Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-13

Gene

Il13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-13 receptor binding Source: RGD

GO - Biological processi

  • cellular response to mechanical stimulus Source: RGD
  • immune response Source: InterPro
  • microglial cell activation Source: RGD
  • negative regulation of complement-dependent cytotoxicity Source: Ensembl
  • negative regulation of endothelial cell apoptotic process Source: Ensembl
  • negative regulation of NAD(P)H oxidase activity Source: RGD
  • negative regulation of neuron death Source: RGD
  • negative regulation of transforming growth factor beta production Source: RGD
  • positive regulation of B cell proliferation Source: RGD
  • positive regulation of connective tissue growth factor production Source: RGD
  • positive regulation of immunoglobulin production Source: RGD
  • positive regulation of ion transport Source: RGD
  • positive regulation of pancreatic stellate cell proliferation Source: RGD
  • positive regulation of protein secretion Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
  • regulation of proton transport Source: RGD
  • response to ethanol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nicotine Source: RGD

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-RNO-6785807 Interleukin-4 and 13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Alternative name(s):
T-cell activation protein P600
Gene namesi
Name:Il13
Synonyms:Il-13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68949 Il13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001555322 – 131Interleukin-13Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi52 ↔ 80By similarity
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi68 ↔ 94By similarity
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP42203
PRIDEiP42203

Expressioni

Gene expression databases

BgeeiENSRNOG00000007652
GenevisibleiP42203 RN

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-13 receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010121

Structurei

3D structure databases

ProteinModelPortaliP42203
SMRiP42203
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
GeneTreeiENSGT00390000003225
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiP42203
KOiK05435
OMAiVYCAALE
OrthoDBiEOG091G10SR
PhylomeDBiP42203
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWVTAVLA LACLGGLATP GPVRRSTSPP VALRELIEEL SNITQDQKTS
60 70 80 90 100
LCNSSMVWSV DLTAGGFCAA LESLTNISSC NAIHRTQRIL NGLCNQKASD
110 120 130
VASSPPDTKI EVAQFISKLL NYSKQLFRYG H
Length:131
Mass (Da):14,093
Last modified:November 1, 1995 - v1
Checksum:iE5008CAB8DE8C201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26913 mRNA Translation: AAA16478.1
PIRiI52290
RefSeqiNP_446280.1, NM_053828.1
UniGeneiRn.9921

Genome annotation databases

EnsembliENSRNOT00000010121; ENSRNOP00000010121; ENSRNOG00000007652
GeneIDi116553
KEGGirno:116553
UCSCiRGD:68949 rat

Similar proteinsi

Entry informationi

Entry nameiIL13_RAT
AccessioniPrimary (citable) accession number: P42203
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health