST | 785 | |
Transmembranei | 829 – 853 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 854 – 1092 | CytoplasmicSequence analysisAdd BLAST | 239 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 43 | Sequence analysisAdd BLAST | 43 | |
ChainiPRO_0000010903 | 44 – 1092 | Leukemia inhibitory factor receptorAdd BLAST | 1049 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 63 | 1 Publication | ||
Disulfide bondi | 80 ↔ 88 | 1 Publication | ||
Glycosylationi | 164 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 199 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 208 ↔ 265 | 1 Publication | ||
Glycosylationi | 238 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 261 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 336 ↔ 346 | 1 Publication | ||
Glycosylationi | 385 | N-linked (GlcNAc...) asparagine4 Publications | 1 | |
Glycosylationi | 402 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 421 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 440 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 453 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 461 ↔ 506 | 1 Publication | ||
Glycosylationi | 476 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 567 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 647 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 658 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 675 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 724 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 782 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 922 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1039 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3515 |
jPOSTi | P42703 |
MaxQBi | P42703 |
PaxDbi | P42703 |
PeptideAtlasi | P42703 |
PRIDEi | P42703 |
PTM databases
GlyConnecti | 2478, 4 N-Linked glycans (3 sites) |
GlyGeni | P42703, 16 sites |
iPTMneti | P42703 |
PhosphoSitePlusi | P42703 |
Expressioni
Tissue specificityi
Placenta, liver, kidney, heart, lung, brain, and embryos. The liver may be the primary site of synthesis of the secreted form.
Gene expression databases
Bgeei | ENSMUSG00000054263, Expressed in cochlea and 311 other tissues |
ExpressionAtlasi | P42703, baseline and differential |
Genevisiblei | P42703, MM |
Interactioni
Subunit structurei
Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR (By similarity).
By similarityGO - Molecular functioni
- ciliary neurotrophic factor receptor binding Source: MGI
- cytokine binding Source: MGI
- growth factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201163, 7 interactors |
DIPi | DIP-5772N |
IntActi | P42703, 4 interactors |
MINTi | P42703 |
STRINGi | 10090.ENSMUSP00000126137 |
Miscellaneous databases
RNActi | P42703, protein |
Structurei
3D structure databases
SMRi | P42703 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42703 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 126 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 330 – 429 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 430 – 529 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 533 – 624 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 622 – 714 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 719 – 828 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 110 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 514 – 518 | WSXWS motif | 5 | |
Motifi | 864 – 872 | Box 1 motif | 9 |
Domaini
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQF6, Eukaryota |
GeneTreei | ENSGT00940000155776 |
HOGENOMi | CLU_283805_0_0_1 |
InParanoidi | P42703 |
OMAi | GYKPQMR |
OrthoDBi | 331447at2759 |
PhylomeDBi | P42703 |
TreeFami | TF338122 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR040817, LIFR_D2 IPR040901, LIFR_N |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF17971, LIFR_D2, 1 hit PF18207, LIFR_N, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 5 hits |
SUPFAMi | SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS01353, HEMATOPO_REC_L_F2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P42703-1) [UniParc]FASTAAdd to basket
Also known as: Membrane
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAYSWWRQP SWMVDNKRSR MTPNLPWLLS ALTLLHLTMH ANGLKRGVQD
60 70 80 90 100
LKCTTNNMRV WDCTWPAPLG VSPGTVKDIC IKDRFHSCHP LETTNVKIPA
110 120 130 140 150
LSPGDHEVTI NYLNGFQSKF TLNEKDVSLI PETPEILDLS ADFFTSSLLL
160 170 180 190 200
KWNDRGSALP HPSNATWEIK VLQNPRTEPV ALVLLNTMLS GKDTVQHWNW
210 220 230 240 250
TSDLPLQCAT HSVSIRWHID SPHFSGYKEW SDWSPLKNIS WIRNTETNVF
260 270 280 290 300
PQDKVVLAGS NMTICCMSPT KVLSGQIGNT LRPLIHLYGQ TVAIHILNIP
310 320 330 340 350
VSENSGTNII FITDDDVYGT VVFAGYPPDV PQKLSCETHD LKEIICSWNP
360 370 380 390 400
GRITGLVGPR NTEYTLFESI SGKSAVFHRI EGLTNETYRL GVQMHPGQEI
410 420 430 440 450
HNFTLTGRNP LGQAQSAVVI NVTERVAPHD PTSLKVKDIN STVVTFSWYL
460 470 480 490 500
PGNFTKINLL CQIEICKANS KKEVRNATIR GAEDSTYHVA VDKLNPYTAY
510 520 530 540 550
TFRVRCSSKT FWKWSRWSDE KRHLTTEATP SKGPDTWREW SSDGKNLIVY
560 570 580 590 600
WKPLPINEAN GKILSYNVSC SLNEETQSVL EIFDPQHRAE IQLSKNDYII
610 620 630 640 650
SVVARNSAGS SPPSKIASME IPNDDITVEQ AVGLGNRIFL TWRHDPNMTC
660 670 680 690 700
DYVIKWCNSS RSEPCLLDWR KVPSNSTETV IESDQFQPGV RYNFYLYGCT
710 720 730 740 750
NQGYQLLRSI IGYVEELAPI VAPNFTVEDT SADSILVKWD DIPVEELRGF
760 770 780 790 800
LRGYLFYFQK GERDTPKTRS LEPHHSDIKL KNITDISQKT LRIADLQGKT
810 820 830 840 850
SYHLVLRAYT HGGLGPEKSM FVVTKENSVG LIIAILIPVA VAVIVGVVTS
860 870 880 890 900
ILCYRKREWI KETFYPDIPN PENCKALQFQ KSVCEGSNAL KTLEMNPCTP
910 920 930 940 950
NNVEVLESRS IVPKIEDTEI ISPVAERPGE RSEVDPENHV VVSYCPPIIE
960 970 980 990 1000
EEITNPAADE VGGASQVVYI DVQSMYQPQA KAEEEQDVDP VVVAGYKPQM
1010 1020 1030 1040 1050
RLPISPAVED TAAEDEEGKT AGYRPQANVN TWNLVSPDSP RSTDSNNEVV
1060 1070 1080 1090
SFGSPCSINS RQFLIPPKDE DSPKSNGGGW SFTNFFQNKP ND
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BRT7 | A0A2I3BRT7_MOUSE | Leukemia inhibitory factor receptor | Lifr | 140 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001686 | 718 – 719 | AP → EA in isoform 2. 4 Publications | 2 | |
Alternative sequenceiVSP_001687 | 720 – 1092 | Missing in isoform 2. 4 PublicationsAdd BLAST | 373 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S73496 mRNA Translation: AAC60698.1 S73495 mRNA Translation: AAC60697.1 D26177 mRNA Translation: BAA05165.1 D17444 mRNA Translation: BAA04258.1 BC031929 mRNA Translation: AAH31929.1 |
CCDSi | CCDS27369.1 [P42703-1] CCDS49577.1 [P42703-2] |
PIRi | JX0312 |
RefSeqi | NP_001106857.1, NM_001113386.1 [P42703-2] NP_038612.1, NM_013584.2 [P42703-1] XP_006520030.1, XM_006519967.3 XP_006520032.1, XM_006519969.3 [P42703-1] XP_006520033.1, XM_006519970.3 [P42703-2] XP_006520034.1, XM_006519971.2 [P42703-2] XP_011243628.1, XM_011245326.2 [P42703-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S73496 mRNA Translation: AAC60698.1 S73495 mRNA Translation: AAC60697.1 D26177 mRNA Translation: BAA05165.1 D17444 mRNA Translation: BAA04258.1 BC031929 mRNA Translation: AAH31929.1 |
CCDSi | CCDS27369.1 [P42703-1] CCDS49577.1 [P42703-2] |
PIRi | JX0312 |
RefSeqi | NP_001106857.1, NM_001113386.1 [P42703-2] NP_038612.1, NM_013584.2 [P42703-1] XP_006520030.1, XM_006519967.3 XP_006520032.1, XM_006519969.3 [P42703-1] XP_006520033.1, XM_006519970.3 [P42703-2] XP_006520034.1, XM_006519971.2 [P42703-2] XP_011243628.1, XM_011245326.2 [P42703-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Q7N | X-ray | 4.00 | A/C | 50-529 | [»] | |
SMRi | P42703 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 201163, 7 interactors |
DIPi | DIP-5772N |
IntActi | P42703, 4 interactors |
MINTi | P42703 |
STRINGi | 10090.ENSMUSP00000126137 |
PTM databases
GlyConnecti | 2478, 4 N-Linked glycans (3 sites) |
GlyGeni | P42703, 16 sites |
iPTMneti | P42703 |
PhosphoSitePlusi | P42703 |
Proteomic databases
CPTACi | non-CPTAC-3515 |
jPOSTi | P42703 |
MaxQBi | P42703 |
PaxDbi | P42703 |
PeptideAtlasi | P42703 |
PRIDEi | P42703 |
Protocols and materials databases
Antibodypediai | 4137, 447 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 3977 |
MGIi | MGI:96788, Lifr |
Phylogenomic databases
eggNOGi | ENOG502QQF6, Eukaryota |
GeneTreei | ENSGT00940000155776 |
HOGENOMi | CLU_283805_0_0_1 |
InParanoidi | P42703 |
OMAi | GYKPQMR |
OrthoDBi | 331447at2759 |
PhylomeDBi | P42703 |
TreeFami | TF338122 |
Enzyme and pathway databases
Reactomei | R-MMU-6788467, IL-6-type cytokine receptor ligand interactions |
Miscellaneous databases
BioGRID-ORCSi | 16880, 2 hits in 17 CRISPR screens |
ChiTaRSi | Lifr, mouse |
EvolutionaryTracei | P42703 |
PROi | PR:P42703 |
RNActi | P42703, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000054263, Expressed in cochlea and 311 other tissues |
ExpressionAtlasi | P42703, baseline and differential |
Genevisiblei | P42703, MM |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR040817, LIFR_D2 IPR040901, LIFR_N |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF17971, LIFR_D2, 1 hit PF18207, LIFR_N, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 5 hits |
SUPFAMi | SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS01353, HEMATOPO_REC_L_F2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIFR_MOUSE | |
Accessioni | P42703Primary (citable) accession number: P42703 Secondary accession number(s): Q5I0Y2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families