UniProtKB - P42345 (MTOR_HUMAN)
Serine/threonine-protein kinase mTOR
MTOR
Functioni
Catalytic activityi
Activity regulationi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- kinase activity Source: MGI
- phosphoprotein binding Source: UniProtKB
- protein domain specific binding Source: Ensembl
- protein kinase activity Source: WormBase
- protein kinase binding Source: Ensembl
- protein serine/threonine kinase activity Source: UniProtKB
- ribosome binding Source: Ensembl
- RNA polymerase III type 1 promoter sequence-specific DNA binding Source: UniProtKB
- RNA polymerase III type 2 promoter sequence-specific DNA binding Source: UniProtKB
- RNA polymerase III type 3 promoter sequence-specific DNA binding Source: UniProtKB
- TFIIIC-class transcription factor complex binding Source: UniProtKB
GO - Biological processi
- 'de novo' pyrimidine nucleobase biosynthetic process Source: Ensembl
- activation of protein kinase B activity Source: Reactome
- anoikis Source: ParkinsonsUK-UCL
- brain development Source: Ensembl
- cardiac muscle cell development Source: Ensembl
- cardiac muscle contraction Source: Ensembl
- cell aging Source: Ensembl
- cell cycle arrest Source: Reactome
- cellular response to amino acid starvation Source: UniProtKB
- cellular response to amino acid stimulus Source: CAFA
- cellular response to hypoxia Source: UniProtKB
- cellular response to leucine Source: CAFA
- cellular response to leucine starvation Source: CAFA
- cellular response to nutrient levels Source: UniProtKB
- cellular response to starvation Source: UniProtKB
- energy reserve metabolic process Source: Ensembl
- germ cell development Source: Ensembl
- heart morphogenesis Source: Ensembl
- heart valve morphogenesis Source: Ensembl
- long-term memory Source: Ensembl
- lysosome organization Source: UniProtKB
- maternal process involved in female pregnancy Source: Ensembl
- mRNA stabilization Source: Ensembl
- multicellular organism growth Source: Ensembl
- negative regulation of autophagy Source: UniProtKB
- negative regulation of calcineurin-NFAT signaling cascade Source: Ensembl
- negative regulation of cell size Source: Ensembl
- negative regulation of cholangiocyte apoptotic process Source: Ensembl
- negative regulation of iodide transmembrane transport Source: Ensembl
- negative regulation of macroautophagy Source: MGI
- negative regulation of muscle atrophy Source: Ensembl
- negative regulation of protein phosphorylation Source: Ensembl
- negative regulation of protein ubiquitination Source: Ensembl
- nucleus localization Source: UniProtKB
- peptidyl-serine phosphorylation Source: UniProtKB
- peptidyl-threonine phosphorylation Source: Ensembl
- phosphorylation Source: UniProtKB
- positive regulation of actin filament polymerization Source: Ensembl
- positive regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
- positive regulation of cholangiocyte proliferation Source: Ensembl
- positive regulation of cytoplasmic translational initiation Source: ARUK-UCL
- positive regulation of dendritic spine development Source: Ensembl
- positive regulation of eating behavior Source: Ensembl
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- positive regulation of gene expression Source: UniProtKB
- positive regulation of glial cell proliferation Source: Ensembl
- positive regulation of granulosa cell proliferation Source: Ensembl
- positive regulation of keratinocyte migration Source: BHF-UCL
- positive regulation of lamellipodium assembly Source: Ensembl
- positive regulation of lipid biosynthetic process Source: UniProtKB
- positive regulation of myotube differentiation Source: Ensembl
- positive regulation of neuron death Source: Ensembl
- positive regulation of neuron maturation Source: Ensembl
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- positive regulation of phosphoprotein phosphatase activity Source: ARUK-UCL
- positive regulation of protein kinase B signaling Source: Ensembl
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of sensory perception of pain Source: Ensembl
- positive regulation of skeletal muscle hypertrophy Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of stress fiber assembly Source: Ensembl
- positive regulation of transcription by RNA polymerase III Source: UniProtKB
- positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: UniProtKB
- positive regulation of translation Source: UniProtKB
- positive regulation of wound healing, spreading of epidermal cells Source: BHF-UCL
- post-embryonic development Source: Ensembl
- protein autophosphorylation Source: MGI
- protein catabolic process Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of brown fat cell differentiation Source: Ensembl
- regulation of carbohydrate utilization Source: Ensembl
- regulation of cell growth Source: UniProtKB
- regulation of cell size Source: CAFA
- regulation of cellular response to heat Source: Reactome
- regulation of circadian rhythm Source: UniProtKB
- regulation of fatty acid beta-oxidation Source: Ensembl
- regulation of glycogen biosynthetic process Source: Ensembl
- regulation of GTPase activity Source: Ensembl
- regulation of locomotor rhythm Source: UniProtKB
- regulation of macroautophagy Source: Reactome
- regulation of membrane permeability Source: Ensembl
- regulation of myelination Source: Ensembl
- regulation of osteoclast differentiation Source: UniProtKB
- regulation of response to food Source: Ensembl
- response to activity Source: Ensembl
- response to amino acid Source: UniProtKB
- response to cocaine Source: Ensembl
- response to insulin Source: Ensembl
- response to morphine Source: Ensembl
- response to nutrient Source: UniProtKB
- response to nutrient levels Source: UniProtKB
- rhythmic process Source: UniProtKB-KW
- ruffle organization Source: Ensembl
- social behavior Source: Ensembl
- spinal cord development Source: Ensembl
- TORC1 signaling Source: UniProtKB
- TOR signaling Source: UniProtKB
- visual learning Source: Ensembl
- voluntary musculoskeletal movement Source: Ensembl
- wound healing Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Biological rhythms |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P42345 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1632852, Macroautophagy R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-3371571, HSF1-dependent transactivation R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer R-HSA-6804757, Regulation of TP53 Degradation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9639288, Amino acids regulate mTORC1 |
SABIO-RKi | P42345 |
SignaLinki | P42345 |
SIGNORi | P42345 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase mTOR (EC:2.7.11.17 Publications)Alternative name(s): FK506-binding protein 12-rapamycin complex-associated protein 1 FKBP12-rapamycin complex-associated protein Mammalian target of rapamycin Short name: mTOR Mechanistic target of rapamycin Rapamycin and FKBP12 target 1 Rapamycin target protein 1 |
Gene namesi | Name:MTOR Synonyms:FRAP, FRAP1, FRAP2, RAFT1, RAPT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198793.12 |
HGNCi | HGNC:3942, MTOR |
MIMi | 601231, gene |
neXtProti | NX_P42345 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
- Microsome membrane 1 Publication
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Nucleus
- PML body By similarity
Lysosome
- Lysosome 3 Publications
- Lysosome membrane 1 Publication
Mitochondrion
- Mitochondrion outer membrane 2 Publications; Peripheral membrane protein 2 Publications; Cytoplasmic side 2 Publications
Other locations
Note: Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113).By similarity4 Publications
Cytosol
- cytosol Source: Reactome
- postsynaptic cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB
- lysosome Source: UniProtKB
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
Nucleus
- nuclear envelope Source: CACAO
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
- PML body Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB
- dendrite Source: Ensembl
- endomembrane system Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- membrane Source: UniProtKB
- neuronal cell body Source: Ensembl
- phagocytic vesicle Source: UniProtKB
- TORC1 complex Source: UniProtKB
- TORC2 complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Lysosome, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, NucleusPathology & Biotechi
Involvement in diseasei
Smith-Kingsmore syndrome (SKS)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078832 | 1490 | W → R in SKS. 1 Publication | 1 | |
Natural variantiVAR_078833 | 1595 | M → I in SKS. 1 PublicationCorresponds to variant dbSNP:rs869312671EnsemblClinVar. | 1 | |
Natural variantiVAR_075072 | 1799 | E → K in SKS; results in increased mTOR signaling. 2 PublicationsCorresponds to variant dbSNP:rs863225264EnsemblClinVar. | 1 | |
Natural variantiVAR_078835 | 1832 | A → T in SKS. 1 PublicationCorresponds to variant dbSNP:rs369088781EnsemblClinVar. | 1 | |
Natural variantiVAR_078836 | 1888 | F → C in SKS. 1 PublicationCorresponds to variant dbSNP:rs869312666EnsemblClinVar. | 1 | |
Natural variantiVAR_078840 | 2327 | M → I in SKS. 1 PublicationCorresponds to variant dbSNP:rs878855328EnsemblClinVar. | 1 |
Focal cortical dysplasia 2 (FCORD2)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078824 | 624 | R → H in FCORD2; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs913197212Ensembl. | 1 | |
Natural variantiVAR_078826 | 1450 | Y → D in FCORD2; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_078827 | 1456 | W → G in FCORD2; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1085307114EnsemblClinVar. | 1 | |
Natural variantiVAR_078828 | 1459 | A → D in FCORD2; somatic mutation; increased TOR signaling. 1 Publication | 1 | |
Natural variantiVAR_078829 | 1459 | A → S in FCORD2; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_078830 | 1460 | L → P in FCORD2; somatic mutation; increased TOR signaling. 2 PublicationsCorresponds to variant dbSNP:rs1057519779EnsemblClinVar. | 1 | |
Natural variantiVAR_078831 | 1483 | C → R in FCORD2; somatic mutation; increased TOR signaling; increased kinase activity. 1 PublicationCorresponds to variant dbSNP:rs1057519914EnsemblClinVar. | 1 | |
Natural variantiVAR_078834 | 1709 | R → H in FCORD2; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777895EnsemblClinVar. | 1 | |
Natural variantiVAR_078837 | 1977 | T → K in FCORD2; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs587777893EnsemblClinVar. | 1 | |
Natural variantiVAR_078838 | 2193 | R → C in FCORD2; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_078839 | 2215 | S → F in FCORD2; somatic mutation; increased TOR signaling. 3 PublicationsCorresponds to variant dbSNP:rs587777894EnsemblClinVar. | 1 | |
Natural variantiVAR_041543 | 2215 | S → Y in FCORD2; also found in a colorectal adenocarcinoma sample; somatic mutation; increased TOR signaling. 3 PublicationsCorresponds to variant dbSNP:rs587777894EnsemblClinVar. | 1 | |
Natural variantiVAR_078841 | 2427 | L → P in FCORD2; somatic mutation; increased TOR signaling; increased kinase activity. 1 PublicationCorresponds to variant dbSNP:rs1085307113EnsemblClinVar. | 1 | |
Natural variantiVAR_078842 | 2427 | L → Q in FCORD2; somatic mutation; increased TOR signaling; increased kinase activity. 1 PublicationCorresponds to variant dbSNP:rs1085307113EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2159 | S → A: Reduces mTORC1-associated S-2481 autophosphorylation; when associated with A-2164. 1 Publication | 1 | |
Mutagenesisi | 2159 | S → D: Stronger phosphorylation of RPS6KB1; when associated with E-2164. 1 Publication | 1 | |
Mutagenesisi | 2164 | T → A: Reduces mTORC1-associated S-2481 autophosphorylation; when associated with A-2159. 1 Publication | 1 | |
Mutagenesisi | 2164 | T → E: Stronger phosphorylation of RPS6KB1; when associated with D-2159. 1 Publication | 1 | |
Mutagenesisi | 2173 | T → A: Increased mTOR kinase activity. 1 Publication | 1 | |
Mutagenesisi | 2340 | H → A: Barely detectable kinase activity. 1 Publication | 1 | |
Mutagenesisi | 2357 | D → E: Kinase-dead mutant, loss of interaction with TM4SF5 and loss of lysosome membrane localization; when associated with I-2364. 1 Publication | 1 | |
Mutagenesisi | 2364 | V → I: Kinase-dead mutant, loss of interaction with TM4SF5 and loss of lysosome membrane localization; when associated with E-2357. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Epilepsy, Mental retardationOrganism-specific databases
DisGeNETi | 2475 |
MalaCardsi | MTOR |
MIMi | 607341, phenotype 616638, phenotype |
OpenTargetsi | ENSG00000198793 |
Orphaneti | 269001, Isolated focal cortical dysplasia type IIa 269008, Isolated focal cortical dysplasia type IIb 457485, Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome |
PharmGKBi | PA28360 |
Miscellaneous databases
Pharosi | P42345, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2842 |
DrugBanki | DB01590, Everolimus DB12010, Fostamatinib DB00337, Pimecrolimus DB06233, Ridaforolimus DB04974, Rimiducid DB05210, SF1126 DB00877, Sirolimus DB06287, Temsirolimus DB05241, XL765 |
DrugCentrali | P42345 |
GuidetoPHARMACOLOGYi | 2109 |
Polymorphism and mutation databases
BioMutai | MTOR |
DMDMi | 1169735 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088808 | 1 – 2549 | Serine/threonine-protein kinase mTORAdd BLAST | 2549 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 567 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1162 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1218 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1261 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 2159 | Phosphoserine1 Publication | 1 | |
Modified residuei | 2164 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 2173 | Phosphothreonine; by PKB/AKT11 Publication | 1 | |
Modified residuei | 2446 | Phosphothreonine; by RPS6KB11 Publication | 1 | |
Modified residuei | 2448 | Phosphoserine; by RPS6KB1Combined sources2 Publications | 1 | |
Modified residuei | 2478 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2481 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-1360 CPTAC-1361 |
EPDi | P42345 |
jPOSTi | P42345 |
MassIVEi | P42345 |
MaxQBi | P42345 |
PaxDbi | P42345 |
PeptideAtlasi | P42345 |
PRIDEi | P42345 |
ProteomicsDBi | 55511 |
PTM databases
iPTMneti | P42345 |
MetOSitei | P42345 |
PhosphoSitePlusi | P42345 |
SwissPalmi | P42345 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198793, Expressed in testis and 180 other tissues |
ExpressionAtlasi | P42345, baseline and differential |
Genevisiblei | P42345, HS |
Organism-specific databases
HPAi | ENSG00000198793, Low tissue specificity |
Interactioni
Subunit structurei
Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC1 complex is a 1 Md obligate dimer of two stoichiometric heterotetramers with overall dimensions of 290 A x 210 A x 135 A. It has a rhomboid shape and a central cavity, the dimeric interfaces are formed by interlocking interactions between the two MTOR and the two RPTOR subunits. The MLST8 subunit forms distal foot-like protuberances, and contacts only one MTOR within the complex, while the small PRAS40 localizes to the midsection of the central core, in close proximity to RPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR.
Interacts with PLPP7 and PML.
Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex.
Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014).
Interacts with UBQLN1.
Interacts with TTI1 and TELO2.
Interacts with CLIP1; phosphorylates and regulates CLIP1.
Interacts with NBN.
Interacts with HTR6 (PubMed:23027611).
Interacts with BRAT1.
Interacts with MEAK7 (via C-terminal domain); the interaction increases upon nutrient stimulation (PubMed:29750193).
Interacts with TM4SF5; the interaction is positively regulated by arginine and is negatively regulated by leucine (PubMed:30956113).
Interacts with GPR137B (PubMed:31036939).
26 PublicationsBinary interactionsi
Hide detailsP42345
GO - Molecular functioni
- identical protein binding Source: IntAct
- phosphoprotein binding Source: UniProtKB
- protein domain specific binding Source: Ensembl
- protein kinase binding Source: Ensembl
- TFIIIC-class transcription factor complex binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108757, 246 interactors |
ComplexPortali | CPX-4402, mTORC2 complex CPX-503, mTORC1 complex |
CORUMi | P42345 |
DIPi | DIP-790N |
IntActi | P42345, 102 interactors |
MINTi | P42345 |
STRINGi | 9606.ENSP00000354558 |
Chemistry databases
BindingDBi | P42345 |
Miscellaneous databases
RNActi | P42345, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P42345 |
SMRi | P42345 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42345 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 16 – 53 | HEAT 1Add BLAST | 38 | |
Repeati | 55 – 99 | HEAT 2Add BLAST | 45 | |
Repeati | 100 – 137 | HEAT 3Add BLAST | 38 | |
Repeati | 138 – 179 | HEAT 4Add BLAST | 42 | |
Repeati | 180 – 220 | HEAT 5Add BLAST | 41 | |
Repeati | 222 – 276 | HEAT 6Add BLAST | 55 | |
Repeati | 277 – 313 | HEAT 7Add BLAST | 37 | |
Repeati | 314 – 364 | HEAT 8Add BLAST | 51 | |
Repeati | 365 – 409 | HEAT 9Add BLAST | 45 | |
Repeati | 410 – 445 | HEAT 10Add BLAST | 36 | |
Repeati | 446 – 494 | HEAT 11Add BLAST | 49 | |
Repeati | 495 – 529 | HEAT 12Add BLAST | 35 | |
Repeati | 530 – 563 | HEAT 13Add BLAST | 34 | |
Repeati | 564 – 596 | HEAT 14Add BLAST | 33 | |
Repeati | 597 – 636 | HEAT 15Add BLAST | 40 | |
Repeati | 637 – 683 | HEAT 16Add BLAST | 47 | |
Repeati | 686 – 724 | HEAT 17Add BLAST | 39 | |
Repeati | 727 – 766 | HEAT 18Add BLAST | 40 | |
Repeati | 769 – 811 | HEAT 19Add BLAST | 43 | |
Repeati | 814 – 853 | HEAT 20Add BLAST | 40 | |
Repeati | 857 – 893 | HEAT 21Add BLAST | 37 | |
Repeati | 894 – 942 | HEAT 22Add BLAST | 49 | |
Repeati | 943 – 988 | HEAT 23Add BLAST | 46 | |
Repeati | 989 – 1027 | HEAT 24Add BLAST | 39 | |
Repeati | 1029 – 1068 | HEAT 25Add BLAST | 40 | |
Repeati | 1069 – 1105 | HEAT 26Add BLAST | 37 | |
Repeati | 1106 – 1144 | HEAT 27Add BLAST | 39 | |
Repeati | 1145 – 1188 | HEAT 28Add BLAST | 44 | |
Repeati | 1189 – 1225 | HEAT 29Add BLAST | 37 | |
Repeati | 1226 – 1273 | HEAT 30Add BLAST | 48 | |
Repeati | 1274 – 1311 | HEAT 31Add BLAST | 38 | |
Repeati | 1312 – 1345 | HEAT 32Add BLAST | 34 | |
Repeati | 1346 – 1382 | TPR 1Add BLAST | 37 | |
Domaini | 1382 – 1982 | FATPROSITE-ProRule annotationAdd BLAST | 601 | |
Repeati | 1383 – 1408 | TPR 2Add BLAST | 26 | |
Repeati | 1409 – 1442 | TPR 3Add BLAST | 34 | |
Repeati | 1443 – 1473 | TPR 4Add BLAST | 31 | |
Repeati | 1474 – 1507 | TPR 5Add BLAST | 34 | |
Repeati | 1508 – 1541 | TPR 6Add BLAST | 34 | |
Repeati | 1542 – 1574 | TPR 7Add BLAST | 33 | |
Repeati | 1575 – 1614 | TPR 8Add BLAST | 40 | |
Repeati | 1615 – 1649 | TPR 9Add BLAST | 35 | |
Repeati | 1650 – 1693 | TPR 10Add BLAST | 44 | |
Repeati | 1694 – 1731 | TPR 11Add BLAST | 38 | |
Repeati | 1732 – 1786 | TPR 12Add BLAST | 55 | |
Repeati | 1787 – 1846 | TPR 13Add BLAST | 60 | |
Repeati | 1898 – 1930 | TPR 14Add BLAST | 33 | |
Repeati | 1931 – 1970 | TPR 15Add BLAST | 40 | |
Repeati | 1971 – 2005 | TPR 16Add BLAST | 35 | |
Domaini | 2182 – 2516 | PI3K/PI4KPROSITE-ProRule annotationAdd BLAST | 335 | |
Domaini | 2517 – 2549 | FATCPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 651 | Interaction with NBN1 PublicationAdd BLAST | 651 | |
Regioni | 2012 – 2144 | Sufficient for interaction with the FKBP1A/rapamycin complexBy similarityAdd BLAST | 133 | |
Regioni | 2258 – 2296 | Interaction with MLST8Add BLAST | 39 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG0891, Eukaryota |
GeneTreei | ENSGT00930000151037 |
HOGENOMi | CLU_000178_7_1_1 |
InParanoidi | P42345 |
OMAi | LNIQRYP |
OrthoDBi | 26975at2759 |
PhylomeDBi | P42345 |
TreeFami | TF105134 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.20.120.150, 1 hit 1.25.10.10, 4 hits 1.25.40.10, 1 hit |
IDEALi | IID00598 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR024585, DUF3385_TOR IPR003152, FATC_dom IPR009076, FRB_dom IPR036738, FRB_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR026683, TOR IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR11139:SF9, PTHR11139:SF9, 1 hit |
Pfami | View protein in Pfam PF11865, DUF3385, 1 hit PF02259, FAT, 1 hit PF02260, FATC, 1 hit PF08771, FRB_dom, 1 hit PF00454, PI3_PI4_kinase, 1 hit |
SMARTi | View protein in SMART SM01346, DUF3385, 1 hit SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF47212, SSF47212, 1 hit SSF48371, SSF48371, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MLGTGPAAAT TAATTSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM
60 70 80 90 100
ELREMSQEES TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN
110 120 130 140 150
ATRIGRFANY LRNLLPSNDP VVMEMASKAI GRLAMAGDTF TAEYVEFEVK
160 170 180 190 200
RALEWLGADR NEGRRHAAVL VLRELAISVP TFFFQQVQPF FDNIFVAVWD
210 220 230 240 250
PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE AEKGFDETLA
260 270 280 290 300
KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC
310 320 330 340 350
KDLMGFGTKP RHITPFTSFQ AVQPQQSNAL VGLLGYSSHQ GLMGFGTSPS
360 370 380 390 400
PAKSTLVESR CCRDLMEEKF DQVCQWVLKC RNSKNSLIQM TILNLLPRLA
410 420 430 440 450
AFRPSAFTDT QYLQDTMNHV LSCVKKEKER TAAFQALGLL SVAVRSEFKV
460 470 480 490 500
YLPRVLDIIR AALPPKDFAH KRQKAMQVDA TVFTCISMLA RAMGPGIQQD
510 520 530 540 550
IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL KMLSLVLMHK
560 570 580 590 600
PLRHPGMPKG LAHQLASPGL TTLPEASDVG SITLALRTLG SFEFEGHSLT
610 620 630 640 650
QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ
660 670 680 690 700
VVADVLSKLL VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL
710 720 730 740 750
NDQVFEIREL AICTVGRLSS MNPAFVMPFL RKMLIQILTE LEHSGIGRIK
760 770 780 790 800
EQSARMLGHL VSNAPRLIRP YMEPILKALI LKLKDPDPDP NPGVINNVLA
810 820 830 840 850
TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA LWTLGQLVAS
860 870 880 890 900
TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK
910 920 930 940 950
VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV
960 970 980 990 1000
SMVALMRIFR DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV
1010 1020 1030 1040 1050
IRVCDGAIRE FLFQQLGMLV SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS
1060 1070 1080 1090 1100
TIILLIEQIV VALGGEFKLY LPQLIPHMLR VFMHDNSPGR IVSIKLLAAI
1110 1120 1130 1140 1150
QLFGANLDDY LHLLLPPIVK LFDAPEAPLP SRKAALETVD RLTESLDFTD
1160 1170 1180 1190 1200
YASRIIHPIV RTLDQSPELR STAMDTLSSL VFQLGKKYQI FIPMVNKVLV
1210 1220 1230 1240 1250
RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSG QGDALASGPV
1260 1270 1280 1290 1300
ETGPMKKLHV STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL
1310 1320 1330 1340 1350
RSCWALAQAY NPMARDLFNA AFVSCWSELN EDQQDELIRS IELALTSQDI
1360 1370 1380 1390 1400
AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI VLLGERAAKC RAYAKALHYK
1410 1420 1430 1440 1450
ELEFQKGPTP AILESLISIN NKLQQPEAAA GVLEYAMKHF GELEIQATWY
1460 1470 1480 1490 1500
EKLHEWEDAL VAYDKKMDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK
1510 1520 1530 1540 1550
WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL
1560 1570 1580 1590 1600
ALHQDLFSLA QQCIDKARDL LDAELTAMAG ESYSRAYGAM VSCHMLSELE
1610 1620 1630 1640 1650
EVIQYKLVPE RREIIRQIWW ERLQGCQRIV EDWQKILMVR SLVVSPHEDM
1660 1670 1680 1690 1700
RTWLKYASLC GKSGRLALAH KTLVLLLGVD PSRQLDHPLP TVHPQVTYAY
1710 1720 1730 1740 1750
MKNMWKSARK IDAFQHMQHF VQTMQQQAQH AIATEDQQHK QELHKLMARC
1760 1770 1780 1790 1800
FLKLGEWQLN LQGINESTIP KVLQYYSAAT EHDRSWYKAW HAWAVMNFEA
1810 1820 1830 1840 1850
VLHYKHQNQA RDEKKKLRHA SGANITNATT AATTAATATT TASTEGSNSE
1860 1870 1880 1890 1900
SEAESTENSP TPSPLQKKVT EDLSKTLLMY TVPAVQGFFR SISLSRGNNL
1910 1920 1930 1940 1950
QDTLRVLTLW FDYGHWPDVN EALVEGVKAI QIDTWLQVIP QLIARIDTPR
1960 1970 1980 1990 2000
PLVGRLIHQL LTDIGRYHPQ ALIYPLTVAS KSTTTARHNA ANKILKNMCE
2010 2020 2030 2040 2050
HSNTLVQQAM MVSEELIRVA ILWHEMWHEG LEEASRLYFG ERNVKGMFEV
2060 2070 2080 2090 2100
LEPLHAMMER GPQTLKETSF NQAYGRDLME AQEWCRKYMK SGNVKDLTQA
2110 2120 2130 2140 2150
WDLYYHVFRR ISKQLPQLTS LELQYVSPKL LMCRDLELAV PGTYDPNQPI
2160 2170 2180 2190 2200
IRIQSIAPSL QVITSKQRPR KLTLMGSNGH EFVFLLKGHE DLRQDERVMQ
2210 2220 2230 2240 2250
LFGLVNTLLA NDPTSLRKNL SIQRYAVIPL STNSGLIGWV PHCDTLHALI
2260 2270 2280 2290 2300
RDYREKKKIL LNIEHRIMLR MAPDYDHLTL MQKVEVFEHA VNNTAGDDLA
2310 2320 2330 2340 2350
KLLWLKSPSS EVWFDRRTNY TRSLAVMSMV GYILGLGDRH PSNLMLDRLS
2360 2370 2380 2390 2400
GKILHIDFGD CFEVAMTREK FPEKIPFRLT RMLTNAMEVT GLDGNYRITC
2410 2420 2430 2440 2450
HTVMEVLREH KDSVMAVLEA FVYDPLLNWR LMDTNTKGNK RSRTRTDSYS
2460 2470 2480 2490 2500
AGQSVEILDG VELGEPAHKK TGTTVPESIH SFIGDGLVKP EALNKKAIQI
2510 2520 2530 2540
INRVRDKLTG RDFSHDDTLD VPTQVELLIK QATSHENLCQ CYIGWCPFW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AKP8 | B1AKP8_HUMAN | Non-specific serine/threonine prote... | MTOR | 754 | Annotation score: | ||
B1AKQ2 | B1AKQ2_HUMAN | Serine/threonine-protein kinase mTO... | MTOR | 161 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 353 | K → N in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 359 | S → N in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 364 | D → N in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 390 | M → L in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 430 | R → L in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 455 – 457 | VLD → GVE in AAC39933 (PubMed:9653645).Curated | 3 | |
Sequence conflicti | 461 | A → G in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 482 – 484 | VFT → FFN in AAC39933 (PubMed:9653645).Curated | 3 | |
Sequence conflicti | 489 | L → V in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 513 | L → I in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 539 | L → V in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 553 | R → C in AAC39933 (PubMed:9653645).Curated | 1 | |
Sequence conflicti | 857 | P → L in BAE06077 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1075 | I → S in AAC39933 (PubMed:9653645).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041537 | 8 | A → S in a lung large cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041538 | 135 | M → T in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_078824 | 624 | R → H in FCORD2; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs913197212Ensembl. | 1 | |
Natural variantiVAR_041539 | 1083 | M → V1 PublicationCorresponds to variant dbSNP:rs56164650EnsemblClinVar. | 1 | |
Natural variantiVAR_041540 | 1134 | A → V1 PublicationCorresponds to variant dbSNP:rs28730685EnsemblClinVar. | 1 | |
Natural variantiVAR_041541 | 1178 | S → F1 Publication |