UniProtKB - P42282 (TTKA_DROME)
Protein tramtrack, alpha isoform
ttk
Functioni
Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform alpha is required to repress genes that promote the R7 cell fate. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. May bind to the region 5'-AGGG[CT]GG-3'. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk.
2 PublicationsCaution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 610 – 638 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 646 – 669 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: FlyBase
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: FlyBase
- metal ion binding Source: UniProtKB-KW
- POZ domain binding Source: FlyBase
- protein homodimerization activity Source: FlyBase
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: FlyBase
GO - Biological processi
- branch fusion, open tracheal system Source: FlyBase
- branching involved in open tracheal system development Source: FlyBase
- chitin-based cuticle development Source: FlyBase
- compound eye cone cell differentiation Source: FlyBase
- compound eye corneal lens morphogenesis Source: FlyBase
- dendrite regeneration Source: FlyBase
- dorsal appendage formation Source: FlyBase
- dorsal trunk growth, open tracheal system Source: FlyBase
- enteroendocrine cell differentiation Source: FlyBase
- epidermal growth factor receptor signaling pathway Source: FlyBase
- myoblast fate specification Source: FlyBase
- negative regulation of photoreceptor cell differentiation Source: FlyBase
- negative regulation of R7 cell differentiation Source: FlyBase
- negative regulation of transcription, DNA-templated Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- peripheral nervous system development Source: FlyBase
- positive regulation of border follicle cell migration Source: FlyBase
- positive regulation of DNA binding Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- R1/R6 development Source: FlyBase
- regulation of cell shape Source: FlyBase
- regulation of compound eye cone cell fate specification Source: FlyBase
- regulation of embryonic cell shape Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of tube size, open tracheal system Source: FlyBase
- sevenless signaling pathway Source: FlyBase
- tracheal outgrowth, open tracheal system Source: FlyBase
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SignaLinki | P42282 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein tramtrack, alpha isoformAlternative name(s): Repressor protein fushi tarazu Tramtrack p88 |
Gene namesi | Name:ttk Synonyms:FTZ-F2 ORF Names:CG1856 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003870, ttk |
VEuPathDBi | VectorBase:FBgn0003870 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: FlyBase
Other locations
- polytene chromosome Source: FlyBase
- transcription repressor complex Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047078 | 1 – 813 | Protein tramtrack, alpha isoformAdd BLAST | 813 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 203 | Phosphoserine1 Publication | 1 | |
Modified residuei | 205 | Phosphoserine1 Publication | 1 | |
Modified residuei | 206 | Phosphoserine1 Publication | 1 | |
Modified residuei | 209 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 682 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P42282 |
PRIDEi | P42282 |
PTM databases
iPTMneti | P42282 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | FBgn0003870, Expressed in saliva-secreting gland and 67 other tissues |
ExpressionAtlasi | P42282, baseline and differential |
Genevisiblei | P42282, DM |
Interactioni
Subunit structurei
Interacts with CoRest/CG33525, suggesting that it acts by recruiting a CoRest-containing corepressor complex.
Interacts with phyl.
2 PublicationsBinary interactionsi
P42282
With | #Exp. | IntAct |
---|---|---|
ebi [Q95RJ9] | 2 | EBI-77008,EBI-421390 |
phyl [Q27934] | 10 | EBI-77008,EBI-77033 |
sina [P21461] | 4 | EBI-77008,EBI-77019 |
GO - Molecular functioni
- POZ domain binding Source: FlyBase
- protein homodimerization activity Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 71315, 84 interactors |
IntActi | P42282, 11 interactors |
STRINGi | 7227.FBpp0085186 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 98 | BTBPROSITE-ProRule annotationAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 148 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 171 – 324 | DisorderedSequence analysisAdd BLAST | 154 | |
Regioni | 356 – 428 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 525 – 585 | DisorderedSequence analysisAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 171 – 185 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 223 – 255 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 256 – 283 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 284 – 324 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 356 – 390 | Polar residuesSequence analysisAdd BLAST | 35 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 610 – 638 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 646 – 669 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QQPP, Eukaryota |
