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Protein

40S ribosomal protein S27

Gene

RPS27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the small ribosomal subunit (PubMed:8706699). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902).1 Publication1 Publication

Caution

Was originally (PubMed:8407955) thought to be a protein that could have played a role as a potentially important mediator of cellular proliferative responses to various growth factors and other environmental signals. Capable of specific binding to a cAMP response element in DNA.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri37 – 59C4-typeSequence analysisAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-68877 Mitotic Prometaphase
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S27
Alternative name(s):
Metallopan-stimulin 1
Short name:
MPS-1
Small ribosomal subunit protein eS271 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS27
Synonyms:MPS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177954.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10416 RPS27

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603702 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P42677

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diamond-Blackfan anemia 17 (DBA17)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:617409

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNET

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DisGeNETi
6232

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
RPS27

MalaCards human disease database

More...
MalaCardsi
RPS27
MIMi617409 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000177954

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
124 Blackfan-Diamond anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34820

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1932893

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS27

Domain mapping of disease mutations (DMDM)

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DMDMi
1171014

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001490512 – 8440S ribosomal protein S27Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P42677

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P42677

PeptideAtlas

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PeptideAtlasi
P42677

PRoteomics IDEntifications database

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PRIDEi
P42677

ProteomicsDB human proteome resource

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ProteomicsDBi
55523

Consortium for Top Down Proteomics

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TopDownProteomicsi
P42677

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P42677

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P42677

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P42677

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a wide variety of actively proliferating cells and tumor tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177954 Expressed in 89 organ(s), highest expression level in endocervix

CleanEx database of gene expression profiles

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CleanExi
HS_RPS27

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P42677 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA066851

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the small ribosomal subunit.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112146, 149 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P42677

Database of interacting proteins

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DIPi
DIP-44182N

Protein interaction database and analysis system

More...
IntActi
P42677, 58 interactors

Molecular INTeraction database

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MINTi
P42677

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357555

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P42677

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P42677

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P42677

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri37 – 59C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1779 Eukaryota
COG2051 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153329

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000252

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P42677

KEGG Orthology (KO)

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KOi
K02978

Identification of Orthologs from Complete Genome Data

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OMAi
FFMDVRC

Database of Orthologous Groups

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OrthoDBi
EOG091G157G

Database for complete collections of gene phylogenies

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PhylomeDBi
P42677

TreeFam database of animal gene trees

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TreeFami
TF300265

Family and domain databases

HAMAP database of protein families

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HAMAPi
MF_00371 Ribosomal_S27e, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000592 Ribosomal_S27e
IPR011332 Ribosomal_zn-bd

The PANTHER Classification System

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PANTHERi
PTHR11594 PTHR11594, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01667 Ribosomal_S27e, 1 hit

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD004466 Ribosomal_S27e, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57829 SSF57829, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01168 RIBOSOMAL_S27E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P42677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA
60 70 80
QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH
Length:84
Mass (Da):9,461
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i242C4466AC8A8900
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y731A0A2R8Y731_HUMAN
40S ribosomal protein S27
RPS27
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5K → R AA sequence (PubMed:8706699).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L19739 mRNA Translation: AAA59867.1
U57847 mRNA Translation: AAB02266.1
AB061845 Genomic DNA Translation: BAB79483.1
AK312070 mRNA Translation: BAG35006.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53239.1
CH471055 Genomic DNA Translation: EAW64624.1
CH471116 Genomic DNA Translation: EAW88871.1
BC002658 mRNA Translation: AAH02658.1
BC070219 mRNA Translation: AAH70219.1
AB007162 Genomic DNA Translation: BAA25825.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1059.1

Protein sequence database of the Protein Information Resource

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PIRi
A48045

NCBI Reference Sequences

More...
RefSeqi
NP_001021.1, NM_001030.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.546291
Hs.654475

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368567; ENSP00000357555; ENSG00000177954

