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Protein

Aryl-phospho-beta-D-glucosidase BglC

Gene

bglC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is able to catalyze the hydrolysis of aryl-phospho-beta-D-glucosides such as 4-methylumbelliferyl-phospho-beta-D-glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Is not essential for growth on arbutin and salicin as the sole carbon source.1 Publication

Catalytic activityi

6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170Proton donorSequence analysis1
Active sitei378NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyciBSUB:BSU03410-MONOMER

Protein family/group databases

CAZyiGH1 Glycoside Hydrolase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl-phospho-beta-D-glucosidase BglC (EC:3.2.1.86)
Alternative name(s):
6-phospho-beta-glucosidase
Gene namesi
Name:bglC
Synonyms:yckE
Ordered Locus Names:BSU03410
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000638741 – 477Aryl-phospho-beta-D-glucosidase BglCAdd BLAST477

Proteomic databases

PaxDbiP42403
PRIDEiP42403

Expressioni

Developmental stagei

Expressed at a low and constant level during growth, sporulation, and spore germination.1 Publication

Inductioni

Is not induced by aryl-beta-D-glucosides such as arbutin, salicin or 4-methylumbelliferyl-beta-D-glucopyranoside (MUG). Is not repressed by glucose.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001908

Structurei

3D structure databases

ProteinModelPortaliP42403
SMRiP42403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Phylogenomic databases

eggNOGiENOG4105CS2 Bacteria
COG2723 LUCA
HOGENOMiHOG000088631
InParanoidiP42403
KOiK01223
OMAiYEANHIA
PhylomeDBiP42403

Family and domain databases

InterProiView protein in InterPro
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10353 PTHR10353, 1 hit
PfamiView protein in Pfam
PF00232 Glyco_hydro_1, 1 hit
PRINTSiPR00131 GLHYDRLASE1
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 1 hit
PS00653 GLYCOSYL_HYDROL_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42403-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIHQHPESFP KHFLWGSASA AYQIEGAWNE DGKGPSVWDV FTKIPGKTFK
60 70 80 90 100
GTNGEIAVDH YHRFKEDVAL MAEMGLKAYR FSVSWPRVFP KGKGEINEAG
110 120 130 140 150
LAFYDSLIDE LLSHHIEPVL TLYHWDLPQA LMDEYGGFES RNIIEDFNHY
160 170 180 190 200
CITLYKRFGD RVKYWVTLNE QNYNFNHGFI TAMHPPGVKD RKRFYEANHI
210 220 230 240 250
AFLANAKAIE SFREYVPEGK IGPSFAYSPA YPLSSHPEDI LAFENAEEFT
260 270 280 290 300
NNWWLDMYCW GTYPQIPFRC LEKQGWAPTI EAGDMDLLAK GKPDFVGVNY
310 320 330 340 350
YQTITYERNP LDGVSEGKMN TTGQKGTNQE TGIPGVFKTK KNPHLTTSNW
360 370 380 390 400
DWTIDPIGLR IGLRRITSRY QLPVFITENG LGEFDKVEDG TVQDDYRIDY
410 420 430 440 450
LRSHLEQCRQ AISDGVDLIG YCSWSFTDLL SWLNGYQKRY GFVYVNRDEE
460 470
STSDLKRLKK KSFYWYQDVI KTNGESL
Length:477
Mass (Da):55,140
Last modified:November 1, 1995 - v1
Checksum:i64045E7E4C1A10E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30762 Genomic DNA Translation: BAA06429.1
D50453 Genomic DNA Translation: BAA08975.1
AL009126 Genomic DNA Translation: CAB12135.1
M21672 Genomic DNA No translation available.
PIRiG69760
RefSeqiNP_388223.1, NC_000964.3
WP_003246242.1, NZ_JNCM01000030.1

Genome annotation databases

EnsemblBacteriaiCAB12135; CAB12135; BSU03410
GeneIDi938317
KEGGibsu:BSU03410
PATRICifig|224308.179.peg.358

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30762 Genomic DNA Translation: BAA06429.1
D50453 Genomic DNA Translation: BAA08975.1
AL009126 Genomic DNA Translation: CAB12135.1
M21672 Genomic DNA No translation available.
PIRiG69760
RefSeqiNP_388223.1, NC_000964.3
WP_003246242.1, NZ_JNCM01000030.1

3D structure databases

ProteinModelPortaliP42403
SMRiP42403
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001908

Protein family/group databases

CAZyiGH1 Glycoside Hydrolase Family 1

Proteomic databases

PaxDbiP42403
PRIDEiP42403

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12135; CAB12135; BSU03410
GeneIDi938317
KEGGibsu:BSU03410
PATRICifig|224308.179.peg.358

Phylogenomic databases

eggNOGiENOG4105CS2 Bacteria
COG2723 LUCA
HOGENOMiHOG000088631
InParanoidiP42403
KOiK01223
OMAiYEANHIA
PhylomeDBiP42403

Enzyme and pathway databases

BioCyciBSUB:BSU03410-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10353 PTHR10353, 1 hit
PfamiView protein in Pfam
PF00232 Glyco_hydro_1, 1 hit
PRINTSiPR00131 GLHYDRLASE1
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 1 hit
PS00653 GLYCOSYL_HYDROL_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBGLC_BACSU
AccessioniPrimary (citable) accession number: P42403
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
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Main funding by: National Institutes of Health

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