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Protein

NK1 transcription factor-related protein 2

Gene

Nkx1-2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in cell specification, particularly in the CNS.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 215HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NK1 transcription factor-related protein 2
Alternative name(s):
Homeobox protein SAX-1
NKX-1.1
Gene namesi
Name:Nkx1-2
Synonyms:Nkx1.1, Sax1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104806 Nkx1-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492901 – 305NK1 transcription factor-related protein 2Add BLAST305

Post-translational modificationi

Phosphorylated by HIPK2 in vitro.1 Publication

Proteomic databases

PaxDbiP42580
PRIDEiP42580

Expressioni

Tissue specificityi

Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain.2 Publications

Developmental stagei

In the embryo, expressed at highest levels at day 10 with levels decreasing during further development.1 Publication

Gene expression databases

BgeeiENSMUSG00000048528
GenevisibleiP42580 MM

Interactioni

Subunit structurei

Interacts with HIPK1, HIPK2, and HIPK3.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052778

Structurei

3D structure databases

ProteinModelPortaliP42580
SMRiP42580
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 96Poly-Glu9
Compositional biasi143 – 148Poly-Arg6
Compositional biasi239 – 242Poly-Gly4

Sequence similaritiesi

Belongs to the NK-1 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000144024
HOVERGENiHBG052632
InParanoidiP42580
KOiK09309
OMAiGPSYLTP
OrthoDBiEOG091G0SCQ
PhylomeDBiP42580
TreeFamiTF316128

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAWQDVGAK AAPSHHKISF SVLDILDPQK FTRAALPPVR LAALEAKKSL
60 70 80 90 100
EEVEAGQDAC SGNPIGSQET PDAVGRGIDP GSPVEGSEAE EEEEAEDAGR
110 120 130 140 150
AHQPERWQGV HEGSPEARAV AVGTEESGAE GLPASPGSPG SPRPRRRRAE
160 170 180 190 200
SSCAKPRRAR TAFTYEQLVA LENKFRATRY LSVCERLNLA LSLSLTETQV
210 220 230 240 250
KIWFQNRRTK WKKQNPGADG AVQAGGGAPQ PGTPGAVAGG GGSATGSSPG
260 270 280 290 300
PPVPGALPYQ TFPTYPATNV LFPAASFPLT TAANGSPFTP FLGPSYLTPF

YAPHL
Length:305
Mass (Da):32,013
Last modified:November 1, 1995 - v1
Checksum:iE02E09A40453FF1B
GO

Sequence cautioni

The sequence AAF43670 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF43672 differs from that shown. Probable cloning artifact.Curated
The sequence AAF43674 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216P → S in AAF43673 (PubMed:10681422).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75384 mRNA Translation: CAA53153.1
AF222443 Genomic DNA Translation: AAF43669.1
AF222443 Genomic DNA Translation: AAF43670.1 Sequence problems.
AF222444 mRNA Translation: AAF43671.1
AF222445 mRNA Translation: AAF43672.1 Sequence problems.
AF223361 mRNA Translation: AAF43673.1
AF223362 mRNA Translation: AAF43674.1 Sequence problems.
BC139757 mRNA Translation: AAI39758.1
U58137 Genomic DNA Translation: AAB06948.1
CCDSiCCDS21924.1
PIRiS41860
RefSeqiNP_033149.1, NM_009123.2
UniGeneiMm.334281
Mm.389981

Genome annotation databases

EnsembliENSMUST00000054562; ENSMUSP00000052778; ENSMUSG00000048528
GeneIDi20231
KEGGimmu:20231
UCSCiuc009kcc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNKX12_MOUSE
AccessioniPrimary (citable) accession number: P42580
Secondary accession number(s): A4QPC3
, Q9JHF2, Q9JKW5, Q9JKW6, Q9JKW9, Q9JKX0, Q9JKX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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