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Protein

Glutamate receptor 2

Gene

GRIA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).By similarity1 Publication

Miscellaneous

The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei471Glutamate2 Publications1
Binding sitei506Glutamate2 Publications1
Binding sitei726Glutamate2 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-399710 Activation of AMPA receptors
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation
SignaLinkiP42262
SIGNORiP42262

Protein family/group databases

TCDBi1.A.10.1.13 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor 2
Short name:
GluR-2
Alternative name(s):
AMPA-selective glutamate receptor 2
GluR-B
GluR-K2
Glutamate receptor ionotropic, AMPA 2
Short name:
GluA2
Gene namesi
Name:GRIA2
Synonyms:GLUR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000120251.18
HGNCiHGNC:4572 GRIA2
MIMi138247 gene
neXtProtiNX_P42262

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 543ExtracellularBy similarityAdd BLAST519
Transmembranei544 – 564HelicalBy similarityAdd BLAST21
Topological domaini565 – 591CytoplasmicBy similarityAdd BLAST27
Intramembranei592 – 607Helical; Pore-formingBy similarityAdd BLAST16
Intramembranei608 – 610By similarity3
Topological domaini611 – 616CytoplasmicBy similarity6
Transmembranei617 – 637HelicalBy similarityAdd BLAST21
Topological domaini638 – 812ExtracellularBy similarityAdd BLAST175
Transmembranei813 – 833Helical; Name=M4Add BLAST21
Topological domaini834 – 883CytoplasmicBy similarityAdd BLAST50

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2891
OpenTargetsiENSG00000120251
PharmGKBiPA28967

Chemistry databases

ChEMBLiCHEMBL4016
DrugBankiDB02057 (S)-AMPA
DB03319 (S)-ATPA
DB01664 (S)-Des-Me-Ampa
DB02347 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid
DB01351 Amobarbital
DB04599 Aniracetam
DB01352 Aprobarbital
DB01483 Barbital
DB01496 Barbituric acid derivative
DB04000 Bromo-Willardiine
DB00237 Butabarbital
DB00241 Butalbital
DB01353 Butethal
DB05047 CX717
DB00898 Ethanol
DB03759 FG-9041
DB02966 Fluoro-Willardiine
DB01354 Heptabarbital
DB01355 Hexobarbital
DB02818 Iodo-Willardiine
DB00142 L-Glutamic Acid
DB00463 Metharbital
DB00849 Methylphenobarbital
DB00312 Pentobarbital
DB01174 Phenobarbital
DB00794 Primidone
DB01346 Quinidine barbiturate
DB02999 Quisqualate
DB00418 Secobarbital
DB04982 Talampanel
DB00306 Talbutal
DB04798 THIO-ATPA
DB00599 Thiopental
DB04129 Willardiine
GuidetoPHARMACOLOGYi445

Polymorphism and mutation databases

BioMutaiGRIA2
DMDMi23831146

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001153225 – 883Glutamate receptor 2Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 330
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi610S-palmitoyl cysteineBy similarity1
Modified residuei683Phosphoserine; by PKCBy similarity1
Modified residuei717Phosphoserine; by PKGBy similarity1
Disulfide bondi739 ↔ 794
Lipidationi836S-palmitoyl cysteineBy similarity1
Modified residuei860PhosphoserineBy similarity1
Modified residuei863PhosphoserineBy similarity1
Modified residuei876PhosphotyrosineBy similarity1
Modified residuei880PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP42262
PeptideAtlasiP42262
PRIDEiP42262
ProteomicsDBi55498
55499 [P42262-2]
55500 [P42262-3]

PTM databases

iPTMnetiP42262
PhosphoSitePlusiP42262
SwissPalmiP42262

Expressioni

Gene expression databases

BgeeiENSG00000120251 Expressed in 150 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_GRIA2
ExpressionAtlasiP42262 baseline and differential
GenevisibleiP42262 HS

