UniProtKB - P42166 (LAP2A_HUMAN)
Lamina-associated polypeptide 2, isoform alpha
TMPO
Functioni
Caution
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- DNA binding Source: UniProtKB-KW
- lamin binding Source: ProtInc
GO - Biological processi
- regulation of transcription, DNA-templated Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | P42166 |
Names & Taxonomyi
Protein namesi | Recommended name: Lamina-associated polypeptide 2, isoform alphaAlternative name(s): Thymopoietin isoform alpha Short name: TP alpha Thymopoietin-related peptide isoform alpha Short name: TPRP isoform alpha Cleaved into the following 2 chains: |
Gene namesi | Name:TMPO Synonyms:LAP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11875, TMPO |
MIMi | 188380, gene |
neXtProti | NX_P42166 |
VEuPathDBi | HostDB:ENSG00000120802.13 |
Subcellular locationi
Nucleus
Other locations
Note: Expressed diffusely throughout the nucleus.
Nucleus
- nuclear envelope Source: ProtInc
- nucleus Source: MGI
Other locations
- chromatin Source: MGI
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Pharmaceutical usei
Keywords - Diseasei
CardiomyopathyOrganism-specific databases
DisGeNETi | 7112 |
GeneReviewsi | TMPO |
MalaCardsi | TMPO |
OpenTargetsi | ENSG00000120802 |
PharmGKBi | PA36576 |
Miscellaneous databases
Pharosi | P42166, Tbio |
Genetic variation databases
BioMutai | TMPO |
DMDMi | 1174689 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000017674 | 2 – 694 | Lamina-associated polypeptide 2, isoform alphaAdd BLAST | 693 | |
PeptideiPRO_0000017675 | 2 – 50 | ThymopoietinAdd BLAST | 49 | |
PeptideiPRO_0000017676 | 33 – 37 | Thymopentin | 5 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 57 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 59 | PhosphoserineCombined sources | 1 | |
Modified residuei | 66 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 74 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 79 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 88 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 154 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 156 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | PhosphoserineBy similarity | 1 | |
Modified residuei | 160 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 164 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 166 | PhosphoserineBy similarity | 1 | |
Modified residuei | 168 | PhosphoserineCombined sources | 1 | |
Modified residuei | 272 | PhosphoserineCombined sources | 1 | |
Modified residuei | 312 | PhosphoserineCombined sources | 1 | |
Modified residuei | 351 | PhosphoserineCombined sources | 1 | |
Modified residuei | 354 | PhosphoserineCombined sources | 1 | |
Modified residuei | 370 | PhosphoserineCombined sources | 1 | |
Modified residuei | 424 | PhosphoserineCombined sources | 1 | |
Modified residuei | 656 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-949 |
EPDi | P42166 |
jPOSTi | P42166 |
MassIVEi | P42166 |
PaxDbi | P42166 |
PeptideAtlasi | P42166 |
PRIDEi | P42166 |
ProteomicsDBi | 55488 [P42166-1] |
PTM databases
GlyGeni | P42166, 2 sites |
iPTMneti | P42166 |
MetOSitei | P42166 |
SwissPalmi | P42166 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000120802, Expressed in intestine and 236 other tissues |
ExpressionAtlasi | P42166, baseline and differential |
Genevisiblei | P42166, HS |
Organism-specific databases
HPAi | ENSG00000120802, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages.
Interacts with CMTM6 (PubMed:28813417).
