UniProtKB - P42209 (SEPT1_MOUSE)
Protein
Septin-1
Gene
Septin1
Organism
Mus musculus (Mouse)
Status
Functioni
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 66 | GTPBy similarity | 1 | |
Binding sitei | 92 | GTP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 229 | GTP; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 244 | GTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 32 – 39 | GTPBy similarity | 8 | |
Nucleotide bindingi | 171 – 179 | GTPBy similarity | 9 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- identical protein binding Source: MGI
- molecular adaptor activity Source: GO_Central
GO - Biological processi
- cellular protein localization Source: GO_Central
- cytoskeleton-dependent cytokinesis Source: GO_Central
- meiotic metaphase plate congression Source: MGI
- regulation of exocytosis Source: GO_Central
- spindle assembly involved in female meiosis Source: MGI
Keywordsi
Biological process | Cell cycle, Cell division |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Septin-1Alternative name(s): Differentiation protein 6 Short name: Protein Diff6 Peanut-like protein 3 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1858916, Septin1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
- centrosome By similarity
Other locations
Note: Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis (By similarity).By similarity
Cytoskeleton
- meiotic spindle Source: MGI
- microtubule cytoskeleton Source: GO_Central
- microtubule organizing center Source: UniProtKB-SubCell
- septin complex Source: GO_Central
- septin ring Source: GO_Central
Other locations
- cell division site Source: GO_Central
- midbody Source: MGI
- synaptic vesicle Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173514 | 1 – 366 | Septin-1Add BLAST | 366 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 247 | PhosphoserineCombined sources | 1 | |
Modified residuei | 250 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 306 | Phosphoserine; by AURKBBy similarity | 1 | |
Modified residuei | 314 | Phosphoserine; by AURKBBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P42209 |
jPOSTi | P42209 |
MaxQBi | P42209 |
PaxDbi | P42209 |
PeptideAtlasi | P42209 |
PRIDEi | P42209 |
2D gel databases
REPRODUCTION-2DPAGEi | P42209 |
PTM databases
iPTMneti | P42209 |
PhosphoSitePlusi | P42209 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000486, Expressed in adult mammalian kidney and 146 other tissues |
Genevisiblei | P42209, MM |
Interactioni
Subunit structurei
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
Interacts with AURKB (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 207602, 1 interactor |
IntActi | P42209, 1 interactor |
STRINGi | 10090.ENSMUSP00000101921 |
Miscellaneous databases
RNActi | P42209, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 295 | Septin-type GPROSITE-ProRule annotationAdd BLAST | 274 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 39 | G1 motifPROSITE-ProRule annotation | 8 | |
Regioni | 89 – 92 | G3 motifPROSITE-ProRule annotation | 4 | |
Regioni | 170 – 173 | G4 motifPROSITE-ProRule annotation | 4 |
Sequence similaritiesi
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG2655, Eukaryota |
GeneTreei | ENSGT00940000161794 |
HOGENOMi | CLU_017718_0_0_1 |
InParanoidi | P42209 |
OMAi | EMKGSIP |
OrthoDBi | 845354at2759 |
TreeFami | TF101079 |
Family and domain databases
CDDi | cd01850, CDC_Septin, 1 hit |
InterProi | View protein in InterPro IPR030379, G_SEPTIN_dom IPR027417, P-loop_NTPase IPR016491, Septin |
Pfami | View protein in Pfam PF00735, Septin, 1 hit |
