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UniProtKB - P42422 (YXDK_BACSU)
Protein
Sensor histidine kinase YxdK
Gene
yxdK
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Probable member of the two-component regulatory system YxdK/YxdJ. May activate YxdJ in response to the antibacterial protein LL-37.
2 PublicationsCatalytic activityi
- ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC:2.7.13.3
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- phosphorelay sensor kinase activity Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Two-component regulatory system |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU39650-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:yxdK Ordered Locus Names:BSU39650 ORF Names:B65E |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 30 – 33 | ExtracellularSequence analysis | 4 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 325 | CytoplasmicSequence analysisAdd BLAST | 271 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074923 | 1 – 325 | Sensor histidine kinase YxdKAdd BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 121 | Phosphohistidine; by autocatalysisPROSITE-ProRule annotation | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P42422 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 325 | Histidine kinasePROSITE-ProRule annotationAdd BLAST | 208 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2205, Bacteria |
InParanoidi | P42422 |
OMAi | LNHEVEI |
PhylomeDBi | P42422 |
Family and domain databases
CDDi | cd00082, HisKA, 1 hit |
Gene3Di | 3.30.565.10, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR005467, His_kinase_dom IPR003661, HisK_dim/P IPR004358, Sig_transdc_His_kin-like_C |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit |
PRINTSi | PR00344, BCTRLSENSOR |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF55874, SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS50109, HIS_KIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P42422-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLFLRSHAV LILLFLLQGL FVFFYYWFAG LHSFSHLFYI LGVQLLILAG
60 70 80 90 100
YLAYRWYKDR GVYHWLSSGQ EGTDIPYLGS SVFCSELYEK QMELIRLQHQ
110 120 130 140 150
KLHETEAKLD ARVTYMNQWV HQVKTPLSVI NLIIQEEDEP VFEQIKKEVR
160 170 180 190 200
QIEFGLETLL YSSRLDLFER DFKIEAVSLS ELLQSVIQSY KRFFIQYRVY
210 220 230 240 250
PKMNVCDDHQ IYTDAKWLKF AIGQVVTNAV KYSAGKSDRL ELNVFCDEDR
260 270 280 290 300
TVLEVKDYGV GIPSQDIKRV FDPYYTGENG RRFQESTGIG LHLVKEITDK
310 320
LNHTVDISSS PGEGTSVRFS FLTKM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14399 Genomic DNA Translation: BAA03301.1 AL009126 Genomic DNA Translation: CAB16001.1 D45912 Genomic DNA Translation: BAA08314.1 |
PIRi | H70073 |
RefSeqi | NP_391844.1, NC_000964.3 WP_003243885.1, NZ_JNCM01000034.1 |
Genome annotation databases
EnsemblBacteriai | CAB16001; CAB16001; BSU_39650 |
GeneIDi | 937487 |
KEGGi | bsu:BSU39650 |
PATRICi | fig|224308.179.peg.4290 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14399 Genomic DNA Translation: BAA03301.1 AL009126 Genomic DNA Translation: CAB16001.1 D45912 Genomic DNA Translation: BAA08314.1 |
PIRi | H70073 |
RefSeqi | NP_391844.1, NC_000964.3 WP_003243885.1, NZ_JNCM01000034.1 |
3D structure databases
AlphaFoldDBi | P42422 |
SMRi | P42422 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU39650 |
Proteomic databases
PaxDbi | P42422 |
Protocols and materials databases
DNASUi | 937487 |
Genome annotation databases
EnsemblBacteriai | CAB16001; CAB16001; BSU_39650 |
GeneIDi | 937487 |
KEGGi | bsu:BSU39650 |
PATRICi | fig|224308.179.peg.4290 |
Phylogenomic databases
eggNOGi | COG2205, Bacteria |
InParanoidi | P42422 |
OMAi | LNHEVEI |
PhylomeDBi | P42422 |
Enzyme and pathway databases
BioCyci | BSUB:BSU39650-MONOMER |
Family and domain databases
CDDi | cd00082, HisKA, 1 hit |
Gene3Di | 3.30.565.10, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR005467, His_kinase_dom IPR003661, HisK_dim/P IPR004358, Sig_transdc_His_kin-like_C |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit |
PRINTSi | PR00344, BCTRLSENSOR |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF55874, SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS50109, HIS_KIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YXDK_BACSU | |
Accessioni | P42422Primary (citable) accession number: P42422 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |