UniProtKB - P42419 (IOLI_BACSU)
Protein
Inosose isomerase
Gene
iolI
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Involved in the reversible interconverion of 2-keto-myo-inositol (2KMI, inosose or 2,4,6/3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5/4,6-pentahydroxycyclohexanone).1 Publication
Catalytic activityi
- EC:5.3.99.111 Publication
Cofactori
Mn2+1 Publication, Fe2+1 Publication, Co2+1 PublicationNote: Binds 1 divalent metal cation per subunit. Can use Mn2+, Fe2+ or Co2+.1 Publication
: myo-inositol degradation into acetyl-CoA Pathwayi
This protein is involved in the pathway myo-inositol degradation into acetyl-CoA, which is part of Polyol metabolism.View all proteins of this organism that are known to be involved in the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 142 | Divalent metal cation | 1 | |
Metal bindingi | 174 | Divalent metal cation | 1 | |
Metal bindingi | 200 | Divalent metal cation | 1 | |
Metal bindingi | 246 | Divalent metal cation | 1 |
GO - Molecular functioni
- isomerase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase |
Ligand | Cobalt, Iron, Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU39680-MONOMER MetaCyc:BSU39680-MONOMER |
BRENDAi | 5.3.99.11, 658 |
UniPathwayi | UPA00076 |
Names & Taxonomyi
Protein namesi | Recommended name: Inosose isomerase (EC:5.3.99.11)Alternative name(s): 2-keto-myo-inositol isomerase Short name: 2KMI isomerase |
Gene namesi | Name:iolI Synonyms:yxdH Ordered Locus Names:BSU39680 ORF Names:B65B |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084215 | 1 – 278 | Inosose isomeraseAdd BLAST | 278 |
Proteomic databases
jPOSTi | P42419 |
PaxDbi | P42419 |
PRIDEi | P42419 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P42419 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42419 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IolI family.Curated
Phylogenomic databases
eggNOGi | COG1082, Bacteria |
InParanoidi | P42419 |
OMAi | YIEIRTM |
PhylomeDBi | P42419 |
Family and domain databases
InterProi | View protein in InterPro IPR036237, Xyl_isomerase-like_sf IPR013022, Xyl_isomerase-like_TIM-brl |
Pfami | View protein in Pfam PF01261, AP_endonuc_2, 1 hit |
SUPFAMi | SSF51658, SSF51658, 1 hit |
i Sequence
Sequence statusi: Complete.
P42419-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLCFNEATT LENSNLKLDL ELCEKHGYDY IEIRTMDKLP EYLKDHSLDD
60 70 80 90 100
LAEYFQTHHI KPLALNALVF FNNRDEKGHN EIITEFKGMM ETCKTLGVKY
110 120 130 140 150
VVAVPLVTEQ KIVKEEIKKS SVDVLTELSD IAEPYGVKIA LEFVGHPQCT
160 170 180 190 200
VNTFEQAYEI VNTVNRDNVG LVLDSFHFHA MGSNIESLKQ ADGKKIFIYH
210 220 230 240 250
IDDTEDFPIG FLTDEDRVWP GQGAIDLDAH LSALKEIGFS DVVSVELFRP
260 270
EYYKLTAEEA IQTAKKTTVD VVSKYFSM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14399 Genomic DNA Translation: BAA03298.1 AL009126 Genomic DNA Translation: CAB16004.1 |
PIRi | A69646 |
RefSeqi | NP_391847.1, NC_000964.3 WP_003244546.1, NZ_JNCM01000034.1 |
Genome annotation databases
EnsemblBacteriai | CAB16004; CAB16004; BSU39680 |
GeneIDi | 937582 |
KEGGi | bsu:BSU39680 |
PATRICi | fig|224308.179.peg.4293 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14399 Genomic DNA Translation: BAA03298.1 AL009126 Genomic DNA Translation: CAB16004.1 |
PIRi | A69646 |
RefSeqi | NP_391847.1, NC_000964.3 WP_003244546.1, NZ_JNCM01000034.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I60 | X-ray | 1.60 | A | 1-278 | [»] | |
1I6N | X-ray | 1.80 | A | 1-278 | [»] | |
SMRi | P42419 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU39680 |
Proteomic databases
jPOSTi | P42419 |
PaxDbi | P42419 |
PRIDEi | P42419 |
Genome annotation databases
EnsemblBacteriai | CAB16004; CAB16004; BSU39680 |
GeneIDi | 937582 |
KEGGi | bsu:BSU39680 |
PATRICi | fig|224308.179.peg.4293 |
Phylogenomic databases
eggNOGi | COG1082, Bacteria |
InParanoidi | P42419 |
OMAi | YIEIRTM |
PhylomeDBi | P42419 |
Enzyme and pathway databases
UniPathwayi | UPA00076 |
BioCyci | BSUB:BSU39680-MONOMER MetaCyc:BSU39680-MONOMER |
BRENDAi | 5.3.99.11, 658 |
Miscellaneous databases
EvolutionaryTracei | P42419 |
Family and domain databases
InterProi | View protein in InterPro IPR036237, Xyl_isomerase-like_sf IPR013022, Xyl_isomerase-like_TIM-brl |
Pfami | View protein in Pfam PF01261, AP_endonuc_2, 1 hit |
SUPFAMi | SSF51658, SSF51658, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IOLI_BACSU | |
Accessioni | P42419Primary (citable) accession number: P42419 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families