4 PublicationsBinary interactionsi
P42166
With | #Exp. | IntAct |
---|---|---|
LMNA [P02545] | 4 | EBI-395393,EBI-351935 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- lamin binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 112967, 454 interactors |
IntActi | P42166, 55 interactors |
MINTi | P42166 |
STRINGi | 9606.ENSP00000266732 |
Miscellaneous databases
RNActi | P42166, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P42166 |
SMRi | P42166 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42166 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 48 | LEM-likePROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 109 – 153 | LEMPROSITE-ProRule annotationAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 49 – 108 | LinkerAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 558 – 657 | By similarityAdd BLAST | 100 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 190 – 196 | Nuclear localization signalSequence analysis | 7 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QWCI, Eukaryota |
GeneTreei | ENSGT00940000154098 |
HOGENOMi | CLU_397364_0_0_1 |
InParanoidi | P42166 |
OrthoDBi | 323585at2759 |
PhylomeDBi | P42166 |
TreeFami | TF328426 |
Family and domain databases
Gene3Di | 1.10.720.40, 2 hits |
InterProi | View protein in InterPro IPR021623, LAP2alpha_C IPR013146, LEM-like_dom IPR011015, LEM/LEM-like_dom_sf IPR003887, LEM_dom |
Pfami | View protein in Pfam PF11560, LAP2alpha, 1 hit PF03020, LEM, 1 hit PF08198, Thymopoietin, 1 hit |
SMARTi | View protein in SMART SM00540, LEM, 1 hit SM01261, Thymopoietin, 1 hit |
SUPFAMi | SSF63451, SSF63451, 2 hits |
PROSITEi | View protein in PROSITE PS50954, LEM, 1 hit PS50955, LEM_LIKE, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR
60 70 80 90 100
PPLPAGTNSK GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD
110 120 130 140 150
KPRQEDKDDL DVTELTNEDL LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR
160 170 180 190 200
EQGTESRSST PLPTISSSAE NTRQNGSNDS DRYSDNEEGK KKEHKKVKST
210 220 230 240 250
RDIVPFSELG TTPSGGGFFQ GISFPEISTR PPLGSTELQA AKKVHTSKGD
260 270 280 290 300
LPREPLVATN LPGRGQLQKL ASERNLFISC KSSHDRCLEK SSSSSSQPEH
310 320 330 340 350
SAMLVSTAAS PSLIKETTTG YYKDIVENIC GREKSGIQPL CPERSHISDQ
360 370 380 390 400
SPLSSKRKAL EESESSQLIS PPLAQAIRDY VNSLLVQGGV GSLPGTSNSM
410 420 430 440 450
PPLDVENIQK RIDQSKFQET EFLSPPRKVP RLSEKSVEER DSGSFVAFQN
460 470 480 490 500
IPGSELMSSF AKTVVSHSLT TLGLEVAKQS QHDKIDASEL SFPFHESILK
510 520 530 540 550
VIEEEWQQVD RQLPSLACKY PVSSREATQI LSVPKVDDEI LGFISEATPL
560 570 580 590 600
GGIQAASTES CNQQLDLALC RAYEAAASAL QIATHTAFVA KAMQADISQA
610 620 630 640 650
AQILSSDPSR THQALGILSK TYDAASYICE AAFDEVKMAA HTMGNATVGR
660 670 680 690
RYLWLKDCKI NLASKNKLAS TPFKGGTLFG GEVCKVIKKR GNKH
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E972 | G5E972_HUMAN | Lamina-associated polypeptide 2, is... | TMPO hCG_2015322 | 414 | Annotation score: | ||
H0YJH7 | H0YJH7_HUMAN | Lamina-associated polypeptide 2, is... | TMPO | 237 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049773 | 238 | L → R. Corresponds to variant dbSNP:rs35998138Ensembl. | 1 | |
Natural variantiVAR_049774 | 293 | S → A. Corresponds to variant dbSNP:rs35645287Ensembl. | 1 | |
Natural variantiVAR_049775 | 317 | T → S. Corresponds to variant dbSNP:rs35969221Ensembl. | 1 | |
Natural variantiVAR_049776 | 416 | K → E. Corresponds to variant dbSNP:rs11838270Ensembl. | 1 | |
Natural variantiVAR_049777 | 478 | K → N. Corresponds to variant dbSNP:rs35761089Ensembl. | 1 | |
Natural variantiVAR_005635 | 599 | Q → E1 PublicationCorresponds to variant dbSNP:rs17459334Ensembl. | 1 | |
