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Entry version 203 (16 Oct 2019)
Sequence version 4 (05 Oct 2010)
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Protein

Aldo-keto reductase family 1 member C3

Gene

AKR1C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. Also inhibited by the flavinoid, rutin, and by selective serotonin inhibitors (SSRIs).

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=142.1 µM for progesterone1 Publication
  2. KM=2.37 µM for 5-alpha-dihydrotestosterone1 Publication
  3. KM=1.0 µM for androstanediol1 Publication
  1. Vmax=20.1 nmol/min/mg enzyme with progesterone as substrate1 Publication
  2. Vmax=1.8 nmol/min/mg enzyme with 5-alpha-dihydrotestosterone as substrate1 Publication
  3. Vmax=4.4 nmol/min/mg enzyme with androstanediol as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei54Important for substrate specificityBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei55Proton donorBy similarity1
Sitei84Lowers pKa of active site TyrBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117SubstrateBy similarity1
Sitei227Involved in ligand recognition and product release1
Sitei306Involved in ligand recognition and product release1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi13 – 22NADPSequence analysis10
Nucleotide bindingi217 – 280NADPBy similarityAdd BLAST64

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03054-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.188 2681
1.1.1.21 2681
1.1.1.213 2681
1.1.1.239 2681
1.1.1.357 2681
1.1.1.64 2681
1.3.1.20 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-5365859 RA biosynthesis pathway
R-HSA-975634 Retinoid metabolism and transport

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P42330

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P42330

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000804
SLP:000001647 [P42330-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldo-keto reductase family 1 member C3 (EC:1.-.-.-)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 5
Short name:
17-beta-HSD 5
3-alpha-HSD type II, brain
3-alpha-hydroxysteroid dehydrogenase type 2 (EC:1.1.1.3575 Publications)
Short name:
3-alpha-HSD type 2
Chlordecone reductase homolog HAKRb
Dihydrodiol dehydrogenase 3
Short name:
DD-3
Short name:
DD3
Dihydrodiol dehydrogenase type I
HA1753
Indanol dehydrogenase (EC:1.1.1.112)
Prostaglandin F synthase (EC:1.1.1.1885 Publications)
Short name:
PGFS
Testosterone 17-beta-dehydrogenase 5 (EC:1.1.1.2395 Publications, EC:1.1.1.645 Publications)
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKR1C3
Synonyms:DDH1, HSD17B5, KIAA0119, PGFS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:386 AKR1C3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603966 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P42330

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi75K → E: No effect on 17beta-HSD activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8644

Open Targets

More...
OpenTargetsi
ENSG00000196139

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24679

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P42330

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4681

Drug and drug target database

More...
DrugBanki
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB07700 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN
DB01536 Androstenedione
DB00997 Doxorubicin
DB02266 Flufenamic Acid
DB13751 Glycyrrhizic acid
DB00328 Indometacin
DB00461 Nabumetone
DB00157 NADH
DB02056 Prostaglandin D2
DB01698 Rutin

DrugCentral

More...
DrugCentrali
P42330

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1382

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AKR1C3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153646

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001246381 – 323Aldo-keto reductase family 1 member C3Add BLAST323

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P42330

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P42330

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P42330

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P42330

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P42330

PeptideAtlas

More...
PeptideAtlasi
P42330

PRoteomics IDEntifications database

More...
PRIDEi
P42330

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4506
55504 [P42330-1]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P42330

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P42330

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P42330

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P42330

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.6 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196139 Expressed in 88 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P42330 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P42330 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010874
HPA068265

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114196, 11 interactors

Protein interaction database and analysis system

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IntActi
P42330, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369927

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P42330

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P42330

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P42330

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1577 Eukaryota
COG0656 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163208

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P42330

KEGG Orthology (KO)

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KOi
K04119

Database of Orthologous Groups

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OrthoDBi
1016440at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P42330

TreeFam database of animal gene trees

More...
TreeFami
TF106492

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06660 Aldo_ket_red, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11732 PTHR11732, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00248 Aldo_ket_red, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000097 AKR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00069 ALDKETRDTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51430 SSF51430, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P42330-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID
60 70 80 90 100
SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE
110 120 130 140 150
NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA
160 170 180 190 200
MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS
210 220 230 240 250
KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR
260 270 280 290 300
TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD
310 320
RNLHYFNSDS FASHPNYPYS DEY
Length:323
Mass (Da):36,853
Last modified:October 5, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86A7690D9498C6FD
GO
Isoform 2 (identifier: P42330-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,364
Checksum:i02F3AC7C2BB5BF78
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSS8A0A0A0MSS8_HUMAN
Aldo-keto reductase family 1 member...
AKR1C3
323Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3Z2S4R3Z2_HUMAN
Aldo-keto reductase family 1 member...
AKR1C3 hCG_19343
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3D5S4R3D5_HUMAN
Aldo-keto reductase family 1 member...
AKR1C3
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA04619 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3S → P no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti6Q → K no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti38T → S in AAF07272 (PubMed:10557352).Curated1
Sequence conflicti75K → E in AAD14011 (PubMed:8274401).Curated1
Sequence conflicti75K → E no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti75K → M in AAB41916 (PubMed:7650035).Curated1
Sequence conflicti89F → S in AAF07272 (PubMed:10557352).Curated1
Sequence conflicti270K → R in AAF07272 (PubMed:10557352).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0132885H → Q7 PublicationsCorresponds to variant dbSNP:rs12529Ensembl.1
Natural variantiVAR_03276766R → Q. Corresponds to variant dbSNP:rs35961894Ensembl.1
Natural variantiVAR_06100177E → G. Corresponds to variant dbSNP:rs11551177Ensembl.1
Natural variantiVAR_032768170R → C. Corresponds to variant dbSNP:rs35575889Ensembl.1
Natural variantiVAR_013289175M → I No effect on 17beta-HSD activity. 3 PublicationsCorresponds to variant dbSNP:rs1131132Ensembl.1
Natural variantiVAR_032769180P → S. Corresponds to variant dbSNP:rs34186955Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557981 – 119Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S68288 mRNA Translation: AAD14011.1
L43839
, L43831, L43832, L43833, L43834, L43835, L43836, L43837, L43838 Genomic DNA Translation: AAB41916.1
AB018580 mRNA Translation: BAA88488.1
AB028065 Genomic DNA Translation: BAA88489.1
AF149416 mRNA Translation: AAF07272.2
AB032157 Genomic DNA Translation: BAA92892.1
D17793 mRNA Translation: BAA04619.2 Different initiation.
BT007286 mRNA Translation: AAP35950.1
AK290365 mRNA Translation: BAF83054.1
AK296829 mRNA Translation: BAG59399.1
AL391427 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86454.1
BC001479 mRNA Translation: AAH01479.1
BC019230 mRNA Translation: AAH19230.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7063.1 [P42330-1]

Protein sequence database of the Protein Information Resource

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PIRi
B57407
I73674

NCBI Reference Sequences

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RefSeqi
NP_001240837.1, NM_001253908.1
NP_003730.4, NM_003739.5 [P42330-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000380554; ENSP00000369927; ENSG00000196139 [P42330-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8644

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8644

UCSC genome browser

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UCSCi
uc001ihu.4 human [P42330-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S68288 mRNA Translation: AAD14011.1
L43839
, L43831, L43832, L43833, L43834, L43835, L43836, L43837, L43838 Genomic DNA Translation: AAB41916.1
AB018580 mRNA Translation: BAA88488.1
AB028065 Genomic DNA Translation: BAA88489.1
AF149416 mRNA Translation: AAF07272.2
AB032157 Genomic DNA Translation: BAA92892.1
D17793 mRNA Translation: BAA04619.2 Different initiation.
BT007286 mRNA Translation: AAP35950.1
AK290365 mRNA Translation: BAF83054.1
AK296829 mRNA Translation: BAG59399.1
AL391427 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86454.1
BC001479 mRNA Translation: AAH01479.1
BC019230 mRNA Translation: AAH19230.1
CCDSiCCDS7063.1 [P42330-1]
PIRiB57407
I73674
RefSeqiNP_001240837.1, NM_001253908.1
NP_003730.4, NM_003739.5 [P42330-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RY0X-ray1.69A/B1-323[»]
1RY8X-ray1.69A/B1-323[»]
1S1PX-ray1.20A1-323[»]
1S1RX-ray2.00A1-323[»]
1S2AX-ray1.70A1-323[»]
1S2CX-ray1.80A1-323[»]
1XF0X-ray2.00A1-323[»]
1ZQ5X-ray1.30A1-323[»]
2F38X-ray2.00A1-323[»]
2FGBX-ray1.35A1-323[»]
3R43X-ray2.00A1-323[»]
3R58X-ray2.30A1-323[»]
3R6IX-ray1.95A1-323[»]
3R7MX-ray2.10A1-323[»]
3R8GX-ray1.80A1-323[»]
3R8HX-ray1.90A1-323[»]
3R94X-ray2.01A1-323[»]
3UFYX-ray1.90A1-323[»]
3UG8X-ray1.73A1-323[»]
3UGRX-ray1.65A1-323[»]
3UWEX-ray1.68A1-323[»]
4DBSX-ray1.85A/B1-323[»]
4DBUX-ray2.53A/B1-323[»]
4DBWX-ray1.80A/B1-323[»]
4DZ5X-ray1.70A1-323[»]
4FA3X-ray2.20A1-323[»]
4FALX-ray2.00A1-323[»]
4FAMX-ray2.00A/B1-323[»]
4H7CX-ray1.97A1-323[»]
4HMNX-ray2.40A1-323[»]
4WDTX-ray1.50A1-323[»]
4WDUX-ray1.70A1-323[»]
4WDWX-ray1.94A/B1-323[»]
4WDXX-ray1.64A/B1-323[»]
4WRHX-ray1.60A1-323[»]
4XVDX-ray2.81A/B1-323[»]
4XVEX-ray1.55A1-323[»]
4YVVX-ray2.30A/B1-323[»]
4YVXX-ray2.30A/B1-323[»]
4ZFCX-ray2.00A/B1-323[»]
5HNTX-ray2.00A/C6-320[»]
5HNUX-ray2.00A/C6-320[»]
5JM5X-ray1.99A/B1-323[»]
6A7BX-ray2.37A/B1-323[»]
6F2UX-ray1.88A/B6-319[»]
6F78X-ray1.30A/B6-323[»]
6GXKX-ray1.70A/B6-323[»]
SMRiP42330
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114196, 11 interactors
IntActiP42330, 9 interactors
STRINGi9606.ENSP00000369927

Chemistry databases

BindingDBiP42330
ChEMBLiCHEMBL4681
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB07700 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN
DB01536 Androstenedione
DB00997 Doxorubicin
DB02266 Flufenamic Acid
DB13751 Glycyrrhizic acid
DB00328 Indometacin
DB00461 Nabumetone
DB00157 NADH
DB02056 Prostaglandin D2
DB01698 Rutin
DrugCentraliP42330
GuidetoPHARMACOLOGYi1382
SwissLipidsiSLP:000000804
SLP:000001647 [P42330-1]

PTM databases

iPTMnetiP42330
PhosphoSitePlusiP42330
SwissPalmiP42330

Polymorphism and mutation databases

BioMutaiAKR1C3
DMDMi308153646

2D gel databases

DOSAC-COBS-2DPAGEiP42330

Proteomic databases

EPDiP42330
jPOSTiP42330
MassIVEiP42330
MaxQBiP42330
PaxDbiP42330
PeptideAtlasiP42330
PRIDEiP42330
ProteomicsDBi4506
55504 [P42330-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8644

Genome annotation databases

EnsembliENST00000380554; ENSP00000369927; ENSG00000196139 [P42330-1]
GeneIDi8644
KEGGihsa:8644
UCSCiuc001ihu.4 human [P42330-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8644
DisGeNETi8644

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AKR1C3
HGNCiHGNC:386 AKR1C3
HPAiCAB010874
HPA068265
MIMi603966 gene
neXtProtiNX_P42330
OpenTargetsiENSG00000196139
PharmGKBiPA24679

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00940000163208
InParanoidiP42330
KOiK04119
OrthoDBi1016440at2759
PhylomeDBiP42330
TreeFamiTF106492

Enzyme and pathway databases

BioCyciMetaCyc:HS03054-MONOMER
BRENDAi1.1.1.188 2681
1.1.1.21 2681
1.1.1.213 2681
1.1.1.239 2681
1.1.1.357 2681
1.1.1.64 2681
1.3.1.20 2681
ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-5365859 RA biosynthesis pathway
R-HSA-975634 Retinoid metabolism and transport
SABIO-RKiP42330
SIGNORiP42330

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AKR1C3 human
EvolutionaryTraceiP42330

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AKR1C3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8644
PharosiP42330

Protein Ontology

More...
PROi
PR:P42330

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196139 Expressed in 88 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP42330 baseline and differential
GenevisibleiP42330 HS

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1C3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42330
Secondary accession number(s): A8K2V0
, B4DL37, Q5T2L1, Q96DJ1, Q96KI8, Q99530, Q9UCX1, Q9UII3, Q9UKL9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 5, 2010
Last modified: October 16, 2019
This is version 203 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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