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Protein

Probable galactarate dehydratase (L-threo-forming)

Gene

garD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of galactarate to form 5-dehydro-4-deoxy-D-glucarate.By similarity

Catalytic activityi

Galactarate = (2R,3S)-2,3-dihydroxy-5-oxohexanedioate + H2O.By similarity

Pathwayi: galactarate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-glycerate from galactarate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable galactarate dehydratase (L-threo-forming) (garD)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway galactarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glycerate from galactarate, the pathway galactarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciBSUB:BSU02510-MONOMER
UniPathwayi
UPA00565;UER00629

Names & Taxonomyi

Protein namesi
Recommended name:
Probable galactarate dehydratase (L-threo-forming) (EC:4.2.1.42)
Short name:
GalcD
Gene namesi
Name:garD
Synonyms:ycbH
Ordered Locus Names:BSU02510
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001722841 – 510Probable galactarate dehydratase (L-threo-forming)Add BLAST510

Proteomic databases

PaxDbiP42240
PRIDEiP42240

Interactioni

Protein-protein interaction databases

IntActiP42240, 1 interactor
STRINGi224308.Bsubs1_010100001388

Structurei

3D structure databases

ProteinModelPortaliP42240
SMRiP42240
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UxaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CTX Bacteria
COG2721 LUCA
HOGENOMiHOG000219063
InParanoidiP42240
KOiK01708
OMAiHSYGCGV
PhylomeDBiP42240

Family and domain databases

InterProiView protein in InterPro
IPR007392 Gal/Altron_deHydtase_C
IPR017654 GarD-like
IPR013974 SAF
PfamiView protein in Pfam
PF04295 GD_AH_C, 1 hit
PF08666 SAF, 1 hit
SMARTiView protein in SMART
SM00858 SAF, 1 hit
TIGRFAMsiTIGR03248 galactar-dH20, 1 hit

Sequencei

Sequence statusi: Complete.

P42240-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMNLRKNQA PLYIKVHEID NTAIIVNDGG LPKGTVFSCG LVLEEDVPQG
60 70 80 90 100
HKVALTDLNQ GDEIVRYGEV IGFADETIKR GSWIREALVR MPAPPALDDL
110 120 130 140 150
PLANRVPQPR PPLEGYTFEG YRNADGSAGT KNILGITTSV QCVVGVLDYA
160 170 180 190 200
VKRIKEELLP KYPNVDDVVP LHHQYGCGVA INAPDAVIPI RTIQNLAKHP
210 220 230 240 250
NFGGEVMVIG LGCEKLLPER IASENDDDIL SLQDHRGFAA MIQSILEMAE
260 270 280 290 300
ERLIRLNSRT RVSCPVSDLV IGLQCGGSDA FSGVTANPAV GYAADLLVRA
310 320 330 340 350
GATVLFSEVT EVRDAIHLLT PRAVSEEVGQ SLIKEMKWYD SYLRRGDADR
360 370 380 390 400
SANPSPGNKK GGLSNVVEKA LGSVAKSGTS PISGVLGPGE RAKQKGLLFA
410 420 430 440 450
ATPASDFVCG TLQLAAGMNL QVFTTGRGTP YGLAAAPVLK VSTRHSLSEH
460 470 480 490 500
WADLIDINAG RIATGEASIE DVGWEIFRTI LDVASGRKQT WADRWGLHND
510
LCLFNPAPVT
Length:510
Mass (Da):54,794
Last modified:June 16, 2009 - v3
Checksum:iC1063C28575ACDED
GO

Sequence cautioni

The sequence BAA06472 differs from that shown. Reason: Frameshift at positions 112 and 199.Curated
The sequence BAA06473 differs from that shown. Reason: Frameshift at positions 112 and 199.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326E → K in BAA06473 (PubMed:7704254).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30808 Genomic DNA Translation: BAA06472.1 Frameshift.
D30808 Genomic DNA Translation: BAA06473.1 Frameshift.
AL009126 Genomic DNA Translation: CAB12045.2
PIRiC69753
RefSeqiNP_388133.2, NC_000964.3
WP_003246362.1, NZ_JNCM01000030.1

Genome annotation databases

EnsemblBacteriaiCAB12045; CAB12045; BSU02510
GeneIDi938407
KEGGibsu:BSU02510
PATRICifig|224308.179.peg.258

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30808 Genomic DNA Translation: BAA06472.1 Frameshift.
D30808 Genomic DNA Translation: BAA06473.1 Frameshift.
AL009126 Genomic DNA Translation: CAB12045.2
PIRiC69753
RefSeqiNP_388133.2, NC_000964.3
WP_003246362.1, NZ_JNCM01000030.1

3D structure databases

ProteinModelPortaliP42240
SMRiP42240
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP42240, 1 interactor
STRINGi224308.Bsubs1_010100001388

Proteomic databases

PaxDbiP42240
PRIDEiP42240

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12045; CAB12045; BSU02510
GeneIDi938407
KEGGibsu:BSU02510
PATRICifig|224308.179.peg.258

Phylogenomic databases

eggNOGiENOG4105CTX Bacteria
COG2721 LUCA
HOGENOMiHOG000219063
InParanoidiP42240
KOiK01708
OMAiHSYGCGV
PhylomeDBiP42240

Enzyme and pathway databases

UniPathwayi
UPA00565;UER00629

BioCyciBSUB:BSU02510-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR007392 Gal/Altron_deHydtase_C
IPR017654 GarD-like
IPR013974 SAF
PfamiView protein in Pfam
PF04295 GD_AH_C, 1 hit
PF08666 SAF, 1 hit
SMARTiView protein in SMART
SM00858 SAF, 1 hit
TIGRFAMsiTIGR03248 galactar-dH20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGARD_BACSU
AccessioniPrimary (citable) accession number: P42240
Secondary accession number(s): P42241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
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Main funding by: National Institutes of Health

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