GeneTreei | ENSGT00940000175057 |
HOGENOMi | CLU_013670_1_0_1 |
InParanoidi | P42282 |
PhylomeDBi | P42282 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKMASQRFCL RWNNHQSNLL SVFDQLLHAE TFTDVTLAVE GQHLKAHKMV
60 70 80 90 100
LSACSPYFNT LFVSHPEKHP IVILKDVPYS DMKSLLDFMY RGEVSVDQER
110 120 130 140 150
LTAFLRVAES LRIKGLTEVN DDKPSPAAAA AGAGATGSES TATTPQLQRI
160 170 180 190 200
QPYLVPQRNR SQAGGLLASA ANAGNTPTLP VQPSLLSSAL MPKRKRGRPR
210 220 230 240 250
KLSGSSNGTG NDYDDFDREN MMNDSSDLGN GKMCNESYSG NDDGSDDNQP
260 270 280 290 300
NAGHTDDLNE SRDSLPSKRS KNSKDHRVVS HHEDNSTSVT PTKATPELSQ
310 320 330 340 350
RLFGSSSTTI SATAPGGSST GPSETISLLE ISDERESAPV HLPTILGLKI
360 370 380 390 400
RAINTTTPAQ QGSPQTPTKS KPKIRQATGS NNSNSLLKQQ LRGGAKDPEV
410 420 430 440 450
PPATRITGAV TPNAALNAEE QSKEMPKKNQ DEVNACIGLH SLANAAEQQA
460 470 480 490 500
AQVASTGNLH HQLLLHMAAN NSMLNTTDYY QQQQQESPSS AGQFMDDDLE
510 520 530 540 550
LLSLNDQQDK SDEPDHEMVT LADENAGLPG YQGNEAEATP AQEDSPAAET
560 570 580 590 600
ATAPPPAPRS GKKGAKRPIQ RRRVRRKAQS TLDDQAEHLT EMSVRGLDLF
610 620 630 640 650
RYASVVEGVY RCTECAKENM QKTFKNKYSF QRHAFLYHEG KHRKVFPCPV
660 670 680 690 700
CSKEFSRPDK MKNHLKMTHE NFTPPKDIGA FSPLKYLISA AAAGDMHATI
710 720 730 740 750
YQQQQDHYHR QLAEQLEQQN ASFDSRDSSL ILPDVKMEHA EDQDAEQEAE
760 770 780 790 800
LSDGGYDASN PAAAAAAMLS LQQDVIIKDE IQISPSPSPT PPASCAVAEG
810
KSLALASTAQ TAT
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4JD39 | A0A0B4JD39_DROME | Tramtrack, isoform H | ttk 0037, 0250, 04, 0438, 05 | 643 | Annotation score: | ||
A0A0B4JDG1 | A0A0B4JDG1_DROME | Tramtrack, isoform G | ttk 0037, 0250, 04, 0438, 05 | 813 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 186 | L → V in CAA77785 (PubMed:1372245).Curated | 1 | |
Sequence conflicti | 186 | L → V in CAA77786 (PubMed:1372245).Curated | 1 | |
Sequence conflicti | 358 | P → R in CAA50633 (PubMed:8504931).Curated | 1 | |
Sequence conflicti | 524 | E → Q in CAA50633 (PubMed:8504931).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71626 mRNA Translation: CAA50633.1 Z11723 mRNA Translation: CAA77785.1 Z11723 mRNA Translation: CAA77786.1 Different initiation. AE014297 Genomic DNA Translation: AAF57179.1 AE014297 Genomic DNA Translation: AAF57180.1 AE014297 Genomic DNA Translation: AAN14282.1 BT025183 mRNA Translation: ABF00108.1 |
PIRi | S36018 |
RefSeqi | NP_001189329.1, NM_001202400.1 [P42282-1] NP_733443.1, NM_170564.3 [P42282-1] NP_733444.1, NM_170565.2 [P42282-1] NP_733445.1, NM_170566.3 [P42282-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0085825; FBpp0085186; FBgn0003870 [P42282-1] FBtr0085827; FBpp0085188; FBgn0003870 [P42282-1] FBtr0085829; FBpp0085190; FBgn0003870 [P42282-1] FBtr0303227; FBpp0292319; FBgn0003870 [P42282-1] |
GeneIDi | 48317 |
KEGGi | dme:Dmel_CG1856 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71626 mRNA Translation: CAA50633.1 Z11723 mRNA Translation: CAA77785.1 Z11723 mRNA Translation: CAA77786.1 Different initiation. AE014297 Genomic DNA Translation: AAF57179.1 AE014297 Genomic DNA Translation: AAF57180.1 AE014297 Genomic DNA Translation: AAN14282.1 BT025183 mRNA Translation: ABF00108.1 |
PIRi | S36018 |
RefSeqi | NP_001189329.1, NM_001202400.1 [P42282-1] NP_733443.1, NM_170564.3 [P42282-1] NP_733444.1, NM_170565.2 [P42282-1] NP_733445.1, NM_170566.3 [P42282-1] |
3D structure databases
SMRi | P42282 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 71315, 84 interactors |
IntActi | P42282, 11 interactors |
STRINGi | 7227.FBpp0085186 |
PTM databases
iPTMneti | P42282 |
Proteomic databases
PaxDbi | P42282 |
PRIDEi | P42282 |
Protocols and materials databases
DNASUi | 48317 |
Genome annotation databases
EnsemblMetazoai | FBtr0085825; FBpp0085186; FBgn0003870 [P42282-1] FBtr0085827; FBpp0085188; FBgn0003870 [P42282-1] FBtr0085829; FBpp0085190; FBgn0003870 [P42282-1] FBtr0303227; FBpp0292319; FBgn0003870 [P42282-1] |
GeneIDi | 48317 |
KEGGi | dme:Dmel_CG1856 |
Organism-specific databases
CTDi | 7272 |
FlyBasei | FBgn0003870, ttk |
VEuPathDBi | VectorBase:FBgn0003870 |
Phylogenomic databases
eggNOGi | ENOG502QQPP, Eukaryota |
GeneTreei | ENSGT00940000175057 |
HOGENOMi | CLU_013670_1_0_1 |
InParanoidi | P42282 |
PhylomeDBi | P42282 |
Enzyme and pathway databases
SignaLinki | P42282 |
Miscellaneous databases
BioGRID-ORCSi | 48317, 0 hits in 1 CRISPR screen |
GenomeRNAii | 48317 |
Gene expression databases
Bgeei | FBgn0003870, Expressed in saliva-secreting gland and 67 other tissues |
ExpressionAtlasi | P42282, baseline and differential |
Genevisiblei | P42282, DM |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TTKA_DROME | |
Accessioni | P42282Primary (citable) accession number: P42282 Secondary accession number(s): A4V3Q3 Q9V9V2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | May 10, 2004 | |
Last modified: | February 23, 2022 | |
This is version 186 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase