UniProtKB - P42224 (STAT1_HUMAN)
Signal transducer and activator of transcription 1-alpha/beta
STAT1
Functioni
Caution
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- double-stranded DNA binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- histone acetyltransferase binding Source: UniProtKB
- histone binding Source: UniProtKB
- identical protein binding Source: IntAct
- nuclear hormone receptor binding Source: UniProtKB
- promoter-specific chromatin binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- repressing transcription factor binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
- ubiquitin-like protein ligase binding Source: UniProtKB
GO - Biological processi
- blood circulation Source: UniProtKB
- cellular response to interferon-beta Source: BHF-UCL
- cellular response to interferon-gamma Source: UniProtKB
- cytokine-mediated signaling pathway Source: GO_Central
- defense response Source: GO_Central
- defense response to virus Source: UniProtKB
- interferon-gamma-mediated signaling pathway Source: BHF-UCL
- interleukin-21-mediated signaling pathway Source: Reactome
- interleukin-27-mediated signaling pathway Source: Reactome
- interleukin-35-mediated signaling pathway Source: Reactome
- interleukin-6-mediated signaling pathway Source: Reactome
- interleukin-9-mediated signaling pathway Source: Reactome
- macrophage derived foam cell differentiation Source: UniProtKB
- metanephric mesenchymal cell differentiation Source: UniProtKB
- metanephric mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
- negative regulation by virus of viral protein levels in host cell Source: AgBase
- negative regulation of angiogenesis Source: UniProtKB
- negative regulation of endothelial cell proliferation Source: UniProtKB
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
- negative regulation of metanephric nephron tubule epithelial cell differentiation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of defense response to virus by host Source: UniProtKB
- positive regulation of erythrocyte differentiation Source: UniProtKB
- positive regulation of interferon-alpha production Source: UniProtKB
- positive regulation of mesenchymal cell proliferation Source: UniProtKB
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription of Notch receptor target Source: Reactome
- receptor signaling pathway via JAK-STAT Source: UniProtKB
- regulation of apoptotic process Source: UniProtKB
- regulation of cell population proliferation Source: GO_Central
- regulation of interferon-gamma-mediated signaling pathway Source: Reactome
- regulation of transcription, DNA-templated Source: GOC
- renal tubule development Source: UniProtKB
- response to cAMP Source: UniProtKB
- response to cytokine Source: UniProtKB
- response to interferon-beta Source: UniProtKB
- response to peptide hormone Source: UniProtKB
- tumor necrosis factor-mediated signaling pathway Source: UniProtKB
- type I interferon signaling pathway Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Antiviral defense, Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P42224 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-1169408, ISG15 antiviral mechanism R-HSA-1433557, Signaling by SCF-KIT R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-186763, Downstream signal transduction R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-877300, Interferon gamma signaling [P42224-1] R-HSA-877312, Regulation of IFNG signaling [P42224-1] R-HSA-8854691, Interleukin-20 family signaling R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8984722, Interleukin-35 Signalling R-HSA-8985947, Interleukin-9 signaling R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9020956, Interleukin-27 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants R-HSA-982772, Growth hormone receptor signaling |
SignaLinki | P42224 |
SIGNORi | P42224 |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcription 1-alpha/betaAlternative name(s): Transcription factor ISGF-3 components p91/p84 |
Gene namesi | Name:STAT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11362, STAT1 |
MIMi | 600555, gene |
neXtProti | NX_P42224 |
VEuPathDBi | HostDB:ENSG00000115415.18 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
Other locations
- Cytoplasm 4 Publications
Note: Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788).3 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: BHF-UCL
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- axon Source: UniProtKB
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB
- perinuclear region of cytoplasm Source: AgBase
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Immunodeficiency 31B (IMD31B)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065815 | 201 | K → N in IMD31B; not deleterious in terms of most STAT1 functions; causes abnormal splicing out of exon 8 from most mRNAs thereby decreasing protein levels by approximately 70%. 1 PublicationCorresponds to variant dbSNP:rs587776870EnsemblClinVar. | 1 | |
Natural variantiVAR_018265 | 600 | L → P in IMD31B; found in an infant who died of a viral-like illness associated with complete STAT1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs137852678EnsemblClinVar. | 1 | |
Natural variantiVAR_075500 | 701 | Y → C in IMD31B; disrupts transactivation activity in response to IFNG. 1 Publication | 1 |
Immunodeficiency 31A (IMD31A)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065816 | 320 | E → Q in IMD31A; affects the DNA-binding activity of the protein. 1 PublicationCorresponds to variant dbSNP:rs137852680EnsemblClinVar. | 1 | |
Natural variantiVAR_065817 | 463 | Q → H in IMD31A; affects the DNA-binding activity of the protein. 1 PublicationCorresponds to variant dbSNP:rs137852679EnsemblClinVar. | 1 | |
Natural variantiVAR_068713 | 637 | K → E in IMD31A; affects both phosphorylation and DNA-binding activity; results in impaired STAT1-mediated cellular response to IFN-gamma and interleukin-27. 1 PublicationCorresponds to variant dbSNP:rs587777705EnsemblClinVar. | 1 | |
Natural variantiVAR_068714 | 673 | K → R in IMD31A; impairs tyrosine phosphorylation; results in impaired STAT1-mediated cellular response to IFN-gamma and interleukin-27. 1 PublicationCorresponds to variant dbSNP:rs587777704EnsemblClinVar. | 1 | |
Natural variantiVAR_018266 | 706 | L → S in IMD31A; loss of GAF and ISGF3 activation; impairs the nuclear accumulation of GAF but not of ISGF3 in heterozygous cells stimulated by IFNs; affects phosphorylation of the protein. 2 PublicationsCorresponds to variant dbSNP:rs137852677EnsemblClinVar. | 1 |
Immunodeficiency 31C (IMD31C)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065934 | 165 | D → G in IMD31C; gain of function mutation associated with increased STAT1 phosphorylation due to impaired nuclear dephosphorylation. 2 PublicationsCorresponds to variant dbSNP:rs387906764EnsemblClinVar. | 1 | |
Natural variantiVAR_065935 | 165 | D → H in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906767EnsemblClinVar. | 1 | |
Natural variantiVAR_065936 | 170 | Y → N in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906766EnsemblClinVar. | 1 | |
Natural variantiVAR_065937 | 174 | C → R in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906763EnsemblClinVar. | 1 | |
Natural variantiVAR_075494 | 179 | N → K in IMD31C; gain of function; increases transactivation activity in response to IFNG. 1 PublicationCorresponds to variant dbSNP:rs587777628EnsemblClinVar. | 1 | |
Natural variantiVAR_065938 | 202 | M → I in IMD31C. 1 Publication | 1 | |
Natural variantiVAR_065939 | 202 | M → V in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906762EnsemblClinVar. | 1 | |
Natural variantiVAR_065940 | 267 | A → V in IMD31C. 2 PublicationsCorresponds to variant dbSNP:rs387906759EnsemblClinVar. | 1 | |
Natural variantiVAR_065941 | 271 | Q → P in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906768EnsemblClinVar. | 1 | |
Natural variantiVAR_065942 | 274 | R → Q in IMD31C; gain of function; increases STAT1 phosphorylation due to impaired nuclear dephosphorylation; increases transactivation activity in response to IFNG. 2 PublicationsCorresponds to variant dbSNP:rs387906760EnsemblClinVar. | 1 | |
