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Entry version 168 (02 Jun 2021)
Sequence version 3 (10 Jan 2003)
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Protein

Phragmoplastin DRP1A

Gene

DRP1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated force-producing protein that is targeted to at the leading edges of the forming cell plate during cytokinesis (PubMed:18612642).

Plays also a major role in plasma membrane maintenance and cell wall integrity with implications in vesicular trafficking, polar cell expansion, vascular formation, and other aspects of plant growth and development, including stigmatic papillae expansion (PubMed:18256049, PubMed:18344418).

Collaboratively with DRP2B, participates in clathrin-coated vesicle formation during endocytosis (PubMed:20231465).

Necessary for BOR1 polar localization in low-boron (B) conditions as well as for BOR1 endocytosis and subsequent degradation under high-concentration of boron (PubMed:27449211).

Has a GTPase activity (PubMed:20171176).

Required for the sterols-dependent dynamic high lipid order observed at the cell plate of dividing cells (PubMed:25234576).

Together with SH3P2, converts the fused vesicles to tubular structures at the cell plate and phragmoplasts during cytokinesis (PubMed:28584166, PubMed:18256049).

With DRP2B and PIP5K3, required for the precise coordination of polar ARAC3/ROP6 and ARAC4/ROP2 placement and subsequent root hair positioning during planar polarity formation in root hair-forming cells, probably by mediating the correct basal-to-planar polarity switching of D6PK into the polar, lipid-enriched domain (PubMed:27251533).

Involved in endocytosis required for cellulose deposition during cell wall formation and elongation (PubMed:18256049).

Interacts with plasma membrane-mimetic liposomes and induces their clustering (PubMed:20171176).

14 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 28 min(-1) with GTP as substrate.1 Publication
  1. KM=99 µM for GTP1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi44 – 49GTPCombined sources1 Publication6
    Nucleotide bindingi212 – 217GTPCombined sources1 Publication6
    Nucleotide bindingi242 – 245GTPCombined sources1 Publication4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Motor protein
    Biological processCell cycle, Cell division, Protein transport, Transport
    LigandGTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    ARA:AT5G42080-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.6.5.5, 399

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phragmoplastin DRP1ACurated (EC:3.6.5.-1 Publication)
    Alternative name(s):
    Dynamin-like protein 11 Publication
    Dynamin-like protein 1A4 Publications
    Dynamin-related protein 1A4 Publications
    Short name:
    AtDRP1A4 Publications
    Protein RADIAL SWELLING 91 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DRP1A4 Publications
    Synonyms:ADL11 Publication, ADL1A4 Publications, AG681 Publication, RSW91 Publication
    Ordered Locus Names:At5g42080Imported
    ORF Names:MJC20.19Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT5G42080

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2165805, AT5G42080

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Vascular discontinuity (PubMed:15923323, PubMed:18344418). Short and swollen roots and hypocotyls due to cellulose-deficient walls associated with increased levels of arabinose, xylose, and galactose in non-cellulosic polysaccharides (PubMed:18256049). Infertility due to the inability of stigmatic papillae to undergo rapid polar expansion prior to fertilization (PubMed:18344418). The alteration of cell wall formation correlates with abnormal phragmoplasts and division plates in dividing cells, as well as reduced cell elongation and disturbed endocytosis (PubMed:18256049). Hypersensitivity to trafficking inhibitors (e.g. brefeldin A, monensin A and latrunculin B) (PubMed:18256049). Both basal and apical shift of ARAC3/ROP6 and ARAC4/ROP2 positioning and broad lateral localization of D6PK in root hair-forming cells leading to basal and apical shift of root hair positions (PubMed:27251533).4 Publications

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi47K → A: Dominant-negative mutation leading to a prolonged residence time of clathrin at the plasma membrane and impaired endocytosis of membrane lipids. Disturbed BOR1 polar localization in low-boron (B) conditions and blocked BOR1 endocytosis and subsequent degradation under high-concentration of boron. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002065771 – 610Phragmoplastin DRP1AAdd BLAST610

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P42697

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P42697

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    224359 [P42697-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P42697

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous. Expressed in leaves (at protein level).4 Publications

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P42697, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P42697, AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Forms homodimer and may homooligomerize and heterooligomerize to form the phragmoplastin complex (PubMed:20171176, PubMed:20231465).

    Interacts with AGD3/VAN3. May interact with CALS1. Binds to AHK2. Binds to SH3P2 (PubMed:28584166).

    Forms a complex made of SH3P2 and DRP1A and triggers its accumulation at the cell plate (PubMed:28584166).

    Interacts with DRP2B at the plasma membrane and in forming clathrin-coated vesicles (CCV) (PubMed:20231465). Binds to PHIP1 (PubMed:18621982).

