UniProtKB - P42700 (RO60_XENLA)
Protein
60 kDa SS-A/Ro ribonucleoprotein
Gene
ro60
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.2 Publications
May play roles in cilia formation and/or maintenance.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 378 | Divalent metal cation2 Publications | 1 | |
Metal bindingi | 380 | Divalent metal cation2 Publications | 1 | |
Metal bindingi | 445 | Divalent metal cation2 Publications | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- misfolded RNA binding Source: MGI
GO - Biological processi
- cell projection organization Source: UniProtKB-KW
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | Cilium biogenesis/degradation |
Ligand | Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 60 kDa SS-A/Ro ribonucleoproteinCuratedShort name: 60 kDa Ro protein Short name: 60 kDa ribonucleoprotein Ro Short name: Ro60Curated Short name: RoRNP Alternative name(s): TROVE domain family member 2 |
Gene namesi | Name:ro60 Synonyms:trove2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-968761, ro60.L |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174171 | 1 – 538 | 60 kDa SS-A/Ro ribonucleoproteinAdd BLAST | 538 |
Proteomic databases
PRIDEi | P42700 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P42700 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42700 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 369 | TROVEPROSITE-ProRule annotationAdd BLAST | 354 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 120 – 284 | RNA-binding2 PublicationsAdd BLAST | 165 | |
Regioni | 361 – 538 | VWFA-like domainCuratedAdd BLAST | 178 |
Domaini
The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity.
The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.2 Publications
Sequence similaritiesi
Belongs to the Ro 60 kDa family.Curated
Family and domain databases
Gene3Di | 3.40.50.410, 3 hits |
InterProi | View protein in InterPro IPR040322, TROVE2 IPR008858, TROVE_dom IPR037214, TROVE_dom_sf IPR036465, vWFA_dom_sf |
PANTHERi | PTHR14202, PTHR14202, 1 hit |
Pfami | View protein in Pfam PF05731, TROVE, 1 hit |
SUPFAMi | SSF140864, SSF140864, 1 hit SSF53300, SSF53300, 1 hit |
PROSITEi | View protein in PROSITE PS50988, TROVE, 1 hit |
i Sequence
Sequence statusi: Complete.
P42700-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEATMDQTQP LNEKQVPNSE GCYVWQVSDM NRLRRFLCFG SEGGTYYIEE
60 70 80 90 100
KKLGQENAEA LLRLIEDGKG CEVVQEIKTF SQEGRAAKQE PTLFALAVCS
110 120 130 140 150
QCSDIKTKQA AFRAVPEVCR IPTHLFTFIQ FKKDLKEGMK CGMWGRALRK
160 170 180 190 200
AVSDWYNTKD ALNLAMAVTK YKQRNGWSHK DLLRLSHIKP ANEGLTMVAK
210 220 230 240 250
YVSKGWKEVQ EAYKEKELSP ETEKVLKYLE ATERVKRTKD ELEIIHLIDE
260 270 280 290 300
YRLVREHLLT IHLKSKEIWK SLLQDMPLTA LLRNLGKMTA DSVLAPASSE
310 320 330 340 350
VSSVCERLTN EKLLKKARIH PFHILVALET YKKGHGNRGK LRWIPDTSIV
360 370 380 390 400
EALDNAFYKS FKLVEPTGKR FLLAIDVSAS MNQRVLGSIL NASVVAAAMC
410 420 430 440 450
MLVARTEKDS HMVAFSDEML PCPITVNMLL HEVVEKMSDI TMGSTDCALP
460 470 480 490 500
MLWAQKTNTA ADIFIVFTDC ETNVEDVHPA TALKQYREKM GIPAKLIVCA
510 520 530
MTSNGFSIAD PDDRGMLDIC GFDSGALDVI RNFTLDLI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L15430 mRNA Translation: AAC38001.1 |
PIRi | I51560 |
RefSeqi | NP_001079344.1, NM_001085875.2 |
Genome annotation databases
GeneIDi | 378688 |
KEGGi | xla:378688 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L15430 mRNA Translation: AAC38001.1 |
PIRi | I51560 |
RefSeqi | NP_001079344.1, NM_001085875.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YVP | X-ray | 2.20 | A/B | 1-538 | [»] | |
1YVR | X-ray | 1.95 | A | 1-538 | [»] | |
2I91 | X-ray | 2.65 | A/B | 1-538 | [»] | |
SMRi | P42700 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | P42700 |
Genome annotation databases
GeneIDi | 378688 |
KEGGi | xla:378688 |
Organism-specific databases
CTDi | 378688 |
Xenbasei | XB-GENE-968761, ro60.L |
Miscellaneous databases
EvolutionaryTracei | P42700 |
Family and domain databases
Gene3Di | 3.40.50.410, 3 hits |
InterProi | View protein in InterPro IPR040322, TROVE2 IPR008858, TROVE_dom IPR037214, TROVE_dom_sf IPR036465, vWFA_dom_sf |
PANTHERi | PTHR14202, PTHR14202, 1 hit |
Pfami | View protein in Pfam PF05731, TROVE, 1 hit |
SUPFAMi | SSF140864, SSF140864, 1 hit SSF53300, SSF53300, 1 hit |
PROSITEi | View protein in PROSITE PS50988, TROVE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RO60_XENLA | |
Accessioni | P42700Primary (citable) accession number: P42700 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families