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Protein

Tyrosine-protein kinase ABL2

Gene

ABL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.5 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Activity regulationi

Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei317ATPPROSITE-ProRule annotation1
Active sitei409Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi294 – 302ATPPROSITE-ProRule annotation9
Nucleotide bindingi362 – 368ATPPROSITE-ProRule annotation7

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • actin monomer binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: UniProtKB
  • manganese ion binding Source: UniProtKB
  • non-membrane spanning protein tyrosine kinase activity Source: GO_Central
  • phosphotyrosine residue binding Source: CAFA
  • protein kinase activity Source: ProtInc
  • protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processCell adhesion
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-428890 Role of ABL in ROBO-SLIT signaling
SignaLinkiP42684
SIGNORiP42684

Protein family/group databases

MoonDBiP42684 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase ABL2 (EC:2.7.10.2)
Alternative name(s):
Abelson murine leukemia viral oncogene homolog 2
Abelson tyrosine-protein kinase 2
Abelson-related gene protein
Tyrosine-protein kinase ARG
Gene namesi
Name:ABL2
Synonyms:ABLL, ARG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143322.19
HGNCiHGNC:77 ABL2
MIMi164690 gene
neXtProtiNX_P42684

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi27
OpenTargetsiENSG00000143322
PharmGKBiPA24414

Chemistry databases

ChEMBLiCHEMBL4014
DrugBankiDB00171 Adenosine triphosphate
DB01254 Dasatinib
DB05184 XL228
GuidetoPHARMACOLOGYi1924

Polymorphism and mutation databases

BioMutaiABL2
DMDMi1168268

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000880522 – 1182Tyrosine-protein kinase ABL2Add BLAST1181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei116PhosphotyrosineBy similarity1
Modified residuei161PhosphotyrosineBy similarity1
Modified residuei174PhosphotyrosineBy similarity1
Modified residuei185PhosphotyrosineBy similarity1
Modified residuei218PhosphotyrosineBy similarity1
Modified residuei231PhosphotyrosineBy similarity1
Modified residuei261Phosphotyrosine; by ABL1 and autocatalysis1 Publication1
Modified residuei272Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei275PhosphoserineCombined sources1
Modified residuei299PhosphotyrosineBy similarity1
Modified residuei303PhosphotyrosineBy similarity1
Modified residuei439Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases1 Publication1
Modified residuei459PhosphotyrosineBy similarity1
Modified residuei568Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei620PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei669PhosphoserineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei671PhosphoserineCombined sources1
Modified residuei683Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei718PhosphotyrosineCombined sources1
Modified residuei776N6-acetyllysineBy similarity1
Modified residuei783PhosphoserineCombined sources1
Modified residuei800PhosphothreonineBy similarity1
Modified residuei817PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Isoform 4 (identifier: P42684-4)
Modified residuei647PhosphotyrosineCombined sources1
Isoform 7 (identifier: P42684-7)
Modified residuei662PhosphotyrosineCombined sources1
Isoform 10 (identifier: P42684-10)
Modified residuei668PhosphotyrosineCombined sources1
Isoform 5 (identifier: P42684-5)
Modified residuei683PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).By similarity
Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP42684
MaxQBiP42684
PaxDbiP42684
PeptideAtlasiP42684
PRIDEiP42684
ProteomicsDBi55528
55529 [P42684-10]
55530 [P42684-2]
55531 [P42684-3]
55532 [P42684-4]
55533 [P42684-5]
55534 [P42684-6]
55535 [P42684-7]
55536 [P42684-8]

PTM databases

iPTMnetiP42684
PhosphoSitePlusiP42684

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000143322 Expressed in 199 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_ABL2
GenevisibleiP42684 HS

Organism-specific databases

HPAiCAB017106
HPA001866
HPA072754

Interactioni

Subunit structurei

Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106545, 43 interactors
CORUMiP42684
DIPiDIP-91N
IntActiP42684, 44 interactors
MINTiP42684
STRINGi9606.ENSP00000427562

Chemistry databases

BindingDBiP42684

Structurei

Secondary structure

11182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP42684
SMRiP42684
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42684

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 167SH3PROSITE-ProRule annotationAdd BLAST61
Domaini173 – 263SH2PROSITE-ProRule annotationAdd BLAST91
Domaini288 – 539Protein kinasePROSITE-ProRule annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 106CAPAdd BLAST105
Regioni694 – 930F-actin-bindingBy similarityAdd BLAST237
Regioni1020 – 1182F-actin-bindingBy similarityAdd BLAST163

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi427 – 451Kinase activation loopBy similarityAdd BLAST25
Motifi658 – 660Nuclear localization signalSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi561 – 564Poly-Ser4
Compositional biasi732 – 739Poly-Gly8
Compositional biasi843 – 1055Pro-richAdd BLAST213
Compositional biasi984 – 988Poly-Pro5

Domaini

Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required to bundle actin filaments (By similarity).By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000119011
HOVERGENiHBG004162
InParanoidiP42684
KOiK08887
OMAiCQRSKIQ
OrthoDBiEOG091G0D46
PhylomeDBiP42684
TreeFamiTF105081

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequences (9)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P42684-1) [UniParc]FASTAAdd to basket
Also known as: IB, 1BLCTL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT
60 70 80 90 100
QHDHFASCVE DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN
110 120 130 140 150
LLGATESDPN LFVALYDFVA SGDNTLSITK GEKLRVLGYN QNGEWSEVRS
160 170 180 190 200
KNGQGWVPSN YITPVNSLEK HSWYHGPVSR SAAEYLLSSL INGSFLVRES
210 220 230 240 250
ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST LAELVHHHST
260 270 280 290 300
VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG
310 320 330 340 350
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV
360 370 380 390 400
CTLEPPFYIV TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL
410 420 430 440 450
EKKNFIHRDL AARNCLVGEN HVVKVADFGL SRLMTGDTYT AHAGAKFPIK
460 470 480 490 500
WTAPESLAYN TFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYDLLEK
510 520 530 540 550
GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE TMFHDSSISE
560 570 580 590 600
EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE
610 620 630 640 650
NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG
660 670 680 690 700
GFFSSFMKKR NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG
710 720 730 740 750
FSFTPAQQEA NLVPPKCYGG SFAQRNLCND DGGGGGGSGT AGGGWSGITG
760 770 780 790 800
FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR SNSTSSMSSG LPEQDRMAMT
810 820 830 840 850
LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES AAPSRERPKA
860 870 880 890 900
KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG
910 920 930 940 950
MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG
960 970 980 990 1000
TDSQGNKFKL LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS
1010 1020 1030 1040 1050
DPTEEPTALT AGQSTSETQE GGKKAALGAV PISGKAGRPV MPPPQVPLPT
1060 1070 1080 1090 1100
SSISPAKMAN GTAGTKVALR KTKQAAEKIS ADKISKEALL ECADLLSSAL
1110 1120 1130 1140 1150
TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV SKLELSLQEL
1160 1170 1180
QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR
Length:1,182
Mass (Da):128,343
Last modified:November 1, 1995 - v1
Checksum:iED93869BC2B14FAA
GO
Isoform 2 (identifier: P42684-2) [UniParc]FASTAAdd to basket
Also known as: IA, 1ASCTL

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MGQQVGRVGE...EGDKTGGSSP → MVLGTVLLPP...ASESALPDLT

Show »
Length:1,146
Mass (Da):124,560
Checksum:iEB47F5DE7CFDAE67
GO
Isoform 3 (identifier: P42684-3) [UniParc]FASTAAdd to basket
Also known as: IC, 1ALCTL

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MGQQVGRVGE...ETGFNIFTQH → MVLGTVLLPP...ASESALPDLT

Show »
Length:1,167
Mass (Da):126,684
Checksum:i0E3923FE9EEEAFEC
GO
Isoform 4 (identifier: P42684-4) [UniParc]FASTAAdd to basket
Also known as: 1ASCTS

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MGQQVGRVGE...EGDKTGGSSP → MVLGTVLLPP...ASESALPDLT
     688-790: Missing.

Show »
Length:1,043
Mass (Da):114,159
Checksum:i973C4751FD7E13F9
GO
Isoform 5 (identifier: P42684-5) [UniParc]FASTAAdd to basket
Also known as: 1BLCTS

The sequence of this isoform differs from the canonical sequence as follows:
     688-790: Missing.

Show »
Length:1,079
Mass (Da):117,942
Checksum:i9916652E5DB8F74D
GO
Isoform 6 (identifier: P42684-6) [UniParc]FASTAAdd to basket
Also known as: 1BSCTL

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.

Show »
Length:1,161
Mass (Da):126,219
Checksum:iA54046CDF6770B1C
GO
Isoform 7 (identifier: P42684-7) [UniParc]FASTAAdd to basket
Also known as: 1BSCTS

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.
     688-790: Missing.

Show »
Length:1,058
Mass (Da):115,817
Checksum:i28DCB354F9917898
GO
Isoform 10 (identifier: P42684-10) [UniParc]FASTAAdd to basket
Also known as: 1ALCTS

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MGQQVGRVGE...ETGFNIFTQH → MVLGTVLLPP...ASESALPDLT
     688-790: Missing.

Show »
Length:1,064
Mass (Da):116,283
Checksum:iAF67137EC553DFE7
GO
Isoform 8 (identifier: P42684-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.
     550-564: EEVAEELGRAASSSS → EVLLHCANQTCITL
     565-1182: Missing.

Note: No experimental confirmation available.
Show »
Length:542
Mass (Da):60,864
Checksum:i89E988F0EFF2ABCF
GO

Sequence cautioni

The sequence CAD98092 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti343 – 344NL → TI no nucleotide entry (PubMed:3787260).Curated2
Sequence conflicti435T → I in AK311045 (PubMed:14702039).Curated1
Sequence conflicti981K → R in CAD98092 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05541178R → H1 PublicationCorresponds to variant dbSNP:rs55655202Ensembl.1
Natural variantiVAR_05541299E → Q Somatic mutation in a breast cancer sample. 1 Publication1
Natural variantiVAR_055413519R → I Somatic mutation in a lung squamous cell carcinoma. 1 Publication1
Natural variantiVAR_055414769T → S1 PublicationCorresponds to variant dbSNP:rs55892721Ensembl.1
Natural variantiVAR_029232930K → R2 PublicationsCorresponds to variant dbSNP:rs17277288Ensembl.1
Natural variantiVAR_029233946V → M1 PublicationCorresponds to variant dbSNP:rs28913889Ensembl.1
Natural variantiVAR_029234996P → R2 PublicationsCorresponds to variant dbSNP:rs28913890Ensembl.1
Natural variantiVAR_0292351085S → N1 PublicationCorresponds to variant dbSNP:rs28913891Ensembl.1
Natural variantiVAR_0292361101T → A1 PublicationCorresponds to variant dbSNP:rs28913892Ensembl.1
Isoform 4 (identifier: P42684-4)
Natural varianti12S → TCombined sourcesCorresponds to variant dbSNP:rs1318056Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0049611 – 73MGQQV…GGSSP → MVLGTVLLPPNSYGRDQDTS LCCLCTEASESALPDLT in isoform 2 and isoform 4. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0171121 – 52MGQQV…IFTQH → MVLGTVLLPPNSYGRDQDTS LCCLCTEASESALPDLT in isoform 3 and isoform 10. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_04177253 – 73Missing in isoform 6, isoform 7 and isoform 8. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_041773550 – 564EEVAE…ASSSS → EVLLHCANQTCITL in isoform 8. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_041774565 – 1182Missing in isoform 8. 1 PublicationAdd BLAST618
Alternative sequenceiVSP_021308688 – 790Missing in isoform 4, isoform 5, isoform 7 and isoform 10. 2 PublicationsAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35296 mRNA Translation: AAA35553.1
FJ542283 mRNA Translation: ACK76601.1
FJ542284 mRNA Translation: ACK76602.1
FJ542285 mRNA Translation: ACK76603.1
FJ542286 mRNA Translation: ACK76604.1
AK311045 mRNA No translation available.
BX538317 mRNA Translation: CAD98092.1 Different initiation.
DQ009672 Genomic DNA Translation: AAY16984.1
AL139132 Genomic DNA No translation available.
AL359179 Genomic DNA No translation available.
AL512326 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91040.1
BC065912 mRNA Translation: AAH65912.1
CCDSiCCDS30947.1 [P42684-1]
CCDS41441.2 [P42684-3]
CCDS44282.1 [P42684-10]
CCDS44283.1 [P42684-8]
CCDS53435.1 [P42684-4]
CCDS53436.1 [P42684-6]
CCDS53437.1 [P42684-7]
CCDS53438.1 [P42684-5]
PIRiA35962
B35962
RefSeqiNP_001129472.1, NM_001136000.2 [P42684-10]
NP_001129473.1, NM_001136001.1 [P42684-8]
NP_001161708.1, NM_001168236.1 [P42684-6]
NP_001161709.1, NM_001168237.1 [P42684-5]
NP_001161710.1, NM_001168238.1 [P42684-7]
NP_001161711.1, NM_001168239.1 [P42684-4]
NP_005149.4, NM_005158.4 [P42684-3]
NP_009298.1, NM_007314.3 [P42684-1]
XP_005245145.1, XM_005245088.2 [P42684-2]
UniGeneiHs.159472

