UniProtKB - P42684 (ABL2_HUMAN)
Tyrosine-protein kinase ABL2
ABL2
Functioni
Catalytic activityi
- EC:2.7.10.2PROSITE-ProRule annotation
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 317 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 409 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 294 – 302 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 362 – 368 | ATPPROSITE-ProRule annotation | 7 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- actin monomer binding Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- magnesium ion binding Source: UniProtKB
- manganese ion binding Source: UniProtKB
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
- phosphotyrosine residue binding Source: CAFA
- protein kinase activity Source: ProtInc
- protein tyrosine kinase activity Source: UniProtKB
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- cellular protein modification process Source: ProtInc
- cellular response to retinoic acid Source: BHF-UCL
- exploration behavior Source: ARUK-UCL
- negative regulation of Rho protein signal transduction Source: ARUK-UCL
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of neuron projection development Source: BHF-UCL
- positive regulation of oxidoreductase activity Source: BHF-UCL
- positive regulation of phospholipase C activity Source: MGI
- regulation of actin cytoskeleton reorganization Source: UniProtKB
- regulation of autophagy Source: UniProtKB
- regulation of cell adhesion Source: UniProtKB
- regulation of cell motility Source: UniProtKB
- regulation of endocytosis Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Cell adhesion |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P42684 |
Reactomei | R-HSA-428890, Role of ABL in ROBO-SLIT signaling |
SignaLinki | P42684 |
SIGNORi | P42684 |
Protein family/group databases
MoonDBi | P42684, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase ABL2 (EC:2.7.10.2)Alternative name(s): Abelson murine leukemia viral oncogene homolog 2 Abelson tyrosine-protein kinase 2 Abelson-related gene protein Tyrosine-protein kinase ARG |
Gene namesi | Name:ABL2 Synonyms:ABLL, ARG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:77, ABL2 |
MIMi | 164690, gene |
neXtProti | NX_P42684 |
VEuPathDBi | HostDB:ENSG00000143322.19 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 27 |
OpenTargetsi | ENSG00000143322 |
PharmGKBi | PA24414 |
Miscellaneous databases
Pharosi | P42684, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4014 |
DrugBanki | DB00171, ATP DB01254, Dasatinib DB12010, Fostamatinib DB07664, K-00546 DB05184, XL228 |
DrugCentrali | P42684 |
GuidetoPHARMACOLOGYi | 1924 |
Genetic variation databases
BioMutai | ABL2 |
DMDMi | 1168268 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000088052 | 2 – 1182 | Tyrosine-protein kinase ABL2Add BLAST | 1181 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 | ||
Modified residuei | 97 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 116 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 161 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 174 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 185 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 218 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 231 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 261 | Phosphotyrosine; by ABL1 and autocatalysis1 Publication | 1 | ||
Modified residuei | 272 | Phosphotyrosine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 275 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 299 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 303 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 439 | Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases1 Publication | 1 | ||
Modified residuei | 459 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 568 | Phosphotyrosine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 620 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 631 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 633 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 655 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 669 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 670 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 671 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 683 | Phosphotyrosine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 718 | PhosphotyrosineCombined sources | 1 | ||
Modified residuei | 776 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 783 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 800 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 817 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 820 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 915 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 936 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: P42684-4) | |||||
Modified residuei | 647 | PhosphotyrosineCombined sources | 1 | ||
Isoform 7 (identifier: P42684-7) | |||||
Modified residuei | 662 | PhosphotyrosineCombined sources | 1 | ||
Isoform 10 (identifier: P42684-10) | |||||
Modified residuei | 668 | PhosphotyrosineCombined sources | 1 | ||
Isoform 5 (identifier: P42684-5) | |||||
Modified residuei | 683 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P42684 |
jPOSTi | P42684 |
MassIVEi | P42684 |
MaxQBi | P42684 |
PaxDbi | P42684 |
PeptideAtlasi | P42684 |
PRIDEi | P42684 |
ProteomicsDBi | 55528 [P42684-1] 55529 [P42684-10] 55530 [P42684-2] 55531 [P42684-3] 55532 [P42684-4] 55533 [P42684-5] 55534 [P42684-6] 55535 [P42684-7] 55536 [P42684-8] |
PTM databases
iPTMneti | P42684 |
PhosphoSitePlusi | P42684 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000143322, Expressed in tendon of biceps brachii and 213 other tissues |
Genevisiblei | P42684, HS |
Organism-specific databases
HPAi | ENSG00000143322, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PSMA7.
Interacts with CTTN.
Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.
