UniProtKB - P42566 (EPS15_HUMAN)
Epidermal growth factor receptor substrate 15
EPS15
Functioni
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 173 – 184 | 1Add BLAST | 12 | |
Calcium bindingi | 236 – 247 | 2Add BLAST | 12 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- calcium ion binding Source: InterPro
- identical protein binding Source: Ensembl
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB-KW
GO - Biological processi
- clathrin coat assembly Source: BHF-UCL
- endocytic recycling Source: BHF-UCL
- endocytosis Source: GO_Central
- endosomal transport Source: GO_Central
- Golgi to endosome transport Source: UniProtKB
- membrane organization Source: Reactome
- negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
- positive regulation of receptor recycling Source: Ensembl
- protein transport Source: UniProtKB-KW
- receptor-mediated endocytosis of virus by host cell Source: CACAO
- regulation of cell population proliferation Source: Ensembl
- vesicle organization Source: UniProtKB
- viral entry into host cell Source: CACAO
Keywordsi
Biological process | Endocytosis, Host-virus interaction, Protein transport, Transport |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P42566 |
Reactomei | R-HSA-182971, EGFR downregulation R-HSA-6807004, Negative regulation of MET activity R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8875360, InlB-mediated entry of Listeria monocytogenes into host cell |
SignaLinki | P42566 |
SIGNORi | P42566 |
Protein family/group databases
MoonDBi | P42566, Curated |
MoonProti | P42566 |
Names & Taxonomyi
Protein namesi | Recommended name: Epidermal growth factor receptor substrate 15Short name: Protein Eps15 Alternative name(s): Protein AF-1p |
Gene namesi | Name:EPS15 Synonyms:AF1P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000085832.16 |
HGNCi | HGNC:3419, EPS15 |
MIMi | 600051, gene |
neXtProti | NX_P42566 |
Subcellular locationi
Plasma membrane
Other locations
Note: Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes.1 Publication
Endosome
- Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Note: Colocalizes with HGS on bilayered clathrin coats on endosomes.
Cytosol
- cytosol Source: HPA
Endosome
- early endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- AP-2 adaptor complex Source: Ensembl
- apical plasma membrane Source: Ensembl
- basal plasma membrane Source: Ensembl
- ciliary membrane Source: Ensembl
- clathrin coat of coated pit Source: GO_Central
- clathrin-coated pit Source: UniProtKB
- plasma membrane Source: HGNC-UCL
Other locations
- aggresome Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Coated pit, Cytoplasm, Endosome, MembranePathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 154 | V → E: Loss of interaction with STON2 NPF motifs. 1 Publication | 1 | |
Mutagenesisi | 169 | W → A: Loss of interaction with STON2 NPF motifs. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 2060 |
OpenTargetsi | ENSG00000085832 |
PharmGKBi | PA27838 |
Miscellaneous databases
Pharosi | P42566, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295760 |
Polymorphism and mutation databases
BioMutai | EPS15 |
DMDMi | 67476728 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000146116 | 2 – 896 | Epidermal growth factor receptor substrate 15Add BLAST | 895 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 108 | PhosphoserineCombined sources | 1 | |
Modified residuei | 140 | PhosphoserineCombined sources | 1 | |
Modified residuei | 323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 324 | PhosphoserineCombined sources | 1 | |
Modified residuei | 467 | PhosphoserineCombined sources | 1 | |
Modified residuei | 470 | PhosphoserineCombined sources | 1 | |
Modified residuei | 485 | PhosphoserineCombined sources | 1 | |
Modified residuei | 562 | PhosphoserineBy similarity | 1 | |
Modified residuei | 563 | PhosphoserineBy similarity | 1 | |
Modified residuei | 746 | PhosphoserineCombined sources | 1 | |
Modified residuei | 777 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 779 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 790 | PhosphoserineCombined sources | 1 | |
Modified residuei | 796 | PhosphoserineCombined sources | 1 | |
Modified residuei | 814 | PhosphoserineCombined sources | 1 | |
Modified residuei | 849 | Phosphotyrosine; by EGFRCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-966 CPTAC-967 |
EPDi | P42566 |
jPOSTi | P42566 |
MassIVEi | P42566 |
MaxQBi | P42566 |
PaxDbi | P42566 |
PeptideAtlasi | P42566 |
PRIDEi | P42566 |
ProteomicsDBi | 55515 [P42566-1] 55516 [P42566-2] |
2D gel databases
OGPi | P42566 |
PTM databases
iPTMneti | P42566 |
PhosphoSitePlusi | P42566 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000085832, Expressed in endothelial cell and 251 other tissues |
ExpressionAtlasi | P42566, baseline and differential |
Genevisiblei | P42566, HS |
Organism-specific databases
HPAi | ENSG00000085832, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SGIP1 (PubMed:26822536).
Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15.
Isoform 2 interacts with HGS and AP2A2.
Part of a complex at least composed of EPS15, HGS, and either STAM or STAM2. Binds AP2A2.
Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1.
Interacts (via its SH3-binding sites) with CRK.
Interacts with SH3BP4/TTP.
Interacts with ERBB2.
Interacts with FCHO1.
Interacts with FCHO2.
Interacts (via EH domains) with DAB2.
Interacts (via UIM repeats) with CORO7 (when ubiquitinated at 'Lys-472').
Interacts (via UIM domains) with UBQLN1 (via ubiquitin-like domain) and can interact with both the ubiquitinated and the non-ubiquitinated forms of UBQLN1.
Interacts with UBQLN2 (By similarity) (PubMed:10757979, PubMed:11062555, PubMed:12551915, PubMed:16159959, PubMed:16314522, PubMed:16325581, PubMed:16903783, PubMed:18199683, PubMed:18200045, PubMed:18362181, PubMed:20448150, PubMed:21762413, PubMed:22484487, PubMed:22648170, PubMed:24768539, PubMed:8662907, PubMed:9721102, PubMed:9723620).
By similarity19 Publications(Microbial infection) Interacts with vaccinia virus protein A36.
1 PublicationBinary interactionsi
Hide detailsP42566
Isoform 1 [P42566-1]
With | #Exp. | IntAct |
---|---|---|
PTPN3 [P26045] | 4 | EBI-15895294,EBI-1047946 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: Ensembl
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 108374, 170 interactors |
CORUMi | P42566 |
DIPi | DIP-33064N |
ELMi | P42566 |
IntActi | P42566, 91 interactors |
MINTi | P42566 |
STRINGi | 9606.ENSP00000360798 |
Miscellaneous databases
RNActi | P42566, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P42566 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42566 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 104 | EH 1PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 128 – 216 | EH 2PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 160 – 195 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 223 – 258 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 224 – 314 | EH 3PROSITE-ProRule annotationAdd BLAST | 91 | |
Repeati | 599 – 601 | 1 | 3 | |
Repeati | 623 – 625 | 2 | 3 | |
Repeati | 629 – 631 | 3 | 3 | |
Repeati | 634 – 636 | 4 | 3 | |
Repeati | 640 – 642 | 5 | 3 | |
Repeati | 645 – 647 | 6 | 3 | |
Repeati | 651 – 653 | 7 | 3 | |
Repeati | 664 – 666 | 8 | 3 | |
Repeati | 672 – 674 | 9 | 3 | |
Repeati | 692 – 694 | 10 | 3 | |
Repeati | 709 – 711 | 11 | 3 | |
Repeati | 737 – 739 | 12 | 3 | |
Repeati | 798 – 800 | 13 | 3 | |
Repeati | 804 – 806 | 14 | 3 | |
Repeati | 825 – 827 | 15 | 3 | |
Domaini | 851 – 870 | UIM 1PROSITE-ProRule annotationAdd BLAST | 20 | |
Domaini | 877 – 896 | UIM 2PROSITE-ProRule annotationAdd BLAST | 20 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 330 | Interaction with DAB2By similarityAdd BLAST | 329 | |
Regioni | 599 – 827 | 15 X 3 AA repeats of D-P-FAdd BLAST | 229 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 768 – 774 | SH3-binding | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 768 – 850 | Pro-richAdd BLAST | 83 |
Domaini
Keywords - Domaini
Repeat, SH3-bindingPhylogenomic databases
eggNOGi | KOG0998, Eukaryota |
GeneTreei | ENSGT00940000155751 |
InParanoidi | P42566 |
OMAi | NSQLNWC |
OrthoDBi | 597979at2759 |
PhylomeDBi | P42566 |
TreeFami | TF324293 |
Family and domain databases
CDDi | cd00052, EH, 3 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom IPR003903, UIM_dom |
Pfami | View protein in Pfam PF12763, EF-hand_4, 3 hits |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00027, EH, 3 hits SM00726, UIM, 3 hits |
