MLLT3

Functionⁱ

Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).5 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	58	Histone H3K9crCombined sources1 Publication	1
Binding siteⁱ	103	Histone H3K9crCombined sources1 Publication	1
Siteⁱ	375	KMT2A/MLL1 fusion point (in acute myeloid leukemia patient CO)1 Publication	1
Siteⁱ	481	KMT2A/MLL1 fusion point (in acute myeloid leukemia patient F1)1 Publication	1

GO - Molecular functionⁱ

chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 25417107
- 27105114
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27105114
- 27545619
lysine-acetylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 25417107
modification-dependent protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27105114
- 27545619

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
negative regulation of canonical Wnt signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 19591803
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 25417107
- 27105114
positive regulation of Wnt signaling pathway, planar cell polarity pathway
Source: MGI
Inferred from genetic interactionⁱ
- 19591803
segment specification Source: Ensembl
transcription by RNA polymerase II Source: Reactome
transcription elongation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-75955 RNA Polymerase II Transcription Elongation
SIGNORⁱ	P42568

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein AF-9 Alternative name(s): ALL1-fused gene from chromosome 9 protein Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein YEATS domain-containing protein 3
Gene namesⁱ	Name:MLLT3Imported Synonyms:AF9, YEATS3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171843.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7136 MLLT3
MIMⁱ	159558 gene
neXtProtⁱ	NX_P42568

Keywords - Cellular componentⁱ

Chromosome, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.2 Publications

A chromosomal aberration involving MLLT3 was observed in a patient with neuromotor development delay, cerebellar ataxia and epilepsy. Translocation t(4;9)(q35;p22).1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	28	F → A: Decreased binding to crotonylated histone H3. Decreased binding to acetylated histone H3. 2 Publications	1
Mutagenesisⁱ	56	H → A: Decreased binding to crotonylated histone H3. Decreased binding to acetylated histone H3. 2 Publications	1
Mutagenesisⁱ	58	S → A: Decreased binding to crotonylated histone H3. Decreased binding to acetylated histone H3. 2 Publications	1
Mutagenesisⁱ	59	F → A: Strongly decreased binding to crotonylated histone H3. Decreased binding to acetylated histone H3. 3 Publications	1
Mutagenesisⁱ	77	G → A: Decreased binding to crotonylated histone H3. Decreased binding to acetylated histone H3. 2 Publications	1
Mutagenesisⁱ	78	Y → A: Strongly decreased binding to crotonylated histone H3. Decreased binding to acetylated histone H3. 3 Publications	1
Mutagenesisⁱ	81	F → A: Decreased binding to acetylated histone H3. 1 Publication	1
Mutagenesisⁱ	103	D → A: Decreased binding to acetylated histone H3. 1 Publication	1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4300
MalaCards human disease database More...MalaCardsⁱ	MLLT3
Open Targets More...OpenTargetsⁱ	ENSG00000171843
Orphanetⁱ	402017 Acute myeloid leukemia with t(9;11)(p22;q23)
PharmGKBⁱ	PA30852

Polymorphism and mutation databases

DMDMⁱ	215273971

DMDMⁱ

215273971

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215921	1 – 568	Protein AF-9Add BLAST		568

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	288	PhosphoserineCombined sources	1
Modified residueⁱ	294	PhosphoserineCombined sources	1
Cross-linkⁱ	339	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	412	PhosphoserineCombined sources	1
Modified residueⁱ	419	PhosphoserineCombined sources	1
Modified residueⁱ	483	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P42568
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P42568
PaxDbⁱ	P42568
PeptideAtlas More...PeptideAtlasⁱ	P42568
PRIDEⁱ	P42568
ProteomicsDBⁱ	55517

PTM databases

iPTMnetⁱ	P42568
PhosphoSitePlusⁱ	P42568

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171843 Expressed in 193 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_MLLT3
ExpressionAtlasⁱ	P42568 baseline and differential
Genevisibleⁱ	P42568 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001824

HPAⁱ

HPA001824

Interactionⁱ

Subunit structureⁱ

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3) (PubMed:20159561, PubMed:20471948, PubMed:22195968, PubMed:23260655, PubMed:25417107). Interacts with BCOR (PubMed:10898795). Interacts with CBX8 (PubMed:11313972). Interacts with ALKBH4 (PubMed:23145062).8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AFF1	P51825	7	EBI-716132,EBI-2610180
AFF4	Q9UHB7	4	EBI-716132,EBI-395282
ALKBH4	Q9NXW9	4	EBI-716132,EBI-8637516
APPBP2	Q92624	3	EBI-716132,EBI-743771
BCOR	Q6W2J9-1	2	EBI-716132,EBI-16028932
CBX8	Q9HC52	2	EBI-716132,EBI-712912
DOT1L	Q8TEK3	6	EBI-716132,EBI-2619253

GO - Molecular functionⁱ

histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27105114
- 27545619
lysine-acetylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 25417107
modification-dependent protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27105114
- 27545619

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110446, 63 interactors
CORUMⁱ	P42568
Database of interacting proteins More...DIPⁱ	DIP-56409N
IntActⁱ	P42568, 37 interactors
STRINGⁱ	9606.ENSP00000369695

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	3 – 19	Combined sources	17
Beta strandⁱ	30 – 37	Combined sources	8
Helixⁱ	39 – 41	Combined sources	3
Helixⁱ	44 – 46	Combined sources	3
Beta strandⁱ	48 – 54	Combined sources	7
Beta strandⁱ	59 – 61	Combined sources	3
Beta strandⁱ	63 – 90	Combined sources	28
Beta strandⁱ	92 – 94	Combined sources	3
Beta strandⁱ	97 – 104	Combined sources	8
Beta strandⁱ	114 – 126	Combined sources	13
Helixⁱ	129 – 137	Combined sources	9
Helixⁱ	504 – 515	Combined sources	12
Helixⁱ	523 – 531	Combined sources	9
Beta strandⁱ	536 – 538	Combined sources	3
Beta strandⁱ	543 – 545	Combined sources	3
Turnⁱ	547 – 549	Combined sources	3
Helixⁱ	552 – 561	Combined sources	10

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP01070
ProteinModelPortalⁱ	P42568
SMRⁱ	P42568
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 112	YEATSPROSITE-ProRule annotationAdd BLAST		105

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	78 – 80	Histone H3K9cr bindingCombined sources1 Publication		3
Regionⁱ	106 – 108	Histone H3K9cr bindingCombined sources1 Publication		3

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	295 – 300	Nuclear localization signalSequence analysis		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	149 – 194	Poly-SerAdd BLAST	46
Compositional biasⁱ	383 – 391	Poly-Ser	9
Compositional biasⁱ	466 – 469	Poly-Pro	4

Domainⁱ

The YEATS domain specifically recognizes and binds acylated histones, with a marked preference histones that are crotonylated (PubMed:27105114, PubMed:27545619). Also binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity (PubMed:25417107, PubMed:27105114).3 Publications

Phylogenomic databases

eggNOGⁱ	KOG3149 Eukaryota COG5033 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039936
HOVERGENⁱ	HBG004191
InParanoidⁱ	P42568
KEGG Orthology (KO) More...KOⁱ	K15187
OMAⁱ	PNRSVHT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06LN
PhylomeDBⁱ	P42568
TreeFamⁱ	TF314586

Family and domain databases

Gene3Dⁱ	2.60.40.1970, 1 hit
InterProⁱ	View protein in InterPro IPR038704 YEAST_sf IPR005033 YEATS
PANTHERⁱ	PTHR23195 PTHR23195, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03366 YEATS, 1 hit
PROSITEⁱ	View protein in PROSITE PS51037 YEATS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P42568-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK 
        60         70         80         90        100
VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF 
       110        120        130        140        150
DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS 
       160        170        180        190        200
SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS TSFSKPHKLM 
       210        220        230        240        250
KEHKEKPSKD SREHKSAFKE PSRDHNKSSK ESSKKPKENK PLKEEKIVPK 
       260        270        280        290        300
MAFKEPKPMS KEPKPDSNLL TITSGQDKKA PSKRPPISDS EELSAKKRKK 
       310        320        330        340        350
SSSEALFKSF SSAPPLILTC SADKKQIKDK SHVKMGKVKI ESETSEKKKS 
       360        370        380        390        400
TLPPFDDIVD PNDSDVEENI SSKSDSEQPS PASSSSSSSS SFTPSQTRQQ 
       410        420        430        440        450
GPLRSIMKDL HSDDNEEESD EVEDNDNDSE MERPVNRGGS RSRRVSLSDG 
       460        470        480        490        500
SDSESSSASS PLHHEPPPPL LKTNNNQILE VKSPIKQSKS DKQIKNGECD 
       510        520        530        540        550
KAYLDELVEL HRRLMTLRER HILQQIVNLI EETGHFHITN TTFDFDLCSL 
       560 
DKTTVRKLQS YLETSGTS

Length:568

Mass (Da):63,351

Last modified:November 25, 2008 - v2

Checksum:ⁱ0A020B7FB34132F9

GO

Isoform 2 (identifier: P42568-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-4: MASS → M

« Hide

        10         20         30         40         50
MCAVQVKLEL GHRAQVRKKP TVEGFTHDWM VFVRGPEHSN IQHFVEKVVF 
        60         70         80         90        100
HLHESFPRPK RVCKDPPYKV EESGYAGFIL PIEVYFKNKE EPRKVRFDYD 
       110        120        130        140        150
LFLHLEGHPP VNHLRCEKLT FNNPTEDFRR KLLKAGGDPN RSIHTSSSSS 
       160        170        180        190        200
SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSTSF SKPHKLMKEH 
       210        220        230        240        250
KEKPSKDSRE HKSAFKEPSR DHNKSSKESS KKPKENKPLK EEKIVPKMAF 
       260        270        280        290        300
KEPKPMSKEP KPDSNLLTIT SGQDKKAPSK RPPISDSEEL SAKKRKKSSS 
       310        320        330        340        350
EALFKSFSSA PPLILTCSAD KKQIKDKSHV KMGKVKIESE TSEKKKSTLP 
       360        370        380        390        400
PFDDIVDPND SDVEENISSK SDSEQPSPAS SSSSSSSSFT PSQTRQQGPL 
       410        420        430        440        450
RSIMKDLHSD DNEEESDEVE DNDNDSEMER PVNRGGSRSR RVSLSDGSDS 
       460        470        480        490        500
ESSSASSPLH HEPPPPLLKT NNNQILEVKS PIKQSKSDKQ IKNGECDKAY 
       510        520        530        540        550
LDELVELHRR LMTLRERHIL QQIVNLIEET GHFHITNTTF DFDLCSLDKT 
       560 
TVRKLQSYLE TSGTS

Note: No experimental confirmation available.

Show »

Length:565

Mass (Da):63,106

Checksum:ⁱE8D74987AC7356CC

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1APT5	B1APT5_HUMAN	Protein AF-9 Protein AF-9	MLLT3	162	Annotation score:
A0A0D9SF09	A0A0D9SF09_HUMAN	Myeloid/lymphoid or mixed-lineage l... Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 3, isoform CRA_a (Protein AF-9)	MLLT3 hCG_1811108	138	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	A → S in AAA58361 (PubMed:8506309).Curated	1
Sequence conflictⁱ	6	A → S in BAG35760 (PubMed:14702039).Curated	1
Sequence conflictⁱ	173	S → G in AAH36089 (PubMed:15489334).Curated	1
Sequence conflictⁱ	419	S → P in BAG35760 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054924	1 – 4	MASS → M in isoform 2. 1 Publication		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13744 mRNA Translation: AAA58361.1 AK301474 mRNA Translation: BAH13491.1 AK312914 mRNA Translation: BAG35760.1 AL354879 Genomic DNA No translation available. AL512635 Genomic DNA No translation available. AL513498 Genomic DNA No translation available. AL163193 Genomic DNA No translation available. AL627410 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58631.1 CH471071 Genomic DNA Translation: EAW58632.1 BC036089 mRNA Translation: AAH36089.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6494.1 [P42568-1] CCDS69579.1 [P42568-2]
PIRⁱ	I39411
NCBI Reference Sequences More...RefSeqⁱ	NP_001273620.1, NM_001286691.1 [P42568-2] NP_004520.2, NM_004529.3 [P42568-1]
UniGeneⁱ	Hs.317248 Hs.591085

Genome annotation databases

Ensemblⁱ	ENST00000380338; ENSP00000369695; ENSG00000171843 [P42568-1] ENST00000630269; ENSP00000485996; ENSG00000171843 [P42568-2]
GeneIDⁱ	4300
KEGGⁱ	hsa:4300
UCSC genome browser More...UCSCⁱ	uc003zoe.3 human [P42568-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P42568	Myeloid/lymphoid or mixed-lineage leukemia translocated to 3 isoform 1 (Fragment)		HUMAN		568	UniRef100_P42568
MLLT3 isoform 1		PONAB		568
Uncharacterized protein		CERAT		568
Uncharacterized protein		NOMLE		568
P42568-2	MLLT3 isoform 4		PONAB		565	UniRef100_A0A2J8XIB9
Uncharacterized protein		CERAT		565
Uncharacterized protein		NOMLE		565

Protein	Similar proteins		Species	Score	Length	Source
P42568	Protein AF-9		MOUSE		569	UniRef90_P42568
Myeloid/lymphoid or mixed-lineage leukemia translocated to 3 isoform 1 (Fragment)		HUMAN		568
MLLT3 isoform 1		PONAB		568
Uncharacterized protein		CERAT		568
Uncharacterized protein		NOMLE		568
+83

Protein	Similar proteins		Species	Score	Length	Source
P42568	Protein AF-9		MOUSE		569	UniRef50_P42568
Myeloid/lymphoid or mixed-lineage leukemia translocated to 3 isoform 1 (Fragment)		HUMAN		568
MLLT3 isoform 1		PONAB		568
Uncharacterized protein		CERAT		568
Uncharacterized protein		NOMLE		568
+134

