Protein tramtrack, alpha isoform

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Drosophila BTB/POZ domains of "ttk group" can form multimers and selectively interact with each other."
    Bonchuk A., Denisov S., Georgiev P., Maksimenko O.
    J. Mol. Biol. 412:423-436(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: FlyBaseInferred from direct assayⁱ
  • Ref.6

    "A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation."
    Dallman J.E., Allopenna J., Bassett A., Travers A., Mandel G.
    J. Neurosci. 24:7186-7193(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH CG33525.
• POZ domain binding Source: FlyBaseInferred from direct assayⁱ
  • "Drosophila BTB/POZ domains of "ttk group" can form multimers and selectively interact with each other."
    Bonchuk A., Denisov S., Georgiev P., Maksimenko O.
    J. Mol. Biol. 412:423-436(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "A double interaction screen identifies positive and negative ftz gene regulators and ftz-interacting proteins."
    Yu Y., Yussa M., Song J., Hirsch J., Pick L.
    Mech. Dev. 83:95-105(1999) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • Ref.2

    "Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities."
    Read D., Manley J.L.
    EMBO J. 11:1035-1044(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DNA-BINDING.
• metal ion binding Source: UniProtKB-KW
• protein homodimerization activity Source: FlyBaseInferred from direct assayⁱ
  • "Drosophila BTB/POZ domains of "ttk group" can form multimers and selectively interact with each other."
    Bonchuk A., Denisov S., Georgiev P., Maksimenko O.
    J. Mol. Biol. 412:423-436(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• R1/R6 development Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc."
    Siddall N.A., Hime G.R., Pollock J.A., Batterham P.
    BMC Dev. Biol. 9:64-64(2009) [PubMed] [Europe PMC] [Abstract]
• branch fusion, open tracheal system Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Tramtrack regulates different morphogenetic events during Drosophila tracheal development."
    Araujo S.J., Cela C., Llimargas M.
    Development 134:3665-3676(2007) [PubMed] [Europe PMC] [Abstract]
• branching involved in open tracheal system development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Tramtrack regulates different morphogenetic events during Drosophila tracheal development."
    Araujo S.J., Cela C., Llimargas M.
    Development 134:3665-3676(2007) [PubMed] [Europe PMC] [Abstract]
• chitin-based cuticle development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Tramtrack regulates different morphogenetic events during Drosophila tracheal development."
    Araujo S.J., Cela C., Llimargas M.
    Development 134:3665-3676(2007) [PubMed] [Europe PMC] [Abstract]
• compound eye cone cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc."
    Siddall N.A., Hime G.R., Pollock J.A., Batterham P.
    BMC Dev. Biol. 9:64-64(2009) [PubMed] [Europe PMC] [Abstract]
• compound eye corneal lens morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc."
    Siddall N.A., Hime G.R., Pollock J.A., Batterham P.
    BMC Dev. Biol. 9:64-64(2009) [PubMed] [Europe PMC] [Abstract]
• dorsal appendage formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis."
    French R.L., Cosand K.A., Berg C.A.
    Dev. Biol. 253:18-35(2003) [PubMed] [Europe PMC] [Abstract]
  • "Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation."
    Boyle M.J., Berg C.A.
    Development 136:4187-4197(2009) [PubMed] [Europe PMC] [Abstract]
  • "Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror."
    Peters N.C., Thayer N.H., Kerr S.A., Tompa M., Berg C.A.
    Dev. Biol. 378:154-169(2013) [PubMed] [Europe PMC] [Abstract]
• dorsal trunk growth, open tracheal system Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Tramtrack regulates different morphogenetic events during Drosophila tracheal development."
    Araujo S.J., Cela C., Llimargas M.
    Development 134:3665-3676(2007) [PubMed] [Europe PMC] [Abstract]
• enteroendocrine cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila."
    Yin C., Xi R.
    Stem Cell Reports 10:43-57(2018) [PubMed] [Europe PMC] [Abstract]
• myoblast fate specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis."
    Ciglar L., Girardot C., Wilczynski B., Braun M., Furlong E.E.
    Development 141:2633-2643(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of R7 cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc."
    Siddall N.A., Hime G.R., Pollock J.A., Batterham P.
    BMC Dev. Biol. 9:64-64(2009) [PubMed] [Europe PMC] [Abstract]
  • "Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack."
    Li S., Li Y., Carthew R.W., Lai Z.-C.
    Cell 90:469-478(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of photoreceptor cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism."
    Tang A.H., Neufeld T.P., Kwan E., Rubin G.M.
    Cell 90:459-467(1997) [PubMed] [Europe PMC] [Abstract]
  • "Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack."
    Li S., Li Y., Carthew R.W., Lai Z.-C.
    Cell 90:469-478(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: FlyBaseInferred from direct assayⁱ
  • Ref.6

    "A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation."
    Dallman J.E., Allopenna J., Bassett A., Travers A., Mandel G.
    J. Neurosci. 24:7186-7193(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH CG33525.
• ovarian follicle cell development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells."
    Jordan K.C., Schaeffer V., Fischer K.A., Gray E.E., Ruohola-Baker H.
    BMC Dev. Biol. 6:16-16(2006) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system development Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development."
    Salzberg A., D'Evelyn D., Schulze K.L., Lee J.K., Strumpf D., Tsai L., Bellen H.J.
    Neuron 13:269-287(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "The Torso signaling pathway modulates a dual transcriptional switch to regulate tailless expression."
    Chen Y.C., Lin S.I., Chen Y.K., Chiang C.S., Liaw G.J.
    Nucleic Acids Res. 37:1061-1072(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of border follicle cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Analysis of cell migration using whole-genome expression profiling of migratory cells in the Drosophila ovary."
    Wang X., Bo J., Bridges T., Dugan K.D., Pan T.C., Chodosh L.A., Montell D.J.
    Dev. Cell 10:483-495(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: FlyBaseInferred from direct assayⁱ
  • "A double interaction screen identifies positive and negative ftz gene regulators and ftz-interacting proteins."
    Yu Y., Yussa M., Song J., Hirsch J., Pick L.
    Mech. Dev. 83:95-105(1999) [PubMed] [Europe PMC] [Abstract]
• regulation of cell shape Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation."
    Boyle M.J., Berg C.A.
    Development 136:4187-4197(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of compound eye cone cell fate specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88."
    Shi Y., Noll M.
    Dev. Biol. 331:68-77(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of embryonic cell shape Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Tramtrack regulates different morphogenetic events during Drosophila tracheal development."
    Araujo S.J., Cela C., Llimargas M.
    Development 134:3665-3676(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of tube size, open tracheal system Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Tramtrack regulates different morphogenetic events during Drosophila tracheal development."
    Araujo S.J., Cela C., Llimargas M.
    Development 134:3665-3676(2007) [PubMed] [Europe PMC] [Abstract]
• sevenless signaling pathway Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack."
    Li S., Li Y., Carthew R.W., Lai Z.-C.
    Cell 90:469-478(1997) [PubMed] [Europe PMC] [Abstract]
• tracheal outgrowth, open tracheal system Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Tramtrack regulates different morphogenetic events during Drosophila tracheal development."
    Araujo S.J., Cela C., Llimargas M.
    Development 134:3665-3676(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• POZ domain binding Source: FlyBaseInferred from direct assayⁱ
  • "Drosophila BTB/POZ domains of "ttk group" can form multimers and selectively interact with each other."
    Bonchuk A., Denisov S., Georgiev P., Maksimenko O.
    J. Mol. Biol. 412:423-436(2011) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: FlyBaseInferred from direct assayⁱ
  • "Drosophila BTB/POZ domains of "ttk group" can form multimers and selectively interact with each other."
    Bonchuk A., Denisov S., Georgiev P., Maksimenko O.
    J. Mol. Biol. 412:423-436(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MKMASQRFCL RWNNHQSNLL SVFDQLLHAE TFTDVTLAVE GQHLKAHKMV 
        60         70         80         90        100
LSACSPYFNT LFVSHPEKHP IVILKDVPYS DMKSLLDFMY RGEVSVDQER 
       110        120        130        140        150
LTAFLRVAES LRIKGLTEVN DDKPSPAAAA AGAGATGSES TATTPQLQRI 
       160        170        180        190        200
QPYLVPQRNR SQAGGLLASA ANAGNTPTLP VQPSLLSSAL MPKRKRGRPR 
       210        220        230        240        250
KLSGSSNGTG NDYDDFDREN MMNDSSDLGN GKMCNESYSG NDDGSDDNQP 
       260        270        280        290        300
NAGHTDDLNE SRDSLPSKRS KNSKDHRVVS HHEDNSTSVT PTKATPELSQ 
       310        320        330        340        350
RLFGSSSTTI SATAPGGSST GPSETISLLE ISDERESAPV HLPTILGLKI 
       360        370        380        390        400
RAINTTTPAQ QGSPQTPTKS KPKIRQATGS NNSNSLLKQQ LRGGAKDPEV 
       410        420        430        440        450
PPATRITGAV TPNAALNAEE QSKEMPKKNQ DEVNACIGLH SLANAAEQQA 
       460        470        480        490        500
AQVASTGNLH HQLLLHMAAN NSMLNTTDYY QQQQQESPSS AGQFMDDDLE 
       510        520        530        540        550
LLSLNDQQDK SDEPDHEMVT LADENAGLPG YQGNEAEATP AQEDSPAAET 
       560        570        580        590        600
ATAPPPAPRS GKKGAKRPIQ RRRVRRKAQS TLDDQAEHLT EMSVRGLDLF 
       610        620        630        640        650
RYASVVEGVY RCTECAKENM QKTFKNKYSF QRHAFLYHEG KHRKVFPCPV 
       660        670        680        690        700
CSKEFSRPDK MKNHLKMTHE NFTPPKDIGA FSPLKYLISA AAAGDMHATI 
       710        720        730        740        750
YQQQQDHYHR QLAEQLEQQN ASFDSRDSSL ILPDVKMEHA EDQDAEQEAE 
       760        770        780        790        800
LSDGGYDASN PAAAAAAMLS LQQDVIIKDE IQISPSPSPT PPASCAVAEG 
       810 
KSLALASTAQ TAT                                         

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase