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Protein

Manganese ABC transporter substrate-binding lipoprotein

Gene

scaA

Organism
Streptococcus gordonii
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the high-affinity ABC transporter complex ScaABC involved in manganese import. Essential for growth under Mn2+-limiting conditions (PubMed:9440518). Also acts as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection (PubMed:7927711).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68ZincBy similarity1
Metal bindingi140ZincBy similarity1
Metal bindingi206ZincBy similarity1
Metal bindingi281ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandManganese, Metal-binding, Zinc

Protein family/group databases

TCDBi3.A.1.15.2 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese ABC transporter substrate-binding lipoproteinCurated
Alternative name(s):
Coaggregation-mediating adhesin1 Publication
Gene namesi
Name:scaA1 Publication
OrganismiStreptococcus gordonii
Taxonomic identifieri1302 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Inactivation of the gene results in both impaired growth and strong inhibition of Mn2+ uptake.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19PROSITE-ProRule annotationAdd BLAST19
ChainiPRO_000003188620 – 310Manganese ABC transporter substrate-binding lipoproteinAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi20S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Expressioni

Inductioni

Induced at low concentrations of extracellular Mn2+ and by the addition of Zn2+.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ScaC), two transmembrane proteins (ScaB) and a solute-binding protein (ScaA).Curated

Structurei

3D structure databases

ProteinModelPortaliP42364
SMRiP42364
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DSE Bacteria
COG0803 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR006129 AdhesinB
IPR006128 Lipoprotein_4
IPR006127 ZnuA-like
PfamiView protein in Pfam
PF01297 ZnuA, 1 hit
PRINTSiPR00691 ADHESINB
PR00690 ADHESNFAMILY
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42364-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKCRFLVLL LLAFVGLAAC SSQKSSTDSS SSKLNVVATN SIIADITKNI
60 70 80 90 100
AGDKINLHSI VPVGQDPHKY EPLPEDVKKT SKADLIFYNG INLETGGNAW
110 120 130 140 150
FTKLVENAQK KENKDYYAVS EGVDVIYLEG QNEKGKEDPH AWLNLENGII
160 170 180 190 200
YAQNIAKRLI EKDPDNKATY EKNLKAYIEK LTALDKEAKE KFNNIPEEKK
210 220 230 240 250
MIVTSEGCPK YFSKAYNVPS AYIWEINTEE EGTPDQIKSL VEKLRKTKVP
260 270 280 290 300
SLFVESSVDD RPMKTVSKDT NIPIYAKIFT DSIAEKGEDG DSYYSMMKYN
310
LDKISEGLAK
Length:310
Mass (Da):34,788
Last modified:November 1, 1995 - v1
Checksum:iD1DEAB1A060BC252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11577 Genomic DNA Translation: AAA71947.1
PIRiT11551

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11577 Genomic DNA Translation: AAA71947.1
PIRiT11551

3D structure databases

ProteinModelPortaliP42364
SMRiP42364
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi3.A.1.15.2 the atp-binding cassette (abc) superfamily

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DSE Bacteria
COG0803 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR006129 AdhesinB
IPR006128 Lipoprotein_4
IPR006127 ZnuA-like
PfamiView protein in Pfam
PF01297 ZnuA, 1 hit
PRINTSiPR00691 ADHESINB
PR00690 ADHESNFAMILY
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTSA_STRGN
AccessioniPrimary (citable) accession number: P42364
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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