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Protein

Sensory rhodopsin II transducer

Gene

htr2

Organism
Natronomonas pharaonis (Natronobacterium pharaonis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPhotoreceptor protein, Receptor, Transducer
Biological processChemotaxis, Sensory transduction
LigandChromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Sensory rhodopsin II transducer
Alternative name(s):
HTR-II
Methyl-accepting phototaxis protein II
Short name:
MPP-II
Gene namesi
Name:htr2
Synonyms:htrII
OrganismiNatronomonas pharaonis (Natronobacterium pharaonis)
Taxonomic identifieri2257 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHaloarculaceaeNatronomonas

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicAdd BLAST22
Transmembranei23 – 43Helical; Name=1Add BLAST21
Topological domaini44 – 59ExtracellularAdd BLAST16
Transmembranei60 – 81Helical; Name=2Add BLAST22
Topological domaini82 – 534CytoplasmicAdd BLAST453

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105551 – 534Sensory rhodopsin II transducerAdd BLAST534

Keywords - PTMi

Methylation

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-35283N
IntActiP42259, 2 interactors
MINTiP42259

Structurei

Secondary structure

1534
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP42259
SMRiP42259
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42259

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 136HAMP 1PROSITE-ProRule annotationAdd BLAST53
Domaini157 – 210HAMP 2PROSITE-ProRule annotationAdd BLAST54
Domaini229 – 465Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST237

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG02320 Archaea
COG0840 LUCA

Family and domain databases

CDDicd06225 HAMP, 1 hit
InterProiView protein in InterPro
IPR004090 Chemotax_Me-accpt_rcpt
IPR003660 HAMP_dom
IPR004089 MCPsignal_dom
PfamiView protein in Pfam
PF00672 HAMP, 1 hit
PF00015 MCPsignal, 1 hit
PRINTSiPR00260 CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304 HAMP, 2 hits
SM00283 MA, 1 hit
PROSITEiView protein in PROSITE
PS50111 CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885 HAMP, 2 hits

Sequencei

Sequence statusi: Complete.

P42259-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLNVSRLLL PSRVRHSYTG KMGAVFIFVG ALTVLFGAIA YGEVTAAAAT
60 70 80 90 100
GDAAAVQEAA VSAILGLIIL LGINLGLVAA TLGGDTAASL STLAAKASRM
110 120 130 140 150
GDGDLDVELE TRREDEIGDL YAAFDEMRQS VRTSLEDAKN AREDAEQAQK
160 170 180 190 200
RAEEINTELQ AEAERFGEVM DRCADGDFTQ RLDAETDNEA MQSIEGSFNE
210 220 230 240 250
MMDGIEALVG RIERFADAVS EDAEAVRANA ESVMEASEDV NRAVQNISDA
260 270 280 290 300
AGDQTETVQQ IALEMDDVSA TTEEVAASAD DIAKTARQAA ETGEAGRETA
310 320 330 340 350
ETAITEMNEV ESRTEQAVAS MEELNEDVRE IGEVSEMIAD IAEQTNILAL
360 370 380 390 400
NASIEAARAD GNSEGFAVVA DEVKALAEET KAATEEIDDL IGTVQDRTQT
410 420 430 440 450
TVDDIRETSD QVSEGVETVE DTVDALERIV DSVERTNDGI QEINQSTDAQ
460 470 480 490 500
ADAAQKATTM VEDMAATSEQ TASDAETAAE TTETQAESVK EVFDLIDGLS
510 520 530
EQADSLSETL SRTDTEEASA ADLDDQPTLA AGDD
Length:534
Mass (Da):56,622
Last modified:November 1, 1995 - v1
Checksum:iCBE8012CC5F278E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35086 Genomic DNA Translation: CAA84468.1
PIRiS55299

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35086 Genomic DNA Translation: CAA84468.1
PIRiS55299

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H2SX-ray1.93B23-82[»]
2F93X-ray2.00B3-114[»]
2F95X-ray2.20B5-157[»]
2RM8NMR-A100-159[»]
4GYCX-ray2.05B1-135[»]
5JJEX-ray1.90B5-157[»]
5JJFX-ray1.90B5-157[»]
5JJJX-ray2.50B5-137[»]
5JJNX-ray2.25B/D5-137[»]
ProteinModelPortaliP42259
SMRiP42259
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35283N
IntActiP42259, 2 interactors
MINTiP42259

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiarCOG02320 Archaea
COG0840 LUCA

Miscellaneous databases

EvolutionaryTraceiP42259

Family and domain databases

CDDicd06225 HAMP, 1 hit
InterProiView protein in InterPro
IPR004090 Chemotax_Me-accpt_rcpt
IPR003660 HAMP_dom
IPR004089 MCPsignal_dom
PfamiView protein in Pfam
PF00672 HAMP, 1 hit
PF00015 MCPsignal, 1 hit
PRINTSiPR00260 CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304 HAMP, 2 hits
SM00283 MA, 1 hit
PROSITEiView protein in PROSITE
PS50111 CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885 HAMP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHTR2_NATPH
AccessioniPrimary (citable) accession number: P42259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 10, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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