SUPFAMi | SSF47473, SSF47473, 3 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 4 hits PS50031, EH, 3 hits PS50330, UIM, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAQLSLT QLSSGNPVYE KYYRQVDTGN TGRVLASDAA AFLKKSGLPD
60 70 80 90 100
LILGKIWDLA DTDGKGILNK QEFFVALRLV ACAQNGLEVS LSSLNLAVPP
110 120 130 140 150
PRFHDTSSPL LISGTSAAEL PWAVKPEDKA KYDAIFDSLS PVNGFLSGDK
160 170 180 190 200
VKPVLLNSKL PVDILGRVWE LSDIDHDGML DRDEFAVAMF LVYCALEKEP
210 220 230 240 250
VPMSLPPALV PPSKRKTWVV SPAEKAKYDE IFLKTDKDMD GFVSGLEVRE
260 270 280 290 300
IFLKTGLPST LLAHIWSLCD TKDCGKLSKD QFALAFHLIS QKLIKGIDPP
310 320 330 340 350
HVLTPEMIPP SDRASLQKNI IGSSPVADFS AIKELDTLNN EIVDLQREKN
360 370 380 390 400
NVEQDLKEKE DTIKQRTSEV QDLQDEVQRE NTNLQKLQAQ KQQVQELLDE
410 420 430 440 450
LDEQKAQLEE QLKEVRKKCA EEAQLISSLK AELTSQESQI STYEEELAKA
460 470 480 490 500
REELSRLQQE TAELEESVES GKAQLEPLQQ HLQDSQQEIS SMQMKLMEMK
510 520 530 540 550
DLENHNSQLN WCSSPHSILV NGATDYCSLS TSSSETANLN EHVEGQSNLE
560 570 580 590 600
SEPIHQESPA RSSPELLPSG VTDENEVTTA VTEKVCSELD NNRHSKEEDP
610 620 630 640 650
FNVDSSSLTG PVADTNLDFF QSDPFVGSDP FKDDPFGKID PFGGDPFKGS
660 670 680 690 700
DPFASDCFFR QSTDPFATSS TDPFSAANNS SITSVETLKH NDPFAPGGTV
710 720 730 740 750
VAASDSATDP FASVFGNESF GGGFADFSTL SKVNNEDPFR SATSSSVSNV
760 770 780 790 800
VITKNVFEET SVKSEDEPPA LPPKIGTPTR PCPLPPGKRS INKLDSPDPF
810 820 830 840 850
KLNDPFQPFP GNDSPKEKDP EIFCDPFTSA TTTTNKEADP SNFANFSAYP
860 870 880 890
SEEDMIEWAK RESEREEEQR LARLNQQEQE DLELAIALSK SEISEA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AUU8 | B1AUU8_HUMAN | Epidermal growth factor receptor su... | EPS15 | 762 | Annotation score: | ||
S4R3U1 | S4R3U1_HUMAN | Epidermal growth factor receptor su... | EPS15 | 90 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 446 | Missing in BX647676 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016142 | 822 | I → M1 PublicationCorresponds to variant dbSNP:rs17567Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036168 | 1 – 314 | Missing in isoform 2. 1 PublicationAdd BLAST | 314 | |
Alternative sequenceiVSP_036169 | 315 – 346 | SLQKN…IVDLQ → MYLKSDSGLGGWITIPAVAD VLKYSCIVCWSS in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07707 mRNA Translation: AAA52101.1 Z29064 mRNA Translation: CAA82305.1 AK313396 mRNA Translation: BAG36194.1 DQ367924 mRNA Translation: ABD34786.1 BX647676 mRNA No translation available. AC104170 Genomic DNA No translation available. AL671986 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06823.1 |
CCDSi | CCDS557.1 [P42566-1] |
PIRi | S43074 |
RefSeqi | NP_001153441.1, NM_001159969.1 [P42566-2] NP_001972.1, NM_001981.2 [P42566-1] |
Genome annotation databases
Ensembli | ENST00000371733; ENSP00000360798; ENSG00000085832 [P42566-1] |
GeneIDi | 2060 |
KEGGi | hsa:2060 |
UCSCi | uc001csq.2, human [P42566-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangement, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07707 mRNA Translation: AAA52101.1 Z29064 mRNA Translation: CAA82305.1 AK313396 mRNA Translation: BAG36194.1 DQ367924 mRNA Translation: ABD34786.1 BX647676 mRNA No translation available. AC104170 Genomic DNA No translation available. AL671986 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06823.1 |
CCDSi | CCDS557.1 [P42566-1] |
PIRi | S43074 |
RefSeqi | NP_001153441.1, NM_001159969.1 [P42566-2] NP_001972.1, NM_001981.2 [P42566-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1C07 | NMR | - | A | 217-311 | [»] | |
1EH2 | NMR | - | A | 121-218 | [»] | |
1F8H | NMR | - | A | 121-215 | [»] | |
1FF1 | NMR | - | A | 121-215 | [»] | |
2IV9 | X-ray | 1.90 | P | 723-730 | [»] | |
2JXC | NMR | - | A | 121-215 | [»] | |
4RH5 | X-ray | 1.60 | B | 846-854 | [»] | |
4RH9 | X-ray | 1.60 | B | 846-854 | [»] | |
4RHG | X-ray | 1.58 | B | 846-854 | [»] | |
4S0G | X-ray | 1.72 | B | 846-854 | [»] | |
5AWT | X-ray | 2.70 | B | 640-649 | [»] | |
5AWU | X-ray | 2.70 | B | 645-654 | [»] | |
5JP2 | X-ray | 2.40 | E/F | 615-637 | [»] | |
SMRi | P42566 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108374, 170 interactors |
CORUMi | P42566 |
DIPi | DIP-33064N |
ELMi | P42566 |
IntActi | P42566, 91 interactors |
MINTi | P42566 |
STRINGi | 9606.ENSP00000360798 |
Chemistry databases
ChEMBLi | CHEMBL4295760 |
Protein family/group databases
MoonDBi | P42566, Curated |
MoonProti | P42566 |
PTM databases
iPTMneti | P42566 |
PhosphoSitePlusi | P42566 |
Polymorphism and mutation databases
BioMutai | EPS15 |
DMDMi | 67476728 |
2D gel databases
OGPi | P42566 |
Proteomic databases
CPTACi | CPTAC-966 CPTAC-967 |
EPDi | P42566 |
jPOSTi | P42566 |
MassIVEi | P42566 |
MaxQBi | P42566 |
PaxDbi | P42566 |
PeptideAtlasi | P42566 |
PRIDEi | P42566 |
ProteomicsDBi | 55515 [P42566-1] 55516 [P42566-2] |
Protocols and materials databases
Antibodypediai | 1916, 237 antibodies |
Genome annotation databases
Ensembli | ENST00000371733; ENSP00000360798; ENSG00000085832 [P42566-1] |
GeneIDi | 2060 |
KEGGi | hsa:2060 |
UCSCi | uc001csq.2, human [P42566-1] |
Organism-specific databases
CTDi | 2060 |
DisGeNETi | 2060 |
EuPathDBi | HostDB:ENSG00000085832.16 |
GeneCardsi | EPS15 |
HGNCi | HGNC:3419, EPS15 |
HPAi | ENSG00000085832, Low tissue specificity |
MIMi | 600051, gene |
neXtProti | NX_P42566 |
OpenTargetsi | ENSG00000085832 |
PharmGKBi | PA27838 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0998, Eukaryota |
GeneTreei | ENSGT00940000155751 |
InParanoidi | P42566 |
OMAi | NSQLNWC |
OrthoDBi | 597979at2759 |
PhylomeDBi | P42566 |
TreeFami | TF324293 |
Enzyme and pathway databases
PathwayCommonsi | P42566 |
Reactomei | R-HSA-182971, EGFR downregulation R-HSA-6807004, Negative regulation of MET activity R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8875360, InlB-mediated entry of Listeria monocytogenes into host cell |
SignaLinki | P42566 |
SIGNORi | P42566 |
Miscellaneous databases
BioGRID-ORCSi | 2060, 3 hits in 844 CRISPR screens |
ChiTaRSi | EPS15, human |
EvolutionaryTracei | P42566 |
GeneWikii | EPS15 |
GenomeRNAii | 2060 |
Pharosi | P42566, Tbio |
PROi | PR:P42566 |
RNActi | P42566, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000085832, Expressed in endothelial cell and 251 other tissues |
ExpressionAtlasi | P42566, baseline and differential |
Genevisiblei | P42566, HS |
Family and domain databases
CDDi | cd00052, EH, 3 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom IPR003903, UIM_dom |
Pfami | View protein in Pfam PF12763, EF-hand_4, 3 hits |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00027, EH, 3 hits SM00726, UIM, 3 hits |
SUPFAMi | SSF47473, SSF47473, 3 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 4 hits PS50031, EH, 3 hits PS50330, UIM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPS15_HUMAN | |
Accessioni | P42566Primary (citable) accession number: P42566 Secondary accession number(s): B2R8J7, D3DPJ2, Q5SRH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | June 7, 2005 | |
Last modified: | December 2, 2020 | |
This is version 219 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations