UniProtKB - P42601 (ALX_ECOLI)
Protein
Putative membrane-bound redox modulator Alx
Gene
alx
Organism
Escherichia coli (strain K12)
Status
Functioni
Has been proposed to be a redox modulator.1 Publication
GO - Biological processi
- cellular response to pH Source: EcoCyc
Enzyme and pathway databases
BioCyci | EcoCyc:G7607-MONOMER |
Protein family/group databases
TCDBi | 2.A.109.1.7, the tellurium ion resistance (terc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Putative membrane-bound redox modulator Alx |
Gene namesi | Name:alx1 Publication Synonyms:ygjT Ordered Locus Names:b3088, JW5515 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 28 – 43 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 44 – 64 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 65 – 89 | PeriplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 111 – 113 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 114 – 134 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 135 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 157 – 198 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 225 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 226 – 246 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 247 – 261 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 286 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 287 – 307 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 321 | CytoplasmicSequence analysis1 PublicationAdd BLAST | 14 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000103410 | 1 – 321 | Putative membrane-bound redox modulator AlxAdd BLAST | 321 |
Proteomic databases
PaxDbi | P42601 |
PRIDEi | P42601 |
Expressioni
Inductioni
By extreme alkaline conditions.2 Publications
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262405, 14 interactors |
STRINGi | 511145.b3088 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TerC family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0861, Bacteria |
HOGENOMi | CLU_045644_1_2_6 |
InParanoidi | P42601 |
PhylomeDBi | P42601 |
Family and domain databases
InterProi | View protein in InterPro IPR005496, Integral_membrane_TerC IPR022369, Integral_membrane_TerC_rswitch |
PANTHERi | PTHR30238:SF0, PTHR30238:SF0, 1 hit |
Pfami | View protein in Pfam PF03741, TerC, 1 hit |
TIGRFAMsi | TIGR03718, R_switched_Alx, 1 hit |
i Sequence
Sequence statusi: Complete.
P42601-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTVGTPLLW GGFAVVVAIM LAIDLLLQGR RGAHAMTMKQ AAAWSLVWVT
60 70 80 90 100
LSLLFNAAFW WYLVQTEGRA VADPQALAFL TGYLIEKSLA VDNVFVWLML
110 120 130 140 150
FSYFSVPAAL QRRVLVYGVL GAIVLRTIMI FTGSWLISQF DWILYIFGAF
160 170 180 190 200
LLFTGVKMAL AHEDESGIGD KPLVRWLRGH LRMTDTIDNE HFFVRKNGLL
210 220 230 240 250
YATPLMLVLI LVELSDVIFA VDSIPAIFAV TTDPFIVLTS NLFAILGLRA
260 270 280 290 300
MYFLLAGVAE RFSMLKYGLA VILVFIGIKM LIVDFYHIPI AVSLGVVFGI
310 320
LVMTFIINAW VNYRHDKQRG G
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 172 – 179 | PLVRWLRG → RWCAGYAV in AAA57890 (PubMed:9278503).Curated | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57890.1 U00096 Genomic DNA Translation: AAT48166.1 AP009048 Genomic DNA Translation: BAE77138.1 |
PIRi | E65097 |
RefSeqi | WP_001098806.1, NZ_STEB01000001.1 YP_026201.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAT48166; AAT48166; b3088 BAE77138; BAE77138; BAE77138 |
GeneIDi | 947607 |
KEGGi | ecj:JW5515 eco:b3088 |
PATRICi | fig|1411691.4.peg.3641 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57890.1 U00096 Genomic DNA Translation: AAT48166.1 AP009048 Genomic DNA Translation: BAE77138.1 |
PIRi | E65097 |
RefSeqi | WP_001098806.1, NZ_STEB01000001.1 YP_026201.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4262405, 14 interactors |
STRINGi | 511145.b3088 |
Protein family/group databases
TCDBi | 2.A.109.1.7, the tellurium ion resistance (terc) family |
Proteomic databases
PaxDbi | P42601 |
PRIDEi | P42601 |
Genome annotation databases
EnsemblBacteriai | AAT48166; AAT48166; b3088 BAE77138; BAE77138; BAE77138 |
GeneIDi | 947607 |
KEGGi | ecj:JW5515 eco:b3088 |
PATRICi | fig|1411691.4.peg.3641 |
Organism-specific databases
EchoBASEi | EB2589 |
Phylogenomic databases
eggNOGi | COG0861, Bacteria |
HOGENOMi | CLU_045644_1_2_6 |
InParanoidi | P42601 |
PhylomeDBi | P42601 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7607-MONOMER |
Miscellaneous databases
PROi | PR:P42601 |
Family and domain databases
InterProi | View protein in InterPro IPR005496, Integral_membrane_TerC IPR022369, Integral_membrane_TerC_rswitch |
PANTHERi | PTHR30238:SF0, PTHR30238:SF0, 1 hit |
Pfami | View protein in Pfam PF03741, TerC, 1 hit |
TIGRFAMsi | TIGR03718, R_switched_Alx, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALX_ECOLI | |
Accessioni | P42601Primary (citable) accession number: P42601 Secondary accession number(s): Q2M9B8, Q6BF48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | October 11, 2004 | |
Last modified: | October 7, 2020 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families