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Protein

Septin-1

Gene

Sept1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66GTPBy similarity1
Binding sitei92GTP; via amide nitrogenBy similarity1
Binding sitei229GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei244GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi171 – 179GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: MGI
  • protein-containing complex scaffold activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-1
Alternative name(s):
Differentiation protein 6
Short name:
Protein Diff6
Peanut-like protein 3
Gene namesi
Name:Sept1
Synonyms:Diff6, Pnutl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1858916 Sept1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735141 – 366Septin-1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei250PhosphothreonineCombined sources1
Modified residuei306Phosphoserine; by AURKBBy similarity1
Modified residuei314Phosphoserine; by AURKBBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP42209
MaxQBiP42209
PaxDbiP42209
PeptideAtlasiP42209
PRIDEiP42209

2D gel databases

REPRODUCTION-2DPAGEiP42209

PTM databases

iPTMnetiP42209
PhosphoSitePlusiP42209

Expressioni

Gene expression databases

BgeeiENSMUSG00000000486 Expressed in 121 organ(s), highest expression level in embryonic stem cell
CleanExiMM_SEPT1
ExpressionAtlasiP42209 baseline and differential
GenevisibleiP42209 MM

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP42209, 1 interactor
STRINGi10090.ENSMUSP00000101921

Structurei

3D structure databases

ProteinModelPortaliP42209
SMRiP42209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 295Septin-type GPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 39G1 motifPROSITE-ProRule annotation8
Regioni89 – 92G3 motifPROSITE-ProRule annotation4
Regioni170 – 173G4 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiP42209
KOiK13737
OMAiWLPVVRY
OrthoDBiEOG091G07TS
TreeFamiTF101079

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P42209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPDAS ARTAQTLTIE RRGVEIEEGG IKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVRFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALMPRET QALKQKIRDQ LKEEEINIYQ
210 220 230 240 250
FPECDSDEDE EFKKQNEEMK ENIPFAVVGS CEVVRDGTRP VRGRRYSWGT
260 270 280 290 300
VEVENPHHCD FLNLRRMLVQ THLQDLKEVT HDLLYEGYRA RCLQSLARPG
310 320 330 340 350
ARDRASRSKL SRQSATEIPL PMLPLADTEK LIREKDEELR RMQEMLEKMQ
360
AQMQQSQAQG EQSDVL
Length:366
Mass (Da):42,020
Last modified:November 3, 2009 - v2
Checksum:iAB619C08D8C74184
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3V3D3Z3V3_MOUSE
Septin-1
Sept1
338Annotation score:
A0A0U1RQA1A0A0U1RQA1_MOUSE
Septin-1
Sept1
328Annotation score:
D3YVG1D3YVG1_MOUSE
Septin-1
Sept1
186Annotation score:
A0A0U1RPA8A0A0U1RPA8_MOUSE
Septin-1
Sept1
145Annotation score:

Sequence cautioni

The sequence AAA37803 differs from that shown. Reason: Frameshift at positions 147 and 155.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99C → F in AAA37803 (PubMed:2174398).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37030 mRNA Translation: AAA37803.1 Frameshift.
BC140998 mRNA Translation: AAI40999.1
BC145081 mRNA Translation: AAI45082.1
CCDSiCCDS40141.1
PIRiJU0319
RefSeqiNP_059489.2, NM_017461.2
UniGeneiMm.18

Genome annotation databases

EnsembliENSMUST00000106314; ENSMUSP00000101921; ENSMUSG00000000486
GeneIDi54204
KEGGimmu:54204
UCSCiuc009juq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37030 mRNA Translation: AAA37803.1 Frameshift.
BC140998 mRNA Translation: AAI40999.1
BC145081 mRNA Translation: AAI45082.1
CCDSiCCDS40141.1
PIRiJU0319
RefSeqiNP_059489.2, NM_017461.2
UniGeneiMm.18

3D structure databases

ProteinModelPortaliP42209
SMRiP42209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP42209, 1 interactor
STRINGi10090.ENSMUSP00000101921

PTM databases

iPTMnetiP42209
PhosphoSitePlusiP42209

2D gel databases

REPRODUCTION-2DPAGEiP42209

Proteomic databases

EPDiP42209
MaxQBiP42209
PaxDbiP42209
PeptideAtlasiP42209
PRIDEiP42209

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106314; ENSMUSP00000101921; ENSMUSG00000000486
GeneIDi54204
KEGGimmu:54204
UCSCiuc009juq.1 mouse

Organism-specific databases

CTDi1731
MGIiMGI:1858916 Sept1

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiP42209
KOiK13737
OMAiWLPVVRY
OrthoDBiEOG091G07TS
TreeFamiTF101079

Miscellaneous databases

PROiPR:P42209
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000486 Expressed in 121 organ(s), highest expression level in embryonic stem cell
CleanExiMM_SEPT1
ExpressionAtlasiP42209 baseline and differential
GenevisibleiP42209 MM

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT1_MOUSE
AccessioniPrimary (citable) accession number: P42209
Secondary accession number(s): B2RU74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 3, 2009
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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