UniProtKB - P42227 (STAT3_MOUSE)
Signal transducer and activator of transcription 3
Stat3
Functioni
Miscellaneous
GO - Molecular functioni
- CCR5 chemokine receptor binding Source: MGI
- chromatin DNA binding Source: UniProtKB
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- glucocorticoid receptor binding Source: MGI
- identical protein binding Source: IntAct
- nuclear receptor activity Source: MGI
- primary miRNA binding Source: MGI
- protein dimerization activity Source: MGI
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II repressing transcription factor binding Source: MGI
- sequence-specific DNA binding Source: MGI
- transcription factor binding Source: UniProtKB
- transcription regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- acute-phase response Source: UniProtKB-KW
- aging Source: Ensembl
- astrocyte differentiation Source: UniProtKB
- cell population proliferation Source: MGI
- cellular response to cytokine stimulus Source: MGI
- cellular response to hormone stimulus Source: MGI
- cellular response to leptin stimulus Source: UniProtKB
- cellular response to organic cyclic compound Source: MGI
- cytokine-mediated signaling pathway Source: GO_Central
- defense response Source: GO_Central
- eating behavior Source: MGI
- energy homeostasis Source: UniProtKB
- eye photoreceptor cell differentiation Source: MGI
- glucose homeostasis Source: UniProtKB
- growth hormone receptor signaling pathway Source: MGI
- growth hormone receptor signaling pathway via JAK-STAT Source: BHF-UCL
- inflammatory response Source: UniProtKB
- interleukin-6-mediated signaling pathway Source: UniProtKB
- intracellular receptor signaling pathway Source: MGI
- leptin-mediated signaling pathway Source: UniProtKB
- modulation of chemical synaptic transmission Source: Ensembl
- mRNA transcription by RNA polymerase II Source: MGI
- negative regulation of autophagy Source: MGI
- negative regulation of cell death Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of glycolytic process Source: MGI
- negative regulation of hydrogen peroxide biosynthetic process Source: MGI
- negative regulation of neuron death Source: MGI
- negative regulation of neuron migration Source: MGI
- negative regulation of primary miRNA processing Source: MGI
- negative regulation of stem cell differentiation Source: MGI
- phosphorylation Source: UniProtKB
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of ATP biosynthetic process Source: MGI
- positive regulation of cell migration Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cytokine production involved in inflammatory response Source: MGI
- positive regulation of erythrocyte differentiation Source: UniProtKB
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of gene silencing by miRNA Source: MGI
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation Source: MGI
- positive regulation of interleukin-10 production Source: MGI
- positive regulation of interleukin-1 beta production Source: MGI
- positive regulation of interleukin-6 production Source: MGI
- positive regulation of interleukin-8 production Source: MGI
- positive regulation of metalloendopeptidase activity Source: MGI
- positive regulation of miRNA mediated inhibition of translation Source: MGI
- positive regulation of NF-kappaB transcription factor activity Source: MGI
- positive regulation of Notch signaling pathway Source: UniProtKB
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of tumor necrosis factor production Source: MGI
- positive regulation of vascular endothelial cell proliferation Source: BHF-UCL
- postsynapse to nucleus signaling pathway Source: MGI
- protein import into nucleus Source: UniProtKB
- radial glial cell differentiation Source: UniProtKB
- receptor signaling pathway via JAK-STAT Source: GO_Central
- regulation of cell cycle Source: UniProtKB
- regulation of cell population proliferation Source: GO_Central
- regulation of feeding behavior Source: UniProtKB
- regulation of mitochondrial membrane permeability Source: MGI
- regulation of multicellular organism growth Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- response to cytokine Source: MGI
- response to drug Source: Ensembl
- response to estradiol Source: MGI
- response to ethanol Source: Ensembl
- response to leptin Source: UniProtKB
- response to peptide hormone Source: GO_Central
- sexual reproduction Source: MGI
- stem cell population maintenance Source: MGI
- temperature homeostasis Source: MGI
- T-helper 17 cell lineage commitment Source: UniProtKB
- T-helper 17 type immune response Source: UniProtKB
- transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Acute phase, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-1059683, Interleukin-6 signaling R-MMU-1266695, Interleukin-7 signaling R-MMU-1433557, Signaling by SCF-KIT R-MMU-186763, Downstream signal transduction R-MMU-6783783, Interleukin-10 signaling R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling R-MMU-8849474, PTK6 Activates STAT3 R-MMU-8854691, Interleukin-20 family signaling R-MMU-8875791, MET activates STAT3 R-MMU-8983432, Interleukin-15 signaling R-MMU-8984722, Interleukin-35 Signalling R-MMU-8985947, Interleukin-9 signaling R-MMU-9008059, Interleukin-37 signaling R-MMU-9020933, Interleukin-23 signaling R-MMU-9020956, Interleukin-27 signaling R-MMU-9020958, Interleukin-21 signaling |
Protein family/group databases
MoonDBi | P42227, Predicted |
MoonProti | P42227 |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcription 3ImportedAlternative name(s): Acute-phase response factor |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103038, Stat3 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
Note: Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity). Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation.By similarity
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrial inner membrane Source: MGI
- mitochondrion Source: MGI
Nucleus
- nuclear chromatin Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- glutamatergic synapse Source: MGI
- postsynaptic density Source: MGI
- RNA polymerase II transcription regulator complex Source: MGI
- Schaffer collateral - CA1 synapse Source: Ensembl
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 77 | V → A: No effect on nuclear import; when associated with A-78 and W-174. 1 Publication | 1 | |
Mutagenesisi | 78 | L → A: No effect on nuclear import; when associated with A-77 and W-174. 1 Publication | 1 | |
Mutagenesisi | 174 | F → W: No effect on nuclear import; when associated with A-77 and A-78. 1 Publication | 1 | |
Mutagenesisi | 609 | R → A: Nuclear localization to the same extent as wild-type; when associated with F-705. 1 Publication | 1 | |
Mutagenesisi | 705 | Y → F: Nuclear localization to the same extent as wild-type; when associated with A-609. 1 Publication | 1 | |
Mutagenesisi | 727 | S → A: Decreased transcriptional activation. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL5402 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000182418 | 2 – 770 | Signal transducer and activator of transcription 3Add BLAST | 769 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 601 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 601 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 615 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 615 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 631 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 631 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 685 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 685 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 705 | Phosphotyrosine; by FER and PTK6Combined sources2 Publications | 1 | |
Modified residuei | 707 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 714 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 727 | PhosphoserineCombined sources | 1 | |
Modified residuei | 727 | Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCECombined sources4 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P42227 |
jPOSTi | P42227 |
MaxQBi | P42227 |
PaxDbi | P42227 |
PeptideAtlasi | P42227 |
PRIDEi | P42227 |
PTM databases
iPTMneti | P42227 |
PhosphoSitePlusi | P42227 |
SwissPalmi | P42227 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000004040, Expressed in subcutaneous adipose tissue and 345 other tissues |
ExpressionAtlasi | P42227, baseline and differential |
Genevisiblei | P42227, MM |
Interactioni
Subunit structurei
Forms a homodimer or a heterodimer with a related family member (at least STAT1).
Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1.
Interacts with IL23R in presence of IL23.
Interacts (via SH2 domain) with NLK.
Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity).
Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity).
Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity).
Interacts with ARL2BP; interaction is enhanced with ARL2.
Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear.
Interacts with BMX.
Interacts with ZIPK/DAPK3.
Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3.
Interacts with STMN3, antagonizing its microtubule-destabilizing activity.
Interacts with the 'Lys-129' acetylated form of BIRC5/survivin.
Interacts with FER.
Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity).
Interacts with FGFR4 (By similarity).
Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status (By similarity).
Interacts with OCAD1 (PubMed:23972987).
Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB (By similarity).
Interacts and may form heterodimers with NHLH1 (PubMed:18356286).
By similarity12 PublicationsBinary interactionsi
Hide detailsP42227
GO - Molecular functioni
- CCR5 chemokine receptor binding Source: MGI
- glucocorticoid receptor binding Source: MGI
- identical protein binding Source: IntAct
- protein dimerization activity Source: MGI
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: MGI
- RNA polymerase II repressing transcription factor binding Source: MGI
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 203523, 31 interactors |
CORUMi | P42227 |
DIPi | DIP-442N |
IntActi | P42227, 31 interactors |
MINTi | P42227 |
STRINGi | 10090.ENSMUSP00000120152 |
Chemistry databases
BindingDBi | P42227 |
Miscellaneous databases
RNActi | P42227, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P42227 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42227 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 580 – 670 | SH2PROSITE-ProRule annotationAdd BLAST | 91 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 150 – 162 | Essential for nuclear importAdd BLAST | 13 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT00990000203570 |
HOGENOMi | CLU_014189_3_0_1 |
InParanoidi | P42227 |
OMAi | GKYCRSE |
PhylomeDBi | P42227 |
TreeFami | TF318648 |
Family and domain databases
CDDi | cd10374, SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
IDEALi | IID50277 |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME
110 120 130 140 150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD
160 170 180 190 200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM
210 220 230 240 250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA
260 270 280 290 300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR
360 370 380 390 400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN
410 420 430 440 450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL
460 470 480 490 500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT
510 520 530 540 550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC
560 570 580 590 600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
610 620 630 640 650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF
660 670 680 690 700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG
710 720 730 740 750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG
760 770
QFESLTFDMD LTSECATSPM
The sequence of this isoform differs from the canonical sequence as follows:
716-770: TTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM → FIDAVWK
The sequence of this isoform differs from the canonical sequence as follows:
701-701: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB7ZC18 | B7ZC18_MOUSE | Signal transducer and activator of ... | Stat3 | 744 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | E → K in AAA19452 (PubMed:7523373).Curated | 1 | |
Sequence conflicti | 25 | S → T in AAA19452 (PubMed:7523373).Curated | 1 | |
Sequence conflicti | 25 | S → T in AAC52612 (PubMed:7568080).Curated | 1 | |
Sequence conflicti | 394 | M → I in AAA37254 (PubMed:7512451).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010475 | 701 | Missing in isoform Del-701. 1 Publication | 1 | |
Alternative sequenceiVSP_006287 | 716 – 770 | TTCSN…ATSPM → FIDAVWK in isoform Stat3B. 1 PublicationAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29278 mRNA Translation: AAA37254.1 U08378 mRNA Translation: AAA56668.1 U06922 mRNA Translation: AAA19452.1 U30709 mRNA Translation: AAC52612.1 AF246978 Genomic DNA Translation: AAL59017.1 AY299489 mRNA Translation: AAQ75418.1 AY299490 mRNA Translation: AAQ75419.1 AL591466 Genomic DNA No translation available. BC003806 mRNA Translation: AAH03806.1 |
CCDSi | CCDS25440.1 [P42227-1] CCDS25441.1 [P42227-2] CCDS48934.1 [P42227-3] |
PIRi | I49508 |
RefSeqi | NP_998824.1, NM_213659.3 [P42227-1] NP_998825.1, NM_213660.3 [P42227-3] |
Genome annotation databases
Ensembli | ENSMUST00000092671; ENSMUSP00000090342; ENSMUSG00000004040 [P42227-3] ENSMUST00000103114; ENSMUSP00000099403; ENSMUSG00000004040 [P42227-2] ENSMUST00000127638; ENSMUSP00000120152; ENSMUSG00000004040 [P42227-1] |
GeneIDi | 20848 |
KEGGi | mmu:20848 |
UCSCi | uc007lmp.1, mouse [P42227-1] uc007lmq.1, mouse [P42227-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29278 mRNA Translation: AAA37254.1 U08378 mRNA Translation: AAA56668.1 U06922 mRNA Translation: AAA19452.1 U30709 mRNA Translation: AAC52612.1 AF246978 Genomic DNA Translation: AAL59017.1 AY299489 mRNA Translation: AAQ75418.1 AY299490 mRNA Translation: AAQ75419.1 AL591466 Genomic DNA No translation available. BC003806 mRNA Translation: AAH03806.1 |
CCDSi | CCDS25440.1 [P42227-1] CCDS25441.1 [P42227-2] CCDS48934.1 [P42227-3] |
PIRi | I49508 |
RefSeqi | NP_998824.1, NM_213659.3 [P42227-1] NP_998825.1, NM_213660.3 [P42227-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BG1 | X-ray | 2.25 | A | 127-715 | [»] | |
3CWG | X-ray | 3.05 | A/B | 127-688 | [»] | |
4E68 | X-ray | 2.58 | A | 127-715 | [»] | |
4ZIA | X-ray | 2.70 | A/B/C/D/E | 3-127 | [»] | |
SMRi | P42227 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 203523, 31 interactors |
CORUMi | P42227 |
DIPi | DIP-442N |
IntActi | P42227, 31 interactors |
MINTi | P42227 |
STRINGi | 10090.ENSMUSP00000120152 |
Chemistry databases
BindingDBi | P42227 |
ChEMBLi | CHEMBL5402 |
Protein family/group databases
MoonDBi | P42227, Predicted |
MoonProti | P42227 |
PTM databases
iPTMneti | P42227 |
PhosphoSitePlusi | P42227 |
SwissPalmi | P42227 |
Proteomic databases
EPDi | P42227 |
jPOSTi | P42227 |
MaxQBi | P42227 |
PaxDbi | P42227 |
PeptideAtlasi | P42227 |
PRIDEi | P42227 |
Protocols and materials databases
ABCDi | P42227, 1 sequenced antibody |
Antibodypediai | 660, 2385 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000092671; ENSMUSP00000090342; ENSMUSG00000004040 [P42227-3] ENSMUST00000103114; ENSMUSP00000099403; ENSMUSG00000004040 [P42227-2] ENSMUST00000127638; ENSMUSP00000120152; ENSMUSG00000004040 [P42227-1] |
GeneIDi | 20848 |
KEGGi | mmu:20848 |
UCSCi | uc007lmp.1, mouse [P42227-1] uc007lmq.1, mouse [P42227-3] |
Organism-specific databases
CTDi | 6774 |
MGIi | MGI:103038, Stat3 |
Phylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT00990000203570 |
HOGENOMi | CLU_014189_3_0_1 |
InParanoidi | P42227 |
OMAi | GKYCRSE |
PhylomeDBi | P42227 |
TreeFami | TF318648 |
Enzyme and pathway databases
Reactomei | R-MMU-1059683, Interleukin-6 signaling R-MMU-1266695, Interleukin-7 signaling R-MMU-1433557, Signaling by SCF-KIT R-MMU-186763, Downstream signal transduction R-MMU-6783783, Interleukin-10 signaling R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling R-MMU-8849474, PTK6 Activates STAT3 R-MMU-8854691, Interleukin-20 family signaling R-MMU-8875791, MET activates STAT3 R-MMU-8983432, Interleukin-15 signaling R-MMU-8984722, Interleukin-35 Signalling R-MMU-8985947, Interleukin-9 signaling R-MMU-9008059, Interleukin-37 signaling R-MMU-9020933, Interleukin-23 signaling R-MMU-9020956, Interleukin-27 signaling R-MMU-9020958, Interleukin-21 signaling |
Miscellaneous databases
BioGRID-ORCSi | 20848, 4 hits in 20 CRISPR screens |
ChiTaRSi | Stat3, mouse |
EvolutionaryTracei | P42227 |
PROi | PR:P42227 |
RNActi | P42227, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004040, Expressed in subcutaneous adipose tissue and 345 other tissues |
ExpressionAtlasi | P42227, baseline and differential |
Genevisiblei | P42227, MM |
Family and domain databases
CDDi | cd10374, SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
IDEALi | IID50277 |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAT3_MOUSE | |
Accessioni | P42227Primary (citable) accession number: P42227 Secondary accession number(s): A2A5D1, B7ZC17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 228 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families