Genome annotation databases

EnsembliENST00000344730; ENSP00000339209; ENSG00000143322 [P42684-10]
ENST00000367623; ENSP00000356595; ENSG00000143322 [P42684-6]
ENST00000392043; ENSP00000375897; ENSG00000143322 [P42684-8]
ENST00000502732; ENSP00000427562; ENSG00000143322 [P42684-1]
ENST00000504405; ENSP00000426831; ENSG00000143322 [P42684-4]
ENST00000507173; ENSP00000423413; ENSG00000143322 [P42684-7]
ENST00000511413; ENSP00000424697; ENSG00000143322 [P42684-5]
ENST00000512653; ENSP00000423578; ENSG00000143322 [P42684-3]
GeneIDi27
KEGGihsa:27
UCSCiuc001gmg.5 human [P42684-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35296 mRNA Translation: AAA35553.1
FJ542283 mRNA Translation: ACK76601.1
FJ542284 mRNA Translation: ACK76602.1
FJ542285 mRNA Translation: ACK76603.1
FJ542286 mRNA Translation: ACK76604.1
AK311045 mRNA No translation available.
BX538317 mRNA Translation: CAD98092.1 Different initiation.
DQ009672 Genomic DNA Translation: AAY16984.1
AL139132 Genomic DNA No translation available.
AL359179 Genomic DNA No translation available.
AL512326 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91040.1
BC065912 mRNA Translation: AAH65912.1
CCDSiCCDS30947.1 [P42684-1]
CCDS41441.2 [P42684-3]
CCDS44282.1 [P42684-10]
CCDS44283.1 [P42684-8]
CCDS53435.1 [P42684-4]
CCDS53436.1 [P42684-6]
CCDS53437.1 [P42684-7]
CCDS53438.1 [P42684-5]
PIRiA35962
B35962
RefSeqiNP_001129472.1, NM_001136000.2 [P42684-10]
NP_001129473.1, NM_001136001.1 [P42684-8]
NP_001161708.1, NM_001168236.1 [P42684-6]
NP_001161709.1, NM_001168237.1 [P42684-5]
NP_001161710.1, NM_001168238.1 [P42684-7]
NP_001161711.1, NM_001168239.1 [P42684-4]
NP_005149.4, NM_005158.4 [P42684-3]
NP_009298.1, NM_007314.3 [P42684-1]
XP_005245145.1, XM_005245088.2 [P42684-2]
UniGeneiHs.159472