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13744 mRNA Translation: AAA58361.1 AK301474 mRNA Translation: BAH13491.1 AK312914 mRNA Translation: BAG35760.1 AL354879 Genomic DNA No translation available. AL512635 Genomic DNA No translation available. AL513498 Genomic DNA No translation available. AL163193 Genomic DNA No translation available. AL627410 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58631.1 CH471071 Genomic DNA Translation: EAW58632.1 BC036089 mRNA Translation: AAH36089.1
CCDSⁱ	CCDS6494.1 [P42568-1] CCDS69579.1 [P42568-2]
PIRⁱ	I39411
RefSeqⁱ	NP_001273620.1, NM_001286691.1 [P42568-2] NP_004520.2, NM_004529.3 [P42568-1]
UniGeneⁱ	Hs.317248 Hs.591085

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LM0	NMR	-	A	490-568	[»]
	2MV7	NMR	-	A	500-568	[»]
	2N4Q	NMR	-	B	500-568	[»]
	2NDF	NMR	-	A	1-138	[»]
	2NDG	NMR	-	A	1-138	[»]
	4TMP	X-ray	2.30	A/C	1-138	[»]
	5HJB	X-ray	2.70	A	1-138	[»]
	5HJD	X-ray	2.81	A/C/E/G/K/N/Q/T	1-138	[»]
DisProtⁱ	DP01070
ProteinModelPortalⁱ	P42568
SMRⁱ	P42568
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110446, 63 interactors
CORUMⁱ	P42568
DIPⁱ	DIP-56409N
IntActⁱ	P42568, 37 interactors
STRINGⁱ	9606.ENSP00000369695

PTM databases

iPTMnetⁱ	P42568
PhosphoSitePlusⁱ	P42568

Polymorphism and mutation databases

DMDMⁱ	215273971

DMDMⁱ

215273971

Proteomic databases

EPDⁱ	P42568
MaxQBⁱ	P42568
PaxDbⁱ	P42568
PeptideAtlasⁱ	P42568
PRIDEⁱ	P42568
ProteomicsDBⁱ	55517

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000380338; ENSP00000369695; ENSG00000171843 [P42568-1] ENST00000630269; ENSP00000485996; ENSG00000171843 [P42568-2]
GeneIDⁱ	4300
KEGGⁱ	hsa:4300
UCSCⁱ	uc003zoe.3 human [P42568-1]

Organism-specific databases

CTDⁱ	4300
DisGeNETⁱ	4300
EuPathDBⁱ	HostDB:ENSG00000171843.15
GeneCardsⁱ	MLLT3
HGNCⁱ	HGNC:7136 MLLT3
HPAⁱ	HPA001824
MalaCardsⁱ	MLLT3
MIMⁱ	159558 gene
neXtProtⁱ	NX_P42568
OpenTargetsⁱ	ENSG00000171843
Orphanetⁱ	402017 Acute myeloid leukemia with t(9;11)(p22;q23)
PharmGKBⁱ	PA30852
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3149 Eukaryota COG5033 LUCA
GeneTreeⁱ	ENSGT00440000039936
HOVERGENⁱ	HBG004191
InParanoidⁱ	P42568
KOⁱ	K15187
OMAⁱ	PNRSVHT
OrthoDBⁱ	EOG091G06LN
PhylomeDBⁱ	P42568
TreeFamⁱ	TF314586

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-75955 RNA Polymerase II Transcription Elongation
SIGNORⁱ	P42568

Miscellaneous databases

ChiTaRSⁱ	MLLT3 human
GeneWikiⁱ	MLLT3
GenomeRNAiⁱ	4300
Protein Ontology More...PROⁱ	PR:P42568
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171843 Expressed in 193 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_MLLT3
ExpressionAtlasⁱ	P42568 baseline and differential
Genevisibleⁱ	P42568 HS

Family and domain databases

Gene3Dⁱ	2.60.40.1970, 1 hit
InterProⁱ	View protein in InterPro IPR038704 YEAST_sf IPR005033 YEATS
PANTHERⁱ	PTHR23195 PTHR23195, 1 hit
Pfamⁱ	View protein in Pfam PF03366 YEATS, 1 hit
PROSITEⁱ	View protein in PROSITE PS51037 YEATS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AF9_HUMAN
Accessionⁱ	P42568Primary (citable) accession number: P42568 Secondary accession number(s): B1AMQ2 , B2R7B3, B7Z755, D3DRJ8, Q8IVB0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P42568 (AF9_HUMAN)

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Protein AF-9

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