UniProtKB - P42166 (LAP2A_HUMAN)

BLAST

>sp|P42166|LAP2A_HUMAN Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSK
GPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDL
LDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDS
DRYSDNEEGKKKEHKKVKSTRDIVPFSELGTTPSGGGFFQGISFPEISTRPPLGSTELQA
AKKVHTSKGDLPREPLVATNLPGRGQLQKLASERNLFISCKSSHDRCLEKSSSSSSQPEH
SAMLVSTAASPSLIKETTTGYYKDIVENICGREKSGIQPLCPERSHISDQSPLSSKRKAL
EESESSQLISPPLAQAIRDYVNSLLVQGGVGSLPGTSNSMPPLDVENIQKRIDQSKFQET
EFLSPPRKVPRLSEKSVEERDSGSFVAFQNIPGSELMSSFAKTVVSHSLTTLGLEVAKQS
QHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSREATQILSVPKVDDEI
LGFISEATPLGGIQAASTESCNQQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA
AQILSSDPSRTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKI
NLASKNKLASTPFKGGTLFGGEVCKVIKKRGNKH

Align

Format
Add to basket Added to basket
History
Entry version 196 (07 Nov 2018)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Lamina-associated polypeptide 2, isoform alpha

Gene

TMPO

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.

TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Caution

TMPO was originally considered a good candidate for dilated cardiomyopathy, and variant Cys-290 has been reported to be a likely pathogenic mutation (PubMed:16247757). However, Cys-290 has a high allele frequency and individuals homozygous for the variant have been reported in ExAC database. Therefore, this variant has been reclassified as a likely benign polymorphism (PubMed:27896284).1 Publication1 Publication

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
DNA binding Source: UniProtKB-KW
lamin binding
Source: ProtInc
Traceable author statementⁱ
- 8530026

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lamina-associated polypeptide 2, isoform alpha Alternative name(s): Thymopoietin isoform alpha Short name: TP alpha Thymopoietin-related peptide isoform alpha Short name: TPRP isoform alpha Cleaved into the following 2 chains: Thymopoietin Short name: TP Alternative name(s): Splenin Thymopentin Alternative name(s): TP5
Gene namesⁱ	Name:TMPO Synonyms:LAP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000120802.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11875 TMPO
MIMⁱ	188380 gene
neXtProtⁱ	NX_P42166

Keywords - Cellular componentⁱ

Chromosome, Nucleus

Pathology & Biotechⁱ

Pharmaceutical useⁱ

TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Used in primary and secondary immune deficiencies, autoimmunity, infections and cancer.

Keywords - Diseaseⁱ

Cardiomyopathy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7112
GeneReviewsⁱ	TMPO
MalaCards human disease database More...MalaCardsⁱ	TMPO
Open Targets More...OpenTargetsⁱ	ENSG00000120802
PharmGKBⁱ	PA36576

Polymorphism and mutation databases

BioMutaⁱ	DLC1
DMDMⁱ	1174689

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000017674	2 – 694	Lamina-associated polypeptide 2, isoform alphaAdd BLAST	693
PeptideⁱPRO_0000017675	2 – 50	ThymopoietinAdd BLAST	49
PeptideⁱPRO_0000017676	33 – 37	Thymopentin	5

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	57	PhosphothreonineCombined sources	1
Modified residueⁱ	59	PhosphoserineCombined sources	1
Modified residueⁱ	66	PhosphoserineCombined sources	1
Modified residueⁱ	67	PhosphoserineCombined sources	1
Modified residueⁱ	74	PhosphothreonineCombined sources	1
Modified residueⁱ	79	PhosphoserineCombined sources	1
Modified residueⁱ	86	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	88	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	154	PhosphothreonineCombined sources	1
Modified residueⁱ	156	PhosphoserineCombined sources	1
Modified residueⁱ	159	PhosphoserineBy similarity	1
Modified residueⁱ	160	PhosphothreonineCombined sources	1
Modified residueⁱ	164	PhosphothreonineCombined sources	1
Modified residueⁱ	166	PhosphoserineBy similarity	1
Modified residueⁱ	168	PhosphoserineCombined sources	1
Modified residueⁱ	272	PhosphoserineCombined sources	1
Modified residueⁱ	312	PhosphoserineCombined sources	1
Modified residueⁱ	351	PhosphoserineCombined sources	1
Modified residueⁱ	354	PhosphoserineCombined sources	1
Modified residueⁱ	370	PhosphoserineCombined sources	1
Modified residueⁱ	424	PhosphoserineCombined sources	1
Modified residueⁱ	656	N6-acetyllysineCombined sources	1

Post-translational modificationⁱ

Phosphorylated in a mitose-specific manner.1 Publication

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	P42166
PaxDbⁱ	P42166
PeptideAtlas More...PeptideAtlasⁱ	P42166
PRIDEⁱ	P42166
ProteomicsDBⁱ	55488

PTM databases

iPTMnetⁱ	P42166
SwissPalmⁱ	P42166

Miscellaneous databases

PMAP-CutDBⁱ	P42166

PMAP-CutDBⁱ

P42166

Expressionⁱ

Tissue specificityⁱ

Expressed in many tissues. Most abundant in adult thymus and fetal liver.

