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Protein

Tyrosine-protein kinase ABL2

Gene

ABL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+, Mn2+

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei317ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei409Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi294 – 302ATPPROSITE-ProRule annotation9
Nucleotide bindingi362 – 368ATPPROSITE-ProRule annotation7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • actin monomer binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: UniProtKB
  • manganese ion binding Source: UniProtKB
  • non-membrane spanning protein tyrosine kinase activity Source: GO_Central
  • phosphotyrosine residue binding Source: CAFA
  • protein kinase activity Source: ProtInc
  • protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processCell adhesion
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.10.2 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-428890 Role of ABL in ROBO-SLIT signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P42684

SIGNOR Signaling Network Open Resource

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SIGNORi
P42684

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P42684 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase ABL2 (EC:2.7.10.2)
Alternative name(s):
Abelson murine leukemia viral oncogene homolog 2
Abelson tyrosine-protein kinase 2
Abelson-related gene protein
Tyrosine-protein kinase ARG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABL2
Synonyms:ABLL, ARG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000143322.19

Human Gene Nomenclature Database

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HGNCi
HGNC:77 ABL2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
164690 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P42684

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
27

Open Targets

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OpenTargetsi
ENSG00000143322

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24414

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4014

Drug and drug target database

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DrugBanki
DB00171 Adenosine triphosphate
DB01254 Dasatinib
DB05184 XL228

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1924

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ABL2

Domain mapping of disease mutations (DMDM)

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DMDMi
1168268

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000880522 – 1182Tyrosine-protein kinase ABL2Add BLAST1181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei97PhosphoserineBy similarity1
Modified residuei116PhosphotyrosineBy similarity1
Modified residuei161PhosphotyrosineBy similarity1
Modified residuei174PhosphotyrosineBy similarity1
Modified residuei185PhosphotyrosineBy similarity1
Modified residuei218PhosphotyrosineBy similarity1
Modified residuei231PhosphotyrosineBy similarity1
Modified residuei261Phosphotyrosine; by ABL1 and autocatalysis1 Publication1
Modified residuei272Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei275PhosphoserineCombined sources1
Modified residuei299PhosphotyrosineBy similarity1
Modified residuei303PhosphotyrosineBy similarity1
Modified residuei439Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases1 Publication1
Modified residuei459PhosphotyrosineBy similarity1
Modified residuei568Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei620PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei669PhosphoserineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei671PhosphoserineCombined sources1
Modified residuei683Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei718PhosphotyrosineCombined sources1
Modified residuei776N6-acetyllysineBy similarity1
Modified residuei783PhosphoserineCombined sources1
Modified residuei800PhosphothreonineBy similarity1
Modified residuei817PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Isoform 4 (identifier: P42684-4)
Modified residuei647PhosphotyrosineCombined sources1
Isoform 7 (identifier: P42684-7)
Modified residuei662PhosphotyrosineCombined sources1
Isoform 10 (identifier: P42684-10)
Modified residuei668PhosphotyrosineCombined sources1
Isoform 5 (identifier: P42684-5)
Modified residuei683PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).By similarity
Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P42684

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P42684

MaxQB - The MaxQuant DataBase

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MaxQBi
P42684

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P42684

PeptideAtlas

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PeptideAtlasi
P42684

PRoteomics IDEntifications database

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PRIDEi
P42684

ProteomicsDB human proteome resource

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ProteomicsDBi
55528
55529 [P42684-10]
55530 [P42684-2]
55531 [P42684-3]
55532 [P42684-4]
55533 [P42684-5]
55534 [P42684-6]
55535 [P42684-7]
55536 [P42684-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P42684

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P42684

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143322 Expressed in 199 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

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CleanExi
HS_ABL2

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P42684 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB017106
HPA001866
HPA072754

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106545, 43 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P42684

Database of interacting proteins

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DIPi
DIP-91N

Protein interaction database and analysis system

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IntActi
P42684, 45 interactors

