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Protein

Signal transducer and activator of transcription 6

Gene

STAT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-186763 Downstream signal transduction
R-HSA-3249367 STAT6-mediated induction of chemokines
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P42226

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P42226

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal transducer and activator of transcription 6
Alternative name(s):
IL-4 Stat
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAT6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166888.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11368 STAT6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601512 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P42226

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi802L → A: Abolishes the interaction with NCOA1; when associated with A-805. 1 Publication1
Mutagenesisi805L → A: Abolishes the interaction with NCOA1; when associated with A-802. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6778

MalaCards human disease database

More...
MalaCardsi
STAT6

Open Targets

More...
OpenTargetsi
ENSG00000166888

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2126 Solitary fibrous tumor

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA339

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5401

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2993

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STAT6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1174459

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001824332 – 847Signal transducer and activator of transcription 6Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei641Phosphotyrosine; by JAK1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).By similarity2 Publications
Mono-ADP-ribosylated by PARP14.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P42226

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P42226

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P42226

PeptideAtlas

More...
PeptideAtlasi
P42226

PRoteomics IDEntifications database

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PRIDEi
P42226

ProteomicsDB human proteome resource

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ProteomicsDBi
55493
55494 [P42226-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P42226

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P42226

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166888 Expressed in 228 organ(s), highest expression level in esophagus

CleanEx database of gene expression profiles

More...
CleanExi
HS_STAT6

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P42226 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P42226 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA001861

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112655, 62 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P42226

Database of interacting proteins

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DIPi
DIP-39855N

Protein interaction database and analysis system

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IntActi
P42226, 35 interactors

Molecular INTeraction database

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MINTi
P42226

STRING: functional protein association networks

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STRINGi
9606.ENSP00000300134

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P42226

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1847
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P42226

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P42226

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P42226

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini517 – 632SH2PROSITE-ProRule annotationAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi802 – 806LXXLL motif5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3667 Eukaryota
ENOG410XPN8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153227

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230988

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107486

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P42226

KEGG Orthology (KO)

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KOi
K11225

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYPPHSH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03O3

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P42226

TreeFam database of animal gene trees

More...
TreeFami
TF318648

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10377 SH2_STAT6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR028187 STAT6_C
IPR035857 STAT6_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction

The PANTHER Classification System

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PANTHERi
PTHR11801 PTHR11801, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF14596 STAT6_C, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P42226-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLWGLVSKM PPEKVQRLYV DFPQHLRHLL GDWLESQPWE FLVGSDAFCC
60 70 80 90 100
NLASALLSDT VQHLQASVGE QGEGSTILQH ISTLESIYQR DPLKLVATFR
110 120 130 140 150
QILQGEKKAV MEQFRHLPMP FHWKQEELKF KTGLRRLQHR VGEIHLLREA
160 170 180 190 200
LQKGAEAGQV SLHSLIETPA NGTGPSEALA MLLQETTGEL EAAKALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGAPFEES LAPLQERCES LVDIYSQLQQ EVGAAGGELE
260 270 280 290 300
PKTRASLTGR LDEVLRTLVT SCFLVEKQPP QVLKTQTKFQ AGVRFLLGLR
310 320 330 340 350
FLGAPAKPPL VRADMVTEKQ ARELSVPQGP GAGAESTGEI INNTVPLENS
360 370 380 390 400
IPGNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFSA SFTLGPGKLP
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTNRGLL PEHFLFLAQK IFNDNSLSME AFQHRSVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSPQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVPATIKMTV
660 670 680 690 700
ERDQPLPTPE LQMPTMVPSY DLGMAPDSSM SMQLGPDMVP QVYPPHSHSI
710 720 730 740 750
PPYQGLSPEE SVNVLSAFQE PHLQMPPSLG QMSLPFDQPH PQGLLPCQPQ
760 770 780 790 800
EHAVSSPDPL LCSDVTMVED SCLSQPVTAF PQGTWIGEDI FPPLLPPTEQ
810 820 830 840
DLTKLLLEGQ GESGGGSLGA QPLLQPSHYG QSGISMSHMD LRANPSW
Length:847
Mass (Da):94,135
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF35075F1C1F2A677
GO
Isoform 2 (identifier: P42226-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.
     175-177: PSE → MEQ

