UniProtKB - P42519 (STAR_DROME)
Protein
Protein Star
Gene
S
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Involved in EGF receptor signaling. Has an early role in photoreceptor development. Interacts with the receptor torpedo in the eye.2 Publications
GO - Biological processi
- behavioral response to ethanol Source: FlyBase
- compound eye photoreceptor cell differentiation Source: FlyBase
- compound eye retinal cell programmed cell death Source: FlyBase
- determination of dorsal identity Source: FlyBase
- determination of genital disc primordium Source: FlyBase
- dorsal appendage formation Source: FlyBase
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: FlyBase
- endosomal transport Source: FlyBase
- epidermal growth factor receptor ligand maturation Source: FlyBase
- epithelial cell proliferation involved in Malpighian tubule morphogenesis Source: FlyBase
- imaginal disc-derived wing morphogenesis Source: FlyBase
- imaginal disc-derived wing vein specification Source: FlyBase
- ommatidial rotation Source: FlyBase
- photoreceptor cell fate determination Source: FlyBase
- positive regulation of protein secretion Source: FlyBase
- regulation of circadian sleep/wake cycle Source: FlyBase
- stem cell fate commitment Source: FlyBase
- stomatogastric nervous system development Source: FlyBase
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Sensory transduction, Vision |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Star |
Gene namesi | Name:S ORF Names:CG4385 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003310, S |
Subcellular locationi
Plasma membrane
Golgi apparatus
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum Source: FlyBase
- integral component of endoplasmic reticulum membrane Source: FlyBase
- perinuclear endoplasmic reticulum Source: FlyBase
Endosome
- late endosome membrane Source: FlyBase
Golgi apparatus
- Golgi apparatus Source: FlyBase
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 279 | CytoplasmicSequence analysisAdd BLAST | 279 | |
Transmembranei | 280 – 300 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 301 – 597 | LumenalSequence analysisAdd BLAST | 297 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072241 | 1 – 597 | Protein StarAdd BLAST | 597 |
Proteomic databases
PaxDbi | P42519 |
Expressioni
Tissue specificityi
In the larval eye disk, expression is first seen at the morphogenetic furrow, then in the developing R2, R5, and R8 cells as well as in the posterior clusters of the disk in additional R cells.1 Publication
Developmental stagei
Expressed in embryos and larvae.1 Publication
Gene expression databases
Bgeei | FBgn0003310, Expressed in female gonad and 73 other tissues |
ExpressionAtlasi | P42519, baseline and differential |
Genevisiblei | P42519, DM |
Interactioni
Subunit structurei
Interacts with Spitz via the lumenal domain and mediates its transport to the Golgi.
Protein-protein interaction databases
BioGRIDi | 59534, 52 interactors |
DIPi | DIP-22174N |
IntActi | P42519, 5 interactors |
MINTi | P42519 |
STRINGi | 7227.FBpp0077658 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 99 – 103 | Poly-Asp | 5 | |
Compositional biasi | 163 – 166 | Poly-Gly | 4 | |
Compositional biasi | 233 – 241 | Poly-His | 9 | |
Compositional biasi | 249 – 261 | Poly-GlyAdd BLAST | 13 | |
Compositional biasi | 352 – 355 | Poly-Ala | 4 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S385, Eukaryota |
HOGENOMi | CLU_457313_0_0_1 |
InParanoidi | P42519 |
OMAi | QDEETSW |
OrthoDBi | 696505at2759 |
PhylomeDBi | P42519 |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P42519-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQQVFSAHP ALAVDQLQQA EQEEHNTSSN HHQQRSATQS RRHTKAAPKK
60 70 80 90 100
FTLSRSCAGG GSGTLSGVHQ QVKPSPSNPA ISPECRKTLP VRTNYAAVDD
110 120 130 140 150
DDDIECEDVD EVNFGQQEKE RERETRQPTK DCGTDETDHV QQRHKNTMTT
160 170 180 190 200
SATAASRHHH QDGGGGDQSD LSSVISSPSV STVSSPLSTP TRLPQALQQQ
210 220 230 240 250
LHCCQKSTGM ESRARTSPQQ IQHPHRQHHQ QQHHHHHHHH HLTAAGCTGG
260 270 280 290 300
GGGGGGSGGS GSCKAKKLDP RLNPSPYRQL LPIALCLLSF AAVFATLIVY
310 320 330 340 350
MDTTEIRHQQ FRLNMSRDYE LNGVAQDDPA LIDFLRQIHM GKYLGKASPK
360 370 380 390 400
VAAAASVGVG PPPNSPRLAA AGSTFGSGNS SGSGADQLAH YVADLVGGKM
410 420 430 440 450
NGAVIQSLSG PLAHLITAPW LSEQLNWMGV LVEPEPRWYF TLRKQNAQRA
460 470 480 490 500
RMQVVHACVS PNTYPKEITI HNEDVRINSL HDEETSWFNS RVKCFPLYTI
510 520 530 540 550
MLACERTEYD LLSLGVQGHE LEILQTLPFD KVKIDVISIH LLEDHEDVAD
560 570 580 590
YVLDITRFLA GKSYKLQRKI GRNYFYQRLN ASASRTRKKD ILLLKTP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA4UZY2 | A4UZY2_DROME | Star, isoform B | S asteroid, Dmel\CG4385, E(Raf)2B, EC2-2, EK2-2 | 597 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31886 mRNA Translation: AAB04161.1 AE014134 Genomic DNA Translation: AAF51425.1 AY113201 mRNA Translation: AAM29206.1 |
RefSeqi | NP_523450.1, NM_078726.4 NP_722674.1, NM_164403.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0077993; FBpp0077658; FBgn0003310 FBtr0077994; FBpp0077659; FBgn0003310 |
GeneIDi | 33281 |
KEGGi | dme:Dmel_CG4385 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31886 mRNA Translation: AAB04161.1 AE014134 Genomic DNA Translation: AAF51425.1 AY113201 mRNA Translation: AAM29206.1 |
RefSeqi | NP_523450.1, NM_078726.4 NP_722674.1, NM_164403.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 59534, 52 interactors |
DIPi | DIP-22174N |
IntActi | P42519, 5 interactors |
MINTi | P42519 |
STRINGi | 7227.FBpp0077658 |
Proteomic databases
PaxDbi | P42519 |
Genome annotation databases
EnsemblMetazoai | FBtr0077993; FBpp0077658; FBgn0003310 FBtr0077994; FBpp0077659; FBgn0003310 |
GeneIDi | 33281 |
KEGGi | dme:Dmel_CG4385 |
Organism-specific databases
CTDi | 33281 |
FlyBasei | FBgn0003310, S |
Phylogenomic databases
eggNOGi | ENOG502S385, Eukaryota |
HOGENOMi | CLU_457313_0_0_1 |
InParanoidi | P42519 |
OMAi | QDEETSW |
OrthoDBi | 696505at2759 |
PhylomeDBi | P42519 |
Miscellaneous databases
BioGRID-ORCSi | 33281, 0 hits in 1 CRISPR screen |
GenomeRNAii | 33281 |
PROi | PR:P42519 |
Gene expression databases
Bgeei | FBgn0003310, Expressed in female gonad and 73 other tissues |
ExpressionAtlasi | P42519, baseline and differential |
Genevisiblei | P42519, DM |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAR_DROME | |
Accessioni | P42519Primary (citable) accession number: P42519 Secondary accession number(s): Q9VPW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase