UniProtKB - P42671 (CAPSH_ADEG1)
Hexon protein
L3
Functioni
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
UniRule annotationMiscellaneous
GO - Molecular functioni
- structural molecule activity Source: UniProtKB-UniRule
GO - Biological processi
- microtubule-dependent intracellular transport of viral material towards nucleus Source: UniProtKB-UniRule
- viral entry into host cell Source: UniProtKB-UniRule
Keywordsi
Biological process | Cytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Virus entry into host cell |
Names & Taxonomyi
Protein namesi | Recommended name: Hexon proteinUniRule annotationShort name: CP-HUniRule annotation Alternative name(s): Protein IIUniRule annotation |
Gene namesi | Name:L3UniRule annotation |
Organismi | Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) |
Taxonomic identifieri | 10553 [NCBI] |
Taxonomic lineagei | Viruses › Varidnaviria › Bamfordvirae › Preplasmiviricota › Tectiliviricetes › Rowavirales › Adenoviridae › Aviadenovirus › Fowl aviadenovirus A |
Virus hosti | Galliformes [TaxID: 8976] |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation Note: Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.UniRule annotation
Keywords - Cellular componenti
Capsid protein, Host nucleus, T=25 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221826 | 1 – 942 | Hexon proteinUniRule annotationAdd BLAST | 942 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 931 | Phosphotyrosine; by hostUniRule annotation | 1 |
Keywords - PTMi
PhosphoproteinExpressioni
Inductioni
Keywords - Developmental stagei
Late proteinInteractioni
Subunit structurei
Homotrimer.
Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base.
Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet.
Interacts with the hexon-interlacing protein; this interaction lashes the hexons together.
Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid.
Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers.
Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly.
UniRule annotationStructurei
3D structure databases
SMRi | P42671 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42671 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.90.249.10, 2 hits 3.90.39.10, 1 hit |
HAMAPi | MF_04051, ADV_CAPSH, 1 hit |
InterProi | View protein in InterPro IPR016108, Adenovirus_Pll_hexon_C IPR016107, Adenovirus_Pll_hexon_N IPR044942, Adenovirus_Pll_hexon_sub2 IPR016110, Adenovirus_Pll_hexon_sub3 IPR037542, ADV_hexon IPR016112, VP_dsDNA_II |
Pfami | View protein in Pfam PF01065, Adeno_hexon, 1 hit PF03678, Adeno_hexon_C, 1 hit |
SUPFAMi | SSF49749, SSF49749, 2 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTALTPDLTT ATPRLQYFHI AGPGTREYLS EDLQQFISAT GSYFDLKNKF
60 70 80 90 100
RQTVVAPTRN VTTEKAQRLQ IRFYPIQTDD TPNSYRVRYS VNVGDSWVLD
110 120 130 140 150
MGATYFDIKG VLDRGPSFKP YGGTAYNPLA PREAIFNTWV ESTGPQTNVV
160 170 180 190 200
GQMTNVYTNQ TRNDKTATLQ QVNSISGVVP NVNLGPGLSQ LASRADVDNI
210 220 230 240 250
GVVGRFAKVD SAGVKQAYGA YVKPVKDDGS QSLNQTAYWL MDNGGTNYLG
260 270 280 290 300
ALAVEDYTQT LSYPDTVLVT PPTAYQQVNS GTMRACRPNY IGFRDNFINL
310 320 330 340 350
LYHDSGVCSG TLNSERSGMN VVVELQDRNT ELSYQYMLAD MMSRHHYFAL
360 370 380 390 400
WNQAVDQYDH DVRVFNNDGY EEGVPTYAFL PDGHGAGEDN GPDLSNVKIY
410 420 430 440 450
TNGQQDKGNV VAGTVSTQLN FGTIPSYEID IAAATRRNFI MSNIADYLPD
460 470 480 490 500
KYKFSIRGFD PVTDNIDPTT YFYMNRRVPL TNVVDLFTNI GARWSVDQMD
510 520 530 540 550
NVNPFNHHRN WGLKYRSQLL GNSRYCRFHI QVPQKYFAIK NLLLLPGTYT
560 570 580 590 600
YEWVLRKDPN MILQSSLGND LRADGAQIVY TEVNLMANFM PMDHNTSNQL
610 620 630 640 650
ELMLRNATND QTFADYLGAK NALYNVPAGS TLLTINIPAR TWEGMRGWSF
660 670 680 690 700
TRLKASETPQ LGAQYDVGFK YSGSIPYSDG TFYLSHTFRS MSVLFDTSIN
710 720 730 740 750
WPGNDRLLTP NLFEIKRPVA TDSEGFTMSQ CDMTKDWFLV QMATNYNYVY
760 770 780 790 800
NGYRFWPDRH YFHYDFLRNF DPMSRQGPNF LDTTLYDLVS STPVVNDTGS
810 820 830 840 850
QPSQDNVRNN SGFIAPRSWP VWTAQQGEAW PANWPYPLIG NDAISSNQTV
860 870 880 890 900
NYKKFLCDNY LWTVPFSSDF MYMGELTDLG QNPMYTNNSH SMVINFELDP
910 920 930 940
MDENTYVYML YGVFDTVRVN QPERNVLAMA YFRTPFATGN AV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46933 Genomic DNA Translation: AAC54912.1 L13161 Genomic DNA Translation: AAA51401.1 |
RefSeqi | NP_043886.1, NC_001720.1 |
Genome annotation databases
GeneIDi | 1476562 |
KEGGi | vg:1476562 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46933 Genomic DNA Translation: AAC54912.1 L13161 Genomic DNA Translation: AAA51401.1 |
RefSeqi | NP_043886.1, NC_001720.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2INY | X-ray | 3.90 | A | 1-942 | [»] | |
SMRi | P42671 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
GeneIDi | 1476562 |
KEGGi | vg:1476562 |
Miscellaneous databases
EvolutionaryTracei | P42671 |
Family and domain databases
Gene3Di | 3.90.249.10, 2 hits 3.90.39.10, 1 hit |
HAMAPi | MF_04051, ADV_CAPSH, 1 hit |
InterProi | View protein in InterPro IPR016108, Adenovirus_Pll_hexon_C IPR016107, Adenovirus_Pll_hexon_N IPR044942, Adenovirus_Pll_hexon_sub2 IPR016110, Adenovirus_Pll_hexon_sub3 IPR037542, ADV_hexon IPR016112, VP_dsDNA_II |
Pfami | View protein in Pfam PF01065, Adeno_hexon, 1 hit PF03678, Adeno_hexon_C, 1 hit |
SUPFAMi | SSF49749, SSF49749, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CAPSH_ADEG1 | |
Accessioni | P42671Primary (citable) accession number: P42671 Secondary accession number(s): Q64758 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families