Molecular INTeraction database

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MINTi
P42684

STRING: functional protein association networks

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STRINGi
9606.ENSP00000427562

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P42684

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECDNMR-A163-268[»]
2KK1NMR-A1058-1182[»]
2XYNX-ray2.81A/B/C279-546[»]
3GVUX-ray2.05A279-546[»]
3HMIX-ray1.65A279-546[»]
3ULRX-ray1.65C563-579[»]
4EIHX-ray1.20A165-273[»]
5NP3X-ray2.00A/B/C/D110-166[»]
5NP5X-ray1.40A/B110-166[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P42684

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P42684

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P42684

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini107 – 167SH3PROSITE-ProRule annotationAdd BLAST61
Domaini173 – 263SH2PROSITE-ProRule annotationAdd BLAST91
Domaini288 – 539Protein kinasePROSITE-ProRule annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 106CAPAdd BLAST105
Regioni694 – 930F-actin-bindingBy similarityAdd BLAST237
Regioni1020 – 1182F-actin-bindingBy similarityAdd BLAST163

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi427 – 451Kinase activation loopBy similarityAdd BLAST25
Motifi658 – 660Nuclear localization signalSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi561 – 564Poly-Ser4
Compositional biasi732 – 739Poly-Gly8
Compositional biasi843 – 1055Pro-richAdd BLAST213
Compositional biasi984 – 988Poly-Pro5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required to bundle actin filaments (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0197 Eukaryota
COG0515 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153838

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004162

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P42684

KEGG Orthology (KO)

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KOi
K08887

Identification of Orthologs from Complete Genome Data

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OMAi
CQRSKIQ

Database of Orthologous Groups

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OrthoDBi
182823at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P42684

TreeFam database of animal gene trees

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TreeFami
TF105081

Family and domain databases

Conserved Domains Database

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CDDi
cd09935 SH2_ABL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401 SH2DOMAIN
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P42684-1) [UniParc]FASTAAdd to basket
Also known as: IB, 1BLCTL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT
60 70 80 90 100
QHDHFASCVE DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN
110 120 130 140 150
LLGATESDPN LFVALYDFVA SGDNTLSITK GEKLRVLGYN QNGEWSEVRS
160 170 180 190 200
KNGQGWVPSN YITPVNSLEK HSWYHGPVSR SAAEYLLSSL INGSFLVRES
210 220 230 240 250
ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST LAELVHHHST
260 270 280 290 300
VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG
310 320 330 340 350
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV
360 370 380 390 400
CTLEPPFYIV TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL
410 420 430 440 450
EKKNFIHRDL AARNCLVGEN HVVKVADFGL SRLMTGDTYT AHAGAKFPIK
460 470 480 490 500
WTAPESLAYN TFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYDLLEK
510 520 530 540 550
GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE TMFHDSSISE
560 570 580 590 600
EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE
610 620 630 640 650
NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG
660 670 680 690 700
GFFSSFMKKR NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG
710 720 730 740 750
FSFTPAQQEA NLVPPKCYGG SFAQRNLCND DGGGGGGSGT AGGGWSGITG
760 770 780 790 800
FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR SNSTSSMSSG LPEQDRMAMT
810 820 830 840 850
LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES AAPSRERPKA
860 870 880 890 900
KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG
910 920 930 940 950
MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG
960 970 980 990 1000
TDSQGNKFKL LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS
1010 1020 1030 1040 1050
DPTEEPTALT AGQSTSETQE GGKKAALGAV PISGKAGRPV MPPPQVPLPT
1060 1070 1080 1090 1100
SSISPAKMAN GTAGTKVALR KTKQAAEKIS ADKISKEALL ECADLLSSAL
1110 1120 1130 1140 1150
TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV SKLELSLQEL
1160 1170 1180
QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR
Length:1,182
Mass (Da):128,343
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED93869BC2B14FAA
GO
Isoform 2 (identifier: P42684-2) [UniParc]FASTAAdd to basket
Also known as: IA, 1ASCTL

