We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P42383 (CH60_HELPY)
Protein
Chaperonin GroEL
Gene
groEL
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
UniRule annotationCatalytic activityi
- ATP + H(2)O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.UniRule annotation EC:5.6.1.7
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 50 | ATPUniRule annotation | 1 | |
Binding sitei | 414 | ATP; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 492 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 29 – 32 | ATPUniRule annotation | 4 | |
Nucleotide bindingi | 86 – 90 | ATPUniRule annotation | 5 |
GO - Molecular functioni
- ATP binding Source: GO_Central
- ATP hydrolysis activity Source: InterPro
- isomerase activity Source: UniProtKB-KW
- unfolded protein binding Source: GO_Central
GO - Biological processi
- chaperone cofactor-dependent protein refolding Source: GO_Central
- protein folding Source: GO_Central
- protein refolding Source: GO_Central
- response to heat Source: GO_Central
Keywordsi
Molecular function | Chaperone, Isomerase |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Chaperonin GroELUniRule annotation (EC:5.6.1.7UniRule annotation)Alternative name(s): 60 kDa chaperoninUniRule annotation Chaperonin-60UniRule annotation Short name: Cpn60UniRule annotation |
Gene namesi | Name:groELUniRule annotation Synonyms:groLUniRule annotation, hsp60, hspB, mopA Ordered Locus Names:HP_0010 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Cytosol
- GroEL-GroES complex Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063389 | 1 – 546 | Chaperonin GroELAdd BLAST | 546 |
Proteomic databases
PaxDbi | P42383 |
Interactioni
Subunit structurei
Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back.
Interacts with the co-chaperonin GroES.
UniRule annotationGO - Molecular functioni
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
DIPi | DIP-3069N |
IntActi | P42383, 11 interactors |
MINTi | P42383 |
STRINGi | 85962.C694_00045 |
Family & Domainsi
Sequence similaritiesi
Belongs to the chaperonin (HSP60) family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0459, Bacteria |
OMAi | TDTDKME |
PhylomeDBi | P42383 |
Family and domain databases
CDDi | cd03344, GroEL, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
HAMAPi | MF_00600, CH60, 1 hit |
InterProi | View protein in InterPro IPR018370, Chaperonin_Cpn60_CS IPR001844, Chaprnin_Cpn60 IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00298, CHAPERONIN60 |
SUPFAMi | SSF48592, SSF48592, 2 hits SSF52029, SSF52029, 1 hit |
TIGRFAMsi | TIGR02348, GroEL, 1 hit |
PROSITEi | View protein in PROSITE PS00296, CHAPERONINS_CPN60, 1 hit |
i Sequence
Sequence statusi: Complete.
P42383-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKEIKFSDS ARNLLFEGVR QLHDAVKVTM GPRGRNVLIQ KSYGAPSITK
60 70 80 90 100
DGVSVAKEIE LSCPVANMGA QLVKEVASKT ADAAGDGTTT ATVLAYSIFK
110 120 130 140 150
EGLRNITAGA NPIEVKRGMD KAAEAIINEL KKASKKVGGK EEITQVATIS
160 170 180 190 200
ANSDHNIGKL IADAMEKVGK DGVITVEEAK GIEDELDVVE GMQFDRGYLS
210 220 230 240 250
PYFVTNAEKM TAQLDNAYIL LTDKKISSMK DILPLLEKTM KEGKPLLIIA
260 270 280 290 300
EDIEGEALTT LVVNKLRGVL NIAAVKAPGF GDRRKEMLKD IAILTGGQVI
310 320 330 340 350
SEELGLSLEN AEVEFLGKAG RIVIDKDNTT IVDGKGHSHD VKDRVAQIKT
360 370 380 390 400
QIASTTSDYD KEKLQERLAK LSGGVAVIKV GAASEVEMKE KKDRVDDALS
410 420 430 440 450
ATKAAVEEGI VIGGGAALIR AAQKVHLNLH DDEKVGYEII MRAIKAPLAQ
460 470 480 490 500
IAINAGYDGG VVVNEVEKHE GHFGFNASNG KYVDMFKEGI IDPLKVERIA
510 520 530 540
LQNAVSVSSL LLTTEATVHE IKEEKAAPAM PDMGGMGGMG GMGGMM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 339 | H → D in CAA52062 (PubMed:8105364).Curated | 1 | |
Sequence conflicti | 527 | A → T in CAA52062 (PubMed:8105364).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 76 | V → D in strain: 85P. | 1 | |
Natural varianti | 123 | A → P in strain: 85P. | 1 | |
Natural varianti | 293 | I → V in strain: 85P. | 1 | |
Natural varianti | 320 – 321 | GR → K in strain: 85P. | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73840 Genomic DNA Translation: CAA52062.1 L23798 Genomic DNA Translation: AAC41441.1 AE000511 Genomic DNA Translation: AAD07080.1 |
PIRi | B64521, S36237 |
RefSeqi | NP_206812.1, NC_000915.1 WP_001040293.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD07080; AAD07080; HP_0010 |
KEGGi | hpy:HP_0010 |
PATRICi | fig|85962.47.peg.9 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73840 Genomic DNA Translation: CAA52062.1 L23798 Genomic DNA Translation: AAC41441.1 AE000511 Genomic DNA Translation: AAD07080.1 |
PIRi | B64521, S36237 |
RefSeqi | NP_206812.1, NC_000915.1 WP_001040293.1, NC_018939.1 |
3D structure databases
SMRi | P42383 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-3069N |
IntActi | P42383, 11 interactors |
MINTi | P42383 |
STRINGi | 85962.C694_00045 |
Proteomic databases
PaxDbi | P42383 |
Genome annotation databases
EnsemblBacteriai | AAD07080; AAD07080; HP_0010 |
KEGGi | hpy:HP_0010 |
PATRICi | fig|85962.47.peg.9 |
Phylogenomic databases
eggNOGi | COG0459, Bacteria |
OMAi | TDTDKME |
PhylomeDBi | P42383 |
Family and domain databases
CDDi | cd03344, GroEL, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
HAMAPi | MF_00600, CH60, 1 hit |
InterProi | View protein in InterPro IPR018370, Chaperonin_Cpn60_CS IPR001844, Chaprnin_Cpn60 IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00298, CHAPERONIN60 |
SUPFAMi | SSF48592, SSF48592, 2 hits SSF52029, SSF52029, 1 hit |
TIGRFAMsi | TIGR02348, GroEL, 1 hit |
PROSITEi | View protein in PROSITE PS00296, CHAPERONINS_CPN60, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CH60_HELPY | |
Accessioni | P42383Primary (citable) accession number: P42383 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families