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECDNMR-A163-268[»]
2KK1NMR-A1058-1182[»]
2XYNX-ray2.81A/B/C279-546[»]
3GVUX-ray2.05A279-546[»]
3HMIX-ray1.65A279-546[»]
3ULRX-ray1.65C563-579[»]
4EIHX-ray1.20A165-273[»]
5NP3X-ray2.00A/B/C/D110-166[»]
5NP5X-ray1.40A/B110-166[»]
ProteinModelPortaliP42684
SMRiP42684
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106545, 43 interactors
CORUMiP42684
DIPiDIP-91N
IntActiP42684, 44 interactors
MINTiP42684
STRINGi9606.ENSP00000427562

Chemistry databases

BindingDBiP42684
ChEMBLiCHEMBL4014
DrugBankiDB00171 Adenosine triphosphate
DB01254 Dasatinib
DB05184 XL228
GuidetoPHARMACOLOGYi1924

Protein family/group databases

MoonDBiP42684 Predicted

PTM databases

iPTMnetiP42684
PhosphoSitePlusiP42684

Polymorphism and mutation databases

BioMutaiABL2
DMDMi1168268

Proteomic databases

EPDiP42684
MaxQBiP42684
PaxDbiP42684
PeptideAtlasiP42684
PRIDEiP42684
ProteomicsDBi55528
55529 [P42684-10]
55530 [P42684-2]
55531 [P42684-3]
55532 [P42684-4]
55533 [P42684-5]
55534 [P42684-6]
55535 [P42684-7]
55536 [P42684-8]

Protocols and materials databases

DNASUi27
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344730; ENSP00000339209; ENSG00000143322 [P42684-10]
ENST00000367623; ENSP00000356595; ENSG00000143322 [P42684-6]
ENST00000392043; ENSP00000375897; ENSG00000143322 [P42684-8]
ENST00000502732; ENSP00000427562; ENSG00000143322 [P42684-1]
ENST00000504405; ENSP00000426831; ENSG00000143322 [P42684-4]
ENST00000507173; ENSP00000423413; ENSG00000143322 [P42684-7]
ENST00000511413; ENSP00000424697; ENSG00000143322 [P42684-5]
ENST00000512653; ENSP00000423578; ENSG00000143322 [P42684-3]
GeneIDi27
KEGGihsa:27
UCSCiuc001gmg.5 human [P42684-1]

Organism-specific databases

CTDi27
DisGeNETi27
EuPathDBiHostDB:ENSG00000143322.19
GeneCardsiABL2
HGNCiHGNC:77 ABL2
HPAiCAB017106
HPA001866
HPA072754
MIMi164690 gene
neXtProtiNX_P42684
OpenTargetsiENSG00000143322
PharmGKBiPA24414
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000119011
HOVERGENiHBG004162
InParanoidiP42684
KOiK08887
OMAiCQRSKIQ
OrthoDBiEOG091G0D46
PhylomeDBiP42684
TreeFamiTF105081

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-428890 Role of ABL in ROBO-SLIT signaling
SignaLinkiP42684
SIGNORiP42684

Miscellaneous databases

ChiTaRSiABL2 human
EvolutionaryTraceiP42684
GeneWikiiABL2
GenomeRNAii27
PROiPR:P42684
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143322 Expressed in 199 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_ABL2
GenevisibleiP42684 HS

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABL2_HUMAN
AccessioniPrimary (citable) accession number: P42684
Secondary accession number(s): A0M8X0
, B7UEF2, B7UEF3, B7UEF4, B7UEF5, Q5T0X6, Q5W0C5, Q6NZY6, Q7Z301
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 210 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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