Natural variantiVAR_065943 | 274 | R → W in IMD31C; gain of function; increases phosphorylation in response to IFNG, IFNA and IL27 due to a loss of dephosphorylation. 3 PublicationsCorresponds to variant dbSNP:rs387906758EnsemblClinVar. | 1 | |
Natural variantiVAR_075495 | 278 | K → E in IMD31C; gain of function; increases phosphorylation in response to IFNG and IFNA due to a loss of dephosphorylation. 1 PublicationCorresponds to variant dbSNP:rs863223398EnsemblClinVar. | 1 | |
Natural variantiVAR_075496 | 285 | Q → R in IMD31C; gain of function; increases transactivation activity in response to IFNG. 1 PublicationCorresponds to variant dbSNP:rs587777629EnsemblClinVar. | 1 | |
Natural variantiVAR_065944 | 286 | K → I in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906761EnsemblClinVar. | 1 | |
Natural variantiVAR_065945 | 288 | T → A in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906765EnsemblClinVar. | 1 | |
Natural variantiVAR_075497 | 298 | K → N in IMD31C; gain of function; increases basal STAT1 phosphorylation levels which are 10-20 fold higher than controls after IFNG stimulation. 1 Publication | 1 | |
Natural variantiVAR_075498 | 384 | G → D in IMD31C; gain of function; increases phosphorylation in response to IFNG and IFNA due to a loss of dephosphorylation. 1 PublicationCorresponds to variant dbSNP:rs796065052EnsemblClinVar. | 1 | |
Natural variantiVAR_075499 | 385 | T → M in IMD31C; gain of function; increases phosphorylation in response to IFNG, IFNA and IL27 due to a loss of dephosphorylation. 2 PublicationsCorresponds to variant dbSNP:rs587777630EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 110 | K → R: Sumoylated. 1 Publication | 1 | |
Mutagenesisi | 114 | K → A: No effect on IFN-alpha-induced STAT1 phosphorylation and nuclear translocation. 1 Publication | 1 | |
Mutagenesisi | 175 | K → A: No effect on IFN-alpha-induced STAT1 phosphorylation and nuclear translocation. 1 Publication | 1 | |
Mutagenesisi | 296 | K → A: No effect on IFN-alpha-induced STAT1 phosphorylation and nuclear translocation. 1 Publication | 1 | |
Mutagenesisi | 366 | K → A: No effect on IFN-alpha-induced STAT1 phosphorylation and nuclear translocation. 1 Publication | 1 | |
Mutagenesisi | 525 | K → A: Strongly reduced IFN-alpha-induced STAT1 phosphorylation and nuclear translocation. Does not affect ability to homodimerize. 1 Publication | 1 | |
Mutagenesisi | 636 – 637 | KK → AA: No effect on IFN-alpha-induced STAT1 phosphorylation and nuclear translocation. 1 Publication | 2 | |
Mutagenesisi | 656 – 658 | AEN → CEC: Enhances STAT1 nuclear translocation and interferon (IFN)-stimulated gene (ISG) expression in response to IFN-beta stimulation. Reduces viral load in infected cultured cells. 1 Publication | 3 | |
Mutagenesisi | 657 | E → Q: Loss of ADP-ribosylation and increased Tyr-701 phosphorylation; when associated with Q-705. 1 Publication | 1 | |
Mutagenesisi | 665 | K → A: No effect on IFN-alpha-induced STAT1 phosphorylation and nuclear translocation. 1 Publication | 1 | |
Mutagenesisi | 701 | Y → E: Not phosphorylated at S-708 upon IFNB induction. 2 Publications | 1 | |
Mutagenesisi | 701 | Y → F: No effect on basal sumoylation. Enhances sumoylation in the presence of MAPK stimulation. Phosphorylated at S-708 upon IFNB induction. 2 Publications | 1 | |
Mutagenesisi | 703 | K → R: Abolishes sumoylation by SUMO1. Increased IFN-gamma-mediated transactivation. 2 Publications | 1 | |
Mutagenesisi | 705 | E → Q: Loss of ADP-ribosylation and increased Tyr-701 phosphorylation; when associated with Q-657. 1 Publication | 1 | |
Mutagenesisi | 708 | S → A: Phosphorylated at Y-701 upon IFNB induction. 1 Publication | 1 | |
Mutagenesisi | 708 | S → D: Not phosphorylated at Y-701 upon IFNB induction. 1 Publication | 1 | |
Mutagenesisi | 727 | S → A: Decreased transcriptional activation. No effect on basal sumoylation. No enhancement of sumoylation on MAPK stimulation. No PRKCD-induced apoptosis. Upon IFNB induction, phosphorylated at Y-701 but not at S-708. 3 Publications | 1 | |
Mutagenesisi | 727 | S → D: No change in enhancement of MAPK-induced sumoylation. Basal interaction with PIAS1. Interaction with PIAS1 increased on MAPK stimulation. 3 Publications | 1 | |
Mutagenesisi | 727 | S → E: No change in enhancement of MAPK-induced sumoylation. 3 Publications | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6772 |
MalaCardsi | STAT1 |
MIMi | 613796, phenotype 614162, phenotype 614892, phenotype |
OpenTargetsi | ENSG00000115415 |
Orphaneti | 391487, Autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome 319595, Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency 391311, Susceptibility to viral and mycobacterial infections due to STAT1 deficiency |
PharmGKBi | PA36183 |
Miscellaneous databases
Pharosi | P42224, Tchem |
Chemistry databases
ChEMBLi | CHEMBL6101 |
Genetic variation databases
BioMutai | STAT1 |
DMDMi | 2507413 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000182410 | 2 – 750 | Signal transducer and activator of transcription 1-alpha/betaAdd BLAST | 749 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 114 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 175 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 296 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 366 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 525 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 637 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 657 | ADP-ribosyl glutamic acid; by PARP141 Publication | 1 | |
Modified residuei | 665 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 701 | Phosphotyrosine; by JAK1, JAK2 or TYK28 Publications | 1 | |
Cross-linki | 703 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 703 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 705 | ADP-ribosyl glutamic acid; by PARP141 Publication | 1 | |
Modified residuei | 708 | Phosphoserine; by IKKE1 Publication | 1 | |
Modified residuei | 727 | Phosphoserine; by MAPK14Combined sources6 Publications | 1 | |
Modified residuei | 745 | Phosphoserine; by IKKEBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, ADP-ribosylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1272 CPTAC-1746 |
EPDi | P42224 |
jPOSTi | P42224 |
MassIVEi | P42224 |
MaxQBi | P42224 |
PaxDbi | P42224 |
PeptideAtlasi | P42224 |
PRIDEi | P42224 |
ProteomicsDBi | 55491 [P42224-1] 55492 [P42224-2] |
PTM databases
CarbonylDBi | P42224 |
iPTMneti | P42224 |
MetOSitei | P42224 |
PhosphoSitePlusi | P42224 |
SwissPalmi | P42224 |
Expressioni
Gene expression databases
Bgeei | ENSG00000115415, Expressed in epithelium of bronchus and 244 other tissues |
ExpressionAtlasi | P42224, baseline and differential |
Genevisiblei | P42224, HS |
Organism-specific databases
HPAi | ENSG00000115415, Low tissue specificity |
Interactioni
Subunit structurei
Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation (PubMed:8605877, PubMed:28753426). Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation (PubMed:8605877). The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9 (By similarity).
Interacts (phosphorylated at Ser-727) with PIAS1; the interaction results in release of STAT1 from its target gene (PubMed:9724754, PubMed:17897103).
Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466' (PubMed:9121453).
Interacts with IFNAR2 (PubMed:9121453).
Found in a complex with NMI and CREBBP/CBP (PubMed:9989503).
Interacts with NMI which is required for CREBBP/CBP recruitment to the complex (PubMed:9989503).
Interacts with PTK2/FAK1 (PubMed:11278462).
Interacts with SRC (By similarity).
Interacts with ERBB4 (phosphorylated) (PubMed:18721752).
Interacts with PARP9 and DTX3L independently of IFN-beta or IFN-gamma-mediated STAT1 'Tyr-701' phosphorylation (PubMed:26479788).
Interacts with histone acetyltransferase EP300/p300 in response to INF-gamma stimulation (PubMed:26479788).
Interacts with OTOP1 (By similarity).
By similarity9 Publications(Microbial infection) Interacts with Sendai virus C', C, Y1 and Y2 proteins, preventing activation of ISRE and GAS promoter.
(Microbial infection) Interacts with Nipah virus P, V and W proteins preventing activation of ISRE and GAS promoter.
(Microbial infection) Interacts with Rabies virus phosphoprotein preventing activation of ISRE and GAS promoter.
