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Protein

Altronate dehydratase

Gene

uxaA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of D-altronate.1 Publication

Catalytic activityi

D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O.1 Publication

Cofactori

Fe2+1 Publication, Mn2+1 PublicationNote: Mn2+ can substitute for iron, but in higher concentrations. Cannot use Fe3+, Ni2+ or Mg2+.1 Publication

Activity regulationi

Is inhibited by high concentrations of Fe2+ (> 2 mM), and by EDTA or other iron chelators in vitro.1 Publication

pH dependencei

Optimum pH is about 7.5. The activity at pH 6.5 and 8.6 is only about 20% of the maximal achievable activity at optimum pH.1 Publication

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

  • altronate dehydratase activity Source: GO_Central
  • ferrous iron binding Source: EcoCyc

GO - Biological processi

  • D-galacturonate catabolic process Source: EcoCyc

Keywordsi

Molecular functionLyase
LigandIron, Manganese

Enzyme and pathway databases

BioCyciEcoCyc:ALTRODEHYDRAT-MONOMER
MetaCyc:ALTRODEHYDRAT-MONOMER
UniPathwayi
UPA00246

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate dehydratase (EC:4.2.1.7)
Alternative name(s):
D-altronate hydro-lyase
Gene namesi
Name:uxaA
Synonyms:ygjW
Ordered Locus Names:b3091, JW3062
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12734 uxaA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001722831 – 495Altronate dehydrataseAdd BLAST495

Proteomic databases

PaxDbiP42604
PRIDEiP42604

Expressioni

Inductioni

Repressed by LeuO and H-NS. Part of the uxaCA operon.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262407, 12 interactors
DIPiDIP-11105N
IntActiP42604, 6 interactors
STRINGi316385.ECDH10B_3267

Structurei

3D structure databases

ProteinModelPortaliP42604
SMRiP42604
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UxaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CTX Bacteria
COG2721 LUCA
HOGENOMiHOG000219064
InParanoidiP42604
KOiK01685
PhylomeDBiP42604

Family and domain databases

InterProiView protein in InterPro
IPR007392 Gal/Altron_deHydtase_C
IPR013974 SAF
PfamiView protein in Pfam
PF04295 GD_AH_C, 1 hit
PF08666 SAF, 1 hit
SMARTiView protein in SMART
SM00858 SAF, 1 hit

Sequencei

Sequence statusi: Complete.

P42604-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQYIKIHALD NVAVALADLA EGTEVSVDNQ TVTLRQDVAR GHKFALTDIA
60 70 80 90 100
KGANVIKYGL PIGYALADIA AGVHVHAHNT RTNLSDLDQY RYQPDFQDLP
110 120 130 140 150
AQAADREVQI YRRANGDVGV RNELWILPTV GCVNGIARQI QNRFLKETNN
160 170 180 190 200
AEGTDGVFLF SHTYGCSQLG DDHINTRTML QNMVRHPNAG AVLVIGLGCE
210 220 230 240 250
NNQVAAFRET LGDIDPERVH FMICQQQDDE IEAGIEHLHQ LYNVMRNDKR
260 270 280 290 300
EPGKLSELKF GLECGGSDGL SGITANPMLG RFSDYVIANG GTTVLTEVPE
310 320 330 340 350
MFGAEQLLMD HCRDEATFEK LVTMVNDFKQ YFIAHDQPIY ENPSPGNKAG
360 370 380 390 400
GITTLEDKSL GCTQKAGSSV VVDVLRYGER LKTPGLNLLS APGNDAVATS
410 420 430 440 450
ALAGAGCHMV LFSTGRGTPY GGFVPTVKIA TNSELAAKKK HWIDFDAGQL
460 470 480 490
IHGKAMPQLL EEFIDTIVEF ANGKQTCNER NDFRELAIFK SGVTL
Length:495
Mass (Da):54,093
Last modified:November 1, 1997 - v3
Checksum:i480B21A93624FF32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA Translation: BAA18901.1
U18997 Genomic DNA Translation: AAA57893.1
U00096 Genomic DNA Translation: AAC76126.1
AP009048 Genomic DNA Translation: BAE77141.1
PIRiH65097
RefSeqiNP_417562.1, NC_000913.3
WP_001199390.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76126; AAC76126; b3091
BAE77141; BAE77141; BAE77141
GeneIDi947603
KEGGiecj:JW3062
eco:b3091
PATRICifig|1411691.4.peg.3638

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA Translation: BAA18901.1
U18997 Genomic DNA Translation: AAA57893.1
U00096 Genomic DNA Translation: AAC76126.1
AP009048 Genomic DNA Translation: BAE77141.1
PIRiH65097
RefSeqiNP_417562.1, NC_000913.3
WP_001199390.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP42604
SMRiP42604
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262407, 12 interactors
DIPiDIP-11105N
IntActiP42604, 6 interactors
STRINGi316385.ECDH10B_3267

Proteomic databases

PaxDbiP42604
PRIDEiP42604

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76126; AAC76126; b3091
BAE77141; BAE77141; BAE77141
GeneIDi947603
KEGGiecj:JW3062
eco:b3091
PATRICifig|1411691.4.peg.3638

Organism-specific databases

EchoBASEiEB2592
EcoGeneiEG12734 uxaA

Phylogenomic databases

eggNOGiENOG4105CTX Bacteria
COG2721 LUCA
HOGENOMiHOG000219064
InParanoidiP42604
KOiK01685
PhylomeDBiP42604

Enzyme and pathway databases

UniPathwayi
UPA00246

BioCyciEcoCyc:ALTRODEHYDRAT-MONOMER
MetaCyc:ALTRODEHYDRAT-MONOMER

Miscellaneous databases

PROiPR:P42604

Family and domain databases

InterProiView protein in InterPro
IPR007392 Gal/Altron_deHydtase_C
IPR013974 SAF
PfamiView protein in Pfam
PF04295 GD_AH_C, 1 hit
PF08666 SAF, 1 hit
SMARTiView protein in SMART
SM00858 SAF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUXAA_ECOLI
AccessioniPrimary (citable) accession number: P42604
Secondary accession number(s): Q2M9B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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