UniProtKB - P42437 (NASF_BACSU)
Protein
Uroporphyrinogen-III C-methyltransferase
Gene
nasF
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalytic activityi
- EC:2.1.1.107
GO - Molecular functioni
- uroporphyrin-III C-methyltransferase activity Source: GO_Central
- uroporphyrinogen-III synthase activity Source: InterPro
GO - Biological processi
- methylation Source: UniProtKB-KW
- oxidation-reduction process Source: InterPro
- siroheme biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Porphyrin biosynthesis |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | BSUB:BSU03280-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)Short name: Urogen III methylase Alternative name(s): SUMT Uroporphyrinogen III methylase Short name: UROM |
Gene namesi | Name:nasF Synonyms:nasBE Ordered Locus Names:BSU03280 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150384 | 1 – 483 | Uroporphyrinogen-III C-methyltransferaseAdd BLAST | 483 |
Proteomic databases
PaxDbi | P42437 |
PRIDEi | P42437 |
Expressioni
Inductioni
Positively regulated by TnrA under nitrogen-limited conditions.2 Publications
Family & Domainsi
Sequence similaritiesi
Belongs to the precorrin methyltransferase family.Curated
Phylogenomic databases
eggNOGi | COG0007, Bacteria COG1587, Bacteria |
InParanoidi | P42437 |
OMAi | IAWKERK |
PhylomeDBi | P42437 |
Family and domain databases
CDDi | cd11642, SUMT, 1 hit |
Gene3Di | 3.30.950.10, 1 hit 3.40.1010.10, 1 hit 3.40.50.10090, 1 hit |
InterProi | View protein in InterPro IPR000878, 4pyrrol_Mease IPR035996, 4pyrrol_Methylase_sf IPR036108, 4pyrrol_syn_uPrphyn_synt_sf IPR014777, 4pyrrole_Mease_sub1 IPR014776, 4pyrrole_Mease_sub2 IPR006366, CobA/CysG_C IPR003043, Uropor_MeTrfase_CS |
Pfami | View protein in Pfam PF00590, TP_methylase, 1 hit |
SUPFAMi | SSF53790, SSF53790, 1 hit SSF69618, SSF69618, 1 hit |
TIGRFAMsi | TIGR01469, cobA_cysG_Cterm, 1 hit |
PROSITEi | View protein in PROSITE PS00839, SUMT_1, 1 hit PS00840, SUMT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P42437-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIMKNGIVYF VGAGPGDPGL LTIKGKQALK EADVILYDRL ANPKLLEFAS
60 70 80 90 100
PDCQFIYCGK LPNRHFMKQK EINALLVEKA LNGLTVVRLK GGDPSVFGRV
110 120 130 140 150
GEEADALHEH GIRYEMVPGI TSGIAAPLYA GIPVTHRDFA SSFAMITAHD
160 170 180 190 200
KSLKGTPNLD WEGLARSVQT LVFYMGVKNL SYICQQLISY GKSPSVPVIV
210 220 230 240 250
IQWGTWGRQR SVKGTLENIQ QKVQEHQITN PAIIVIGDIV NFQTHSWFES
260 270 280 290 300
KPLIGRHLMV VTHGEDEDPL ADKLRDSGAD LIEWPKWRTE NMPVNEEILR
310 320 330 340 350
KIGTFEDVFF TSRRAVCEFF RALASQKIDI RQLTAKLSAA SEQAKTELEK
360 370 380 390 400
RGFLVTAIQP DSEKRLVVGS RHAVENMQKH ESCSFYITHE NVIDDRFTHM
410 420 430 440 450
IQRTISESPL HMVICPNKLS VQQLINGGEQ IGILPEPSAS RPPIVCIGDD
460 470 480
SAAGIYGFTA VQEQDELLAF IHNQHAEKKL LHT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D30689 Genomic DNA Translation: BAA06356.1 D50453 Genomic DNA Translation: BAA08962.1 AL009126 Genomic DNA Translation: CAB12122.1 |
PIRi | I40031 |
RefSeqi | NP_388210.1, NC_000964.3 WP_003234641.1, NZ_JNCM01000030.1 |
Genome annotation databases
EnsemblBacteriai | CAB12122; CAB12122; BSU03280 |
GeneIDi | 938324 |
KEGGi | bsu:BSU03280 |
PATRICi | fig|224308.43.peg.336 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D30689 Genomic DNA Translation: BAA06356.1 D50453 Genomic DNA Translation: BAA08962.1 AL009126 Genomic DNA Translation: CAB12122.1 |
PIRi | I40031 |
RefSeqi | NP_388210.1, NC_000964.3 WP_003234641.1, NZ_JNCM01000030.1 |
3D structure databases
SMRi | P42437 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU03280 |
Proteomic databases
PaxDbi | P42437 |
PRIDEi | P42437 |
Genome annotation databases
EnsemblBacteriai | CAB12122; CAB12122; BSU03280 |
GeneIDi | 938324 |
KEGGi | bsu:BSU03280 |
PATRICi | fig|224308.43.peg.336 |
Phylogenomic databases
eggNOGi | COG0007, Bacteria COG1587, Bacteria |
InParanoidi | P42437 |
OMAi | IAWKERK |
PhylomeDBi | P42437 |
Enzyme and pathway databases
BioCyci | BSUB:BSU03280-MONOMER |
Family and domain databases
CDDi | cd11642, SUMT, 1 hit |
Gene3Di | 3.30.950.10, 1 hit 3.40.1010.10, 1 hit 3.40.50.10090, 1 hit |
InterProi | View protein in InterPro IPR000878, 4pyrrol_Mease IPR035996, 4pyrrol_Methylase_sf IPR036108, 4pyrrol_syn_uPrphyn_synt_sf IPR014777, 4pyrrole_Mease_sub1 IPR014776, 4pyrrole_Mease_sub2 IPR006366, CobA/CysG_C IPR003043, Uropor_MeTrfase_CS |
Pfami | View protein in Pfam PF00590, TP_methylase, 1 hit |
SUPFAMi | SSF53790, SSF53790, 1 hit SSF69618, SSF69618, 1 hit |
TIGRFAMsi | TIGR01469, cobA_cysG_Cterm, 1 hit |
PROSITEi | View protein in PROSITE PS00839, SUMT_1, 1 hit PS00840, SUMT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NASF_BACSU | |
Accessioni | P42437Primary (citable) accession number: P42437 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families