UniProtKB - P42329 (ALDH_GEOSE)
Protein
Aldehyde dehydrogenase, thermostable
Gene
aldHT
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Functioni
Oxidizes several aliphatic aldehydes, particularly c6-aliphatic aldehyde and hexanal, but does not oxidize benzaldehyde.
Catalytic activityi
Temperature dependencei
Optimum temperature is 55-60 degrees Celsius.
: ethanol degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Aldehyde dehydrogenase, Aldehyde dehydrogenase, thermostable (aldHT)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 255 | By similarity | 1 | |
Active sitei | 289 | By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 233 – 238 | NADBy similarity | 6 |
GO - Molecular functioni
- aldehyde dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC
GO - Biological processi
- ethanol catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
UniPathwayi | UPA00780;UER00768 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:aldHT |
Organismi | Geobacillus stearothermophilus (Bacillus stearothermophilus) |
Taxonomic identifieri | 1422 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056442 | 1 – 488 | Aldehyde dehydrogenase, thermostableAdd BLAST | 488 |
Interactioni
Subunit structurei
Homotetramer.
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
P42329-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVQTEIKTY FNYINGNWVS SVSNNVEPSI NPANRHDIVG YVQRSTLEDV
60 70 80 90 100
NEAVTAANEA QTSWWKRSGV ERGEYLYKAA HILEQCLQDI AETMTREMGK
110 120 130 140 150
TLAEAKAETM RGVHILRYYA GEGARKIGDV IPSSDSEGLL FTTRVPLGVV
160 170 180 190 200
GVISPWNFPV AIPIWKMAPA LVYGNTVVLK PASETAVTAA KVIECFHEAG
210 220 230 240 250
FPKGVVNMVC GSGSVVGQGI ANHPDIDGVT FTGSNTVGKQ VGRAAFERGA
260 270 280 290 300
KYQLEMGGKN PVIVAKDADL DLAVEGTISG GLRSTGQKCT ATSRVFIERE
310 320 330 340 350
VYEPFKAKLL ERVKQLKIGN GLDAETWMGP CASESQFHTV LSYIEKGKSE
360 370 380 390 400
GAKLIYGGNR CLEGELANGF FVEPTIFEDV DLQMTIAREE IFGPVLALIQ
410 420 430 440 450
VDSIEEAIKL ANDTEYGLSA SIYTKNIGNA LEFIKDIEAG LIKVNAETAG
460 470 480
VEFQAPFGGM KQSSSHSREQ GQAAIEFFTS IKTVFVKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13846 Genomic DNA Translation: BAA02975.1 |
PIRi | I39769 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13846 Genomic DNA Translation: BAA02975.1 |
PIRi | I39769 |
3D structure databases
SMRi | P42329 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00780;UER00768 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALDH_GEOSE | |
Accessioni | P42329Primary (citable) accession number: P42329 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 11, 2019 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families