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UniProtKB - P42684 (ABL2_HUMAN)

Entry version 229 (02 Jun 2021)
Sequence version 1 (01 Nov 1995)
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Protein

Tyrosine-protein kinase ABL2

Gene

ABL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+, Mn2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei317ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei409Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi294 – 302ATPPROSITE-ProRule annotation9
Nucleotide bindingi362 – 368ATPPROSITE-ProRule annotation7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processCell adhesion
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.10.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P42684

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-428890, Role of ABL in ROBO-SLIT signaling
R-HSA-9706369, Negative regulation of FLT3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P42684

SIGNOR Signaling Network Open Resource

More...SIGNORi		P42684

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P42684, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase ABL2 (EC:2.7.10.2)
Alternative name(s):
Abelson murine leukemia viral oncogene homolog 2
Abelson tyrosine-protein kinase 2
Abelson-related gene protein
Tyrosine-protein kinase ARG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABL2
Synonyms:ABLL, ARG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:77, ABL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164690, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P42684

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143322.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27

Open Targets

More...OpenTargetsi		ENSG00000143322

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24414

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P42684, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4014

Drug and drug target database

More...DrugBanki		DB00171, ATP
DB01254, Dasatinib
DB12010, Fostamatinib
DB07664, K-00546
DB05184, XL228

DrugCentral

More...DrugCentrali		P42684

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1924

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ABL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		1168268

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000880522 – 1182Tyrosine-protein kinase ABL2Add BLAST1181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei97PhosphoserineBy similarity1
Modified residuei116PhosphotyrosineBy similarity1
Modified residuei161PhosphotyrosineBy similarity1
Modified residuei174PhosphotyrosineBy similarity1
Modified residuei185PhosphotyrosineBy similarity1
Modified residuei218PhosphotyrosineBy similarity1
Modified residuei231PhosphotyrosineBy similarity1
Modified residuei261Phosphotyrosine; by ABL1 and autocatalysis1 Publication1
Modified residuei272Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei275PhosphoserineCombined sources1
Modified residuei299PhosphotyrosineBy similarity1
Modified residuei303PhosphotyrosineBy similarity1
Modified residuei439Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases1 Publication1
Modified residuei459PhosphotyrosineBy similarity1
Modified residuei568Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei620PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei669PhosphoserineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei671PhosphoserineCombined sources1
Modified residuei683Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei718PhosphotyrosineCombined sources1
Modified residuei776N6-acetyllysineBy similarity1
Modified residuei783PhosphoserineCombined sources1
Modified residuei800PhosphothreonineBy similarity1
Modified residuei817PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Isoform 4 (identifier: P42684-4)
Modified residuei647PhosphotyrosineCombined sources1
Isoform 7 (identifier: P42684-7)
Modified residuei662PhosphotyrosineCombined sources1
Isoform 10 (identifier: P42684-10)
Modified residuei668PhosphotyrosineCombined sources1
Isoform 5 (identifier: P42684-5)
Modified residuei683PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).By similarity
Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P42684

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P42684

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P42684

MaxQB - The MaxQuant DataBase

More...MaxQBi		P42684

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P42684

PeptideAtlas

More...PeptideAtlasi		P42684

PRoteomics IDEntifications database

More...PRIDEi		P42684

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55528 [P42684-1]
55529 [P42684-10]
55530 [P42684-2]
55531 [P42684-3]
55532 [P42684-4]
55533 [P42684-5]
55534 [P42684-6]
55535 [P42684-7]
55536 [P42684-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P42684

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P42684

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143322, Expressed in tendon of biceps brachii and 213 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P42684, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143322, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PSMA7.

Interacts with CTTN.

Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106545, 53 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P42684

Database of interacting proteins

More...DIPi		DIP-91N

Protein interaction database and analysis system

More...IntActi		P42684, 55 interactors

Molecular INTeraction database

More...MINTi		P42684

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000427562

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P42684

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P42684, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P42684

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P42684

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P42684

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini107 – 167SH3PROSITE-ProRule annotationAdd BLAST61
Domaini173 – 263SH2PROSITE-ProRule annotationAdd BLAST91
Domaini288 – 539Protein kinasePROSITE-ProRule annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni2 – 106CAPAdd BLAST105
Regioni60 – 80DisorderedSequence analysisAdd BLAST21
Regioni611 – 641DisorderedSequence analysisAdd BLAST31
Regioni654 – 674DisorderedSequence analysisAdd BLAST21
Regioni694 – 930F-actin-bindingBy similarityAdd BLAST237
Regioni763 – 794DisorderedSequence analysisAdd BLAST32
Regioni807 – 851DisorderedSequence analysisAdd BLAST45
Regioni964 – 1024DisorderedSequence analysisAdd BLAST61
Regioni1020 – 1182F-actin-bindingBy similarityAdd BLAST163

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi427 – 451Kinase activation loopBy similarityAdd BLAST25
Motifi658 – 660Nuclear localization signalSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi774 – 793Polar residuesSequence analysisAdd BLAST20
Compositional biasi807 – 826Polar residuesSequence analysisAdd BLAST20
Compositional biasi828 – 851Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi966 – 980Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1000 – 1021Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required to bundle actin filaments (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4278, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153838

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002795_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P42684

Identification of Orthologs from Complete Genome Data

More...OMAi		PPKCCGG

Database of Orthologous Groups

More...OrthoDBi		182823at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P42684

TreeFam database of animal gene trees

More...TreeFami		TF105081

Family and domain databases

Conserved Domains Database

More...CDDi		cd09935, SH2_ABL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035837, ABL_SH2
IPR015015, F-actin-binding
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08919, F_actin_bind, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF00017, SH2, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00401, SH2DOMAIN
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00808, FABD, 1 hit
SM00252, SH2, 1 hit
SM00326, SH3, 1 hit
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P42684-1) [UniParc]FASTAAdd to basket
Also known as: IB, 1BLCTL

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT 
        60         70         80         90        100
QHDHFASCVE DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN 
       110        120        130        140        150
LLGATESDPN LFVALYDFVA SGDNTLSITK GEKLRVLGYN QNGEWSEVRS 
       160        170        180        190        200
KNGQGWVPSN YITPVNSLEK HSWYHGPVSR SAAEYLLSSL INGSFLVRES 
       210        220        230        240        250
ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST LAELVHHHST 
       260        270        280        290        300
VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG 
       310        320        330        340        350
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV 
       360        370        380        390        400
CTLEPPFYIV TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL 
       410        420        430        440        450
EKKNFIHRDL AARNCLVGEN HVVKVADFGL SRLMTGDTYT AHAGAKFPIK 
       460        470        480        490        500
WTAPESLAYN TFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYDLLEK 
       510        520        530        540        550
GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE TMFHDSSISE 
       560        570        580        590        600
EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE 
       610        620        630        640        650
NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG 
       660        670        680        690        700
GFFSSFMKKR NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG 
       710        720        730        740        750
FSFTPAQQEA NLVPPKCYGG SFAQRNLCND DGGGGGGSGT AGGGWSGITG 
       760        770        780        790        800
FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR SNSTSSMSSG LPEQDRMAMT 
       810        820        830        840        850
LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES AAPSRERPKA 
       860        870        880        890        900
KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG 
       910        920        930        940        950
MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG 
       960        970        980        990       1000
TDSQGNKFKL LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS 
      1010       1020       1030       1040       1050
DPTEEPTALT AGQSTSETQE GGKKAALGAV PISGKAGRPV MPPPQVPLPT 
      1060       1070       1080       1090       1100
SSISPAKMAN GTAGTKVALR KTKQAAEKIS ADKISKEALL ECADLLSSAL 
      1110       1120       1130       1140       1150
TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV SKLELSLQEL 
      1160       1170       1180 
QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR
Length:1,182
Mass (Da):128,343
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED93869BC2B14FAA
GO
Isoform 2 (identifier: P42684-2) [UniParc]FASTAAdd to basket
Also known as: IA, 1ASCTL

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MGQQVGRVGE...EGDKTGGSSP → MVLGTVLLPP...ASESALPDLT

Show »
Length:1,146
Mass (Da):124,560
Checksum:iEB47F5DE7CFDAE67
GO
Isoform 3 (identifier: P42684-3) [UniParc]FASTAAdd to basket
Also known as: IC, 1ALCTL

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MGQQVGRVGE...ETGFNIFTQH → MVLGTVLLPP...ASESALPDLT

Show »
Length:1,167
Mass (Da):126,684
Checksum:i0E3923FE9EEEAFEC
GO
Isoform 4 (identifier: P42684-4) [UniParc]FASTAAdd to basket
Also known as: 1ASCTS

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MGQQVGRVGE...EGDKTGGSSP → MVLGTVLLPP...ASESALPDLT
     688-790: Missing.

