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Protein

RNA-binding protein 34

Gene

RBM34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 34
Alternative name(s):
RNA-binding motif protein 34
Gene namesi
Name:RBM34
Synonyms:KIAA0117
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188739.14
HGNCiHGNC:28965 RBM34
neXtProtiNX_P42696

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188739
PharmGKBiPA142671094

Polymorphism and mutation databases

BioMutaiRBM34
DMDMi57013870

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817901 – 430RNA-binding protein 34Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei151N6-acetyllysineBy similarity1
Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei288PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP42696
MaxQBiP42696
PaxDbiP42696
PeptideAtlasiP42696
PRIDEiP42696
ProteomicsDBi55541
55542 [P42696-2]

2D gel databases

SWISS-2DPAGEiP42696

PTM databases

CarbonylDBiP42696
iPTMnetiP42696
PhosphoSitePlusiP42696

Expressioni

Gene expression databases

BgeeiENSG00000188739 Expressed in 102 organ(s), highest expression level in testis
CleanExiHS_RBM34
ExpressionAtlasiP42696 baseline and differential
GenevisibleiP42696 HS

Organism-specific databases

HPAiHPA028606

Interactioni

Protein-protein interaction databases

BioGridi116668, 148 interactors
IntActiP42696, 20 interactors
MINTiP42696
STRINGi9606.ENSP00000386226

Structurei

3D structure databases

ProteinModelPortaliP42696
SMRiP42696
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 280RRM 1PROSITE-ProRule annotationAdd BLAST96
Domaini287 – 364RRM 2PROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the RRM RBM34 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00390000011249
HOGENOMiHOG000060230
HOVERGENiHBG052167
InParanoidiP42696
KOiK14837
OMAiRFRSVIP
OrthoDBiEOG091G0GEH
PhylomeDBiP42696
TreeFamiTF313083

Family and domain databases

CDDicd12394 RRM1_RBM34, 1 hit
cd12395 RRM2_RBM34, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034220 RBM34_RRM1
IPR034221 RBM34_RRM2
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P42696-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALEGMSKRK RKRSVQEGEN PDDGVRGSPP EDYRLGQVAS SLFRGEHHSR
60 70 80 90 100
GGTGRLASLF SSLEPQIQPV YVPVPKQTIK KTKRNEEEES TSQIERPLSQ
110 120 130 140 150
EPAKKVKAKK KHTNAEKKLA DRESALASAD LEEEIHQKQG QKRKNSQPGV
160 170 180 190 200
KVADRKILDD TEDTVVSQRK KIQINQEEER LKNERTVFVG NLPVTCNKKK
210 220 230 240 250
LKSFFKEYGQ IESVRFRSLI PAEGTLSKKL AAIKRKIHPD QKNINAYVVF
260 270 280 290 300
KEESAATQAL KRNGAQIADG FRIRVDLASE TSSRDKRSVF VGNLPYKVEE
310 320 330 340 350
SAIEKHFLDC GSIMAVRIVR DKMTGIGKGF GYVLFENTDS VHLALKLNNS
360 370 380 390 400
ELMGRKLRVM RSVNKEKFKQ QNSNPRLKNV SKPKQGLNFT SKTAEGHPKS
410 420 430
LFIGEKAVLL KTKKKGQKKS GRPKKQRKQK
Length:430
Mass (Da):48,565
Last modified:October 10, 2003 - v2
Checksum:i6BA5C901E1C7C935
GO
Isoform 2 (identifier: P42696-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-225: IPAEGT → VCFIPP
     226-430: Missing.

Note: May be due to an intron retention.
Show »
Length:225
Mass (Da):25,577
Checksum:iB15E8AB7214E9D68
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2V2A2A2V2_HUMAN
RNA-binding protein 34
RBM34
408Annotation score:
Q5TCT4Q5TCT4_HUMAN
RNA-binding protein 34
RBM34
211Annotation score:
H7C5M1H7C5M1_HUMAN
RNA-binding protein 34
RBM34
86Annotation score:

Sequence cautioni

The sequence AAH29451 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA07503 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF85051 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94I → V in BAF85051 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037037220 – 225IPAEGT → VCFIPP in isoform 2. 1 Publication6
Alternative sequenceiVSP_037038226 – 430Missing in isoform 2. 1 PublicationAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38491 mRNA Translation: BAA07503.1 Different initiation.
AK292362 mRNA Translation: BAF85051.1 Different initiation.
AL133418 Genomic DNA No translation available.
AL732292 Genomic DNA No translation available.
BC029451 mRNA Translation: AAH29451.1 Different initiation.
CCDSiCCDS41477.2 [P42696-1]
RefSeqiNP_001333667.1, NM_001346738.1
NP_055829.2, NM_015014.3 [P42696-1]
UniGeneiHs.535224

Genome annotation databases

EnsembliENST00000408888; ENSP00000386226; ENSG00000188739 [P42696-1]
GeneIDi23029
KEGGihsa:23029
UCSCiuc001hwn.3 human [P42696-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38491 mRNA Translation: BAA07503.1 Different initiation.
AK292362 mRNA Translation: BAF85051.1 Different initiation.
AL133418 Genomic DNA No translation available.
AL732292 Genomic DNA No translation available.
BC029451 mRNA Translation: AAH29451.1 Different initiation.
CCDSiCCDS41477.2 [P42696-1]
RefSeqiNP_001333667.1, NM_001346738.1
NP_055829.2, NM_015014.3 [P42696-1]
UniGeneiHs.535224

3D structure databases

ProteinModelPortaliP42696
SMRiP42696
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116668, 148 interactors
IntActiP42696, 20 interactors
MINTiP42696
STRINGi9606.ENSP00000386226

PTM databases

CarbonylDBiP42696
iPTMnetiP42696
PhosphoSitePlusiP42696

Polymorphism and mutation databases

BioMutaiRBM34
DMDMi57013870

2D gel databases

SWISS-2DPAGEiP42696

Proteomic databases

EPDiP42696
MaxQBiP42696
PaxDbiP42696
PeptideAtlasiP42696
PRIDEiP42696
ProteomicsDBi55541
55542 [P42696-2]

Protocols and materials databases

DNASUi23029
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408888; ENSP00000386226; ENSG00000188739 [P42696-1]
GeneIDi23029
KEGGihsa:23029
UCSCiuc001hwn.3 human [P42696-1]

Organism-specific databases

CTDi23029
EuPathDBiHostDB:ENSG00000188739.14
GeneCardsiRBM34
HGNCiHGNC:28965 RBM34
HPAiHPA028606
neXtProtiNX_P42696
OpenTargetsiENSG00000188739
PharmGKBiPA142671094
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00390000011249
HOGENOMiHOG000060230
HOVERGENiHBG052167
InParanoidiP42696
KOiK14837
OMAiRFRSVIP
OrthoDBiEOG091G0GEH
PhylomeDBiP42696
TreeFamiTF313083

Miscellaneous databases

ChiTaRSiRBM34 human
GeneWikiiRBM34
GenomeRNAii23029
PROiPR:P42696

Gene expression databases

BgeeiENSG00000188739 Expressed in 102 organ(s), highest expression level in testis
CleanExiHS_RBM34
ExpressionAtlasiP42696 baseline and differential
GenevisibleiP42696 HS

Family and domain databases

CDDicd12394 RRM1_RBM34, 1 hit
cd12395 RRM2_RBM34, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034220 RBM34_RRM1
IPR034221 RBM34_RRM2
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRBM34_HUMAN
AccessioniPrimary (citable) accession number: P42696
Secondary accession number(s): A8K8J7, Q8N2Z8, Q9H5A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 10, 2003
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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