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UniProtKB - P42166 (LAP2A_HUMAN)

Entry version 215 (02 Jun 2021)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Lamina-associated polypeptide 2, isoform alpha

Gene

TMPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.

TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Caution

TMPO was originally considered a good candidate for dilated cardiomyopathy, and variant Cys-290 has been reported to be a likely pathogenic mutation (PubMed:16247757). However, Cys-290 has a high allele frequency and individuals homozygous for the variant have been reported in ExAC database. Therefore, this variant has been reclassified as a likely benign polymorphism (PubMed:27896284).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P42166

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lamina-associated polypeptide 2, isoform alpha
Alternative name(s):
Thymopoietin isoform alpha
Short name:
TP alpha
Thymopoietin-related peptide isoform alpha
Short name:
TPRP isoform alpha
Cleaved into the following 2 chains:
Thymopoietin
Short name:
TP
Alternative name(s):
Splenin
Thymopentin
Alternative name(s):
TP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMPO
Synonyms:LAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11875, TMPO

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		188380, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P42166

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120802.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Used in primary and secondary immune deficiencies, autoimmunity, infections and cancer.

Keywords - Diseasei

Cardiomyopathy

Organism-specific databases

DisGeNET

More...DisGeNETi		7112

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TMPO

MalaCards human disease database

More...MalaCardsi		TMPO

Open Targets

More...OpenTargetsi		ENSG00000120802

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36576

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P42166, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMPO

Domain mapping of disease mutations (DMDM)

More...DMDMi		1174689

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000176742 – 694Lamina-associated polypeptide 2, isoform alphaAdd BLAST693
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_00000176752 – 50ThymopoietinAdd BLAST49
PeptideiPRO_000001767633 – 37Thymopentin5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57PhosphothreonineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei74PhosphothreonineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei86Omega-N-methylarginineBy similarity1
Modified residuei88Omega-N-methylarginineBy similarity1
Modified residuei154PhosphothreonineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei159PhosphoserineBy similarity1
Modified residuei160PhosphothreonineCombined sources1
Modified residuei164PhosphothreonineCombined sources1
Modified residuei166PhosphoserineBy similarity1
Modified residuei168PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei656N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in a mitose-specific manner.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-949

Encyclopedia of Proteome Dynamics

More...EPDi		P42166

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P42166

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P42166

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P42166

PeptideAtlas

More...PeptideAtlasi		P42166

PRoteomics IDEntifications database

More...PRIDEi		P42166

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55488 [P42166-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P42166, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P42166

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P42166

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P42166

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues. Most abundant in adult thymus and fetal liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120802, Expressed in intestine and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P42166, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P42166, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120802, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages.

Interacts with CMTM6 (PubMed:28813417).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112967, 458 interactors

Protein interaction database and analysis system

More...IntActi		P42166, 56 interactors

Molecular INTeraction database

More...MINTi		P42166

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000266732

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P42166, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1694
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P42166

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P42166

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P42166

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 48LEM-likePROSITE-ProRule annotationAdd BLAST44
Domaini109 – 153LEMPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 117DisorderedSequence analysisAdd BLAST71
Regioni49 – 108LinkerAdd BLAST60
Regioni150 – 209DisorderedSequence analysisAdd BLAST60
Regioni338 – 368DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili558 – 657By similarityAdd BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi190 – 196Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi93 – 110Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi153 – 179Polar residuesSequence analysisAdd BLAST27
Compositional biasi180 – 202Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
The C-terminal domain forms a four-stranded coiled coil.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LEM family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWCI, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154098

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_397364_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P42166

Database of Orthologous Groups

More...OrthoDBi		323585at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P42166

TreeFam database of animal gene trees

More...TreeFami		TF328426

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.720.40, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021623, LAP2alpha_C
IPR013146, LEM-like_dom
IPR011015, LEM/LEM-like_dom_sf
IPR003887, LEM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11560, LAP2alpha, 1 hit
PF03020, LEM, 1 hit
PF08198, Thymopoietin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00540, LEM, 1 hit
SM01261, Thymopoietin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF63451, SSF63451, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50954, LEM, 1 hit
PS50955, LEM_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P42166-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR 
        60         70         80         90        100
PPLPAGTNSK GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD 
       110        120        130        140        150
KPRQEDKDDL DVTELTNEDL LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR 
       160        170        180        190        200
EQGTESRSST PLPTISSSAE NTRQNGSNDS DRYSDNEEGK KKEHKKVKST 
       210        220        230        240        250
RDIVPFSELG TTPSGGGFFQ GISFPEISTR PPLGSTELQA AKKVHTSKGD 
       260        270        280        290        300
LPREPLVATN LPGRGQLQKL ASERNLFISC KSSHDRCLEK SSSSSSQPEH 
       310        320        330        340        350
SAMLVSTAAS PSLIKETTTG YYKDIVENIC GREKSGIQPL CPERSHISDQ 
       360        370        380        390        400
SPLSSKRKAL EESESSQLIS PPLAQAIRDY VNSLLVQGGV GSLPGTSNSM 
       410        420        430        440        450
PPLDVENIQK RIDQSKFQET EFLSPPRKVP RLSEKSVEER DSGSFVAFQN 
       460        470        480        490        500
IPGSELMSSF AKTVVSHSLT TLGLEVAKQS QHDKIDASEL SFPFHESILK 
       510        520        530        540        550
VIEEEWQQVD RQLPSLACKY PVSSREATQI LSVPKVDDEI LGFISEATPL 
       560        570        580        590        600
GGIQAASTES CNQQLDLALC RAYEAAASAL QIATHTAFVA KAMQADISQA 
       610        620        630        640        650
AQILSSDPSR THQALGILSK TYDAASYICE AAFDEVKMAA HTMGNATVGR 
       660        670        680        690 
RYLWLKDCKI NLASKNKLAS TPFKGGTLFG GEVCKVIKKR GNKH
Length:694
Mass (Da):75,492
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B514B0FB61D0D75
GO
Isoform Beta (identifier: P42167-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P42167.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:454
Mass (Da):50,670
GO
Isoform Gamma (identifier: P42167-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P42167.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:345
Mass (Da):38,738
GO
Isoform Zeta (identifier: P42167-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P42167.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:248
Mass (Da):27,388
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E972G5E972_HUMAN
Lamina-associated polypeptide 2, is...
TMPO hCG_2015322
414Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJH7H0YJH7_HUMAN
Lamina-associated polypeptide 2, is...
TMPO
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049773238L → R. Corresponds to variant dbSNP:rs35998138Ensembl.1
Natural variantiVAR_049774293S → A. Corresponds to variant dbSNP:rs35645287Ensembl.1
Natural variantiVAR_049775317T → S. Corresponds to variant dbSNP:rs35969221Ensembl.1
Natural variantiVAR_049776416K → E. Corresponds to variant dbSNP:rs11838270Ensembl.1
Natural variantiVAR_049777478K → N. Corresponds to variant dbSNP:rs35761089Ensembl.1
Natural variantiVAR_005635599Q → E1 PublicationCorresponds to variant dbSNP:rs17459334Ensembl.1
Natural variantiVAR_049778690R → C Affects the interaction with LMNA. 1 PublicationCorresponds to variant dbSNP:rs17028450Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U09086 mRNA Translation: AAB60329.1
U18270 U18268 Genomic DNA Translation: AAB60433.1
S76736 mRNA Translation: AAB33958.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9064.1 [P42166-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G01161

NCBI Reference Sequences

More...RefSeqi		NP_003267.1, NM_003276.2 [P42166-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000266732; ENSP00000266732; ENSG00000120802 [P42166-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7112

UCSC genome browser

More...UCSCi		uc001tfh.3, human [P42166-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09086 mRNA Translation: AAB60329.1
U18270 U18268 Genomic DNA Translation: AAB60433.1
S76736 mRNA Translation: AAB33958.1
CCDSiCCDS9064.1 [P42166-1]
PIRiG01161
RefSeqiNP_003267.1, NM_003276.2 [P42166-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GJJNMR-A1-168[»]
1H9ENMR-A2-57[»]
1H9FNMR-A103-159[»]
BMRBiP42166
SMRiP42166
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112967, 458 interactors
IntActiP42166, 56 interactors
MINTiP42166
STRINGi9606.ENSP00000266732

PTM databases

GlyGeniP42166, 2 sites
iPTMnetiP42166
MetOSiteiP42166
SwissPalmiP42166

Genetic variation databases

BioMutaiTMPO
DMDMi1174689

Proteomic databases

CPTACiCPTAC-949
EPDiP42166
jPOSTiP42166
MassIVEiP42166
PaxDbiP42166
PeptideAtlasiP42166
PRIDEiP42166
ProteomicsDBi55488 [P42166-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2387, 380 antibodies

The DNASU plasmid repository

More...DNASUi		7112

Genome annotation databases

EnsembliENST00000266732; ENSP00000266732; ENSG00000120802 [P42166-1]
GeneIDi7112
UCSCiuc001tfh.3, human [P42166-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7112
DisGeNETi7112

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMPO
GeneReviewsiTMPO
HGNCiHGNC:11875, TMPO
HPAiENSG00000120802, Tissue enhanced (lymphoid)
MalaCardsiTMPO
MIMi188380, gene
neXtProtiNX_P42166
OpenTargetsiENSG00000120802
PharmGKBiPA36576
VEuPathDBiHostDB:ENSG00000120802.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWCI, Eukaryota
GeneTreeiENSGT00940000154098
HOGENOMiCLU_397364_0_0_1
InParanoidiP42166
OrthoDBi323585at2759
PhylomeDBiP42166
TreeFamiTF328426

Enzyme and pathway databases

PathwayCommonsiP42166

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7112, 12 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMPO, human
EvolutionaryTraceiP42166

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Thymopoietin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7112
PharosiP42166, Tbio
RNActiP42166, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120802, Expressed in intestine and 237 other tissues
ExpressionAtlasiP42166, baseline and differential
GenevisibleiP42166, HS

Family and domain databases

Gene3Di1.10.720.40, 2 hits
InterProiView protein in InterPro
IPR021623, LAP2alpha_C
IPR013146, LEM-like_dom
IPR011015, LEM/LEM-like_dom_sf
IPR003887, LEM_dom
PfamiView protein in Pfam
PF11560, LAP2alpha, 1 hit
PF03020, LEM, 1 hit
PF08198, Thymopoietin, 1 hit
SMARTiView protein in SMART
SM00540, LEM, 1 hit
SM01261, Thymopoietin, 1 hit
SUPFAMiSSF63451, SSF63451, 2 hits
PROSITEiView protein in PROSITE
PS50954, LEM, 1 hit
PS50955, LEM_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAP2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42166
Secondary accession number(s): P08918
, P08919, Q14860, Q16295
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 215 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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