    8 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    19463, 11 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-37642N

    Protein interaction database and analysis system

    More...
    IntActi
    P42697, 8 interactors

    Molecular INTeraction database

    More...
    MINTi
    P42697

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT5G42080.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1610
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P42697

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 300Dynamin-type GPROSITE-ProRule annotationAdd BLAST270
    Domaini518 – 610GEDPROSITE-ProRule annotationAdd BLAST93

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 48G1 motifPROSITE-ProRule annotation8
    Regioni67 – 69G2 motifPROSITE-ProRule annotation3
    Regioni142 – 145G3 motifPROSITE-ProRule annotation4
    Regioni211 – 214G4 motifPROSITE-ProRule annotation4
    Regioni241 – 244G5 motifPROSITE-ProRule annotation4

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0446, Eukaryota

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P42697

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VDAIHYV

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P42697

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd08771, DLP_1, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001401, Dynamin_GTPase
    IPR019762, Dynamin_GTPase_CS
    IPR022812, Dynamin_SF
    IPR000375, Dynamin_stalk
    IPR030381, G_DYNAMIN_dom
    IPR003130, GED
    IPR020850, GED_dom
    IPR027417, P-loop_NTPase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11566, PTHR11566, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01031, Dynamin_M, 1 hit
    PF00350, Dynamin_N, 1 hit
    PF02212, GED, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00195, DYNAMIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00053, DYNc, 1 hit
    SM00302, GED, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540, SSF52540, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00410, G_DYNAMIN_1, 1 hit
    PS51718, G_DYNAMIN_2, 1 hit
    PS51388, GED, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: P42697-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MENLISLVNK IQRACTALGD HGDSSALPTL WDSLPAIAVV GGQSSGKSSV
    60 70 80 90 100
    LESIVGKDFL PRGSGIVTRR PLVLQLQKID DGTREYAEFL HLPRKKFTDF
    110 120 130 140 150
    AAVRKEIQDE TDRETGRSKA ISSVPIHLSI YSPNVVNLTL IDLPGLTKVA
    160 170 180 190 200
    VDGQSDSIVK DIENMVRSYI EKPNCIILAI SPANQDLATS DAIKISREVD
    210 220 230 240 250
    PSGDRTFGVL TKIDLMDKGT DAVEILEGRS FKLKYPWVGV VNRSQADINK
    260 270 280 290 300
    NVDMIAARKR EREYFSNTTE YRHLANKMGS EHLAKMLSKH LERVIKSRIP
    310 320 330 340 350
    GIQSLINKTV LELETELSRL GKPIAADAGG KLYSIMEICR LFDQIFKEHL
    360 370 380 390 400
    DGVRAGGEKV YNVFDNQLPA ALKRLQFDKQ LAMDNIRKLV TEADGYQPHL
    410 420 430 440 450
    IAPEQGYRRL IESSIVSIRG PAEASVDTVH AILKDLVHKS VNETVELKQY
    460 470 480 490 500
    PALRVEVTNA AIESLDKMRE GSKKATLQLV DMECSYLTVD FFRKLPQDVE
    510 520 530 540 550
    KGGNPTHSIF DRYNDSYLRR IGSNVLSYVN MVCAGLRNSI PKSIVYCQVR
    560 570 580 590 600
    EAKRSLLDHF FAELGTMDMK RLSSLLNEDP AIMERRSAIS KRLELYRAAQ
    610
    SEIDAVAWSK
    Length:610
    Mass (Da):68,172
    Last modified:January 10, 2003 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE77E9EDBC603D91
    GO
    Isoform 2 (identifier: P42697-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         430-610: Missing.

    Show »
    Length:429
    Mass (Da):47,533
    Checksum:iFA88FAFE16D7DCE1
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F4K015F4K015_ARATH
    Dynamin-like protein
    DL1 ADL1, ADL1A, AG68, DRP1A, dynamin-like protein
    604Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAB63528 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50V → A in AAM19784 (PubMed:14593172).Curated1
    Sequence conflicti50V → A in AAN46817 (PubMed:14593172).Curated1
    Sequence conflicti167R → Q in AAB63528 (PubMed:9342876).Curated1
    Sequence conflicti367Q → H in AAM65743 (Ref. 7) Curated1
    Sequence conflicti423 – 424EA → KT in AAB63528 (PubMed:9342876).Curated2

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009187430 – 610Missing in isoform 2. 2 PublicationsAdd BLAST181

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L38614 mRNA Translation: AAA84446.1
    L36939 mRNA Translation: AAB63528.1 Frameshift.
    AB017067 Genomic DNA Translation: BAB08441.1
    CP002688 Genomic DNA Translation: AED94763.1
    CP002688 Genomic DNA Translation: AED94764.1
    CP002688 Genomic DNA Translation: ANM69643.1
    AY094408 mRNA Translation: AAM19784.1
    BT001063 mRNA Translation: AAN46817.1
    BT025994 mRNA Translation: ABG25083.1
    AY088201 mRNA Translation: AAM65743.1
    AK230240 mRNA Translation: BAF02045.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S59558

