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UniProtKB - P42331 (RHG25_HUMAN)

Entry version 175 (10 Feb 2021)
Sequence version 2 (26 May 2009)
Previous versions | rss
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Protein

Rho GTPase-activating protein 25

Gene

ARHGAP25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P42331

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-194840, Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 25
Alternative name(s):
Rho-type GTPase-activating protein 25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP25
Synonyms:KIAA0053
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28951, ARHGAP25

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610587, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P42331

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163219.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9938

Open Targets

More...OpenTargetsi		ENSG00000163219

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134941737

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P42331, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARHGAP25

Domain mapping of disease mutations (DMDM)

More...DMDMi		238054314

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567161 – 645Rho GTPase-activating protein 25Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei362PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei406PhosphothreonineBy similarity1
Modified residuei536PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P42331

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P42331

MaxQB - The MaxQuant DataBase

More...MaxQBi		P42331

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P42331

PeptideAtlas

More...PeptideAtlasi		P42331

PRoteomics IDEntifications database

More...PRIDEi		P42331

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20155
33928
55505 [P42331-1]
55506 [P42331-2]
55507 [P42331-3]
55508 [P42331-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P42331

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P42331

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P42331

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163219, Expressed in blood and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P42331, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P42331, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163219, Group enriched (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115264, 30 interactors

Protein interaction database and analysis system

More...IntActi		P42331, 25 interactors

Molecular INTeraction database

More...MINTi		P42331

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386911

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P42331, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1645
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P42331

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P42331

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 151PHPROSITE-ProRule annotationAdd BLAST106
Domaini159 – 353Rho-GAPPROSITE-ProRule annotationAdd BLAST195

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili541 – 644Sequence analysisAdd BLAST104

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4270, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020795_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P42331

Identification of Orthologs from Complete Genome Data

More...OMAi		DVKPQGC

Database of Orthologous Groups

More...OrthoDBi		917149at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P42331

TreeFam database of animal gene trees

More...TreeFami		TF323577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P42331-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLKLPRNWD FNLKVEAAKI ARSRSVMTGE QMAAFHPSST PNPLERPIKM 
        60         70         80         90        100
GWLKKQRSIV KNWQQRYFVL RAQQLYYYKD EEDTKPQGCM YLPGCTIKEI 
       110        120        130        140        150
ATNPEEAGKF VFEIIPASWD QNRMGQDSYV LMASSQAEME EWVKFLRRVA 
       160        170        180        190        200
GTPCGVFGQR LDETVAYEQK FGPHLVPILV EKCAEFILEH GRNEEGIFRL 
       210        220        230        240        250
PGQDNLVKQL RDAFDAGERP SFDRDTDVHT VASLLKLYLR DLPEPVVPWS 
       260        270        280        290        300
QYEGFLLCGQ LTNADEAKAQ QELMKQLSIL PRDNYSLLSY ICRFLHEIQL 
       310        320        330        340        350
NCAVNKMSVD NLATVIGVNL IRSKVEDPAV IMRGTPQIQR VMTMMIRDHE 
       360        370        380        390        400
VLFPKSKDIP LSPPAQKNDP KKAPVARSSV GWDATEDLRI SRTDSFSSMT 
       410        420        430        440        450
SDSDTTSPTG QQPSDAFPED SSKVPREKPG DWKMQSRKRT QTLPNRKCFL 
       460        470        480        490        500
TSAFQGANSS KMEIFKNEFW SPSSEAKAGE GHRRTMSQDL RQLSDSQRTS 
       510        520        530        540        550
TYDNVPSLPG SPGEEASALS SQACDSKGDT LASPNSETGP GKKNSGEEEI 
       560        570        580        590        600
DSLQRMVQEL RKEIETQKQM YEEQIKNLEK ENYDVWAKVV RLNEELEKEK 
       610        620        630        640 
KKSAALEISL RNMERSREDV EKRNKALEEE VKEFVKSMKE PKTEA
Length:645
Mass (Da):73,435
Last modified:May 26, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D54323CA5571754
GO
Isoform 2 (identifier: P42331-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MSLKLPRNWDFNLKVEAAK → MSLGQSACLFLS
     155-155: G → GA
     400-645: TSDSDTTSPT...KSMKEPKTEA → VRCREPSCFH...LSKSSFYWHL

Show »
Length:458
Mass (Da):51,779
Checksum:i73BC028BC8A2923E
GO
Isoform 3 (identifier: P42331-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MSLKLPRNWDFNLKVEAAK → MSLGQSACLFLS

Show »
Length:638
Mass (Da):72,431
Checksum:i0B2897FB44880871
GO
Isoform 4 (identifier: P42331-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-155: G → GA

Show »
Length:646
Mass (Da):73,506
Checksum:i975E9D31C3740E42
GO
Isoform 5 (identifier: P42331-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-155: Missing.