4 PublicationsBinary interactionsi
Hide detailsP42684
Isoform 3 [P42684-3]
With | #Exp. | IntAct |
---|---|---|
ABI2 - isoform 2 [Q9NYB9-2] | 3 | EBI-10693977,EBI-11096309 |
TRIP10 - isoform 2 [Q15642-2] | 3 | EBI-10693977,EBI-6550597 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- actin monomer binding Source: UniProtKB
- phosphotyrosine residue binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 106545, 50 interactors |
CORUMi | P42684 |
DIPi | DIP-91N |
IntActi | P42684, 55 interactors |
MINTi | P42684 |
STRINGi | 9606.ENSP00000427562 |
Chemistry databases
BindingDBi | P42684 |
Miscellaneous databases
RNActi | P42684, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P42684 |
SMRi | P42684 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42684 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 107 – 167 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 173 – 263 | SH2PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 288 – 539 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 106 | CAPAdd BLAST | 105 | |
Regioni | 694 – 930 | F-actin-bindingBy similarityAdd BLAST | 237 | |
Regioni | 1020 – 1182 | F-actin-bindingBy similarityAdd BLAST | 163 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 427 – 451 | Kinase activation loopBy similarityAdd BLAST | 25 | |
Motifi | 658 – 660 | Nuclear localization signalSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 561 – 564 | Poly-Ser | 4 | |
Compositional biasi | 732 – 739 | Poly-Gly | 8 | |
Compositional biasi | 843 – 1055 | Pro-richAdd BLAST | 213 | |
Compositional biasi | 984 – 988 | Poly-Pro | 5 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG4278, Eukaryota |
GeneTreei | ENSGT00940000153838 |
HOGENOMi | CLU_002795_0_0_1 |
InParanoidi | P42684 |
OMAi | PPKCCGG |
OrthoDBi | 182823at2759 |
PhylomeDBi | P42684 |
TreeFami | TF105081 |
Family and domain databases
CDDi | cd09935, SH2_ABL, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035837, ABL_SH2 IPR015015, F-actin-binding IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF08919, F_actin_bind, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00808, FABD, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
s (9)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT
60 70 80 90 100
QHDHFASCVE DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN
110 120 130 140 150
LLGATESDPN LFVALYDFVA SGDNTLSITK GEKLRVLGYN QNGEWSEVRS
160 170 180 190 200
KNGQGWVPSN YITPVNSLEK HSWYHGPVSR SAAEYLLSSL INGSFLVRES
210 220 230 240 250
ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST LAELVHHHST
260 270 280 290 300
VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG
310 320 330 340 350
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV
360 370 380 390 400
CTLEPPFYIV TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL
410 420 430 440 450
EKKNFIHRDL AARNCLVGEN HVVKVADFGL SRLMTGDTYT AHAGAKFPIK
460 470 480 490 500
WTAPESLAYN TFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYDLLEK
510 520 530 540 550
GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE TMFHDSSISE
560 570 580 590 600
EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE
610 620 630 640 650
NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG
660 670 680 690 700
GFFSSFMKKR NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG
710 720 730 740 750
FSFTPAQQEA NLVPPKCYGG SFAQRNLCND DGGGGGGSGT AGGGWSGITG
760 770 780 790 800
FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR SNSTSSMSSG LPEQDRMAMT
810 820 830 840 850
LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES AAPSRERPKA
860 870 880 890 900
KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG
910 920 930 940 950
MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG
960 970 980 990 1000
TDSQGNKFKL LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS
1010 1020 1030 1040 1050
DPTEEPTALT AGQSTSETQE GGKKAALGAV PISGKAGRPV MPPPQVPLPT
1060 1070 1080 1090 1100
SSISPAKMAN GTAGTKVALR KTKQAAEKIS ADKISKEALL ECADLLSSAL
1110 1120 1130 1140 1150
TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV SKLELSLQEL
1160 1170 1180
QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR
The sequence of this isoform differs from the canonical sequence as follows:
1-52: MGQQVGRVGE...ETGFNIFTQH → MVLGTVLLPP...ASESALPDLT
688-790: Missing.