Show »
Length:1,043
Mass (Da):114,159
Checksum:i973C4751FD7E13F9
GO
Isoform 5 (identifier: P42684-5) [UniParc]FASTAAdd to basket
Also known as: 1BLCTS

The sequence of this isoform differs from the canonical sequence as follows:
     688-790: Missing.

Show »
Length:1,079
Mass (Da):117,942
Checksum:i9916652E5DB8F74D
GO
Isoform 6 (identifier: P42684-6) [UniParc]FASTAAdd to basket
Also known as: 1BSCTL

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.

Show »
Length:1,161
Mass (Da):126,219
Checksum:iA54046CDF6770B1C
GO
Isoform 7 (identifier: P42684-7) [UniParc]FASTAAdd to basket
Also known as: 1BSCTS

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.
     688-790: Missing.

Show »
Length:1,058
Mass (Da):115,817
Checksum:i28DCB354F9917898
GO
Isoform 10 (identifier: P42684-10) [UniParc]FASTAAdd to basket
Also known as: 1ALCTS

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MGQQVGRVGE...ETGFNIFTQH → MVLGTVLLPP...ASESALPDLT
     688-790: Missing.

Show »
Length:1,064
Mass (Da):116,283
Checksum:iAF67137EC553DFE7
GO
Isoform 8 (identifier: P42684-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.
     550-564: EEVAEELGRAASSSS → EVLLHCANQTCITL
     565-1182: Missing.

Show »
Length:542
Mass (Da):60,864
Checksum:i89E988F0EFF2ABCF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD98092 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti343 – 344NL → TI no nucleotide entry (PubMed:3787260).Curated2
Sequence conflicti435T → I in AK311045 (PubMed:14702039).Curated1
Sequence conflicti981K → R in CAD98092 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05541178R → H1 PublicationCorresponds to variant dbSNP:rs55655202Ensembl.1
Natural variantiVAR_05541299E → Q Somatic mutation in a breast cancer sample. 1 Publication1
Natural variantiVAR_055413519R → I Somatic mutation in a lung squamous cell carcinoma. 1 Publication1
Natural variantiVAR_055414769T → S1 PublicationCorresponds to variant dbSNP:rs55892721Ensembl.1
Natural variantiVAR_029232930K → R2 PublicationsCorresponds to variant dbSNP:rs17277288EnsemblClinVar.1
Natural variantiVAR_029233946V → M1 PublicationCorresponds to variant dbSNP:rs28913889Ensembl.1
Natural variantiVAR_029234996P → R2 PublicationsCorresponds to variant dbSNP:rs28913890Ensembl.1
Natural variantiVAR_0292351085S → N1 PublicationCorresponds to variant dbSNP:rs28913891Ensembl.1
Natural variantiVAR_0292361101T → A1 PublicationCorresponds to variant dbSNP:rs28913892Ensembl.1
Isoform 4 (identifier: P42684-4)
Natural variantiVAR_08289512S → TCombined sources1 PublicationCorresponds to variant dbSNP:rs1318056Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0049611 – 73MGQQV…GGSSP → MVLGTVLLPPNSYGRDQDTS LCCLCTEASESALPDLT in isoform 2 and isoform 4. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0171121 – 52MGQQV…IFTQH → MVLGTVLLPPNSYGRDQDTS LCCLCTEASESALPDLT in isoform 3 and isoform 10. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_04177253 – 73Missing in isoform 6, isoform 7 and isoform 8. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_041773550 – 564EEVAE…ASSSS → EVLLHCANQTCITL in isoform 8. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_041774565 – 1182Missing in isoform 8. 1 PublicationAdd BLAST618
Alternative sequenceiVSP_021308688 – 790Missing in isoform 4, isoform 5, isoform 7 and isoform 10. 2 PublicationsAdd BLAST103