Natural variantiVAR_049778 | 690 | R → C Affects the interaction with LMNA. 1 PublicationCorresponds to variant dbSNP:rs17028450Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09086 mRNA Translation: AAB60329.1 U18270 , U18266, U18267, U18268 Genomic DNA Translation: AAB60433.1 S76736 mRNA Translation: AAB33958.1 |
CCDSi | CCDS9064.1 [P42166-1] |
PIRi | G01161 |
RefSeqi | NP_003267.1, NM_003276.2 [P42166-1] |
Genome annotation databases
Ensembli | ENST00000266732; ENSP00000266732; ENSG00000120802 [P42166-1] |
GeneIDi | 7112 |
UCSCi | uc001tfh.3, human [P42166-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09086 mRNA Translation: AAB60329.1 U18270 , U18266, U18267, U18268 Genomic DNA Translation: AAB60433.1 S76736 mRNA Translation: AAB33958.1 |
CCDSi | CCDS9064.1 [P42166-1] |
PIRi | G01161 |
RefSeqi | NP_003267.1, NM_003276.2 [P42166-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GJJ | NMR | - | A | 1-168 | [»] | |
1H9E | NMR | - | A | 2-57 | [»] | |
1H9F | NMR | - | A | 103-159 | [»] | |
BMRBi | P42166 | |||||
SMRi | P42166 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112967, 454 interactors |
IntActi | P42166, 55 interactors |
MINTi | P42166 |
STRINGi | 9606.ENSP00000266732 |
PTM databases
GlyGeni | P42166, 2 sites |
iPTMneti | P42166 |
MetOSitei | P42166 |
SwissPalmi | P42166 |
Genetic variation databases
BioMutai | TMPO |
DMDMi | 1174689 |
Proteomic databases
CPTACi | CPTAC-949 |
EPDi | P42166 |
jPOSTi | P42166 |
MassIVEi | P42166 |
PaxDbi | P42166 |
PeptideAtlasi | P42166 |
PRIDEi | P42166 |
ProteomicsDBi | 55488 [P42166-1] |
Protocols and materials databases
Antibodypediai | 2387, 380 antibodies |
DNASUi | 7112 |
Genome annotation databases
Ensembli | ENST00000266732; ENSP00000266732; ENSG00000120802 [P42166-1] |
GeneIDi | 7112 |
UCSCi | uc001tfh.3, human [P42166-1] |
Organism-specific databases
CTDi | 7112 |
DisGeNETi | 7112 |
GeneCardsi | TMPO |
GeneReviewsi | TMPO |
HGNCi | HGNC:11875, TMPO |
HPAi | ENSG00000120802, Tissue enhanced (lymphoid) |
MalaCardsi | TMPO |
MIMi | 188380, gene |
neXtProti | NX_P42166 |
OpenTargetsi | ENSG00000120802 |
PharmGKBi | PA36576 |
VEuPathDBi | HostDB:ENSG00000120802.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWCI, Eukaryota |
GeneTreei | ENSGT00940000154098 |
HOGENOMi | CLU_397364_0_0_1 |
InParanoidi | P42166 |
OrthoDBi | 323585at2759 |
PhylomeDBi | P42166 |
TreeFami | TF328426 |
Enzyme and pathway databases
PathwayCommonsi | P42166 |
Miscellaneous databases
BioGRID-ORCSi | 7112, 12 hits in 997 CRISPR screens |
ChiTaRSi | TMPO, human |
EvolutionaryTracei | P42166 |
GeneWikii | Thymopoietin |
GenomeRNAii | 7112 |
Pharosi | P42166, Tbio |
RNActi | P42166, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120802, Expressed in intestine and 236 other tissues |
ExpressionAtlasi | P42166, baseline and differential |
Genevisiblei | P42166, HS |
Family and domain databases
Gene3Di | 1.10.720.40, 2 hits |
InterProi | View protein in InterPro IPR021623, LAP2alpha_C IPR013146, LEM-like_dom IPR011015, LEM/LEM-like_dom_sf IPR003887, LEM_dom |
Pfami | View protein in Pfam PF11560, LAP2alpha, 1 hit PF03020, LEM, 1 hit PF08198, Thymopoietin, 1 hit |
SMARTi | View protein in SMART SM00540, LEM, 1 hit SM01261, Thymopoietin, 1 hit |
SUPFAMi | SSF63451, SSF63451, 2 hits |
PROSITEi | View protein in PROSITE PS50954, LEM, 1 hit PS50955, LEM_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAP2A_HUMAN | |
Accessioni | P42166Primary (citable) accession number: P42166 Secondary accession number(s): P08918 Q16295 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 214 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families