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 343 – 344 | NL → TI no nucleotide entry (PubMed:3787260).Curated | 2 | |
Sequence conflicti | 435 | T → I in AK311045 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 981 | K → R in CAD98092 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_055411 | 78 | R → H1 PublicationCorresponds to variant dbSNP:rs55655202Ensembl. | 1 | ||
Natural variantiVAR_055412 | 99 | E → Q Somatic mutation in a breast cancer sample. 1 Publication | 1 | ||
Natural variantiVAR_055413 | 519 | R → I Somatic mutation in a lung squamous cell carcinoma. 1 Publication | 1 | ||
Natural variantiVAR_055414 | 769 | T → S1 PublicationCorresponds to variant dbSNP:rs55892721Ensembl. | 1 | ||
Natural variantiVAR_029232 | 930 | K → R2 PublicationsCorresponds to variant dbSNP:rs17277288EnsemblClinVar. | 1 | ||
Natural variantiVAR_029233 | 946 | V → M1 PublicationCorresponds to variant dbSNP:rs28913889Ensembl. | 1 | ||
Natural variantiVAR_029234 | 996 | P → R2 PublicationsCorresponds to variant dbSNP:rs28913890Ensembl. | 1 | ||
Natural variantiVAR_029235 | 1085 | S → N1 PublicationCorresponds to variant dbSNP:rs28913891Ensembl. | 1 | ||
Natural variantiVAR_029236 | 1101 | T → A1 PublicationCorresponds to variant dbSNP:rs28913892Ensembl. | 1 | ||
Isoform 4 (identifier: P42684-4) | |||||
Natural variantiVAR_082895 | 12 | S → TCombined sources1 PublicationCorresponds to variant dbSNP:rs1318056Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004961 | 1 – 73 | MGQQV…GGSSP → MVLGTVLLPPNSYGRDQDTS LCCLCTEASESALPDLT in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 73 | |
Alternative sequenceiVSP_017112 | 1 – 52 | MGQQV…IFTQH → MVLGTVLLPPNSYGRDQDTS LCCLCTEASESALPDLT in isoform 3 and isoform 10. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_041772 | 53 – 73 | Missing in isoform 6, isoform 7 and isoform 8. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_041773 | 550 – 564 | EEVAE…ASSSS → EVLLHCANQTCITL in isoform 8. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_041774 | 565 – 1182 | Missing in isoform 8. 1 PublicationAdd BLAST | 618 | |
Alternative sequenceiVSP_021308 | 688 – 790 | Missing in isoform 4, isoform 5, isoform 7 and isoform 10. 2 PublicationsAdd BLAST | 103 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ECD | NMR | - | A | 163-268 | [»] | |
2KK1 | NMR | - | A | 1058-1182 | [»] | |
2XYN | X-ray | 2.81 | A/B/C | 279-546 | [»] | |
3GVU | X-ray | 2.05 | A | 279-546 | [»] | |
3HMI | X-ray | 1.65 | A | 279-546 | [»] | |
3ULR | X-ray | 1.65 | C | 563-579 | [»] | |
4EIH | X-ray | 1.20 | A | 165-273 | [»] | |
5NP3 | X-ray | 2.00 | A/B/C/D | 110-166 | [»] | |
5NP5 | X-ray | 1.40 | A/B | 110-166 | [»] | |
BMRBi | P42684 | |||||
SMRi | P42684 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106545, 50 interactors |
CORUMi | P42684 |
DIPi | DIP-91N |
IntActi | P42684, 55 interactors |
MINTi | P42684 |
STRINGi | 9606.ENSP00000427562 |
Chemistry databases
BindingDBi | P42684 |
ChEMBLi | CHEMBL4014 |
DrugBanki | DB00171, ATP DB01254, Dasatinib DB12010, Fostamatinib DB07664, K-00546 DB05184, XL228 |
DrugCentrali | P42684 |
GuidetoPHARMACOLOGYi | 1924 |
Protein family/group databases
MoonDBi | P42684, Predicted |
PTM databases
iPTMneti | P42684 |
PhosphoSitePlusi | P42684 |
Genetic variation databases
BioMutai | ABL2 |
DMDMi | 1168268 |
Proteomic databases
EPDi | P42684 |
jPOSTi | P42684 |
MassIVEi | P42684 |
MaxQBi | P42684 |
PaxDbi | P42684 |
PeptideAtlasi | P42684 |
PRIDEi | P42684 |
ProteomicsDBi | 55528 [P42684-1] 55529 [P42684-10] 55530 [P42684-2] 55531 [P42684-3] 55532 [P42684-4] 55533 [P42684-5] 55534 [P42684-6] 55535 [P42684-7] 55536 [P42684-8] |
Protocols and materials databases
Antibodypediai | 736, 463 antibodies |
DNASUi | 27 |
Genome annotation databases
Organism-specific databases
CTDi | 27 |
DisGeNETi | 27 |
GeneCardsi | ABL2 |
HGNCi | HGNC:77, ABL2 |
HPAi | ENSG00000143322, Low tissue specificity |
MIMi | 164690, gene |
neXtProti | NX_P42684 |
OpenTargetsi | ENSG00000143322 |
PharmGKBi | PA24414 |
VEuPathDBi | HostDB:ENSG00000143322.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4278, Eukaryota |
GeneTreei | ENSGT00940000153838 |
HOGENOMi | CLU_002795_0_0_1 |
InParanoidi | P42684 |
OMAi | PPKCCGG |
OrthoDBi | 182823at2759 |
PhylomeDBi | P42684 |
TreeFami | TF105081 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P42684 |
Reactomei | R-HSA-428890, Role of ABL in ROBO-SLIT signaling |
SignaLinki | P42684 |
SIGNORi | P42684 |
Miscellaneous databases
BioGRID-ORCSi | 27, 4 hits in 903 CRISPR screens |
ChiTaRSi | ABL2, human |
EvolutionaryTracei | P42684 |
GeneWikii | ABL2 |
GenomeRNAii | 27 |
Pharosi | P42684, Tchem |
PROi | PR:P42684 |
RNActi | P42684, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143322, Expressed in tendon of biceps brachii and 213 other tissues |
Genevisiblei | P42684, HS |
Family and domain databases
CDDi | cd09935, SH2_ABL, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035837, ABL_SH2 IPR015015, F-actin-binding IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF08919, F_actin_bind, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00808, FABD, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABL2_HUMAN | |
Accessioni | P42684Primary (citable) accession number: P42684 Secondary accession number(s): A0M8X0 Q7Z301 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 227 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index