Show »
Length:606
Mass (Da):69,017
Checksum:iC203F76F8BA05A6F
GO
Isoform 6 (identifier: P42331-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MSLKLPRNWDFNLKVEAAK → MSLGQSACLFLS
     155-155: G → GA

Show »
Length:639
Mass (Da):72,502
Checksum:iA618E1940495D15D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4P1H7C4P1_HUMAN
Rho GTPase-activating protein 25
ARHGAP25
505Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JB56C9JB56_HUMAN
Rho GTPase-activating protein 25
ARHGAP25
339Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z8K7B7Z8K7_HUMAN
Rho GTPase-activating protein 25
ARHGAP25
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAV9F8WAV9_HUMAN
Rho GTPase-activating protein 25
ARHGAP25
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDF6F8WDF6_HUMAN
Rho GTPase-activating protein 25
ARHGAP25
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA06125 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049142192R → W. Corresponds to variant dbSNP:rs3749130Ensembl.1
Natural variantiVAR_049143555R → S1 PublicationCorresponds to variant dbSNP:rs4241344Ensembl.1
Natural variantiVAR_049144556M → T1 PublicationCorresponds to variant dbSNP:rs10177248Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0373451 – 19MSLKL…VEAAK → MSLGQSACLFLS in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_045391117 – 155Missing in isoform 5. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_010275155G → GA in isoform 2, isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_010276400 – 645TSDSD…PKTEA → VRCREPSCFHWVLPLVQAIP CKACSRVAIWGVLGDAVAVG AAATDSSEHTLKAWPLSKSS FYWHL in isoform 2. 1 PublicationAdd BLAST246

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D29642 mRNA Translation: BAA06125.2 Different initiation.
AK290396 mRNA Translation: BAF83085.1
AK297056 mRNA Translation: BAH12484.1
AC097495 Genomic DNA No translation available.
AC105054 Genomic DNA No translation available.
AC112700 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99866.1
BC039591 mRNA Translation: AAH39591.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33214.2 [P42331-4]
CCDS46312.1 [P42331-3]
CCDS54363.1 [P42331-5]
CCDS54364.1 [P42331-6]

Protein sequence database of the Protein Information Resource

More...PIRi		C59430

NCBI Reference Sequences

More...RefSeqi		NP_001007232.2, NM_001007231.2 [P42331-4]
NP_001159748.1, NM_001166276.1 [P42331-6]
NP_001159749.1, NM_001166277.1 [P42331-5]
NP_055697.1, NM_014882.2 [P42331-3]
XP_005264732.1, XM_005264675.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000409030; ENSP00000386863; ENSG00000163219 [P42331-3]
ENST00000409202; ENSP00000386911; ENSG00000163219 [P42331-4]
ENST00000409220; ENSP00000386241; ENSG00000163219 [P42331-6]
ENST00000467265; ENSP00000420583; ENSG00000163219 [P42331-5]
ENST00000497079; ENSP00000417139; ENSG00000163219 [P42331-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9938

UCSC genome browser

More...UCSCi		uc002sev.4, human [P42331-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29642 mRNA Translation: BAA06125.2 Different initiation.
AK290396 mRNA Translation: BAF83085.1
AK297056 mRNA Translation: BAH12484.1
AC097495 Genomic DNA No translation available.
AC105054 Genomic DNA No translation available.
AC112700 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99866.1
BC039591 mRNA Translation: AAH39591.1
CCDSiCCDS33214.2 [P42331-4]
CCDS46312.1 [P42331-3]
CCDS54363.1 [P42331-5]
CCDS54364.1 [P42331-6]
PIRiC59430
RefSeqiNP_001007232.2, NM_001007231.2 [P42331-4]
NP_001159748.1, NM_001166276.1 [P42331-6]
NP_001159749.1, NM_001166277.1 [P42331-5]
NP_055697.1, NM_014882.2 [P42331-3]
XP_005264732.1, XM_005264675.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V89NMR-A47-151[»]
SMRiP42331
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115264, 30 interactors
IntActiP42331, 25 interactors
MINTiP42331
STRINGi9606.ENSP00000386911

PTM databases

CarbonylDBiP42331
iPTMnetiP42331
PhosphoSitePlusiP42331

Genetic variation databases

BioMutaiARHGAP25
DMDMi238054314

Proteomic databases

jPOSTiP42331
MassIVEiP42331
MaxQBiP42331
PaxDbiP42331
PeptideAtlasiP42331
PRIDEiP42331
ProteomicsDBi20155
33928
55505 [P42331-1]
55506 [P42331-2]
55507 [P42331-3]
55508 [P42331-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30948, 389 antibodies

Genome annotation databases

EnsembliENST00000409030; ENSP00000386863; ENSG00000163219 [P42331-3]
ENST00000409202; ENSP00000386911; ENSG00000163219 [P42331-4]
ENST00000409220; ENSP00000386241; ENSG00000163219 [P42331-6]
ENST00000467265; ENSP00000420583; ENSG00000163219 [P42331-5]
ENST00000497079; ENSP00000417139; ENSG00000163219 [P42331-2]
GeneIDi9938
KEGGihsa:9938
UCSCiuc002sev.4, human [P42331-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9938
DisGeNETi9938

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARHGAP25
HGNCiHGNC:28951, ARHGAP25
HPAiENSG00000163219, Group enriched (blood, lymphoid tissue)
MIMi610587, gene
neXtProtiNX_P42331
OpenTargetsiENSG00000163219
PharmGKBiPA134941737
VEuPathDBiHostDB:ENSG00000163219.11

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4270, Eukaryota
GeneTreeiENSGT00950000183015
HOGENOMiCLU_020795_1_0_1
InParanoidiP42331
OMAiDVKPQGC
OrthoDBi917149at2759
PhylomeDBiP42331
TreeFamiTF323577

Enzyme and pathway databases

PathwayCommonsiP42331
ReactomeiR-HSA-194840, Rho GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9938, 1 hit in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARHGAP25, human
EvolutionaryTraceiP42331

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9938
PharosiP42331, Tbio

Protein Ontology

More...PROi		PR:P42331
RNActiP42331, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163219, Expressed in blood and 195 other tissues
ExpressionAtlasiP42331, baseline and differential
GenevisibleiP42331, HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG25_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42331
Secondary accession number(s): A8K2Y1
, B7Z498, E9PFQ7, G5E9G2, Q8IXQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 26, 2009
Last modified: February 10, 2021
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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