Show »
Length:673
Mass (Da):74,456
Checksum:i7A050ADF43A669BB
GO
Isoform 3 (identifier: P42226-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Note: No experimental confirmation available.
Show »
Length:737
Mass (Da):81,748
Checksum:i8A076ABC6053A831
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PNW1A0A1W2PNW1_HUMAN
Signal transducer and activator of ...
STAT6
679Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2X7G3V2X7_HUMAN
Signal transducer and activator of ...
STAT6
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJH6H0YJH6_HUMAN
Signal transducer and activator of ...
STAT6
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2M3G3V2M3_HUMAN
Signal transducer and activator of ...
STAT6
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V568G3V568_HUMAN
Signal transducer and activator of ...
STAT6
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5K5G3V5K5_HUMAN
Signal transducer and activator of ...
STAT6
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3E9G3V3E9_HUMAN
Signal transducer and activator of ...
STAT6
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V370G3V370_HUMAN
Signal transducer and activator of ...
STAT6
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5FBW6Q5FBW6_HUMAN
Signal transducer and activator of ...
STAT6
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2L2G3V2L2_HUMAN
Signal transducer and activator of ...
STAT6
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149E → Q in AAC67525 (PubMed:9782085).Curated1
Sequence conflicti246G → D in BAH14513 (PubMed:14702039).Curated1
Sequence conflicti733S → N in AAC67525 (PubMed:9782085).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013094181M → R1 PublicationCorresponds to variant dbSNP:rs3024952Ensembl.1
Natural variantiVAR_059812419D → N. Corresponds to variant dbSNP:rs11172102Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0318711 – 174Missing in isoform 2. 1 PublicationAdd BLAST174
Alternative sequenceiVSP_0452821 – 110Missing in isoform 3. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_031872175 – 177PSE → MEQ in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U16031 mRNA Translation: AAA57193.1
AF067575, AF067572, AF067573 Genomic DNA Translation: AAC67525.1
AB103089 mRNA Translation: BAD89432.1
AK290431 mRNA Translation: BAF83120.1
AK316142 mRNA Translation: BAH14513.1
AF417842 Genomic DNA Translation: AAL06595.1
AC023237 Genomic DNA No translation available.
BC075852 mRNA Translation: AAH75852.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53804.1 [P42226-3]
CCDS8931.1 [P42226-1]

Protein sequence database of the Protein Information Resource

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PIRi
A54740

NCBI Reference Sequences

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RefSeqi
NP_001171549.1, NM_001178078.1 [P42226-1]
NP_001171550.1, NM_001178079.1 [P42226-1]
NP_001171551.1, NM_001178080.1 [P42226-3]
NP_003144.3, NM_003153.4 [P42226-1]
XP_006719638.1, XM_006719575.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.524518

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000300134; ENSP00000300134; ENSG00000166888 [P42226-1]
ENST00000454075; ENSP00000401486; ENSG00000166888 [P42226-1]
ENST00000537215; ENSP00000444530; ENSG00000166888 [P42226-3]
ENST00000538913; ENSP00000445409; ENSG00000166888 [P42226-3]
ENST00000543873; ENSP00000438451; ENSG00000166888 [P42226-1]
ENST00000556155; ENSP00000451742; ENSG00000166888 [P42226-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6778

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6778

UCSC genome browser

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UCSCi
uc001sna.5 human [P42226-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16031 mRNA Translation: AAA57193.1
AF067575, AF067572, AF067573 Genomic DNA Translation: AAC67525.1
AB103089 mRNA Translation: BAD89432.1
AK290431 mRNA Translation: BAF83120.1
AK316142 mRNA Translation: BAH14513.1
AF417842 Genomic DNA Translation: AAL06595.1
AC023237 Genomic DNA No translation available.
BC075852 mRNA Translation: AAH75852.1
CCDSiCCDS53804.1 [P42226-3]
CCDS8931.1 [P42226-1]
PIRiA54740
RefSeqiNP_001171549.1, NM_001178078.1 [P42226-1]
NP_001171550.1, NM_001178079.1 [P42226-1]
NP_001171551.1, NM_001178080.1 [P42226-3]
NP_003144.3, NM_003153.4 [P42226-1]
XP_006719638.1, XM_006719575.2
UniGeneiHs.524518

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OJ5X-ray2.20B795-808[»]
4Y5UX-ray2.71A/B113-658[»]
4Y5WX-ray3.10A/B/C/D113-658[»]
5D39X-ray3.20A/B/C/D123-658[»]
5NWMNMR-B783-814[»]
5NWXX-ray2.51B783-814[»]
ProteinModelPortaliP42226
SMRiP42226
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112655, 62 interactors
CORUMiP42226
DIPiDIP-39855N
IntActiP42226, 35 interactors
MINTiP42226
STRINGi9606.ENSP00000300134

Chemistry databases

BindingDBiP42226
ChEMBLiCHEMBL5401
GuidetoPHARMACOLOGYi2993

PTM databases

iPTMnetiP42226
PhosphoSitePlusiP42226

Polymorphism and mutation databases

BioMutaiSTAT6
DMDMi1174459

Proteomic databases

EPDiP42226
MaxQBiP42226
PaxDbiP42226
PeptideAtlasiP42226
PRIDEiP42226
ProteomicsDBi55493
55494 [P42226-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6778
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300134; ENSP00000300134; ENSG00000166888 [P42226-1]
ENST00000454075; ENSP00000401486; ENSG00000166888 [P42226-1]
ENST00000537215; ENSP00000444530; ENSG00000166888 [P42226-3]
ENST00000538913; ENSP00000445409; ENSG00000166888 [P42226-3]
ENST00000543873; ENSP00000438451; ENSG00000166888 [P42226-1]
ENST00000556155; ENSP00000451742; ENSG00000166888 [P42226-1]
GeneIDi6778
KEGGihsa:6778
UCSCiuc001sna.5 human [P42226-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6778
DisGeNETi6778
EuPathDBiHostDB:ENSG00000166888.10

GeneCards: human genes, protein and diseases

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GeneCardsi
STAT6
HGNCiHGNC:11368 STAT6
HPAiHPA001861
MalaCardsiSTAT6
MIMi601512 gene
neXtProtiNX_P42226
OpenTargetsiENSG00000166888
Orphaneti2126 Solitary fibrous tumor
PharmGKBiPA339

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00940000153227
HOGENOMiHOG000230988
HOVERGENiHBG107486
InParanoidiP42226
KOiK11225
OMAiVYPPHSH
OrthoDBiEOG091G03O3
PhylomeDBiP42226
TreeFamiTF318648

Enzyme and pathway databases

ReactomeiR-HSA-186763 Downstream signal transduction
R-HSA-3249367 STAT6-mediated induction of chemokines
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkiP42226
SIGNORiP42226

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
STAT6 human
EvolutionaryTraceiP42226

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STAT6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6778

Protein Ontology

More...
PROi
PR:P42226

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166888 Expressed in 228 organ(s), highest expression level in esophagus
CleanExiHS_STAT6
ExpressionAtlasiP42226 baseline and differential
GenevisibleiP42226 HS

Family and domain databases

CDDicd10377 SH2_STAT6, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR028187 STAT6_C
IPR035857 STAT6_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF14596 STAT6_C, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAT6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42226
Secondary accession number(s): A8K316
, B7ZA27, F5GXI9, Q5FBW5, Q71UP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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