Organism-specific databases

HPAiCAB007812
HPA008441

Interactioni

Subunit structurei

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with GRIP2. Isoform 1, but not isoform 3, interacts with PICK1/PRKCABP. Interacts with GRIA1 and SYNDIG1. Interacts with LRFN1 (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts with OLFM2 (By similarity). Interacts with AP4B1, AP4E1 and AP4M1; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (By similarity). Forms a complex with NSG1, GRIP1 and STX12; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi109148, 32 interactors
CORUMiP42262
DIPiDIP-42852N
IntActiP42262, 15 interactors
MINTiP42262
STRINGi9606.ENSP00000264426

Chemistry databases

BindingDBiP42262

Structurei

Secondary structure

1883
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP42262
SMRiP42262
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42262

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni499 – 501Glutamate binding3
Regioni675 – 676Glutamate binding2

Domaini

The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054 Eukaryota
ENOG410XPSH LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000234372
HOVERGENiHBG051839
InParanoidiP42262
KOiK05198
OMAiHAVPYVS
OrthoDBiEOG091G11CB
PhylomeDBiP42262
TreeFamiTF315232

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform Flop (identifier: P42262-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ
60 70 80 90 100
FSTSEFRLTP HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI
110 120 130 140 150
TSFCGTLHVS FITPSFPTDG THPFVIQMRP DLKGALLSLI EYYQWDKFAY
160 170 180 190 200
LYDSDRGLST LQAVLDSAAE KKWQVTAINV GNINNDKKDE MYRSLFQDLE
210 220 230 240 250
LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL GFTDGDLLKI
260 270 280 290 300
QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT TTIKYTSALT
310 320 330 340 350
YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ
360 370 380 390 400
VQVEGLSGNI KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT
410 420 430 440 450
ELPSGNDTSG LENKTVVVTT ILESPYVMMK KNHEMLEGNE RYEGYCVDLA
460 470 480 490 500
AEIAKHCGFK YKLTIVGDGK YGARDADTKI WNGMVGELVY GKADIAIAPL
510 520 530 540 550
TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI
560 570 580 590 600
VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF
610 620 630 640 650
SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM
660 670 680 690 700
VSPIESAEDL SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP
710 720 730 740 750
SVFVRTTAEG VARVRKSKGK YAYLLESTMN EYIEQRKPCD TMKVGGNLDS
760 770 780 790 800
KGYGIATPKG SSLRNAVNLA VLKLNEQGLL DKLKNKWWYD KGECGSGGGD
810 820 830 840 850
SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR AEAKRMKVAK
860 870 880
NAQNINPSSS QNSQNFATYK EGYNVYGIES VKI
Length:883
Mass (Da):98,821
Last modified:October 10, 2002 - v3
Checksum:i6DAB96C76D1D8448
GO
Isoform Flip (identifier: P42262-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-800: NAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD → TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSG

Show »
Length:883
Mass (Da):98,878
Checksum:i882141AC054254F8
GO
Isoform 3 (identifier: P42262-3) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     848-883: VAKNAQNINP...NVYGIESVKI → MTLNDAMRNK...GMNVSVTDLS

Show »
Length:901
Mass (Da):100,594
Checksum:i6E668073D621EFBB
GO
Isoform 4 (identifier: P42262-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     765-800: NAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD → TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSG

Note: No experimental confirmation available.
Show »
Length:836
Mass (Da):93,775
Checksum:i1B3F13BC745D4A45
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W7L6F8W7L6_HUMAN
Glutamate receptor 2
GRIA2
730Annotation score:
H0Y972H0Y972_HUMAN
Glutamate receptor 2
GRIA2
214Annotation score:
D6RDX5D6RDX5_HUMAN
Glutamate receptor 2
GRIA2
124Annotation score:
D6R9Z0D6R9Z0_HUMAN
Glutamate receptor 2
GRIA2
145Annotation score:
D6REK8D6REK8_HUMAN
Glutamate receptor 2
GRIA2
104Annotation score:
D6RFM6D6RFM6_HUMAN
Glutamate receptor 2
GRIA2
57Annotation score:
D6RBV7D6RBV7_HUMAN
Glutamate receptor 2
GRIA2
48Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140I → V in AAH10574 (PubMed:15489334).Curated1
Sequence conflicti241G → E in AAA58631 (PubMed:8003671).Curated1
Sequence conflicti415T → I in AAH28736 (PubMed:15489334).Curated1
Sequence conflicti764R → G in AAA58631 (PubMed:8003671).Curated1

