UniProtKB - P42626 (YHAM_ECOLI)
Protein
UPF0597 protein YhaM
Gene
yhaM
Organism
Escherichia coli (strain K12)
Status
Functioni
Plays a role in L-cysteine detoxification; it has been speculated to be a cysteine desulfhydrase (PubMed:27435271).1 Publication
GO - Molecular functioni
- L-cysteine desulfhydrase activity Source: EcoCyc
GO - Biological processi
- cysteine catabolic process Source: UniProtKB
- L-cysteine catabolic process to pyruvate Source: EcoCyc
- response to L-cysteine Source: EcoCyc
Enzyme and pathway databases
BioCyci | EcoCyc:G7622-MONOMER MetaCyc:G7622-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: UPF0597 protein YhaMUniRule annotation |
Gene namesi | Name:yhaMUniRule annotation Synonyms:yhaN Ordered Locus Names:b4470, JW5518 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Slightly increased sensitivity to excess L-cysteine, the effect is more pronounced in M9 minimal medium. Cells produce about 9% of wild-type levels of hydrogen sulfide in the presence of excess cysteine.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169448 | 1 – 436 | UPF0597 protein YhaMAdd BLAST | 436 |
Proteomic databases
PaxDbi | P42626 |
PRIDEi | P42626 |
Expressioni
Inductioni
Transcription induced by L-cysteine (in vivo), under control of DecR. Member of the dlsT(yhaO)-yhaM operon.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259262, 13 interactors |
STRINGi | 511145.b4470 |
Family & Domainsi
Sequence similaritiesi
Belongs to the UPF0597 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG3681, Bacteria |
HOGENOMi | CLU_051840_0_0_6 |
InParanoidi | P42626 |
PhylomeDBi | P42626 |
Family and domain databases
HAMAPi | MF_01845, UPF0597, 1 hit |
InterProi | View protein in InterPro IPR005130, Ser_deHydtase-like_asu IPR021144, UPF0597 |
PANTHERi | PTHR30501, PTHR30501, 1 hit |
Pfami | View protein in Pfam PF03313, SDH_alpha, 1 hit |
PIRSFi | PIRSF006054, UCP006054, 1 hit |
i Sequence
Sequence statusi: Complete.
P42626-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFDSTLNPLW QRYILAVQEE VKPALGCTEP ISLALAAAVA AAELEGPVER
60 70 80 90 100
VEAWVSPNLM KNGLGVTVPG TGMVGLPIAA ALGALGGNAN AGLEVLKDAT
110 120 130 140 150
AQAIADAKAL LAAGKVSVKI QEPCDEILFS RAKVWNGEKW ACVTIVGGHT
160 170 180 190 200
NIVHIETHDG VVFTQQACVA EGEQESPLTV LSRTTLAEIL KFVNEVPFAA
210 220 230 240 250
IRFILDSAKL NCALSQEGLS GKWGLHIGAT LEKQCERGLL AKDLSSSIVI
260 270 280 290 300
RTSAASDARM GGATLPAMSN SGSGNQGITA TMPVVVVAEH FGADDERLAR
310 320 330 340 350
ALMLSHLSAI YIHNQLPRLS ALCAATTAAM GAAAGMAWLV DGRYETISMA
360 370 380 390 400
ISSMIGDVSG MICDGASNSC AMKVSTSASA AWKAVLMALD DTAVTGNEGI
410 420 430
VAHDVEQSIA NLCALASHSM QQTDRQIIEI MASKAR
Sequence cautioni
The sequence AAA57912 differs from that shown. Reason: Frameshift.Curated
The sequence AAA57913 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57912.1 Frameshift. U18997 Genomic DNA Translation: AAA57913.1 Frameshift. U00096 Genomic DNA Translation: AAT48167.1 AP009048 Genomic DNA Translation: BAE77158.1 |
RefSeqi | WP_000460499.1, NZ_LN832404.1 YP_026202.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAT48167; AAT48167; b4470 BAE77158; BAE77158; BAE77158 |
GeneIDi | 2847723 57728235 |
KEGGi | ecj:JW5518 eco:b4470 |
PATRICi | fig|511145.12.peg.3204 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57912.1 Frameshift. U18997 Genomic DNA Translation: AAA57913.1 Frameshift. U00096 Genomic DNA Translation: AAT48167.1 AP009048 Genomic DNA Translation: BAE77158.1 |
RefSeqi | WP_000460499.1, NZ_LN832404.1 YP_026202.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259262, 13 interactors |
STRINGi | 511145.b4470 |
Proteomic databases
PaxDbi | P42626 |
PRIDEi | P42626 |
Genome annotation databases
EnsemblBacteriai | AAT48167; AAT48167; b4470 BAE77158; BAE77158; BAE77158 |
GeneIDi | 2847723 57728235 |
KEGGi | ecj:JW5518 eco:b4470 |
PATRICi | fig|511145.12.peg.3204 |
Organism-specific databases
EchoBASEi | EB2608 |
Phylogenomic databases
eggNOGi | COG3681, Bacteria |
HOGENOMi | CLU_051840_0_0_6 |
InParanoidi | P42626 |
PhylomeDBi | P42626 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7622-MONOMER MetaCyc:G7622-MONOMER |
Miscellaneous databases
PROi | PR:P42626 |
Family and domain databases
HAMAPi | MF_01845, UPF0597, 1 hit |
InterProi | View protein in InterPro IPR005130, Ser_deHydtase-like_asu IPR021144, UPF0597 |
PANTHERi | PTHR30501, PTHR30501, 1 hit |
Pfami | View protein in Pfam PF03313, SDH_alpha, 1 hit |
PIRSFi | PIRSF006054, UCP006054, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YHAM_ECOLI | |
Accessioni | P42626Primary (citable) accession number: P42626 Secondary accession number(s): P42627, Q2M998, Q6BF47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - SIMILARITY comments
Index of protein domains and families