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MGQQVGRVGE...EGDKTGGSSP → MVLGTVLLPP...ASESALPDLT

Show »
Length:1,146
Mass (Da):124,560
Checksum:iEB47F5DE7CFDAE67
GO
Isoform 3 (identifier: P42684-3) [UniParc]FASTAAdd to basket
Also known as: IC, 1ALCTL

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MGQQVGRVGE...ETGFNIFTQH → MVLGTVLLPP...ASESALPDLT

Show »
Length:1,167
Mass (Da):126,684
Checksum:i0E3923FE9EEEAFEC
GO
Isoform 4 (identifier: P42684-4) [UniParc]FASTAAdd to basket
Also known as: 1ASCTS

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MGQQVGRVGE...EGDKTGGSSP → MVLGTVLLPP...ASESALPDLT
     688-790: Missing.

Show »
Length:1,043
Mass (Da):114,159
Checksum:i973C4751FD7E13F9
GO
Isoform 5 (identifier: P42684-5) [UniParc]FASTAAdd to basket
Also known as: 1BLCTS

The sequence of this isoform differs from the canonical sequence as follows:
     688-790: Missing.

Show »
Length:1,079
Mass (Da):117,942
Checksum:i9916652E5DB8F74D
GO
Isoform 6 (identifier: P42684-6) [UniParc]FASTAAdd to basket
Also known as: 1BSCTL

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.

Show »
Length:1,161
Mass (Da):126,219
Checksum:iA54046CDF6770B1C
GO
Isoform 7 (identifier: P42684-7) [UniParc]FASTAAdd to basket
Also known as: 1BSCTS

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.
     688-790: Missing.

Show »
Length:1,058
Mass (Da):115,817
Checksum:i28DCB354F9917898
GO
Isoform 10 (identifier: P42684-10) [UniParc]FASTAAdd to basket
Also known as: 1ALCTS

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MGQQVGRVGE...ETGFNIFTQH → MVLGTVLLPP...ASESALPDLT
     688-790: Missing.

Show »
Length:1,064
Mass (Da):116,283
Checksum:iAF67137EC553DFE7
GO
Isoform 8 (identifier: P42684-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-73: Missing.
     550-564: EEVAEELGRAASSSS → EVLLHCANQTCITL
     565-1182: Missing.

Note: No experimental confirmation available.
Show »
Length:542
Mass (Da):60,864
Checksum:i89E988F0EFF2ABCF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD98092 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti343 – 344NL → TI no nucleotide entry (PubMed:3787260).Curated2
Sequence conflicti435T → I in AK311045 (PubMed:14702039).Curated1
Sequence conflicti981K → R in CAD98092 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05541178R → H1 PublicationCorresponds to variant dbSNP:rs55655202Ensembl.1
Natural variantiVAR_05541299E → Q Somatic mutation in a breast cancer sample. 1 Publication1
Natural variantiVAR_055413519R → I Somatic mutation in a lung squamous cell carcinoma. 1 Publication1
Natural variantiVAR_055414769T → S1 PublicationCorresponds to variant dbSNP:rs55892721Ensembl.1
Natural variantiVAR_029232930K → R2 PublicationsCorresponds to variant dbSNP:rs17277288Ensembl.1
Natural variantiVAR_029233946V → M1 PublicationCorresponds to variant dbSNP:rs28913889Ensembl.1
Natural variantiVAR_029234996P → R2 PublicationsCorresponds to variant dbSNP:rs28913890Ensembl.1
Natural variantiVAR_0292351085S → N1 PublicationCorresponds to variant dbSNP:rs28913891Ensembl.1
Natural variantiVAR_0292361101T → A1 PublicationCorresponds to variant dbSNP:rs28913892Ensembl.1
Isoform 4 (identifier: P42684-4)
Natural varianti12S → TCombined sourcesCorresponds to variant dbSNP:rs1318056Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0049611 – 73MGQQV…GGSSP → MVLGTVLLPPNSYGRDQDTS LCCLCTEASESALPDLT in isoform 2 and isoform 4. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0171121 – 52MGQQV…IFTQH → MVLGTVLLPPNSYGRDQDTS LCCLCTEASESALPDLT in isoform 3 and isoform 10. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_04177253 – 73Missing in isoform 6, isoform 7 and isoform 8. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_041773550 – 564EEVAE…ASSSS → EVLLHCANQTCITL in isoform 8. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_041774565 – 1182Missing in isoform 8. 1 PublicationAdd BLAST618
Alternative sequenceiVSP_021308688 – 790Missing in isoform 4, isoform 5, isoform 7 and isoform 10. 2 PublicationsAdd BLAST103

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M35296 mRNA Translation: AAA35553.1
FJ542283 mRNA Translation: ACK76601.1
FJ542284 mRNA Translation: ACK76602.1
FJ542285 mRNA Translation: ACK76603.1
FJ542286 mRNA Translation: ACK76604.1
AK311045 mRNA No translation available.
BX538317 mRNA Translation: CAD98092.1 Different initiation.
DQ009672 Genomic DNA Translation: AAY16984.1
AL139132 Genomic DNA No translation available.
AL359179 Genomic DNA No translation available.
AL512326 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91040.1
BC065912 mRNA Translation: AAH65912.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30947.1 [P42684-1]
CCDS41441.2 [P42684-3]
CCDS44282.1 [P42684-10]
CCDS44283.1 [P42684-8]
CCDS53435.1 [P42684-4]
CCDS53436.1 [P42684-6]
CCDS53437.1 [P42684-7]
CCDS53438.1 [P42684-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
A35962
B35962

NCBI Reference Sequences

More...
RefSeqi
NP_001129472.1, NM_001136000.2 [P42684-10]
NP_001129473.1, NM_001136001.1 [P42684-8]
NP_001161708.1, NM_001168236.1 [P42684-6]
NP_001161709.1, NM_001168237.1 [P42684-5]
NP_001161710.1, NM_001168238.1 [P42684-7]
NP_001161711.1, NM_001168239.1 [P42684-4]
NP_005149.4, NM_005158.4 [P42684-3]
NP_009298.1, NM_007314.3 [P42684-1]
XP_005245145.1, XM_005245088.2 [P42684-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.159472

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344730; ENSP00000339209; ENSG00000143322 [P42684-10]
ENST00000367623; ENSP00000356595; ENSG00000143322 [P42684-6]
ENST00000392043; ENSP00000375897; ENSG00000143322 [P42684-8]
ENST00000502732; ENSP00000427562; ENSG00000143322 [P42684-1]
ENST00000504405; ENSP00000426831; ENSG00000143322 [P42684-4]
ENST00000507173; ENSP00000423413; ENSG00000143322 [P42684-7]
ENST00000511413; ENSP00000424697; ENSG00000143322 [P42684-5]
ENST00000512653; ENSP00000423578; ENSG00000143322 [P42684-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27

UCSC genome browser

More...
UCSCi
uc001gmg.5 human [P42684-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35296 mRNA Translation: AAA35553.1
FJ542283 mRNA Translation: ACK76601.1
FJ542284 mRNA Translation: ACK76602.1
FJ542285 mRNA Translation: ACK76603.1
FJ542286 mRNA Translation: ACK76604.1
AK311045 mRNA No translation available.
BX538317 mRNA Translation: CAD98092.1 Different initiation.
DQ009672 Genomic DNA Translation: AAY16984.1
AL139132 Genomic DNA No translation available.
AL359179 Genomic DNA No translation available.
AL512326 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91040.1
BC065912 mRNA Translation: AAH65912.1
CCDSiCCDS30947.1 [P42684-1]
CCDS41441.2 [P42684-3]
CCDS44282.1 [P42684-10]
CCDS44283.1 [P42684-8]
CCDS53435.1 [P42684-4]
CCDS53436.1 [P42684-6]
CCDS53437.1 [P42684-7]
CCDS53438.1 [P42684-5]
PIRiA35962
B35962
RefSeqiNP_001129472.1, NM_001136000.2 [P42684-10]
NP_001129473.1, NM_001136001.1 [P42684-8]
NP_001161708.1, NM_001168236.1 [P42684-6]
NP_001161709.1, NM_001168237.1 [P42684-5]
NP_001161710.1, NM_001168238.1 [P42684-7]
NP_001161711.1, NM_001168239.1 [P42684-4]
NP_005149.4, NM_005158.4 [P42684-3]
NP_009298.1, NM_007314.3 [P42684-1]
XP_005245145.1, XM_005245088.2 [P42684-2]
UniGeneiHs.159472