RNA editingi

Edited at position 607.1 Publication
Partially edited. Fully edited in the brain. Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium, whereas the unedited (Q) forms are highly permeable to divalent ions.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_000303607Q → R in RNA edited version. 2 PublicationsCorresponds to variant dbSNP:rs17850674Ensembl.1
Natural variantiVAR_037055608Q → R1 PublicationCorresponds to variant dbSNP:rs17850675Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559201 – 47Missing in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_053350765 – 800NAVNL…SGGGD → TPVNLAVLKLSEQGVLDKLK NKWWYDKGECGAKDSG in isoform Flip and isoform 4. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_029309848 – 883VAKNA…ESVKI → MTLNDAMRNKARLSITGSTG ENGRVMTPEFPKAVHAVPYV SPGMGMNVSVTDLS in isoform 3. CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20814 mRNA Translation: AAA58631.1
AC079233 Genomic DNA No translation available.
AC112240 Genomic DNA No translation available.
BC010574 mRNA Translation: AAH10574.1
BC028736 mRNA Translation: AAH28736.2
CCDSiCCDS3797.1 [P42262-2]
CCDS43274.1 [P42262-1]
CCDS43275.1 [P42262-4]
PIRiI58181
RefSeqiNP_000817.2, NM_000826.3
NP_001077088.1, NM_001083619.1
NP_001077089.1, NM_001083620.1
XP_016863605.1, XM_017008116.1
XP_016863606.1, XM_017008117.1
UniGeneiHs.32763

Genome annotation databases

EnsembliENST00000264426; ENSP00000264426; ENSG00000120251 [P42262-1]
ENST00000296526; ENSP00000296526; ENSG00000120251 [P42262-2]
ENST00000393815; ENSP00000377403; ENSG00000120251 [P42262-4]
ENST00000507898; ENSP00000426845; ENSG00000120251 [P42262-4]
ENST00000645636; ENSP00000495569; ENSG00000120251 [P42262-3]
GeneIDi2891
KEGGihsa:2891
UCSCiuc003ipk.5 human [P42262-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20814 mRNA Translation: AAA58631.1
AC079233 Genomic DNA No translation available.
AC112240 Genomic DNA No translation available.
BC010574 mRNA Translation: AAH10574.1
BC028736 mRNA Translation: AAH28736.2
CCDSiCCDS3797.1 [P42262-2]
CCDS43274.1 [P42262-1]
CCDS43275.1 [P42262-4]
PIRiI58181
RefSeqiNP_000817.2, NM_000826.3
NP_001077088.1, NM_001083619.1
NP_001077089.1, NM_001083620.1
XP_016863605.1, XM_017008116.1
XP_016863606.1, XM_017008117.1
UniGeneiHs.32763

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WJWX-ray1.80A25-412[»]
2WJXX-ray4.10A/B/C25-412[»]
2XHDX-ray1.80A/B413-527[»]
A/B653-796[»]
3R7XX-ray2.10A/B413-527[»]
A/B653-796[»]
3RN8X-ray1.70A/B/C413-527[»]
A/B/C653-812[»]
3RNNX-ray1.75A/B/C413-527[»]
A/B/C653-812[»]
3UA8X-ray1.90A413-527[»]
A653-796[»]
5H8SX-ray1.70A/B/C413-527[»]
A/B/C653-796[»]
5YBFX-ray1.50A/B/C/D/E/F413-527[»]
A/B/C/D/E/F653-796[»]
5YBGX-ray1.52A/B/C/D/E/F413-527[»]
A/B/C/D/E/F653-796[»]
ProteinModelPortaliP42262
SMRiP42262
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109148, 32 interactors
CORUMiP42262
DIPiDIP-42852N
IntActiP42262, 15 interactors
MINTiP42262
STRINGi9606.ENSP00000264426

