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Protein

UPF0597 protein YhaM

Gene

yhaM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in L-cysteine detoxification; it has been speculated to be a cysteine desulfhydrase (PubMed:27435271).1 Publication

GO - Biological processi

  • cysteine catabolic process Source: UniProtKB
  • response to L-cysteine Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7622-MONOMER
MetaCyc:G7622-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0597 protein YhaMUniRule annotation
Gene namesi
Name:yhaMUniRule annotation
Synonyms:yhaN
Ordered Locus Names:b4470, JW5518
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12752 yhaM

Pathology & Biotechi

Disruption phenotypei

Slightly increased sensitivity to excess L-cysteine, the effect is more pronounced in M9 minimal medium. Cells produce about 9% of wild-type levels of hydrogen sulfide in the presence of excess cysteine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001694481 – 436UPF0597 protein YhaMAdd BLAST436

Proteomic databases

PaxDbiP42626
PRIDEiP42626

Expressioni

Inductioni

Transcription induced by L-cysteine (in vivo), under control of DecR. Member of the dlsT(yhaO)-yhaM operon.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259262, 13 interactors
STRINGi316385.ECDH10B_3284

Structurei

3D structure databases

ProteinModelPortaliP42626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0597 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEM Bacteria
COG3681 LUCA
HOGENOMiHOG000237280
InParanoidiP42626
OMAiGAMIPVM
PhylomeDBiP42626

Family and domain databases

HAMAPiMF_01845 UPF0597, 1 hit
InterProiView protein in InterPro
IPR005130 Ser_deHydtase-like_asu
IPR021144 UPF0597
PANTHERiPTHR30501 PTHR30501, 1 hit
PfamiView protein in Pfam
PF03313 SDH_alpha, 1 hit
PIRSFiPIRSF006054 UCP006054, 1 hit

Sequencei

Sequence statusi: Complete.

P42626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDSTLNPLW QRYILAVQEE VKPALGCTEP ISLALAAAVA AAELEGPVER
60 70 80 90 100
VEAWVSPNLM KNGLGVTVPG TGMVGLPIAA ALGALGGNAN AGLEVLKDAT
110 120 130 140 150
AQAIADAKAL LAAGKVSVKI QEPCDEILFS RAKVWNGEKW ACVTIVGGHT
160 170 180 190 200
NIVHIETHDG VVFTQQACVA EGEQESPLTV LSRTTLAEIL KFVNEVPFAA
210 220 230 240 250
IRFILDSAKL NCALSQEGLS GKWGLHIGAT LEKQCERGLL AKDLSSSIVI
260 270 280 290 300
RTSAASDARM GGATLPAMSN SGSGNQGITA TMPVVVVAEH FGADDERLAR
310 320 330 340 350
ALMLSHLSAI YIHNQLPRLS ALCAATTAAM GAAAGMAWLV DGRYETISMA
360 370 380 390 400
ISSMIGDVSG MICDGASNSC AMKVSTSASA AWKAVLMALD DTAVTGNEGI
410 420 430
VAHDVEQSIA NLCALASHSM QQTDRQIIEI MASKAR
Length:436
Mass (Da):45,361
Last modified:October 11, 2004 - v3
Checksum:i3506FB665AAE2BBB
GO

Sequence cautioni

The sequence AAA57912 differs from that shown. Reason: Frameshift at position 185.Curated
The sequence AAA57913 differs from that shown. Reason: Frameshift at position 185.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57912.1 Frameshift.
U18997 Genomic DNA Translation: AAA57913.1 Frameshift.
U00096 Genomic DNA Translation: AAT48167.1
AP009048 Genomic DNA Translation: BAE77158.1
RefSeqiWP_000460499.1, NZ_LN832404.1
YP_026202.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48167; AAT48167; b4470
BAE77158; BAE77158; BAE77158
GeneIDi2847723
KEGGiecj:JW5518
eco:b4470
PATRICifig|511145.12.peg.3204

Similar proteinsi

Entry informationi

Entry nameiYHAM_ECOLI
AccessioniPrimary (citable) accession number: P42626
Secondary accession number(s): P42627, Q2M998, Q6BF47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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