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M35296 mRNA Translation: AAA35553.1
FJ542283 mRNA Translation: ACK76601.1
FJ542284 mRNA Translation: ACK76602.1
FJ542285 mRNA Translation: ACK76603.1
FJ542286 mRNA Translation: ACK76604.1
AK311045 mRNA No translation available.
BX538317 mRNA Translation: CAD98092.1 Different initiation.
DQ009672 Genomic DNA Translation: AAY16984.1
AL139132 Genomic DNA No translation available.
AL359179 Genomic DNA No translation available.
AL512326 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91040.1
BC065912 mRNA Translation: AAH65912.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30947.1 [P42684-1]
CCDS41441.2 [P42684-3]
CCDS44282.1 [P42684-10]
CCDS44283.1 [P42684-8]
CCDS53435.1 [P42684-4]
CCDS53436.1 [P42684-6]
CCDS53437.1 [P42684-7]
CCDS53438.1 [P42684-5]

Protein sequence database of the Protein Information Resource

More...PIRi		A35962
B35962

NCBI Reference Sequences

More...RefSeqi		NP_001129472.1, NM_001136000.2 [P42684-10]
NP_001129473.1, NM_001136001.1 [P42684-8]
NP_001161708.1, NM_001168236.1 [P42684-6]
NP_001161709.1, NM_001168237.1 [P42684-5]
NP_001161710.1, NM_001168238.1 [P42684-7]
NP_001161711.1, NM_001168239.1 [P42684-4]
NP_005149.4, NM_005158.4 [P42684-3]
NP_009298.1, NM_007314.3 [P42684-1]
XP_005245145.1, XM_005245088.2 [P42684-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344730; ENSP00000339209; ENSG00000143322 [P42684-10]
ENST00000367623; ENSP00000356595; ENSG00000143322 [P42684-6]
ENST00000392043; ENSP00000375897; ENSG00000143322 [P42684-8]
ENST00000502732; ENSP00000427562; ENSG00000143322 [P42684-1]
ENST00000504405; ENSP00000426831; ENSG00000143322 [P42684-4]
ENST00000507173; ENSP00000423413; ENSG00000143322 [P42684-7]
ENST00000511413; ENSP00000424697; ENSG00000143322 [P42684-5]
ENST00000512653; ENSP00000423578; ENSG00000143322 [P42684-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27

UCSC genome browser

More...UCSCi		uc001gmg.5, human [P42684-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35296 mRNA Translation: AAA35553.1
FJ542283 mRNA Translation: ACK76601.1
FJ542284 mRNA Translation: ACK76602.1
FJ542285 mRNA Translation: ACK76603.1
FJ542286 mRNA Translation: ACK76604.1
AK311045 mRNA No translation available.
BX538317 mRNA Translation: CAD98092.1 Different initiation.
DQ009672 Genomic DNA Translation: AAY16984.1
AL139132 Genomic DNA No translation available.
AL359179 Genomic DNA No translation available.
AL512326 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91040.1
BC065912 mRNA Translation: AAH65912.1
CCDSiCCDS30947.1 [P42684-1]
CCDS41441.2 [P42684-3]
CCDS44282.1 [P42684-10]
CCDS44283.1 [P42684-8]
CCDS53435.1 [P42684-4]
CCDS53436.1 [P42684-6]
CCDS53437.1 [P42684-7]
CCDS53438.1 [P42684-5]
PIRiA35962
B35962
RefSeqiNP_001129472.1, NM_001136000.2 [P42684-10]
NP_001129473.1, NM_001136001.1 [P42684-8]
NP_001161708.1, NM_001168236.1 [P42684-6]
NP_001161709.1, NM_001168237.1 [P42684-5]
NP_001161710.1, NM_001168238.1 [P42684-7]
NP_001161711.1, NM_001168239.1 [P42684-4]
NP_005149.4, NM_005158.4 [P42684-3]
NP_009298.1, NM_007314.3 [P42684-1]
XP_005245145.1, XM_005245088.2 [P42684-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECDNMR-A163-268[»]
2KK1NMR-A1058-1182[»]
2XYNX-ray2.81A/B/C279-546[»]
3GVUX-ray2.05A279-546[»]
3HMIX-ray1.65A279-546[»]
3ULRX-ray1.65C563-579[»]
4EIHX-ray1.20A165-273[»]
5NP3X-ray2.00A/B/C/D110-166[»]
5NP5X-ray1.40A/B110-166[»]
BMRBiP42684
SMRiP42684
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106545, 53 interactors
CORUMiP42684
DIPiDIP-91N
IntActiP42684, 55 interactors
MINTiP42684
STRINGi9606.ENSP00000427562

Chemistry databases

BindingDBiP42684
ChEMBLiCHEMBL4014
DrugBankiDB00171, ATP
DB01254, Dasatinib
DB12010, Fostamatinib
DB07664, K-00546
DB05184, XL228
DrugCentraliP42684
GuidetoPHARMACOLOGYi1924

Protein family/group databases

MoonDBiP42684, Predicted

PTM databases

iPTMnetiP42684
PhosphoSitePlusiP42684

Genetic variation databases

BioMutaiABL2
DMDMi1168268

Proteomic databases

EPDiP42684
jPOSTiP42684
MassIVEiP42684
MaxQBiP42684
PaxDbiP42684
PeptideAtlasiP42684
PRIDEiP42684
ProteomicsDBi55528 [P42684-1]
55529 [P42684-10]
55530 [P42684-2]
55531 [P42684-3]
55532 [P42684-4]
55533 [P42684-5]
55534 [P42684-6]
55535 [P42684-7]
55536 [P42684-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		736, 478 antibodies

The DNASU plasmid repository

More...DNASUi		27

Genome annotation databases

EnsembliENST00000344730; ENSP00000339209; ENSG00000143322 [P42684-10]
ENST00000367623; ENSP00000356595; ENSG00000143322 [P42684-6]
ENST00000392043; ENSP00000375897; ENSG00000143322 [P42684-8]
ENST00000502732; ENSP00000427562; ENSG00000143322 [P42684-1]
ENST00000504405; ENSP00000426831; ENSG00000143322 [P42684-4]
ENST00000507173; ENSP00000423413; ENSG00000143322 [P42684-7]
ENST00000511413; ENSP00000424697; ENSG00000143322 [P42684-5]
ENST00000512653; ENSP00000423578; ENSG00000143322 [P42684-3]
GeneIDi27
KEGGihsa:27
UCSCiuc001gmg.5, human [P42684-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27
DisGeNETi27

GeneCards: human genes, protein and diseases

More...GeneCardsi		ABL2
HGNCiHGNC:77, ABL2
HPAiENSG00000143322, Low tissue specificity
MIMi164690, gene
neXtProtiNX_P42684
OpenTargetsiENSG00000143322
PharmGKBiPA24414
VEuPathDBiHostDB:ENSG00000143322.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4278, Eukaryota
GeneTreeiENSGT00940000153838
HOGENOMiCLU_002795_0_0_1
InParanoidiP42684
OMAiPPKCCGG
OrthoDBi182823at2759
PhylomeDBiP42684
TreeFamiTF105081

Enzyme and pathway databases

BRENDAi2.7.10.2, 2681
PathwayCommonsiP42684
ReactomeiR-HSA-428890, Role of ABL in ROBO-SLIT signaling
R-HSA-9706369, Negative regulation of FLT3
SignaLinkiP42684
SIGNORiP42684

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27, 4 hits in 1023 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ABL2, human
EvolutionaryTraceiP42684

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ABL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27
PharosiP42684, Tchem

Protein Ontology

More...PROi		PR:P42684
RNActiP42684, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143322, Expressed in tendon of biceps brachii and 213 other tissues
GenevisibleiP42684, HS

Family and domain databases

CDDicd09935, SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035837, ABL_SH2
IPR015015, F-actin-binding
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF08919, F_actin_bind, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF00017, SH2, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00401, SH2DOMAIN
PR00109, TYRKINASE
SMARTiView protein in SMART
SM00808, FABD, 1 hit
SM00252, SH2, 1 hit
SM00326, SH3, 1 hit
SM00219, TyrKc, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42684
Secondary accession number(s): A0M8X0
, B7UEF2, B7UEF3, B7UEF4, B7UEF5, Q5T0X6, Q5W0C5, Q6NZY6, Q7Z301
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 2, 2021
This is version 229 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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