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001331306.1, NM_001344434.1 [P42697-1]
    NP_568602.3, NM_123573.3 [P42697-2]
    NP_851120.1, NM_180789.3 [P42697-1]

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT5G42080.1; AT5G42080.1; AT5G42080 [P42697-1]
    AT5G42080.2; AT5G42080.2; AT5G42080 [P42697-2]
    AT5G42080.4; AT5G42080.4; AT5G42080 [P42697-1]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    834213

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT5G42080.1; AT5G42080.1; AT5G42080 [P42697-1]
    AT5G42080.2; AT5G42080.2; AT5G42080 [P42697-2]
    AT5G42080.4; AT5G42080.4; AT5G42080 [P42697-1]

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT5G42080

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L38614 mRNA Translation: AAA84446.1
    L36939 mRNA Translation: AAB63528.1 Frameshift.
    AB017067 Genomic DNA Translation: BAB08441.1
    CP002688 Genomic DNA Translation: AED94763.1
    CP002688 Genomic DNA Translation: AED94764.1
    CP002688 Genomic DNA Translation: ANM69643.1
    AY094408 mRNA Translation: AAM19784.1
    BT001063 mRNA Translation: AAN46817.1
    BT025994 mRNA Translation: ABG25083.1
    AY088201 mRNA Translation: AAM65743.1
    AK230240 mRNA Translation: BAF02045.1
    PIRiS59558
    RefSeqiNP_001331306.1, NM_001344434.1 [P42697-1]
    NP_568602.3, NM_123573.3 [P42697-2]
    NP_851120.1, NM_180789.3 [P42697-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3T34X-ray2.40A/B1-325[»]
    A/B579-606[»]
    3T35X-ray3.59A/B/C/D1-325[»]
    A/B/C/D579-606[»]
    SMRiP42697
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi19463, 11 interactors
    DIPiDIP-37642N
    IntActiP42697, 8 interactors
    MINTiP42697
    STRINGi3702.AT5G42080.1

    PTM databases

    iPTMnetiP42697

    Proteomic databases

    PaxDbiP42697
    PRIDEiP42697
    ProteomicsDBi224359 [P42697-1]

    Genome annotation databases

    EnsemblPlantsiAT5G42080.1; AT5G42080.1; AT5G42080 [P42697-1]
    AT5G42080.2; AT5G42080.2; AT5G42080 [P42697-2]
    AT5G42080.4; AT5G42080.4; AT5G42080 [P42697-1]
    GeneIDi834213
    GrameneiAT5G42080.1; AT5G42080.1; AT5G42080 [P42697-1]
    AT5G42080.2; AT5G42080.2; AT5G42080 [P42697-2]
    AT5G42080.4; AT5G42080.4; AT5G42080 [P42697-1]
    KEGGiath:AT5G42080

    Organism-specific databases

    AraportiAT5G42080
    TAIRilocus:2165805, AT5G42080

    Phylogenomic databases

    eggNOGiKOG0446, Eukaryota
    InParanoidiP42697
    OMAiVDAIHYV
    PhylomeDBiP42697

    Enzyme and pathway databases

    BioCyciARA:AT5G42080-MONOMER
    BRENDAi3.6.5.5, 399

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P42697

    Gene expression databases

    ExpressionAtlasiP42697, baseline and differential
    GenevisibleiP42697, AT

    Family and domain databases

    CDDicd08771, DLP_1, 1 hit
    InterProiView protein in InterPro
    IPR001401, Dynamin_GTPase
    IPR019762, Dynamin_GTPase_CS
    IPR022812, Dynamin_SF
    IPR000375, Dynamin_stalk
    IPR030381, G_DYNAMIN_dom
    IPR003130, GED
    IPR020850, GED_dom
    IPR027417, P-loop_NTPase
    PANTHERiPTHR11566, PTHR11566, 1 hit
    PfamiView protein in Pfam
    PF01031, Dynamin_M, 1 hit
    PF00350, Dynamin_N, 1 hit
    PF02212, GED, 1 hit
    PRINTSiPR00195, DYNAMIN
    SMARTiView protein in SMART
    SM00053, DYNc, 1 hit
    SM00302, GED, 1 hit
    SUPFAMiSSF52540, SSF52540, 1 hit
    PROSITEiView protein in PROSITE
    PS00410, G_DYNAMIN_1, 1 hit
    PS51718, G_DYNAMIN_2, 1 hit
    PS51388, GED, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRP1A_ARATH
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42697
    Secondary accession number(s): Q0WLG2
    , Q1EBU0, Q39118, Q8L9V5, Q8LPS7
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 10, 2003
    Last modified: June 2, 2021
    This is version 168 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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