Chemistry databases

BindingDBiP42262
ChEMBLiCHEMBL4016
DrugBankiDB02057 (S)-AMPA
DB03319 (S)-ATPA
DB01664 (S)-Des-Me-Ampa
DB02347 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid
DB01351 Amobarbital
DB04599 Aniracetam
DB01352 Aprobarbital
DB01483 Barbital
DB01496 Barbituric acid derivative
DB04000 Bromo-Willardiine
DB00237 Butabarbital
DB00241 Butalbital
DB01353 Butethal
DB05047 CX717
DB00898 Ethanol
DB03759 FG-9041
DB02966 Fluoro-Willardiine
DB01354 Heptabarbital
DB01355 Hexobarbital
DB02818 Iodo-Willardiine
DB00142 L-Glutamic Acid
DB00463 Metharbital
DB00849 Methylphenobarbital
DB00312 Pentobarbital
DB01174 Phenobarbital
DB00794 Primidone
DB01346 Quinidine barbiturate
DB02999 Quisqualate
DB00418 Secobarbital
DB04982 Talampanel
DB00306 Talbutal
DB04798 THIO-ATPA
DB00599 Thiopental
DB04129 Willardiine
GuidetoPHARMACOLOGYi445

Protein family/group databases

TCDBi1.A.10.1.13 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

PTM databases

iPTMnetiP42262
PhosphoSitePlusiP42262
SwissPalmiP42262

Polymorphism and mutation databases

BioMutaiGRIA2
DMDMi23831146

Proteomic databases

PaxDbiP42262
PeptideAtlasiP42262
PRIDEiP42262
ProteomicsDBi55498
55499 [P42262-2]
55500 [P42262-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264426; ENSP00000264426; ENSG00000120251 [P42262-1]
ENST00000296526; ENSP00000296526; ENSG00000120251 [P42262-2]
ENST00000393815; ENSP00000377403; ENSG00000120251 [P42262-4]
ENST00000507898; ENSP00000426845; ENSG00000120251 [P42262-4]
ENST00000645636; ENSP00000495569; ENSG00000120251 [P42262-3]
GeneIDi2891
KEGGihsa:2891
UCSCiuc003ipk.5 human [P42262-1]

Organism-specific databases

CTDi2891
DisGeNETi2891
EuPathDBiHostDB:ENSG00000120251.18
GeneCardsiGRIA2
HGNCiHGNC:4572 GRIA2
HPAiCAB007812
HPA008441
MIMi138247 gene
neXtProtiNX_P42262
OpenTargetsiENSG00000120251
PharmGKBiPA28967
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1054 Eukaryota
ENOG410XPSH LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000234372
HOVERGENiHBG051839
InParanoidiP42262
KOiK05198
OMAiHAVPYVS
OrthoDBiEOG091G11CB
PhylomeDBiP42262
TreeFamiTF315232

Enzyme and pathway databases

ReactomeiR-HSA-399710 Activation of AMPA receptors
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation
SignaLinkiP42262
SIGNORiP42262

Miscellaneous databases

ChiTaRSiGRIA2 human
EvolutionaryTraceiP42262
GeneWikiiGRIA2
GenomeRNAii2891
PROiPR:P42262
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120251 Expressed in 150 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_GRIA2
ExpressionAtlasiP42262 baseline and differential
GenevisibleiP42262 HS

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRIA2_HUMAN
AccessioniPrimary (citable) accession number: P42262
Secondary accession number(s): A8MT92, I6L997, Q96FP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 10, 2002
Last modified: November 7, 2018
This is version 195 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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