UniProtKB - P42216 (KPSU5_ECOLX)
Protein
3-deoxy-manno-octulosonate cytidylyltransferase
Gene
kpsU
Organism
Escherichia coli
Status
Functioni
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation
Catalytic activityi
- 3-deoxy-α-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-β-D-manno-octulosonate + diphosphateUniRule annotationEC:2.7.7.38UniRule annotation
: CMP-3-deoxy-D-manno-octulosonate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB_1), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB_2), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB), 3-deoxy-manno-octulosonate cytidylyltransferase (kpsU), 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.
Pathwayi: lipopolysaccharide biosynthesis
This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.
GO - Molecular functioni
- 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniRule
- lipopolysaccharide biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipopolysaccharide biosynthesis |
Enzyme and pathway databases
BRENDAi | 2.7.7.38, 2026 |
UniPathwayi | UPA00030 UPA00358;UER00476 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)Alternative name(s): CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation Short name: CKSUniRule annotation Short name: CMP-KDO synthaseUniRule annotation |
Gene namesi | Name:kpsU |
Organismi | Escherichia coli |
Taxonomic identifieri | 562 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Chemistry databases
DrugBanki | DB04482, Cmp-2-Keto-3-Deoxy-Octulosonic Acid DB04555, Cytidine-5'-Diphosphate DB03403, Cytidine-5'-Monophosphate DB02431, Cytidine-5'-Triphosphate DB03721, N-acetyl-alpha-neuraminic acid |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000188523 | 2 – 246 | 3-deoxy-manno-octulosonate cytidylyltransferaseAdd BLAST | 245 |
Proteomic databases
PRIDEi | P42216 |
Interactioni
Subunit structurei
Homodimer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P42216 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42216 |
Family & Domainsi
Sequence similaritiesi
Belongs to the KdsB family.UniRule annotation
Phylogenomic databases
OrthoDBi | 1345588at2 |
Family and domain databases
CDDi | cd02517, CMP-KDO-Synthetase, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
HAMAPi | MF_00057, KdsB, 1 hit |
InterProi | View protein in InterPro IPR003329, Cytidylyl_trans IPR004528, KdsB IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF02348, CTP_transf_3, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
TIGRFAMsi | TIGR00466, kdsB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P42216-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKAVIVIPA RYGSSRLPGK PLLDIVGKPM IQHVYERALQ VAGVAEVWVA
60 70 80 90 100
TDDPRVEQAV QAFGGKAIMT RNDHESGTDR LVEVMHKVEA DIYINLQGDE
110 120 130 140 150
PMIRPRDVET LLQGMRDDPA LPVATLCHAI SAAEAAEPST VKVVVNTRQD
160 170 180 190 200
ALYFSRSPIP YPRNAEKARY LKHVGIYAYR RDVLQNYSQL PESMPEQAES
210 220 230 240
LEQLRLMNAG INIRTFEVAA TGPGVDTPAC LEKVRALMAQ ELAENA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74567 Genomic DNA Translation: CAA52657.1 S76943 Genomic DNA Translation: AAB33584.1 |
PIRi | C48492 |
RefSeqi | WP_000030749.1, NZ_WWEL01000034.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74567 Genomic DNA Translation: CAA52657.1 S76943 Genomic DNA Translation: AAB33584.1 |
PIRi | C48492 |
RefSeqi | WP_000030749.1, NZ_WWEL01000034.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GQ9 | X-ray | 2.60 | A/B | 2-246 | [»] | |
1GQC | X-ray | 2.60 | A/B | 2-246 | [»] | |
1H6J | X-ray | 2.32 | A/B | 2-246 | [»] | |
1H7E | X-ray | 1.83 | A/B | 2-246 | [»] | |
1H7F | X-ray | 2.12 | A/B | 2-246 | [»] | |
1H7G | X-ray | 2.13 | A/B | 2-246 | [»] | |
1H7H | X-ray | 2.30 | A/B | 2-246 | [»] | |
1H7T | X-ray | 2.48 | A/B | 2-246 | [»] | |
SMRi | P42216 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
DrugBanki | DB04482, Cmp-2-Keto-3-Deoxy-Octulosonic Acid DB04555, Cytidine-5'-Diphosphate DB03403, Cytidine-5'-Monophosphate DB02431, Cytidine-5'-Triphosphate DB03721, N-acetyl-alpha-neuraminic acid |
Proteomic databases
PRIDEi | P42216 |
Phylogenomic databases
OrthoDBi | 1345588at2 |
Enzyme and pathway databases
UniPathwayi | UPA00030 UPA00358;UER00476 |
BRENDAi | 2.7.7.38, 2026 |
Miscellaneous databases
EvolutionaryTracei | P42216 |
Family and domain databases
CDDi | cd02517, CMP-KDO-Synthetase, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
HAMAPi | MF_00057, KdsB, 1 hit |
InterProi | View protein in InterPro IPR003329, Cytidylyl_trans IPR004528, KdsB IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF02348, CTP_transf_3, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
TIGRFAMsi | TIGR00466, kdsB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KPSU5_ECOLX | |
Accessioni | P42216Primary (citable) accession number: P42216 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | October 7, 2020 | |
This is version 124 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families