2 Publications(Microbial infection) Interacts with HCV core protein; the interaction results in STAT1 degradation.
1 Publication(Microbial infection) Interacts with ebolavirus protein VP24.
1 PublicationBinary interactionsi
Hide detailsP42224
STAT1 - isoform Alpha [P42224-1]
With | #Exp. | IntAct |
---|---|---|
KDM3A [Q9Y4C1] | 8 | EBI-15711971,EBI-2515339 |
itself | 3 | EBI-15711971,EBI-15711971 |
P06498 from Human adenovirus C serotype 5. | 2 | EBI-15711971,EBI-16085959 |
STAT1 - isoform Beta [P42224-2]
With | #Exp. | IntAct |
---|---|---|
itself | 4 | EBI-15712015,EBI-15712015 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- enzyme binding Source: UniProtKB
- histone acetyltransferase binding Source: UniProtKB
- histone binding Source: UniProtKB
- identical protein binding Source: IntAct
- nuclear hormone receptor binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- repressing transcription factor binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
- ubiquitin-like protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112649, 196 interactors |
ComplexPortali | CPX-6016, ISGF3 complex CPX-6041, STAT1/STAT3 complex CPX-6042, STAT1/STAT4 complex CPX-6048, STAT1 homodimer |
CORUMi | P42224 |
DIPi | DIP-46140N |
IntActi | P42224, 163 interactors |
MINTi | P42224 |
STRINGi | 9606.ENSP00000354394 |
Chemistry databases
BindingDBi | P42224 |
Miscellaneous databases
RNActi | P42224, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P42224 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42224 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 573 – 670 | SH2PROSITE-ProRule annotationAdd BLAST | 98 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 136 – 317 | 1 PublicationAdd BLAST | 182 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH2 domainPhylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT01010000222348 |
HOGENOMi | CLU_014189_3_0_1 |
InParanoidi | P42224 |
OMAi | DTMMNAV |
OrthoDBi | 327469at2759 |
PhylomeDBi | P42224 |
TreeFami | TF318648 |
Family and domain databases
CDDi | cd10372, SH2_STAT1, 1 hit |
DisProti | DP00962 |
Gene3Di | 1.10.532.10, 1 hit 1.10.8.1200, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
IDEALi | IID00046 |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR038295, STAT1_C_sf IPR035859, STAT1_SH2 IPR022752, STAT1_TAZ2-bd_C IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12162, STAT1_TAZ2bind, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV
60 70 80 90 100
SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ
110 120 130 140 150
MSMIIYSCLK EERKILENAQ RFNQAQSGNI QSTVMLDKQK ELDSKVRNVK
160 170 180 190 200
DKVMCIEHEI KSLEDLQDEY DFKCKTLQNR EHETNGVAKS DQKQEQLLLK
210 220 230 240 250
KMYLMLDNKR KEVVHKIIEL LNVTELTQNA LINDELVEWK RRQQSACIGG
260 270 280 290 300
PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQV
310 320 330 340 350
LWDRTFSLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK
360 370 380 390 400
LQELNYNLKV KVLFDKDVNE RNTVKGFRKF NILGTHTKVM NMEESTNGSL
410 420 430 440 450
AAEFRHLQLK EQKNAGTRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET
460 470 480 490 500
TSLPVVVISN VSQLPSGWAS ILWYNMLVAE PRNLSFFLTP PCARWAQLSE
510 520 530 540 550
VLSWQFSSVT KRGLNVDQLN MLGEKLLGPN ASPDGLIPWT RFCKENINDK
560 570 580 590 600
NFPFWLWIES ILELIKKHLL PLWNDGCIMG FISKERERAL LKDQQPGTFL
610 620 630 640 650
LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN
660 670 680 690 700
YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG
710 720 730 740 750
YIKTELISVS EVHPSRLQTT DNLLPMSPEE FDEVSRIVGS VEFDSMMNTV
The sequence of this isoform differs from the canonical sequence as follows:
713-750: Missing.
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KPM9 | J3KPM9_HUMAN | Signal transducer and activator of ... | STAT1 | 714 | Annotation score: | ||
A0A669KB53 | A0A669KB53_HUMAN | Signal transducer and activator of ... | STAT1 | 791 | Annotation score: | ||
A0A669KB56 | A0A669KB56_HUMAN | Signal transducer and activator of ... | STAT1 | 748 | Annotation score: | ||
A0A669KB68 | A0A669KB68_HUMAN | Signal transducer and activator of ... | STAT1 | 748 | Annotation score: | ||
A0A669KBA4 | A0A669KBA4_HUMAN | Signal transducer and activator of ... | STAT1 | 779 | Annotation score: | ||
A0A669KBI6 | A0A669KBI6_HUMAN | Signal transducer and activator of ... | STAT1 | 716 | Annotation score: | ||
A0A669KB52 | A0A669KB52_HUMAN | Signal transducer and activator of ... | STAT1 | 636 | Annotation score: | ||
E7EPD2 | E7EPD2_HUMAN | Signal transducer and activator of ... | STAT1 | 377 | Annotation score: | ||
A0A669KB75 | A0A669KB75_HUMAN | Signal transducer and activator of ... | STAT1 | 572 | Annotation score: | ||
D2KFR9 | D2KFR9_HUMAN | Signal transducer and activator of ... | STAT1 | 193 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | A → T in ADA59516 (Ref. 2) Curated | 1 | |
Sequence conflicti | 307 | S → G in BAF85293 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 718 | Q → R in CAH18430 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034521 | 30 | I → T. Corresponds to variant dbSNP:rs34255470Ensembl. | 1 | |
Natural variantiVAR_065934 | 165 | D → G in IMD31C; gain of function mutation associated with increased STAT1 phosphorylation due to impaired nuclear dephosphorylation. 2 PublicationsCorresponds to variant dbSNP:rs387906764EnsemblClinVar. | 1 | |
Natural variantiVAR_065935 | 165 | D → H in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906767EnsemblClinVar. | 1 | |
Natural variantiVAR_065936 | 170 | Y → N in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906766EnsemblClinVar. | 1 | |
Natural variantiVAR_065937 | 174 | C → R in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906763EnsemblClinVar. | 1 | |
Natural variantiVAR_075494 | 179 | N → K in IMD31C; gain of function; increases transactivation activity in response to IFNG. 1 PublicationCorresponds to variant dbSNP:rs587777628EnsemblClinVar. | 1 | |
Natural variantiVAR_065815 | 201 | K → N in IMD31B; not deleterious in terms of most STAT1 functions; causes abnormal splicing out of exon 8 from most mRNAs thereby decreasing protein levels by approximately 70%. 1 PublicationCorresponds to variant dbSNP:rs587776870EnsemblClinVar. | 1 | |
Natural variantiVAR_065938 | 202 | M → I in IMD31C. 1 Publication | 1 | |
Natural variantiVAR_065939 | 202 | M → V in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906762EnsemblClinVar. | 1 | |
Natural variantiVAR_065940 | 267 | A → V in IMD31C. 2 PublicationsCorresponds to variant dbSNP:rs387906759EnsemblClinVar. | 1 | |
Natural variantiVAR_065941 | 271 | Q → P in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906768EnsemblClinVar. | 1 | |
Natural variantiVAR_065942 | 274 | R → Q in IMD31C; gain of function; increases STAT1 phosphorylation due to impaired nuclear dephosphorylation; increases transactivation activity in response to IFNG. 2 PublicationsCorresponds to variant dbSNP:rs387906760EnsemblClinVar. | 1 | |
Natural variantiVAR_065943 | 274 | R → W in IMD31C; gain of function; increases phosphorylation in response to IFNG, IFNA and IL27 due to a loss of dephosphorylation. 3 PublicationsCorresponds to variant dbSNP:rs387906758EnsemblClinVar. | 1 | |
Natural variantiVAR_075495 | 278 | K → E in IMD31C; gain of function; increases phosphorylation in response to IFNG and IFNA due to a loss of dephosphorylation. 1 PublicationCorresponds to variant dbSNP:rs863223398EnsemblClinVar. | 1 | |
Natural variantiVAR_075496 | 285 | Q → R in IMD31C; gain of function; increases transactivation activity in response to IFNG. 1 PublicationCorresponds to variant dbSNP:rs587777629EnsemblClinVar. | 1 | |
Natural variantiVAR_065944 | 286 | K → I in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906761EnsemblClinVar. | 1 | |
Natural variantiVAR_065945 | 288 | T → A in IMD31C. 1 PublicationCorresponds to variant dbSNP:rs387906765EnsemblClinVar. | 1 | |
Natural variantiVAR_075497 | 298 | K → N in IMD31C; gain of function; increases basal STAT1 phosphorylation levels which are 10-20 fold higher than controls after IFNG stimulation. 1 Publication | 1 | |
Natural variantiVAR_065816 | 320 | E → Q in IMD31A; affects the DNA-binding activity of the protein. 1 PublicationCorresponds to variant dbSNP:rs137852680EnsemblClinVar. | 1 | |
Natural variantiVAR_075498 | 384 | G → D in IMD31C; gain of function; increases phosphorylation in response to IFNG and IFNA due to a loss of dephosphorylation. 1 Publication |