UniProtKB - P42252 (TATCD_BACSU)
Protein
Sec-independent protein translocase protein TatCd
Gene
tatC1
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Required for PhoD secretion. TatCd promotes membrane localization of TatAd via domain specific interactions. TatCd is required for stabile production of TatAd as well as for its maintenance.UniRule annotation1 Publication
Miscellaneous
B.subtilis possesses two minimal, substrate-specific, Tat translocases: TatAd-TatCd and TatAy-TatCy, each one composed of a TatA and a TatC protein. TatA is bifunctional and performs the function of both the TatA and TatB proteins of Gram-negative organisms.
GO - Molecular functioni
- proton motive force dependent protein transmembrane transporter activity Source: GO_Central
GO - Biological processi
- intracellular protein transmembrane transport Source: GO_Central
- protein transport by the Tat complex Source: GO_Central
Keywordsi
Biological process | Protein transport, Translocation, Transport |
Enzyme and pathway databases
BioCyci | BSUB:BSU02640-MONOMER |
Protein family/group databases
TCDBi | 2.A.64.3.1 the twin arginine targeting (tat) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sec-independent protein translocase protein TatCdUniRule annotation |
Gene namesi | Name:tatC1UniRule annotation Synonyms:tatCd, ycbT Ordered Locus Names:BSU02640 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
- Cell membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 19 – 39 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 60 – 80 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 150 – 170 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 188 – 208 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 209 – 229 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of plasma membrane Source: UniProtKB-UniRule
- TAT protein transport complex Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Depletion of TatCd results in a drastic reduction of TatAd.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000098095 | 1 – 242 | Sec-independent protein translocase protein TatCdAdd BLAST | 242 |
Proteomic databases
PaxDbi | P42252 |
PRIDEi | P42252 |
Expressioni
Inductioni
Expressed under conditions of phosphate starvation.
Interactioni
Subunit structurei
Forms a complex with TatAd. Two types of complexes exist: one composed of TatAd and TatCd, and another composed only of TatAd.
UniRule annotation1 PublicationProtein-protein interaction databases
IntActi | P42252, 24 interactors |
STRINGi | 224308.BSU02640 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 128 – 149 | Interaction with TatAdAdd BLAST | 22 | |
Regioni | 171 – 187 | Interaction with TatAdAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the TatC family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105DCX Bacteria COG0805 LUCA |
HOGENOMi | HOG000245380 |
InParanoidi | P42252 |
KOi | K03118 |
OMAi | EMSFLDH |
PhylomeDBi | P42252 |
Family and domain databases
HAMAPi | MF_00902 TatC, 1 hit |
InterProi | View protein in InterPro IPR019820 Sec-indep_translocase_CS IPR002033 TatC |
PANTHERi | PTHR30371 PTHR30371, 1 hit |
Pfami | View protein in Pfam PF00902 TatC, 1 hit |
PRINTSi | PR01840 TATCFAMILY |
TIGRFAMsi | TIGR00945 tatC, 1 hit |
PROSITEi | View protein in PROSITE PS01218 TATC, 1 hit |
i Sequence
Sequence statusi: Complete.
P42252-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKKETHLIG HLEELRRRII VTLAAFFLFL ITAFLFVQDI YDWLIRDLDG
60 70 80 90 100
KLAVLGPSEI LWVYMMLSGI CAIAASIPVA AYQLWRFVAP ALTKTERKVT
110 120 130 140 150
LMYIPGLFAL FLAGISFGYF VLFPIVLSFL THLSSGHFET MFTADRYFRF
160 170 180 190 200
MVNLSLPFGF LFEMPLVVMF LTRLGILNPY RLAKARKLSY FLLIVVSILI
210 220 230 240
TPPDFISDFL VMIPLLVLFE VSVTLSAFVY KKRMREETAA AA
Sequence cautioni
The sequence BAA06484 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 101 | L → I in BAA06484 (PubMed:7704254).Curated | 1 | |
Sequence conflicti | 104 | I → IMYI in BAA06484 (PubMed:7704254).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D30808 Genomic DNA Translation: BAA06484.1 Frameshift. AL009126 Genomic DNA Translation: CAB12058.2 X66034 Genomic DNA No translation available. |
PIRi | D69754 |
RefSeqi | NP_388146.2, NC_000964.3 WP_003246495.1, NZ_JNCM01000030.1 |
Genome annotation databases
EnsemblBacteriai | CAB12058; CAB12058; BSU02640 |
GeneIDi | 938395 |
KEGGi | bsu:BSU02640 |
PATRICi | fig|224308.179.peg.274 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D30808 Genomic DNA Translation: BAA06484.1 Frameshift. AL009126 Genomic DNA Translation: CAB12058.2 X66034 Genomic DNA No translation available. |
PIRi | D69754 |
RefSeqi | NP_388146.2, NC_000964.3 WP_003246495.1, NZ_JNCM01000030.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P42252, 24 interactors |
STRINGi | 224308.BSU02640 |
Protein family/group databases
TCDBi | 2.A.64.3.1 the twin arginine targeting (tat) family |
Proteomic databases
PaxDbi | P42252 |
PRIDEi | P42252 |
Genome annotation databases
EnsemblBacteriai | CAB12058; CAB12058; BSU02640 |
GeneIDi | 938395 |
KEGGi | bsu:BSU02640 |
PATRICi | fig|224308.179.peg.274 |
Phylogenomic databases
eggNOGi | ENOG4105DCX Bacteria COG0805 LUCA |
HOGENOMi | HOG000245380 |
InParanoidi | P42252 |
KOi | K03118 |
OMAi | EMSFLDH |
PhylomeDBi | P42252 |
Enzyme and pathway databases
BioCyci | BSUB:BSU02640-MONOMER |
Family and domain databases
HAMAPi | MF_00902 TatC, 1 hit |
InterProi | View protein in InterPro IPR019820 Sec-indep_translocase_CS IPR002033 TatC |
PANTHERi | PTHR30371 PTHR30371, 1 hit |
Pfami | View protein in Pfam PF00902 TatC, 1 hit |
PRINTSi | PR01840 TATCFAMILY |
TIGRFAMsi | TIGR00945 tatC, 1 hit |
PROSITEi | View protein in PROSITE PS01218 TATC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TATCD_BACSU | |
Accessioni | P42252Primary (citable) accession number: P42252 Secondary accession number(s): O31468 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | June 16, 2009 | |
Last modified: | October 16, 2019 | |
This is version 126 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Bacillus subtilis
Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList