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Protein

Aldo-keto reductase family 1 member C3

Gene

AKR1C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

Catalytic activityi

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.
A 3-alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H.5 Publications
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.5 Publications
Testosterone + NAD+ = androstenedione + NADH.5 Publications
Testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH.5 Publications
Indan-1-ol + NAD(P)+ = indanone + NAD(P)H.

Activity regulationi

Strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. Also inhibited by the flavinoid, rutin, and by selective serotonin inhibitors (SSRIs).

Kineticsi

  1. KM=142.1 µM for progesterone1 Publication
  2. KM=2.37 µM for 5-alpha-dihydrotestosterone1 Publication
  3. KM=1.0 µM for androstanediol1 Publication
  1. Vmax=20.1 nmol/min/mg enzyme with progesterone as substrate1 Publication
  2. Vmax=1.8 nmol/min/mg enzyme with 5-alpha-dihydrotestosterone as substrate1 Publication
  3. Vmax=4.4 nmol/min/mg enzyme with androstanediol as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei54Important for substrate specificityBy similarity1
Active sitei55Proton donorBy similarity1
Sitei84Lowers pKa of active site TyrBy similarity1
Binding sitei117SubstrateBy similarity1
Sitei227Involved in ligand recognition and product release1
Sitei306Involved in ligand recognition and product release1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 22NADPSequence analysis10
Nucleotide bindingi217 – 280NADPBy similarityAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS03054-MONOMER
BRENDAi1.1.1.188 2681
1.1.1.21 2681
1.1.1.213 2681
1.1.1.239 2681
1.1.1.357 2681
1.1.1.64 2681
1.3.1.20 2681
ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-5365859 RA biosynthesis pathway
R-HSA-975634 Retinoid metabolism and transport
SABIO-RKiP42330
SIGNORiP42330

Chemistry databases

SwissLipidsiSLP:000000804
SLP:000001647 [P42330-1]

Names & Taxonomyi

Protein namesi
Recommended name:
Aldo-keto reductase family 1 member C3 (EC:1.-.-.-)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 5
Short name:
17-beta-HSD 5
3-alpha-HSD type II, brain
3-alpha-hydroxysteroid dehydrogenase type 2 (EC:1.1.1.3575 Publications)
Short name:
3-alpha-HSD type 2
Chlordecone reductase homolog HAKRb
Dihydrodiol dehydrogenase 3
Short name:
DD-3
Short name:
DD3
Dihydrodiol dehydrogenase type I
HA1753
Indanol dehydrogenase (EC:1.1.1.112)
Prostaglandin F synthase (EC:1.1.1.1885 Publications)
Short name:
PGFS
Testosterone 17-beta-dehydrogenase 5 (EC:1.1.1.2395 Publications, EC:1.1.1.645 Publications)
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
Gene namesi
Name:AKR1C3
Synonyms:DDH1, HSD17B5, KIAA0119, PGFS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000196139.12
HGNCiHGNC:386 AKR1C3
MIMi603966 gene
neXtProtiNX_P42330

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi75K → E: No effect on 17beta-HSD activity. 1 Publication1

Organism-specific databases

DisGeNETi8644
OpenTargetsiENSG00000196139
PharmGKBiPA24679

Chemistry databases

ChEMBLiCHEMBL4681
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB01536 4-Androstenedione
DB00905 Bimatoprost
DB00997 Doxorubicin
DB02266 Flufenamic Acid
DB00157 NADH
DB01698 Rutin
GuidetoPHARMACOLOGYi1382

Polymorphism and mutation databases

BioMutaiAKR1C3
DMDMi308153646

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246381 – 323Aldo-keto reductase family 1 member C3Add BLAST323

Proteomic databases

EPDiP42330
MaxQBiP42330
PaxDbiP42330
PeptideAtlasiP42330
PRIDEiP42330
ProteomicsDBi55504

2D gel databases

DOSAC-COBS-2DPAGEiP42330

PTM databases

iPTMnetiP42330
PhosphoSitePlusiP42330

Expressioni

Tissue specificityi

Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.6 Publications

Gene expression databases

BgeeiENSG00000196139 Expressed in 88 organ(s), highest expression level in right lobe of liver
CleanExiHS_AKR1C3
ExpressionAtlasiP42330 baseline and differential
GenevisibleiP42330 HS

Organism-specific databases

HPAiCAB010874
HPA068265

Interactioni

Protein-protein interaction databases

BioGridi114196, 9 interactors
IntActiP42330, 5 interactors
STRINGi9606.ENSP00000369927

Chemistry databases

BindingDBiP42330

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP42330
SMRiP42330
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42330

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOVERGENiHBG000020
InParanoidiP42330
KOiK04119
OrthoDBiEOG091G0D69
PhylomeDBiP42330
TreeFamiTF106492

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P42330-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID
60 70 80 90 100
SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE
110 120 130 140 150
NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA
160 170 180 190 200
MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS
210 220 230 240 250
KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR
260 270 280 290 300
TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD
310 320
RNLHYFNSDS FASHPNYPYS DEY
Length:323
Mass (Da):36,853
Last modified:October 5, 2010 - v4
Checksum:i86A7690D9498C6FD
GO
Isoform 2 (identifier: P42330-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,364
Checksum:i02F3AC7C2BB5BF78
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSS8A0A0A0MSS8_HUMAN
Aldo-keto reductase family 1 member...
AKR1C3
323Annotation score:
S4R3Z2S4R3Z2_HUMAN
Aldo-keto reductase family 1 member...
AKR1C3 hCG_19343
300Annotation score:
S4R3D5S4R3D5_HUMAN
Aldo-keto reductase family 1 member...
AKR1C3
155Annotation score:

Sequence cautioni

The sequence BAA04619 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → P no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti6Q → K no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti38T → S in AAF07272 (PubMed:10557352).Curated1
Sequence conflicti75K → E in AAD14011 (PubMed:8274401).Curated1
Sequence conflicti75K → E no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti75K → M in AAB41916 (PubMed:7650035).Curated1
Sequence conflicti89F → S in AAF07272 (PubMed:10557352).Curated1
Sequence conflicti270K → R in AAF07272 (PubMed:10557352).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0132885H → Q7 PublicationsCorresponds to variant dbSNP:rs12529Ensembl.1
Natural variantiVAR_03276766R → Q. Corresponds to variant dbSNP:rs35961894Ensembl.1
Natural variantiVAR_06100177E → G. Corresponds to variant dbSNP:rs11551177Ensembl.1
Natural variantiVAR_032768170R → C. Corresponds to variant dbSNP:rs35575889Ensembl.1
Natural variantiVAR_013289175M → I No effect on 17beta-HSD activity. 3 PublicationsCorresponds to variant dbSNP:rs1131132Ensembl.1
Natural variantiVAR_032769180P → S. Corresponds to variant dbSNP:rs34186955Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557981 – 119Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S68288 mRNA Translation: AAD14011.1
L43839
, L43831, L43832, L43833, L43834, L43835, L43836, L43837, L43838 Genomic DNA Translation: AAB41916.1
AB018580 mRNA Translation: BAA88488.1
AB028065 Genomic DNA Translation: BAA88489.1
AF149416 mRNA Translation: AAF07272.2
AB032157 Genomic DNA Translation: BAA92892.1
D17793 mRNA Translation: BAA04619.2 Different initiation.
BT007286 mRNA Translation: AAP35950.1
AK290365 mRNA Translation: BAF83054.1
AK296829 mRNA Translation: BAG59399.1
AL391427 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86454.1
BC001479 mRNA Translation: AAH01479.1
BC019230 mRNA Translation: AAH19230.1
CCDSiCCDS7063.1 [P42330-1]
PIRiB57407
I73674
RefSeqiNP_001240837.1, NM_001253908.1
NP_003730.4, NM_003739.5 [P42330-1]
UniGeneiHs.78183

Genome annotation databases

EnsembliENST00000380554; ENSP00000369927; ENSG00000196139 [P42330-1]
GeneIDi8644
KEGGihsa:8644
UCSCiuc001ihu.4 human [P42330-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S68288 mRNA Translation: AAD14011.1
L43839
, L43831, L43832, L43833, L43834, L43835, L43836, L43837, L43838 Genomic DNA Translation: AAB41916.1
AB018580 mRNA Translation: BAA88488.1
AB028065 Genomic DNA Translation: BAA88489.1
AF149416 mRNA Translation: AAF07272.2
AB032157 Genomic DNA Translation: BAA92892.1
D17793 mRNA Translation: BAA04619.2 Different initiation.
BT007286 mRNA Translation: AAP35950.1
AK290365 mRNA Translation: BAF83054.1
AK296829 mRNA Translation: BAG59399.1
AL391427 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86454.1
BC001479 mRNA Translation: AAH01479.1
BC019230 mRNA Translation: AAH19230.1
CCDSiCCDS7063.1 [P42330-1]
PIRiB57407
I73674
RefSeqiNP_001240837.1, NM_001253908.1
NP_003730.4, NM_003739.5 [P42330-1]
UniGeneiHs.78183

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RY0X-ray1.69A/B1-323[»]
1RY8X-ray1.69A/B1-323[»]
1S1PX-ray1.20A1-323[»]
1S1RX-ray2.00A1-323[»]
1S2AX-ray1.70A1-323[»]
1S2CX-ray1.80A1-323[»]
1XF0X-ray2.00A1-323[»]
1ZQ5X-ray1.30A1-323[»]
2F38X-ray2.00A1-323[»]
2FGBX-ray1.35A1-323[»]
3R43X-ray2.00A1-323[»]
3R58X-ray2.30A1-323[»]
3R6IX-ray1.95A1-323[»]
3R7MX-ray2.10A1-323[»]
3R8GX-ray1.80A1-323[»]
3R8HX-ray1.90A1-323[»]
3R94X-ray2.01A1-323[»]
3UFYX-ray1.90A1-323[»]
3UG8X-ray1.73A1-323[»]
3UGRX-ray1.65A1-323[»]
3UWEX-ray1.68A1-323[»]
4DBSX-ray1.85A/B1-323[»]
4DBUX-ray2.53A/B1-323[»]
4DBWX-ray1.80A/B1-323[»]
4DZ5X-ray1.70A1-323[»]
4FA3X-ray2.20A1-323[»]
4FALX-ray2.00A1-323[»]
4FAMX-ray2.00A/B1-323[»]
4H7CX-ray1.97A1-323[»]
4HMNX-ray2.40A1-323[»]
4WDTX-ray1.50A1-323[»]
4WDUX-ray1.70A1-323[»]
4WDWX-ray1.94A/B1-323[»]
4WDXX-ray1.64A/B1-323[»]
4WRHX-ray1.60A1-323[»]
4XVDX-ray2.81A/B1-323[»]
4XVEX-ray1.55A1-323[»]
4YVVX-ray2.30A/B1-323[»]
4YVXX-ray2.30A/B1-323[»]
4ZFCX-ray2.00A/B1-323[»]
5HNTX-ray2.00A/C6-320[»]
5HNUX-ray2.00A/C6-320[»]
5JM5X-ray1.99A/B1-323[»]
6F2UX-ray1.88A/B6-319[»]
6F78X-ray1.30A/B6-323[»]
ProteinModelPortaliP42330
SMRiP42330
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114196, 9 interactors
IntActiP42330, 5 interactors
STRINGi9606.ENSP00000369927

Chemistry databases

BindingDBiP42330
ChEMBLiCHEMBL4681
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB01536 4-Androstenedione
DB00905 Bimatoprost
DB00997 Doxorubicin
DB02266 Flufenamic Acid
DB00157 NADH
DB01698 Rutin
GuidetoPHARMACOLOGYi1382
SwissLipidsiSLP:000000804
SLP:000001647 [P42330-1]

PTM databases

iPTMnetiP42330
PhosphoSitePlusiP42330

Polymorphism and mutation databases

BioMutaiAKR1C3
DMDMi308153646

2D gel databases

DOSAC-COBS-2DPAGEiP42330

Proteomic databases

EPDiP42330
MaxQBiP42330
PaxDbiP42330
PeptideAtlasiP42330
PRIDEiP42330
ProteomicsDBi55504

Protocols and materials databases

DNASUi8644
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380554; ENSP00000369927; ENSG00000196139 [P42330-1]
GeneIDi8644
KEGGihsa:8644
UCSCiuc001ihu.4 human [P42330-1]

Organism-specific databases

CTDi8644
DisGeNETi8644
EuPathDBiHostDB:ENSG00000196139.12
GeneCardsiAKR1C3
HGNCiHGNC:386 AKR1C3
HPAiCAB010874
HPA068265
MIMi603966 gene
neXtProtiNX_P42330
OpenTargetsiENSG00000196139
PharmGKBiPA24679
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOVERGENiHBG000020
InParanoidiP42330
KOiK04119
OrthoDBiEOG091G0D69
PhylomeDBiP42330
TreeFamiTF106492

Enzyme and pathway databases

BioCyciMetaCyc:HS03054-MONOMER
BRENDAi1.1.1.188 2681
1.1.1.21 2681
1.1.1.213 2681
1.1.1.239 2681
1.1.1.357 2681
1.1.1.64 2681
1.3.1.20 2681
ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-5365859 RA biosynthesis pathway
R-HSA-975634 Retinoid metabolism and transport
SABIO-RKiP42330
SIGNORiP42330

Miscellaneous databases

ChiTaRSiAKR1C3 human
EvolutionaryTraceiP42330
GeneWikiiAKR1C3
GenomeRNAii8644
PROiPR:P42330
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196139 Expressed in 88 organ(s), highest expression level in right lobe of liver
CleanExiHS_AKR1C3
ExpressionAtlasiP42330 baseline and differential
GenevisibleiP42330 HS

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAK1C3_HUMAN
AccessioniPrimary (citable) accession number: P42330
Secondary accession number(s): A8K2V0
, B4DL37, Q5T2L1, Q96DJ1, Q96KI8, Q99530, Q9UCX1, Q9UII3, Q9UKL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 195 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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