PIRSFi | PIRSF006698, Septin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51719, G_SEPTIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P42209-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPDAS ARTAQTLTIE RRGVEIEEGG IKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVRFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALMPRET QALKQKIRDQ LKEEEINIYQ
210 220 230 240 250
FPECDSDEDE EFKKQNEEMK ENIPFAVVGS CEVVRDGTRP VRGRRYSWGT
260 270 280 290 300
VEVENPHHCD FLNLRRMLVQ THLQDLKEVT HDLLYEGYRA RCLQSLARPG
310 320 330 340 350
ARDRASRSKL SRQSATEIPL PMLPLADTEK LIREKDEELR RMQEMLEKMQ
360
AQMQQSQAQG EQSDVL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z3V3 | D3Z3V3_MOUSE | Septin-1 | Septin1 Sept1 | 338 | Annotation score: | ||
A0A0U1RQA1 | A0A0U1RQA1_MOUSE | Septin-1 | Septin1 Sept1 | 328 | Annotation score: | ||
D3YVG1 | D3YVG1_MOUSE | Septin-1 | Septin1 Sept1 | 186 | Annotation score: | ||
A0A0U1RPA8 | A0A0U1RPA8_MOUSE | Septin-1 | Septin1 Sept1 | 145 | Annotation score: |
Sequence cautioni
The sequence AAA37803 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 99 | C → F in AAA37803 (PubMed:2174398).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37030 mRNA Translation: AAA37803.1 Frameshift. BC140998 mRNA Translation: AAI40999.1 BC145081 mRNA Translation: AAI45082.1 |
CCDSi | CCDS40141.1 |
PIRi | JU0319 |
RefSeqi | NP_059489.2, NM_017461.2 |
Genome annotation databases
Ensembli | ENSMUST00000106314; ENSMUSP00000101921; ENSMUSG00000000486 |
GeneIDi | 54204 |
KEGGi | mmu:54204 |
UCSCi | uc009juq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37030 mRNA Translation: AAA37803.1 Frameshift. BC140998 mRNA Translation: AAI40999.1 BC145081 mRNA Translation: AAI45082.1 |
CCDSi | CCDS40141.1 |
PIRi | JU0319 |
RefSeqi | NP_059489.2, NM_017461.2 |
3D structure databases
SMRi | P42209 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207602, 1 interactor |
IntActi | P42209, 1 interactor |
STRINGi | 10090.ENSMUSP00000101921 |
PTM databases
iPTMneti | P42209 |
PhosphoSitePlusi | P42209 |
2D gel databases
REPRODUCTION-2DPAGEi | P42209 |
Proteomic databases
EPDi | P42209 |
jPOSTi | P42209 |
MaxQBi | P42209 |
PaxDbi | P42209 |
PeptideAtlasi | P42209 |
PRIDEi | P42209 |
Protocols and materials databases
Antibodypediai | 27233, 257 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000106314; ENSMUSP00000101921; ENSMUSG00000000486 |
GeneIDi | 54204 |
KEGGi | mmu:54204 |
UCSCi | uc009juq.1, mouse |
Organism-specific databases
CTDi | 1731 |
MGIi | MGI:1858916, Septin1 |
Phylogenomic databases
eggNOGi | KOG2655, Eukaryota |
GeneTreei | ENSGT00940000161794 |
HOGENOMi | CLU_017718_0_0_1 |
InParanoidi | P42209 |
OMAi | EMKGSIP |
OrthoDBi | 845354at2759 |
TreeFami | TF101079 |
Miscellaneous databases
BioGRID-ORCSi | 54204, 0 hits in 16 CRISPR screens |
ChiTaRSi | Sept1, mouse |
PROi | PR:P42209 |
RNActi | P42209, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000486, Expressed in adult mammalian kidney and 146 other tissues |
Genevisiblei | P42209, MM |
Family and domain databases
CDDi | cd01850, CDC_Septin, 1 hit |
InterProi | View protein in InterPro IPR030379, G_SEPTIN_dom IPR027417, P-loop_NTPase IPR016491, Septin |
Pfami | View protein in Pfam PF00735, Septin, 1 hit |
PIRSFi | PIRSF006698, Septin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51719, G_SEPTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SEPT1_MOUSE | |
Accessioni | P42209Primary (citable) accession number: P42209 Secondary accession number(s): B2RU74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families