Database of genes from NCBI RefSeq genomes

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GeneIDi
6232

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6232

UCSC genome browser

More...
UCSCi
uc001fdv.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19739 mRNA Translation: AAA59867.1
U57847 mRNA Translation: AAB02266.1
AB061845 Genomic DNA Translation: BAB79483.1
AK312070 mRNA Translation: BAG35006.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53239.1
CH471055 Genomic DNA Translation: EAW64624.1
CH471116 Genomic DNA Translation: EAW88871.1
BC002658 mRNA Translation: AAH02658.1
BC070219 mRNA Translation: AAH70219.1
AB007162 Genomic DNA Translation: BAA25825.1
CCDSiCCDS1059.1
PIRiA48045
RefSeqiNP_001021.1, NM_001030.4
UniGeneiHs.546291
Hs.654475

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sb1-84[»]
4V6Xelectron microscopy5.00Ab1-84[»]
5A2Qelectron microscopy3.90b2-83[»]
5AJ0electron microscopy3.50Bb1-84[»]
5FLXelectron microscopy3.90b1-84[»]
5LKSelectron microscopy3.60Sb1-84[»]
5OA3electron microscopy4.30b2-83[»]
5T2Celectron microscopy3.60AV1-84[»]
5VYCX-ray6.00b1/b2/b3/b4/b5/b61-84[»]
6EK0electron microscopy2.90Sb1-84[»]
6FECelectron microscopy6.30Y1-84[»]
6G18electron microscopy3.60b1-84[»]
6G4Selectron microscopy4.00b1-84[»]
6G4Welectron microscopy4.50b1-84[»]
6G51electron microscopy4.10b1-84[»]
6G53electron microscopy4.50b1-84[»]
6G5Helectron microscopy3.60b1-84[»]
6G5Ielectron microscopy3.50b1-84[»]
ProteinModelPortaliP42677
SMRiP42677
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112146, 149 interactors
CORUMiP42677
DIPiDIP-44182N
IntActiP42677, 58 interactors
MINTiP42677
STRINGi9606.ENSP00000357555

Chemistry databases

BindingDBiP42677
ChEMBLiCHEMBL1932893

PTM databases

iPTMnetiP42677
PhosphoSitePlusiP42677
SwissPalmiP42677

Polymorphism and mutation databases

BioMutaiRPS27
DMDMi1171014

Proteomic databases

EPDiP42677
PaxDbiP42677
PeptideAtlasiP42677
PRIDEiP42677
ProteomicsDBi55523
TopDownProteomicsiP42677

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6232
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368567; ENSP00000357555; ENSG00000177954
GeneIDi6232
KEGGihsa:6232
UCSCiuc001fdv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6232
DisGeNETi6232
EuPathDBiHostDB:ENSG00000177954.11

GeneCards: human genes, protein and diseases

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GeneCardsi
RPS27
GeneReviewsiRPS27

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0033569
HIX0164279
HGNCiHGNC:10416 RPS27
HPAiHPA066851
MalaCardsiRPS27
MIMi603702 gene
617409 phenotype
neXtProtiNX_P42677
OpenTargetsiENSG00000177954
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34820

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1779 Eukaryota
COG2051 LUCA
GeneTreeiENSGT00940000153329
HOVERGENiHBG000252
InParanoidiP42677
KOiK02978
OMAiFFMDVRC
OrthoDBiEOG091G157G
PhylomeDBiP42677
TreeFamiTF300265

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-68877 Mitotic Prometaphase
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS27 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPS27

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6232

Protein Ontology

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PROi
PR:P42677

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000177954 Expressed in 89 organ(s), highest expression level in endocervix
CleanExiHS_RPS27
GenevisibleiP42677 HS

Family and domain databases

HAMAPiMF_00371 Ribosomal_S27e, 1 hit
InterProiView protein in InterPro
IPR000592 Ribosomal_S27e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR11594 PTHR11594, 1 hit
PfamiView protein in Pfam
PF01667 Ribosomal_S27e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004466 Ribosomal_S27e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01168 RIBOSOMAL_S27E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42677
Secondary accession number(s): Q5T4L6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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