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECDNMR-A163-268[»]
2KK1NMR-A1058-1182[»]
2XYNX-ray2.81A/B/C279-546[»]
3GVUX-ray2.05A279-546[»]
3HMIX-ray1.65A279-546[»]
3ULRX-ray1.65C563-579[»]
4EIHX-ray1.20A165-273[»]
5NP3X-ray2.00A/B/C/D110-166[»]
5NP5X-ray1.40A/B110-166[»]
ProteinModelPortaliP42684
SMRiP42684
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106545, 43 interactors
CORUMiP42684
DIPiDIP-91N
IntActiP42684, 45 interactors
MINTiP42684
STRINGi9606.ENSP00000427562

Chemistry databases

BindingDBiP42684
ChEMBLiCHEMBL4014
DrugBankiDB00171 Adenosine triphosphate
DB01254 Dasatinib
DB05184 XL228
GuidetoPHARMACOLOGYi1924

Protein family/group databases

MoonDBiP42684 Predicted

PTM databases

iPTMnetiP42684
PhosphoSitePlusiP42684

Polymorphism and mutation databases

BioMutaiABL2
DMDMi1168268

Proteomic databases

EPDiP42684
jPOSTiP42684
MaxQBiP42684
PaxDbiP42684
PeptideAtlasiP42684
PRIDEiP42684
ProteomicsDBi55528
55529 [P42684-10]
55530 [P42684-2]
55531 [P42684-3]
55532 [P42684-4]
55533 [P42684-5]
55534 [P42684-6]
55535 [P42684-7]
55536 [P42684-8]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344730; ENSP00000339209; ENSG00000143322 [P42684-10]
ENST00000367623; ENSP00000356595; ENSG00000143322 [P42684-6]
ENST00000392043; ENSP00000375897; ENSG00000143322 [P42684-8]
ENST00000502732; ENSP00000427562; ENSG00000143322 [P42684-1]
ENST00000504405; ENSP00000426831; ENSG00000143322 [P42684-4]
ENST00000507173; ENSP00000423413; ENSG00000143322 [P42684-7]
ENST00000511413; ENSP00000424697; ENSG00000143322 [P42684-5]
ENST00000512653; ENSP00000423578; ENSG00000143322 [P42684-3]
GeneIDi27
KEGGihsa:27
UCSCiuc001gmg.5 human [P42684-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27
DisGeNETi27
EuPathDBiHostDB:ENSG00000143322.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABL2
HGNCiHGNC:77 ABL2
HPAiCAB017106
HPA001866
HPA072754
MIMi164690 gene
neXtProtiNX_P42684
OpenTargetsiENSG00000143322
PharmGKBiPA24414

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000153838
HOVERGENiHBG004162
InParanoidiP42684
KOiK08887
OMAiCQRSKIQ
OrthoDBi182823at2759
PhylomeDBiP42684
TreeFamiTF105081

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-428890 Role of ABL in ROBO-SLIT signaling
SignaLinkiP42684
SIGNORiP42684

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABL2 human
EvolutionaryTraceiP42684

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27

Protein Ontology

More...
PROi
PR:P42684

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143322 Expressed in 199 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_ABL2
GenevisibleiP42684 HS

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42684
Secondary accession number(s): A0M8X0
, B7UEF2, B7UEF3, B7UEF4, B7UEF5, Q5T0X6, Q5W0C5, Q6NZY6, Q7Z301
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 16, 2019
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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