Gene expression databases

Bgeeⁱ	ENSG00000120802 Expressed in 223 organ(s), highest expression level in intestine
CleanExⁱ	HS_TMPO
ExpressionAtlasⁱ	P42166 baseline and differential
Genevisibleⁱ	P42166 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009847

HPAⁱ

CAB009847

Interactionⁱ

Subunit structureⁱ

Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages. Interacts with CMTM6 (PubMed:28813417).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LMNA	P02545	4	EBI-395393,EBI-351935

With

Entry

#Exp.

IntAct

Notes

LMNA

P02545

EBI-395393,EBI-351935

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
lamin binding
Source: ProtInc
Traceable author statementⁱ
- 8530026

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112967, 117 interactors
IntActⁱ	P42166, 42 interactors
Molecular INTeraction database More...MINTⁱ	P42166
STRINGⁱ	9606.ENSP00000266732

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	8 – 11	Combined sources	4
Helixⁱ	13 – 22	Combined sources	10
Beta strandⁱ	29 – 31	Combined sources	3
Helixⁱ	34 – 39	Combined sources	6
Turnⁱ	40 – 42	Combined sources	3
Beta strandⁱ	43 – 45	Combined sources	3
Turnⁱ	46 – 48	Combined sources	3
Beta strandⁱ	113 – 115	Combined sources	3
Helixⁱ	117 – 122	Combined sources	6
Beta strandⁱ	123 – 125	Combined sources	3
Turnⁱ	126 – 128	Combined sources	3
Beta strandⁱ	136 – 138	Combined sources	3
Helixⁱ	139 – 145	Combined sources	7
Helixⁱ	147 – 152	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P42166
SMRⁱ	P42166
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P42166

EvolutionaryTraceⁱ

P42166

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 48	LEM-likePROSITE-ProRule annotationAdd BLAST		44
Domainⁱ	109 – 153	LEMPROSITE-ProRule annotationAdd BLAST		45

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	49 – 108	LinkerAdd BLAST		60

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	558 – 657	By similarityAdd BLAST		100

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	190 – 196	Nuclear localization signalSequence analysis		7

Domainⁱ

The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.

The C-terminal domain forms a four-stranded coiled coil.By similarity

Sequence similaritiesⁱ

Belongs to the LEM family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IT7C Eukaryota ENOG4111J0N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048934
HOGENOMⁱ	HOG000060228
HOVERGENⁱ	HBG081890
InParanoidⁱ	P42166
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03A8
PhylomeDBⁱ	P42166
TreeFamⁱ	TF328426

Family and domain databases

Gene3Dⁱ	1.10.720.40, 2 hits
InterProⁱ	View protein in InterPro IPR021623 LAP2alpha_C IPR013146 LEM-like_dom IPR011015 LEM/LEM-like_dom_sf IPR003887 LEM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11560 LAP2alpha, 1 hit PF03020 LEM, 1 hit PF08198 Thymopoietin, 1 hit
SMARTⁱ	View protein in SMART SM00540 LEM, 1 hit SM01261 Thymopoietin, 1 hit
SUPFAMⁱ	SSF63451 SSF63451, 2 hits
PROSITEⁱ	View protein in PROSITE PS50954 LEM, 1 hit PS50955 LEM_LIKE, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform Alpha (identifier: P42166-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR 
        60         70         80         90        100
PPLPAGTNSK GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD 
       110        120        130        140        150
KPRQEDKDDL DVTELTNEDL LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR 
       160        170        180        190        200
EQGTESRSST PLPTISSSAE NTRQNGSNDS DRYSDNEEGK KKEHKKVKST 
       210        220        230        240        250
RDIVPFSELG TTPSGGGFFQ GISFPEISTR PPLGSTELQA AKKVHTSKGD 
       260        270        280        290        300
LPREPLVATN LPGRGQLQKL ASERNLFISC KSSHDRCLEK SSSSSSQPEH 
       310        320        330        340        350
SAMLVSTAAS PSLIKETTTG YYKDIVENIC GREKSGIQPL CPERSHISDQ 
       360        370        380        390        400
SPLSSKRKAL EESESSQLIS PPLAQAIRDY VNSLLVQGGV GSLPGTSNSM 
       410        420        430        440        450
PPLDVENIQK RIDQSKFQET EFLSPPRKVP RLSEKSVEER DSGSFVAFQN 
       460        470        480        490        500
IPGSELMSSF AKTVVSHSLT TLGLEVAKQS QHDKIDASEL SFPFHESILK 
       510        520        530        540        550
VIEEEWQQVD RQLPSLACKY PVSSREATQI LSVPKVDDEI LGFISEATPL 
       560        570        580        590        600
GGIQAASTES CNQQLDLALC RAYEAAASAL QIATHTAFVA KAMQADISQA 
       610        620        630        640        650
AQILSSDPSR THQALGILSK TYDAASYICE AAFDEVKMAA HTMGNATVGR 
       660        670        680        690 
RYLWLKDCKI NLASKNKLAS TPFKGGTLFG GEVCKVIKKR GNKH

Length:694

Mass (Da):75,492

Last modified:January 23, 2007 - v2

Checksum:ⁱ1B514B0FB61D0D75

Isoform Beta (identifier: P42167-1) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry P42167.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:454

Mass (Da):50,670

Isoform Gamma (identifier: P42167-2) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry P42167.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:345

Mass (Da):38,738

Isoform Zeta (identifier: P42167-3) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry P42167.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Inhibits LAP2beta-mediated repression.

Length:248

Mass (Da):27,388

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G5E972	G5E972_HUMAN	Lamina-associated polypeptide 2, is... Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoform CRA_d)	TMPO hCG_2015322	414	Annotation score:
H0YJH7	H0YJH7_HUMAN	Lamina-associated polypeptide 2, is... Lamina-associated polypeptide 2, isoforms beta/gamma	TMPO	237	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049773	238	L → R. Corresponds to variant dbSNP:rs35998138EnsemblClinVar.	1
Natural variantⁱVAR_049774	293	S → A. Corresponds to variant dbSNP:rs35645287EnsemblClinVar.	1
Natural variantⁱVAR_049775	317	T → S. Corresponds to variant dbSNP:rs35969221EnsemblClinVar.	1
Natural variantⁱVAR_049776	416	K → E. Corresponds to variant dbSNP:rs11838270EnsemblClinVar.	1
Natural variantⁱVAR_049777	478	K → N. Corresponds to variant dbSNP:rs35761089EnsemblClinVar.	1
Natural variantⁱVAR_005635	599	Q → E1 PublicationCorresponds to variant dbSNP:rs17459334EnsemblClinVar.	1
Natural variantⁱVAR_049778	690	R → C Polymorphism; affects the interaction with LMNA. 1 PublicationCorresponds to variant dbSNP:rs17028450EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09086 mRNA Translation: AAB60329.1 U18270 , U18266, U18267, U18268 Genomic DNA Translation: AAB60433.1 S76736 mRNA Translation: AAB33958.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9064.1 [P42166-1]
PIRⁱ	G01161
NCBI Reference Sequences More...RefSeqⁱ	NP_003267.1, NM_003276.2 [P42166-1]
UniGeneⁱ	Hs.11355

Genome annotation databases

Ensemblⁱ	ENST00000266732; ENSP00000266732; ENSG00000120802 [P42166-1]
GeneIDⁱ	7112
UCSC genome browser More...UCSCⁱ	uc001tfh.3 human [P42166-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P42167-2	Thymopoietin, isoform CRA_a		HUMAN		345	UniRef100_A0A024RBH7
Uncharacterized protein		PANPA		345
Lamina-associated polypeptide 2, isoforms beta/gamma variant (Fragment)		HUMAN		378

Protein	Similar proteins		Species	Score	Length	Source
P42166	Uncharacterized protein		AOTNA		703	UniRef90_P42166
Thymopoietin isoform alpha		MACMU		695
Uncharacterized protein		CERAT		695
Uncharacterized protein		RHIRO		695
Uncharacterized protein		RHIBE		695
+31
P42167-2	Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma		MOUSE		343	UniRef90_Q61029-4
Thymopoietin, isoform CRA_a		HUMAN		345
Uncharacterized protein		PANPA		345
Uncharacterized protein		CERAT		345
Thymopoietin isoform gamma		MACMU		345
+57
P42167-3	TMPO isoform 7		PONAB		248	UniRef90_P42167-3
TMPO isoform 7		PANTR		248
Uncharacterized protein		CERAT		248
Uncharacterized protein		RHIRO		248
Uncharacterized protein		RHIBE		248
+7

Protein	Similar proteins		Species	Score	Length	Source
P42166	Lamina-associated polypeptide 2, isoforms alpha/zeta	)	MOUSE		693	UniRef50_P42166
Uncharacterized protein		AOTNA		703
Uncharacterized protein		PAPAN		695
Uncharacterized protein		MACFA		695
Uncharacterized protein		RHIRO		695
+91
P42167-2	Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma		MOUSE		343	UniRef50_Q61029-4
thymopoietin isoform X3		Yangtze finless porpoise		345
Uncharacterized protein		CERAT		345
Thymopoietin		GORGO		345
Thymopoietin isoform gamma		CALJA		345
+123
P42167-3	TMPO isoform 7		PANTR		248	UniRef50_P42167-3
Uncharacterized protein		RHIRO		248
Uncharacterized protein		RHIBE		248
Uncharacterized protein		PAPAN		248
TMPO isoform 7		PONAB		248
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09086 mRNA Translation: AAB60329.1 U18270 , U18266, U18267, U18268 Genomic DNA Translation: AAB60433.1 S76736 mRNA Translation: AAB33958.1
CCDSⁱ	CCDS9064.1 [P42166-1]
PIRⁱ	G01161
RefSeqⁱ	NP_003267.1, NM_003276.2 [P42166-1]
UniGeneⁱ	Hs.11355

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GJJ	NMR	-	A	1-168	[»]
	1H9E	NMR	-	A	2-57	[»]
	1H9F	NMR	-	A	103-159	[»]
ProteinModelPortalⁱ	P42166
SMRⁱ	P42166
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112967, 117 interactors
IntActⁱ	P42166, 42 interactors
MINTⁱ	P42166
STRINGⁱ	9606.ENSP00000266732

PTM databases

iPTMnetⁱ	P42166
SwissPalmⁱ	P42166

Polymorphism and mutation databases

BioMutaⁱ	DLC1
DMDMⁱ	1174689

Proteomic databases

EPDⁱ	P42166
PaxDbⁱ	P42166
PeptideAtlasⁱ	P42166
PRIDEⁱ	P42166
ProteomicsDBⁱ	55488

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7112
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000266732; ENSP00000266732; ENSG00000120802 [P42166-1]
GeneIDⁱ	7112
UCSCⁱ	uc001tfh.3 human [P42166-1]

Organism-specific databases

CTDⁱ	7112
DisGeNETⁱ	7112
EuPathDBⁱ	HostDB:ENSG00000120802.13
GeneCardsⁱ	TMPO
GeneReviewsⁱ	TMPO
HGNCⁱ	HGNC:11875 TMPO
HPAⁱ	CAB009847
MalaCardsⁱ	TMPO
MIMⁱ	188380 gene
neXtProtⁱ	NX_P42166
OpenTargetsⁱ	ENSG00000120802
PharmGKBⁱ	PA36576
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IT7C Eukaryota ENOG4111J0N LUCA
GeneTreeⁱ	ENSGT00510000048934
HOGENOMⁱ	HOG000060228
HOVERGENⁱ	HBG081890
InParanoidⁱ	P42166
OrthoDBⁱ	EOG091G03A8
PhylomeDBⁱ	P42166
TreeFamⁱ	TF328426

Miscellaneous databases

ChiTaRSⁱ	TMPO human
EvolutionaryTraceⁱ	P42166
GeneWikiⁱ	Thymopoietin
GenomeRNAiⁱ	7112
PMAP-CutDBⁱ	P42166
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000120802 Expressed in 223 organ(s), highest expression level in intestine
CleanExⁱ	HS_TMPO
ExpressionAtlasⁱ	P42166 baseline and differential
Genevisibleⁱ	P42166 HS

Family and domain databases

Gene3Dⁱ	1.10.720.40, 2 hits
InterProⁱ	View protein in InterPro IPR021623 LAP2alpha_C IPR013146 LEM-like_dom IPR011015 LEM/LEM-like_dom_sf IPR003887 LEM_dom
Pfamⁱ	View protein in Pfam PF11560 LAP2alpha, 1 hit PF03020 LEM, 1 hit PF08198 Thymopoietin, 1 hit
SMARTⁱ	View protein in SMART SM00540 LEM, 1 hit SM01261 Thymopoietin, 1 hit
SUPFAMⁱ	SSF63451 SSF63451, 2 hits
PROSITEⁱ	View protein in PROSITE PS50954 LEM, 1 hit PS50955 LEM_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LAP2A_HUMAN
Accessionⁱ	P42166Primary (citable) accession number: P42166 Secondary accession number(s): P08918 , P08919, Q14860, Q16295
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 196 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P42166 (LAP2A_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Lamina-associated polypeptide 2, isoform alpha

TMPO

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